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Journal Article
Nature, ISSN 0028-0836, 04/2015, Volume 520, Issue 7546, pp. 186 - 191
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 01/2017, Volume 13, Issue 1, pp. 9 - 11
Journal Article
Nature Communications, ISSN 2041-1723, 05/2017, Volume 8, Issue 1, p. 15058
Precisely measuring the location and frequency of DNA double-strand breaks (DSBs) along the genome is instrumental to understanding genomic fragility, but... 
RECOMBINATION | SPECIFICITIES | CAS9 NUCLEASES | ENDONUCLEASES | HUMAN-CELLS | MULTIDISCIPLINARY SCIENCES | OFF-TARGET CLEAVAGE | CPF1 | GAMMA-H2AX | CRISPR-CAS9 | SEQ
Journal Article
Nature Communications, ISSN 2041-1723, 12/2019, Volume 10, Issue 1, pp. 212 - 8
The type-V CRISPR effector Cas12b (formerly known as C2c1) has been challenging to develop for genome editing in human cells, at least in part due to the high... 
COMPLEX | ENDONUCLEASE | RNA | RECOGNITION | MULTIDISCIPLINARY SCIENCES | DIVERSITY | CLEAVAGE | Temperature requirements | CRISPR | Lymphocytes | Cell lines | Genomes | Lymphocytes T | Nuclease | High temperature | Mutation | Ribonucleic acid--RNA | Genetic modification | Deoxyribonucleic acid--DNA
Journal Article
Molecular Cell, ISSN 1097-2765, 08/2017, Volume 67, Issue 4, pp. 633 - 645.e3
The RNA-guided Cpf1 (also known as Cas12a) nuclease associates with a CRISPR RNA (crRNA) and cleaves the double-stranded DNA target complementary to the crRNA... 
CRISPR-Cas | Cpf1 | crystal structure | protospacer adjacent motif | Cas12a | SYSTEM | COMPLEX | ENDONUCLEASE | DUAL-RNA | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CPF1 | GUIDE RNA | CAS9 | TARGET DNA RECOGNITION | REVEALS | CELL BIOLOGY | CRISPR-Associated Proteins - chemistry | Endonucleases - genetics | Nucleic Acid Heteroduplexes - genetics | RNA, Guide - genetics | RNA, Guide - metabolism | Humans | Bacterial Proteins - chemistry | Crystallography, X-Ray | Structure-Activity Relationship | Endonucleases - metabolism | Nucleic Acid Heteroduplexes - metabolism | RNA, Guide - chemistry | Clustered Regularly Interspaced Short Palindromic Repeats | HEK293 Cells | Clostridiales - genetics | Acidaminococcus - genetics | Nucleic Acid Conformation | Binding Sites | Escherichia coli - enzymology | CRISPR-Associated Proteins - genetics | Bacterial Proteins - genetics | Models, Molecular | Acidaminococcus - enzymology | DNA - metabolism | Endonucleases - chemistry | Nucleic Acid Heteroduplexes - chemistry | DNA - genetics | DNA - chemistry | Escherichia coli - genetics | CRISPR-Associated Proteins - metabolism | CRISPR-Cas Systems | Protein Binding | Bacterial Proteins - metabolism | Protein Conformation | Clostridiales - enzymology | Nucleases | DNA binding proteins | RNA | Structure | Genomics | Crystals | Enzymes
Journal Article