X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (43) 43
animals (36) 36
humans (36) 36
mice (33) 33
male (32) 32
rheumatology (30) 30
female (29) 29
middle aged (26) 26
scleroderma, systemic - metabolism (24) 24
disease models, animal (23) 23
fibroblasts (23) 23
fibroblasts - metabolism (22) 22
systemic-sclerosis (22) 22
scleroderma, systemic - pathology (21) 21
adult (20) 20
aged (20) 20
disease (20) 20
fibrosis (20) 20
extracellular-matrix (19) 19
research (19) 19
scleroderma (19) 19
cells, cultured (18) 18
collagen (15) 15
proteins (15) 15
mice, knockout (14) 14
skin - metabolism (14) 14
skin - pathology (14) 14
gene expression (13) 13
immunoglobulins (13) 13
abridged index medicus (12) 12
experimental dermal fibrosis (12) 12
transforming growth factor beta - metabolism (12) 12
care and treatment (11) 11
case-control studies (11) 11
extracellular matrix (11) 11
fibroblasts - drug effects (11) 11
systemic scleroderma (11) 11
fibroblasts - pathology (10) 10
fibrosis - chemically induced (10) 10
fibrosis - metabolism (10) 10
fibrosis - pathology (10) 10
growth-factor-beta (10) 10
scleroderma, systemic - genetics (10) 10
signal transduction - physiology (10) 10
young adult (10) 10
cerebrospinal fluid (9) 9
clinical trials (9) 9
dermal fibrosis (9) 9
kinases (9) 9
pathogenesis (9) 9
rodents (9) 9
signal transduction - drug effects (9) 9
transforming growth factors (9) 9
biopsy (8) 8
bleomycin - toxicity (8) 8
creutzfeldt-jakob disease (8) 8
kinase (8) 8
mice, inbred c57bl (8) 8
mortality (8) 8
skin - drug effects (8) 8
studies (8) 8
collagen - metabolism (7) 7
expression (7) 7
medical research (7) 7
prion diseases (7) 7
risk factors (7) 7
skin (7) 7
610 medicine & health (6) 6
dementia (6) 6
experiments (6) 6
fibroblast activation (6) 6
growth factors (6) 6
pathway (6) 6
rheumatology clinic and institute of physical medicine (6) 6
analysis (5) 5
biomarkers - cerebrospinal fluid (5) 5
clinical neurology (5) 5
dermis - pathology (5) 5
fibrosis - prevention & control (5) 5
inflammation (5) 5
inhibition (5) 5
líquid cefalorraquidi (5) 5
malalties per prions (5) 5
mechanisms (5) 5
mice, transgenic (5) 5
neurosciences (5) 5
prevention (5) 5
rna, small interfering - genetics (5) 5
scleroderma, systemic - prevention & control (5) 5
skin diseases - chemically induced (5) 5
skin diseases - pathology (5) 5
transforming growth factor beta - pharmacology (5) 5
activation (4) 4
alzheimers-disease (4) 4
article (4) 4
bleomycin (4) 4
cells (4) 4
creutzfeldt-jakob syndrome - diagnosis (4) 4
dosage and administration (4) 4
enzyme inhibitors - pharmacology (4) 4
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Annals of the Rheumatic Diseases, ISSN 0003-4967, 06/2014, Volume 73, Issue 6, pp. 1232 - 1239
Objectives Activated Wnt signalling with decreased expression of endogenous inhibitors has recently been characterised as a central pathomechanism in systemic... 
TARGETED DISRUPTION | DNA METHYLATION | EPIGENETIC INACTIVATION | MOUSE MODEL | EXPERIMENTAL DERMAL FIBROSIS | TYROSINE KINASE INHIBITOR | SKIN FIBROSIS | FRIZZLED-RELATED PROTEIN-1 | EXTRACELLULAR-MATRIX | RHEUMATOLOGY | IDIOPATHIC PULMONARY-FIBROSIS | Leukocytes, Mononuclear - metabolism | Epigenesis, Genetic | Humans | Middle Aged | Male | DNA (Cytosine-5-)-Methyltransferases - antagonists & inhibitors | Promoter Regions, Genetic - genetics | Case-Control Studies | Young Adult | Adult | Female | Fibroblasts - metabolism | DNA (Cytosine-5-)-Methyltransferase 1 | Membrane Proteins - genetics | Enzyme Inhibitors - pharmacology | Intercellular Signaling Peptides and Proteins - genetics | Scleroderma, Systemic - genetics | Azacitidine - analogs & derivatives | DNA Methylation - genetics | Down-Regulation - drug effects | Down-Regulation - genetics | Azacitidine - pharmacology | Animals | Wnt Signaling Pathway - drug effects | Wnt Signaling Pathway - genetics | Fibroblasts - drug effects | Aged | Mice | DNA Methylation - drug effects | Polymerase chain reaction | Epigenetic inheritance | Usage | Systemic scleroderma | Methyltransferases | Scleroderma (Disease) | Research | Risk factors | Proteins | Enzymes | Immunoglobulins | DNA methylation | Epigenetics | Clinical trials | Fibroblasts | Extracellular matrix | Kinases | Gene expression | Deoxyribonucleic acid--DNA
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 04/2013, Volume 72, Issue 4, pp. 614 - 620
Objectives Epigenetic modifications such as DNA methylation and histone acetylation have been implicated in the pathogenesis of systemic sclerosis. However,... 
SCLERODERMA FIBROBLASTS | METHYLATION | EPIGENETICS | COLLAGEN EXPRESSION | DISEASE | EXTRACELLULAR-MATRIX | MECHANISMS | RHEUMATOLOGY | SYSTEMIC-SCLEROSIS | PREVENTS | T-CELLS | Scleroderma, Diffuse - metabolism | Fibroblasts - enzymology | Antibiotics, Antineoplastic - pharmacology | Humans | Middle Aged | Male | Fibrosis - metabolism | Epigenesis, Genetic - physiology | Young Adult | Scleroderma, Diffuse - pathology | Fos-Related Antigen-2 - metabolism | Jumonji Domain-Containing Histone Demethylases - antagonists & inhibitors | Scleroderma, Diffuse - chemically induced | Adult | Mice, Inbred DBA | Epigenesis, Genetic - drug effects | DNA Methylation - physiology | Disease Models, Animal | Fibrosis - chemically induced | Cells, Cultured | Enzyme Inhibitors - pharmacology | Fibroblasts - pathology | Collagen - metabolism | Animals | Bleomycin - pharmacology | Dermis - pathology | Mice | Fibrosis - pathology | Histones - metabolism | DNA Methylation - drug effects | Jumonji Domain-Containing Histone Demethylases - metabolism | Care and treatment | Fibrosis | Histones | Influence | Genetic aspects | Research | Methylation | Chromatin | Immunoglobulins | Disease | Pathogenesis | Gene expression | Experiments | Proteins | Studies | Biopsy | Collagen | DNA methylation | Epigenetics | Fibroblasts | Extracellular matrix | Deoxyribonucleic acid--DNA | Cancer
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 05/2012, Volume 71, Issue 5, pp. 785 - 789
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 03/2012, Volume 71, Issue 3, pp. 400 - 407
Background Osteophyte formation is a common phenomenon in arthritis. Bone formation by endochondral ossification is considered a key pathophysiological process... 
SPONDYLOARTHRITIS | LOCALIZATION | TUMOR-NECROSIS-FACTOR | BONE-FORMATION | ANKYLOSING-SPONDYLITIS | OSTEOARTHRITIS | RHEUMATOLOGY | ENDOCHONDRAL BONE | CHONDROCYTE | PROGRESSION | CARTILAGE | Arthritis, Experimental - drug therapy | Male | Hedgehog Proteins - physiology | Osteophyte - prevention & control | Biphenyl Compounds - therapeutic use | Arthritis, Experimental - pathology | Cell Differentiation - genetics | Osteophyte - pathology | Biphenyl Compounds - pharmacology | Cartilage, Articular - metabolism | Bone and Bones - metabolism | Smoothened Receptor | Receptors, G-Protein-Coupled - physiology | Chondrocytes - pathology | Drug Evaluation, Preclinical - methods | Osteophyte - etiology | Mice, Inbred C57BL | Arthritis, Experimental - complications | Hedgehog Proteins - antagonists & inhibitors | Periosteum - pathology | Up-Regulation - drug effects | Osteoblasts - pathology | Animals | Signal Transduction - drug effects | Receptors, G-Protein-Coupled - antagonists & inhibitors | Signal Transduction - physiology | Mice | Microscopy, Fluorescence | Hypertrophy | Enzyme inhibitors | Endochondral ossification | Physiological aspects | Development and progression | Dosage and administration | Bone spurs | Research | Hedgehog proteins | Proteins | Polyethylene glycol | Collagen | Colleges & universities | Arthritis | Inflammation
Journal Article
NATURE MEDICINE, ISSN 1078-8956, 02/2015, Volume 21, Issue 2, pp. 150 - 158
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 07/2011, Volume 70, Issue 7, pp. 1304 - 1310
Background Dermal fibroblasts from patients with systemic sclerosis (SSc) release excessive amounts of collagen resulting in tissue fibrosis. The molecular... 
CELLS | INHIBITION | ALAGILLE-SYNDROME | PATHWAY | MUTATIONS | RHEUMATOLOGY | EXPRESSION | PROMOTES | DERMAL FIBROSIS | HUMAN JAGGED1 | PROGRESSION | Fibroblasts - physiology | Skin - metabolism | Humans | Middle Aged | Scleroderma, Systemic - pathology | Calcium-Binding Proteins - antagonists & inhibitors | Male | Membrane Proteins - pharmacology | Dose-Response Relationship, Drug | Young Adult | Receptors, Notch - antagonists & inhibitors | Serrate-Jagged Proteins | Adult | Female | Skin - pathology | Fibroblasts - metabolism | Jagged-1 Protein | Myofibroblasts - pathology | Dipeptides - pharmacology | Extracellular Matrix - drug effects | Scleroderma, Systemic - metabolism | Cells, Cultured | Receptors, Notch - physiology | Recombinant Proteins - pharmacology | Collagen - metabolism | Membrane Proteins - antagonists & inhibitors | Cell Differentiation - drug effects | Intercellular Signaling Peptides and Proteins - pharmacology | Fibroblasts - drug effects | Signal Transduction - physiology | Aged | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Calcium-Binding Proteins - pharmacology | Physiological aspects | Fibroblasts | Research | Systemic scleroderma | Collagen | Scleroderma (Disease) | Proteins | Immunoglobulins | Pulmonary fibrosis | Biopsy | Clinical trials | Ligands | Smooth muscle | Extracellular matrix | Growth factors
Journal Article
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 01/2017, Volume 76, Issue 1, pp. 244 - 251
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 06/2015, Volume 74, Issue 6, pp. 1317 - 1324
Journal Article