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Journal of Cellular Biochemistry, ISSN 0730-2312, 10/2013, Volume 114, Issue 10, pp. 2415 - 2429
Journal Article
Journal Article
Frontiers in pharmacology, ISSN 1663-9812, 2017, Volume 8, p. 975
The NLRP3 inflammasome plays a critical role in mediating the innate immune defense against pathogenic infections, but aberrant activation of NLRP3... 
Journal Article
Oncotarget, ISSN 1949-2553, 2017, Volume 8, Issue 1, pp. 95 - 109
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2015, Volume 10, Issue 5, p. e0124355
Cucurbitacins, the natural triterpenoids possessing many biological activities, have been reported to suppress the mTORC1/p70S6K pathway and to induce... 
ACTIN AGGREGATION | CELLS | APOPTOSIS | ACTIVATED PROTEIN-KINASE | PHOSPHORYLATION | PATHWAY | MULTIDISCIPLINARY SCIENCES | GROWTH | P62/SQSTM1 | CANCER | COFILIN | RNA, Small Interfering - genetics | AMP-Activated Protein Kinases - metabolism | Triterpenes - pharmacology | Microtubule-Associated Proteins - genetics | TOR Serine-Threonine Kinases - metabolism | Microtubule-Associated Proteins - metabolism | Humans | Gene Expression Regulation, Neoplastic | Multiprotein Complexes - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Autophagy - drug effects | Autophagy-Related Protein-1 Homolog | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - antagonists & inhibitors | TOR Serine-Threonine Kinases - antagonists & inhibitors | Multiprotein Complexes - metabolism | Lysosomes - metabolism | TOR Serine-Threonine Kinases - genetics | MCF-7 Cells | Phosphorylation - drug effects | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Lysosomes - drug effects | Cell Survival - drug effects | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Signal Transduction | Ribosomal Protein S6 Kinases, 70-kDa - antagonists & inhibitors | Lysosomal-Associated Membrane Protein 2 - genetics | Protein-Serine-Threonine Kinases - genetics | Ribosomal Protein S6 Kinases, 70-kDa - genetics | Microtubule-Associated Proteins - antagonists & inhibitors | Autophagy-Related Protein 5 | Cell Line, Tumor | HeLa Cells | Antineoplastic Agents, Phytogenic - pharmacology | AMP-Activated Protein Kinases - genetics | Lysosomal-Associated Membrane Protein 2 - metabolism | RNA, Small Interfering - metabolism | Molecular mechanics | Cytoskeleton | Research | Protein kinases | Analysis | Cucurbitaceae | TOR protein | Phosphorylation | Triterpenoids | Homeostasis | Activation | Kinases | Autophagy | Substrates | Recruitment | Signaling | Penicillin | Life sciences | Human behavior | Adapter proteins | Phagocytosis | Cancer
Journal Article
Frontiers in Pharmacology, ISSN 1663-9812, 01/2018, Volume 8
The NLRP3 inflammasome plays a critical role in mediating the innate immune defense against pathogenic infections, but aberrant activation of NLRP3... 
Protein kinase A | Scutellarin | Pyroptosis | Macrophages | NLRP3 inflammasome | BV-2 MICROGLIA | MECHANISM | INJURY | PYROPTOTIC CELL-DEATH | pyroptosis | macrophages | INHIBITION | DISEASES | PATHWAY | SEPTIC SHOCK | PHARMACOLOGY & PHARMACY | protein kinase A | GASDERMIN-D | CEREBRAL-ISCHEMIA | scutellarin | Flavonoids | Care and treatment | Flavones | Bioflavonoids | Sepsis | Development and progression | Health aspects
Journal Article
by Zeng, QZ and Yang, F and Li, CG and Xu, LH and He, XH and Mai, FY and Zeng, CY and Zhang, CC and Zha, QB and Ouyang, DY
FRONTIERS IN IMMUNOLOGY, ISSN 1664-3224, 01/2019, Volume 10, p. 72
Microtubules play critical roles in regulating the activation of NLRP3 inflammasome and microtubule-destabilizing agents such as colchicine have been shown to... 
paclitaxel | MICROTUBULES | IMMUNOLOGY | NLRP3 inflammasome | CELL-LINES | CANCER | SIRT2 | epothilone B | COLCHICINE | TAXOL | MEC-17 | HOST-DEFENSE | DIFFERENTIATION | TUBULIN | BINDING | CYTOTOXICITY | alpha-tubulin acetylation | Dosage and administration | Immune response | Research | Macrophages | Paclitaxel | α-tubulin acetylation
Journal Article
Journal Article
Oncotarget, ISSN 1949-2553, 2015, Volume 6, Issue 32, pp. 32468 - 32483
Pepper, a daily-used seasoning for promoting appetite, is widely used in folk medicine for treating gastrointestinal diseases. Piperine is the major alkaloid... 
Bacterial infection | MTORC1 | Piperine | SLC7A5/SLC3A2 | Peritoneal macrophages | Immunology and Microbiology Section | Immune response and Immunity | CELLS | COMPLEX | SIGNALS | piperine | bacterial infection | MTOR | CELL BIOLOGY | RESPONSES | AMINO-ACIDS | INFLAMMATION | IN-VIVO | peritoneal macrophages | INHIBITOR | mTORC1 | EXPRESSION
Journal Article
Inflammation, ISSN 0360-3997, 6/2015, Volume 38, Issue 3, pp. 1093 - 1102
The anti-inflammatory effect of piperine has been largely investigated in macrophages, but its activity on epithelial cells in inflammatory settings is... 
Pathology | CXCL8 | Medicine & Public Health | Rheumatology | Internal Medicine | piperine | epithelial-like cells | Pharmacology/Toxicology | lipopolysaccharide | MAPKs | APOPTOSIS | INVOLVEMENT | MONOCYTES | RECEPTOR | IMMUNOLOGY | IL-8 | INTESTINAL EPITHELIAL-CELLS | CELL BIOLOGY | RESPONSES | PEPTIDE-1 INTERLEUKIN-8 | CYTOKINE PRODUCTION | INHIBITION | Inflammatory Bowel Diseases - drug therapy | Cell Line | Cell Survival - drug effects | Interleukin-8 - genetics | Alkaloids - pharmacology | Epithelial Cells - metabolism | Anti-Inflammatory Agents - pharmacology | Interleukin-8 - biosynthesis | Down-Regulation | Humans | JNK Mitogen-Activated Protein Kinases - biosynthesis | RNA, Messenger - genetics | p38 Mitogen-Activated Protein Kinases - biosynthesis | NF-kappa B - metabolism | Lipopolysaccharides | HT29 Cells | MAP Kinase Signaling System - drug effects | Piperidines - pharmacology | Inflammation - drug therapy | Polyunsaturated Alkamides - pharmacology | Cell Proliferation - drug effects | Interleukin-8 - metabolism | Benzodioxoles - pharmacology | Mitogen-Activated Protein Kinases - metabolism | Prevention | Complications and side effects | Heterocyclic aromatic compounds | Physiological aspects | Development and progression | Dosage and administration | Inflammation | Genetic aspects | Research | Mitogen-activated protein kinases
Journal Article
Journal of Proteomics, ISSN 1874-3919, 09/2011, Volume 74, Issue 10, pp. 2180 - 2193
Gossypol (GOS), a BH3 mimetic, has been investigated as a sensitizing co-therapy to radiation and chemotherapy in treatment of metastatic prostate cancer. In... 
Valproic acid | Synergistic activity | Gossypol | Prostate cancer | DNA damage | APOPTOSIS | STRAND BREAK REPAIR | PROTEIN-KINASE | DNA-DAMAGE | BIOCHEMICAL RESEARCH METHODS | HISTONE H2AX | LYSINE ACETYLATION | IN-VITRO | ENDOPLASMIC-RETICULUM | UP-REGULATION | TRANSFORMED-CELLS | Proteins | Divalproex | Glucose metabolism | Chemotherapy | Nuclear radiation | Analysis | Cancer cells | Physiological aspects | Cancer
Journal Article