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1. Full Text Photoinduced Electron Transfer of DNA/Ag Nanoclusters Modulated by G‑Quadruplex/Hemin Complex for the Construction of Versatile Biosensors
by Zhang, Libing and Zhu, Jinbo and Guo, Shaojun and Li, Tao and Li, Jing and Wang, Erkang
Journal of the American Chemical Society, ISSN 0002-7863, 02/2013, Volume 135, Issue 7, pp. 2403 - 2406
Photoinduced electron transfer (PET) has been observed for the first time between DNA/Ag fluorescent nanoclusters (NCs) and G-quadruplex/hemin complexes,... 
FLUORESCENT SILVER NANOCLUSTERS | AG NANOCLUSTERS | FLUOROPHORES | MOLECULAR BEACONS | SENSING PLATFORM | CDSE/ZNS QUANTUM DOTS | SENSORS | CHEMISTRY, MULTIDISCIPLINARY | CARBON NANOTUBES | PROBES | WATER | Fluorescent Dyes - chemistry | DNA - chemistry | Electron Transport | Metal Nanoparticles - chemistry | Biosensing Techniques | Silver - chemistry | Hemin - chemistry | G-Quadruplexes | Usage | Protein folding | Research | Nucleotide sequencing | Biosensors | Electron transport | Methods | DNA sequencing
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2. Full Text DNA-grafted hemin with preferable catalytic properties than G-quadruplex/hemin for fluorescent miRNA biosensing
by Li, Jia and Yuan, Taixian and Yang, Tiantian and Xu, Lulu and Zhang, Lutan and Huang, Lizhen and Cheng, Wei and Ding, Shijia
Sensors & Actuators: B. Chemical, ISSN 0925-4005, 10/2018, Volume 271, pp. 239 - 246
Nucleic acids-based hemin mimetic enzymes have attracted substantial attention as catalysts in extensive biosensing applications. But the reformative modes and... 
Catalytic activity | Biomimetic enzyme | Biosensing | G-quadruplex/Hemin | DNA-grafted hemin | ELECTROCHEMISTRY | CHEMISTRY, ANALYTICAL | COMPLEX | OXIDE | CHEMILUMINESCENCE | PEROXIDASE-MIMICKING DNAZYME | SENSORS | NANOPARTICLES | INSTRUMENTS & INSTRUMENTATION | ENZYME | LABELS | Enzymes | Yuan (China) | Medical colleges | MicroRNA | Analysis | DNA | Genetic research | Cellular signal transduction
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3. Full Text A Supramolecular‐Hydrogel‐Encapsulated Hemin as an Artificial Enzyme to Mimic Peroxidase
by Wang, Qigang and Yang, Zhimou and Zhang, Xieqiu and Xiao, Xudong and Chang, Chi K and Xu, Bing
Angewandte Chemie International Edition, ISSN 1433-7851, 06/2007, Volume 46, Issue 23, pp. 4285 - 4289
Faking it: The use of a supramolecular hydrogel as the structural component of artificial enzymes provides a new and useful approach to the development of... 
enzyme mimetics | hydrogels | biotransformations | heterogeneous catalysis | hemin | Heterogeneous catalysis | Hemin | Hydrogels | Enzyme mimetics | Biotransformations | CATALYSIS | DESIGN | RECOGNITION | NANOFIBERS | ORGANOGEL | ORGANIC LIQUIDS | GELATION | CHEMISTRY, MULTIDISCIPLINARY | BIOMATERIALS | SMALL-MOLECULE HYDROGELS | MOSSBAUER | Particle Size | Hydrogel, Polyethylene Glycol Dimethacrylate - chemistry | Macromolecular Substances - chemistry | Oxidation-Reduction | Time Factors | Hemin - chemistry | Molecular Structure | Enzyme Activation | Horseradish Peroxidase - chemistry
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4. Full Text Fabrication of polyethyleneimine-functionalized reduced graphene oxide-hemin-bovine serum albumin (PEI-rGO-hemin-BSA) nanocomposites as peroxidase mimetics for the detection of multiple metabolites
by Zhang, Xiaoyue and Yu, You and Shen, Jinglin and Qi, Wei and Wang, Hua
Analytica Chimica Acta, ISSN 0003-2670, 09/2019, Volume 1070, pp. 80 - 87
The ultrasensitive bioassays are increasingly demanded for disease diagnosis and environmental monitoring. The combined unique natures of the components in... 
Polyethyleneimine-functionalized reduced graphene oxide | Nanocomposites | Metabolites | Hemin-bovine serum albumin | Peroxidase mimetics | GOLD NANOPARTICLES | graphene oxide | CATALYSIS | CHEMISTRY, ANALYTICAL | MAGNETIC NANOPARTICLES | H2O2 | PROBES | ARTIFICIAL ENZYME | METAL NANOCLUSTERS | GLUCOSE | Polyethyleneimine-functionalized reduced | SENSITIVE COLORIMETRIC DETECTION | HYDROGEN-PEROXIDE | Choline - metabolism | Nanocomposites - chemistry | Oxidation-Reduction | Humans | Lactic Acid - metabolism | Choline - analysis | Metabolic Diseases - diagnosis | Cholesterol - metabolism | Animals | Cattle | Polyethyleneimine - chemistry | Cholesterol - analysis | Glucose - metabolism | Hemin - chemistry | Serum Albumin, Bovine - chemistry | Graphite - chemistry | Glucose - analysis | Lactic Acid - analysis | Peroxidase - metabolism | Oxidases | Lactates | Crosslinked polymers | Graphene | Choline | Graphite | Albumin | Peroxidase | Glucose | Environmental monitoring | Dextrose | Lactate oxidase | Polyethyleneimine | Bovine serum albumin | Glucose oxidase | Bioassays | Crosslinking | Cholesterol oxidase | Serum albumin | Medical diagnosis | Disease control | Cholesterol | Fabrication | Hemin | Choline oxidase | Lactic acid | Diagnosis
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5. Full Text Enhanced Peroxidase‐Like Properties of Graphene–Hemin‐Composite Decorated with Au Nanoflowers as Electrochemical Aptamer Biosensor for the Detection of K562 Leukemia Cancer Cells
by Liu, Jing and Cui, Meirong and Niu, Li and Zhou, Hong and Zhang, Shusheng
Chemistry – A European Journal, ISSN 0947-6539, 12/2016, Volume 22, Issue 50, pp. 18001 - 18008
Graphene composites with hemin and gold nanoparticles show a better performance for hydrogen peroxide decomposition compared to that of the three components... 
gold | cancer cells | peroxidase mimics | aptamer biosensing | graphene | Aptamer biosensing | Gold | Peroxidase mimics | Graphene | Cancer cells | GOLD NANOPARTICLES | GLYCAN EXPRESSION | MIMETIC ACTIVITY | COLORIMETRIC DETECTION | TERNARY COMPOSITE | CHEMISTRY, MULTIDISCIPLINARY | QUANTUM DOTS | DYNAMIC EVALUATION | SYNERGISTIC CATALYST | METAL-ORGANIC FRAMEWORKS | SURFACE CARBOHYDRATE | Gold - chemistry | Leukemia - pathology | Electrochemical Techniques | Oxidation-Reduction | Humans | Metal Nanoparticles - chemistry | Peroxidase - chemistry | K562 Cells | Leukemia - diagnosis | Biosensing Techniques - methods | Catalysis | Graphite - chemistry | Peroxidase - metabolism | Hydrogen peroxide | Analysis | Leukemia | Graphite | Detectors | Peroxidase | Electric properties | Nanoparticles | Morphology | Nanostructure | Biosensors | Leukemias | Cancer
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6. DNA-grafted hemin with preferable catalytic properties than G-quadruplex/hemin for fluorescent miRNA biosensing
by Jia Li and Taixian Yuan and Tiantian Yang and Lulu Xu and Lutan Zhang and Lizhen Huang and Wei Cheng and Shijia Ding
Sensors and Actuators. Part B, Chemical, ISSN 0925-4005, 10/2018, Volume 271, p. 239
Nucleic acids-based hemin mimetic enzymes have attracted substantial attention as catalysts in extensive biosensing applications. But the reformative modes and... 
Enzymes | Properties (attributes) | Biomimetics | Catalysts | Reaction kinetics | Fluorescence | Oxidation | Catalytic activity | Catalysis | Nucleic acids | Biosensors | Deoxyribonucleic acid--DNA
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7. Full Text The Porphyromonas gingivalis ferric uptake regulator orthologue binds hemin and regulates hemin-responsive biofilm development
by Butler, Catherine A and Dashper, Stuart G and Zhang, Lianyi and Seers, Christine A and Mitchell, Helen L and Catmull, Deanne V and Glew, Michelle D and Heath, Jacqueline E and Tan, Yan and Khan, Hasnah S.G and Reynolds, Eric C
PLoS ONE, ISSN 1932-6203, 11/2014, Volume 9, Issue 11, p. e111168
Porphyromonas gingivalis is a Gram-negative pathogen associated with the biofilm-mediated disease chronic periodontitis. P. gingivalis biofilm formation is... 
IRON-METABOLISM | PROTEIN SECONDARY STRUCTURE | BACTEROIDES | MULTIDISCIPLINARY SCIENCES | STRAIN ATCC 33277 | ESCHERICHIA-COLI | GENE-EXPRESSION | FUR REPRESSOR | DEGRADATION | METAL UPTAKE | HELICOBACTER-PYLORI | Hemin - metabolism | DNA, Bacterial - genetics | Heme - metabolism | Biological Transport | DNA, Bacterial - metabolism | Bacterial Proteins - genetics | Biofilms - growth & development | Porphyromonas gingivalis - metabolism | Repressor Proteins - genetics | Bacterial Proteins - metabolism | Repressor Proteins - metabolism | Porphyromonas gingivalis - genetics | Iron compounds | Oxidative stress | Dental schools | Transcription | Genes | Gram-positive bacteria | Homeostasis | Iron | Proteins | Protoporphyrin | E coli | Heme | Bacteria | Gram-negative bacteria | Recombinant | Binding | Pathogens | Enzymes | RNA polymerase | Gene expression | Zinc | Biofilms | Hemin | Periodontitis | Oral hygiene | Genetic engineering | Dimers | Protoporphyrin IX | Binding sites
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8. Full Text Electrochemical non-enzyme sensor for detecting clenbuterol (CLB) based on MoS2-Au-PEI-hemin layered nanocomposites
by Yang, Dapeng and Yang, Yayun and Zhang, Huan and Huang, Chusen and Jia, Nengqing
Biosensors and Bioelectronics, ISSN 0956-5663, 03/2017, Volume 89, pp. 461 - 467
Clenbuterol (CLB), a kind of β -adrenergic agonists, could disrupt cardiovascular and central nervous system. In this work, a new electrochemical non-enzyme... 
Electrochemical non-enzyme sensor | Clenbuterol (CLB) | MoS2-Au-PEI-hemin nanocomposites | 2-D nanomaterial | MoS | Au-PEI-hemin nanocomposites | ELECTROCHEMISTRY | CHEMISTRY, ANALYTICAL | SALBUTAMOL | HEMIN | GRAPHENE | RACTOPAMINE | NANOSCIENCE & NANOTECHNOLOGY | CARBON NANOTUBES | MASS-SPECTROMETRY | NANOPARTICLES | BIOPHYSICS | MODIFIED ELECTRODE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | HYDROGEN-PEROXIDE | IMMUNOSENSOR | Index Medicus | Electrodes | Scanning electron microscopy | Nanocomposites | Central nervous system | Chromium | Nanostructure | Sensors | Biosensors
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9. Full Text Design strategy for a novel electrochemically active–inactive switching molecular beacon based on Hemin for SNPs and insulin detection directly in homogenous solution
by Dai, Shiyan and Zhang, Wei and Shao, Lin and Shao, Shuang and Tang, Yujiao and Liu, Ting and Cheng, Guifang and He, Pingang and Fang, Yuzhi
Talanta, ISSN 0039-9140, 12/2018, Volume 190, pp. 313 - 320
Herein, a novel and convenient electrochemically active–inactive switching molecular beacon based on hemin (Hs-MB) has been designed for easy discrimination of... 
Electrochemical detection | Hemin | Single nucleotide polymorphisms | Hs-MB | Insulin | CHEMISTRY, ANALYTICAL | Cell Line | Limit of Detection | Insulin - analysis | Glucose - pharmacology | Insulin - metabolism | Solutions | Insulin - chemistry | Electrochemistry | Hemin - chemistry | Biosensing Techniques - methods | Polymorphism, Single Nucleotide | Oligonucleotide Probes - chemistry | Insulin - genetics | Insulin Secretion | Pancreatic beta cells | Chromosomes | Electric properties
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10. Full Text A novel label-free and signal-on electrochemical aptasensor based on the autonomous assembly of hemin/G-quadruplex and direct electron transfer of hemin
by Wang, Suyun and Wang, Chunyan and Qian, Yong and Zhang, Yu and Meng, Siyao and Li, Yuanhong and Gao, Fenglei
Sensors & Actuators: B. Chemical, ISSN 0925-4005, 01/2017, Volume 238, pp. 434 - 440
In this study, we developed a signal-on and label-free aptasensor based on the direct electron transfer of hemin and signal amplification by target-catalyzed... 
Hemin | Label-free | Aptasensor | Signal-on | ELECTROCHEMISTRY | CHEMISTRY, ANALYTICAL | FLUORESCENCE POLARIZATION | THROMBIN DETECTION | SMALL-MOLECULE | APTAMER-BASED BIOSENSOR | FREE COLORIMETRIC APTASENSOR | ULTRASENSITIVE DETECTION | SENSITIVE DETECTION | ENZYME-FREE | INSTRUMENTS & INSTRUMENTATION | Label free | RECYCLING AMPLIFICATION | HYBRIDIZATION CHAIN-REACTION | Drugstores | Medical colleges | Sensors | Electron transport | Mass spectrometry | Pharmacy | Amplification | Electrodes | Proteins | Deoxyribonucleic acid | Migration | Electron transfer | Assembly
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11. Full Text Hemin protects against oxygen–glucose deprivation-induced apoptosis activation via neuroglobin in SH-SY5Y cells
by Wang, Yun-Jia and Peng, Qian-Yi and Deng, Song-Yun and Chen, Cai-Xia and Wu, Long and Huang, Li and Zhang, Li-Na
Neurochemical Research, ISSN 0364-3190, 8/2017, Volume 42, Issue 8, pp. 2208 - 2217
This study aimed to investigate the mechanism underlying the neuroprotective effect of hemin in oxygen–glucose deprivation (OGD)-treated neurons. OGD-treated... 
Neurochemistry | Biochemistry, general | Neurology | Neuroprotection | SH-SY5Y | Neurosciences | Biomedicine | Hemin | Neuroglobin | Oxygen–glucose deprivation | Cell Biology | OXIDATIVE STRESS | Oxygen-glucose deprivation | BIOCHEMISTRY & MOLECULAR BIOLOGY | INJURY | RATS | INDUCTION | NEUROSCIENCES | OVEREXPRESSION | HYPOXIC-ISCHEMIC ENCEPHALOPATHY | NEURONS | PROTEINS | BRAIN | Cell Survival - drug effects | Cell Hypoxia - drug effects | Cell Hypoxia - physiology | Apoptosis - drug effects | Humans | Globins - biosynthesis | Glucose - deficiency | Neuroprotective Agents - pharmacology | Nerve Tissue Proteins - biosynthesis | Cell Line, Tumor | Neurons - metabolism | Apoptosis - physiology | Hemin - pharmacology | Neurons - drug effects | Cell Survival - physiology | Cytochrome c | Analysis | Heme | Fluorescein | Glucose | Dextrose | Apoptosis | Cytochrome | Fluorescein isothiocyanate | Peroxiredoxin | Flow cytometry | Staining | Propidium iodide | Activation | Mitochondrial DNA | Thioredoxin | Neuroblastoma cells | Mitochondria | Cell activation | Transfection | Ischemia | Inhibition | Pretreatment | Activation analysis | Deprivation | Oxygen | Iodides | Heme oxygenase (decyclizing) | Isothiocyanate | siRNA | Oxygenase | Cytometry | Hypoxia | Annexin V | Viability
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12. Full Text Hemin immobilized into metal-organic frameworks as an electrochemical biosensor for 2,4,6-trichlorophenol
by Zhang, Ting and Wang, Lu and Gao, Congwei and Zhao, Chaoyue and Wang, Yang and Wang, Jianmin
Nanotechnology, ISSN 0957-4484, 01/2018, Volume 29, Issue 7, p. 074003
Hemin immobilized into copper-based metal-organic frameworks was successfully prepared and used as a new electrode material for sensitive electrochemical... 
electrochemical biosensor | hemin | Metal-organic frameworks | 2,4,6-trichlorophenol | CATALYSIS | PHYSICS, APPLIED | CARBON | PERFORMANCE | MATERIALS SCIENCE, MULTIDISCIPLINARY | CHLOROPHENOLS | NANOSCIENCE & NANOTECHNOLOGY | PEROXIDASE | FACILE SYNTHESIS | ENZYME | GAS-CHROMATOGRAPHY | ELECTRODE | SOLID-PHASE EXTRACTION
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13. Full Text Hemin impairs resolution of inflammation via microRNA‐144‐3p‐dependent downregulation of ALX/FPR2
by Sun, Guixiang and Lu, Yao and Zhao, Lu and Xia, Wenjun and Zhang, Han and Wang, Linfeng and Zhang, Linjing and Wen, Aiqing
Transfusion, ISSN 0041-1132, 01/2019, Volume 59, Issue 1, pp. 196 - 206
BACKGROUND The pathomechanisms of complications due to blood transfusion are not fully understood. Elevated levels of heme derived from stored RBCs are thought... 
STORAGE | RECRUITMENT | RECEPTOR 2 | THERAPY | NEUTROPHIL MIGRATION | TRANSFUSION | TOXICITY | DIFFERENTIATED HL-60 CELLS | HEMATOLOGY | BLOOD | MICRORNA | Animal models | Transfusion | RNA-directed DNA polymerase | Lipoxin A4 | Complications | MiRNA | Inflammatory response | Leukocytes (neutrophilic) | Inflammation | Ribonucleic acid--RNA | Assaying | Chemotaxis | Blood transfusion | Polymerase chain reaction | Proteins | White blood cells | Hemin | 3' Untranslated regions | Rodents | Heme | Infiltration | Inhibition | Peritonitis
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14. Full Text In Situ Generation of Electron Acceptor for Photoelectrochemical Biosensing via Hemin-Mediated Catalytic Reaction
by Zang, Yang and Lei, Jianping and Zhang, Lei and Ju, Huangxian
Analytical Chemistry, ISSN 0003-2700, 12/2014, Volume 86, Issue 24, pp. 12362 - 12368
A novel photoelectrochemical sensing strategy is designed for DNA detection on the basis of in situ generation of an electron acceptor via the catalytic... 
DNA DETECTION | LABEL-FREE | CHEMISTRY, ANALYTICAL | ELECTROCHEMICAL BIOSENSOR | PEROXIDASE-MIMICKING DNAZYME | CDSE/ZNS QUANTUM DOTS | GRAPHENE-SUPPORTED HEMIN | SYNERGETIC CATALYSIS | CARBON NANOTUBES | EXONUCLEASE III | SIGNAL AMPLIFICATION | Base Sequence | Biosensing Techniques | Hemin - chemistry | Electrochemical Techniques - methods | Catalysis | DNA Primers | Electrons | Photochemical Processes | Hydroxides | Chemical properties | Quantum dots | Analysis | Tellurium | Electric properties
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15. Full Text How Proximal Nucleobases Regulate the Catalytic Activity of G‑Quadruplex/Hemin DNAzymes
by Chen, Jielin and Zhang, Yingying and Cheng, Mingpan and Guo, Yuehua and Šponer, Jiri and Monchaud, David and Mergny, Jean-Louis and Ju, Huangxian and Zhou, Jun
ACS Catalysis, ISSN 2155-5435, 12/2018, Volume 8, Issue 12, pp. 11352 - 11361
G-quadruplexes (G4s) are versatile catalytic DNAs when combined with hemin. Despite the repertoire of catalytically competent G4/hemin complexes studied so... 
DNAzyme | G4/hemin complex | G4-based catalyst | proximal nucleobases | G-quartet | TOPOLOGY | RNA | REPAIR THYMINE DIMERS | COMPLEXES | CHEMISTRY, PHYSICAL | ACTIVITY ENHANCEMENT | PEROXIDASE-ACTIVITY | ENZYME | DNA | BINDING-SITE | INSIGHTS | Chemical Sciences | Catalysis
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