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1. Full Text Output Feedback Stabilization of Linear Systems With Actuator Saturation
by Fen Wu and Zongli Lin and Qian Zheng
IEEE Transactions on Automatic Control, ISSN 0018-9286, 01/2007, Volume 52, Issue 1, pp. 122 - 128
The note presents a method for designing an output feedback law that stabilizes a linear system subject to actuator saturation with a large domain of... 
Linear systems | State feedback | Design methodology | Nonlinear control systems | invariant set | Control systems | Linear matrix inequalities | Actuator saturation | Design optimization | Constraint optimization | Hydraulic actuators | domain of attraction | Output feedback | stability | Stability | Domain of attraction | Invariant set | DESIGN | GLOBAL STABILIZATION | AMPLITUDE | output feedback | DISTURBANCE | ENGINEERING, ELECTRICAL & ELECTRONIC | LMI APPROACH | PLACEMENT | BOUNDED CONTROLS | SUBJECT | actuator saturation | AUTOMATION & CONTROL SYSTEMS | Actuators | Research | Mathematical analysis | Matrices | Coefficients | Matrix methods
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2. Full Text High-fidelity CRISPR-Cas9 nucleases with no detectable genome-wide off-target effects
by Kleinstiver, Benjamin P and Pattanayak, Vikram and Prew, Michelle S and Tsai, Shengdar Q and Nguyen, Nhu T and Zheng, Zongli and Joung, J. Keith
Nature, ISSN 0028-0836, 01/2016, Volume 529, Issue 7587, pp. 490 - 495
CRISPR-Cas9 nucleases are widely used for genome editing but can induce unwanted off-target mutations. Existing strategies for reducing genome-wide off-target... 
COMPLEX | SPECIFICITY | DUAL-RNA | TALENS | DNA | MULTIDISCIPLINARY SCIENCES | RNA-GUIDED ENDONUCLEASE | INTERROGATION | CRISPR/CAS9 SYSTEMS | CAS9 | CLEAVAGE | Endonucleases - genetics | Reproducibility of Results | CRISPR-Associated Proteins - genetics | Humans | Substrate Specificity | DNA - metabolism | Endonucleases - metabolism | DNA-Binding Proteins - genetics | Sequence Analysis, DNA | Genome, Human - genetics | RNA - genetics | DNA - genetics | DNA-Binding Proteins - metabolism | Streptococcus pyogenes - genetics | Genetic Engineering | Base Sequence | CRISPR-Associated Proteins - metabolism | CRISPR-Cas Systems - physiology | Streptococcus pyogenes - enzymology | Protein Binding | Clustered Regularly Interspaced Short Palindromic Repeats - genetics | Mutation | Physiological aspects | Nucleases | Genetic aspects | Research | DNA binding proteins | Genetic variation | Genomes | Kinases | Experiments | Deoxyribonucleic acid--DNA
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3. Full Text GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases
by Tsai, Shengdar Q and Zheng, Zongli and Nguyen, Nhu T and Liebers, Matthew and Topkar, Ved V and Thapar, Vishal and Wyvekens, Nicolas and Khayter, Cyd and Iafrate, A John and Le, Long P and Aryee, Martin J and Joung, J Keith
Nature Biotechnology, ISSN 1087-0156, 2015, Volume 33, Issue 2, pp. 187 - 198
CRISPR RNA-guided nucleases (RGNs) are widely used genome-editing reagents, but methods to delineate their genome-wide, off-target cleavage activities have... 
ENDONUCLEASE | SPECIFICITY | DUAL-RNA | NICKASES | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | HUMAN-CELLS | DNA | SITES | SYSTEMS | IDENTIFICATION | REVEALS | Cell Line | RNA, Guide - genetics | Oligodeoxyribonucleotides - genetics | RNA Editing - genetics | Humans | High-Throughput Nucleotide Sequencing | Genome, Human | CRISPR-Cas Systems - genetics | DNA Breaks, Double-Stranded | Nucleases | Genome-wide association studies | Gene targeting | Research | RNA | Ribonucleic acid--RNA | Enzymes | Genomics
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4. Full Text Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition
by Kleinstiver, Benjamin P and Prew, Michelle S and Tsai, Shengdar Q and Nguyen, Nhu T and Topkar, Ved V and Zheng, Zongli and Joung, J. Keith
Nature Biotechnology, ISSN 1087-0156, 12/2015, Volume 33, Issue 12, pp. 1293 - 1298
CRISPR-Cas9 nucleases target specific DNA sequences using a guide RNA but also require recognition of a protospacer adjacent motif (PAM) by the Cas9 protein.... 
ENDONUCLEASE | EVOLUTION | DUAL-RNA | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | CRYSTAL-STRUCTURE | DNA | GUIDE RNA | CAS9 | NUCLEASES | Genetic aspects | Nucleotide sequencing | Gene expression | Observations | Methods | Staphylococcus aureus | DNA sequencing | Microbiology | Molecular biology | Bacteria
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5. Full Text Engineered CRISPR-Cas9 nucleases with altered PAM specificities
by Kleinstiver, Benjamin P and Prew, Michelle S and Tsai, Shengdar Q and Topkar, Ved V and Nguyen, Nhu T and Zheng, Zongli and Gonzales, Andrew P. W and Li, Zhuyun and Peterson, Randall T and Yeh, Jing-Ruey Joanna and Aryee, Martin J and Joung, J. Keith
Nature, ISSN 0028-0836, 07/2015, Volume 523, Issue 7561, pp. 481 - 485
Although CRISPR-Cas9 nucleases are widely used for genome editing(1,2), the range of sequences that Cas9 can recognize is constrained by the need for a... 
ENDONUCLEASE | RECOGNITION | DUAL-RNA | MULTIDISCIPLINARY SCIENCES | CAS9 | CLEAVAGE | DIRECTED EVOLUTION | Cell Line | Staphylococcus aureus - enzymology | Protein Engineering - methods | CRISPR-Associated Proteins - genetics | Humans | Genome - genetics | Streptococcus thermophilus - enzymology | Directed Molecular Evolution | Mutation - genetics | Substrate Specificity - genetics | Zebrafish - embryology | Zebrafish - genetics | Animals | Nucleotide Motifs | CRISPR-Associated Proteins - metabolism | Streptococcus pyogenes - enzymology | CRISPR-Cas Systems | Amino Acid Substitution - genetics | Clustered Regularly Interspaced Short Palindromic Repeats - genetics | Mutagenesis | Plasmids | Genes | Genetic engineering | Genomes | Mutation | Experiments | Binding sites
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6. Full Text Crizotinib in ROS1-Rearranged Non–Small-Cell Lung Cancer
by Shaw, Alice T and Ou, Sai-Hong I and Bang, Yung-Jue and Camidge, D. Ross and Solomon, Benjamin J and Salgia, Ravi and Riely, Gregory J and Varella-Garcia, Marileila and Shapiro, Geoffrey I and Costa, Daniel B and Doebele, Robert C and Le, Long Phi and Zheng, Zongli and Tan, Weiwei and Stephenson, Patricia and Shreeve, S. Martin and Tye, Lesley M and Christensen, James G and Wilner, Keith D and Clark, Jeffrey W and Iafrate, A. John
The New England Journal of Medicine, ISSN 0028-4793, 11/2014, Volume 371, Issue 21, pp. 1963 - 1971
About 1% of non–small-cell lung cancers have ROS1 rearrangements. This oncogene is inhibited by crizotinib. In a cohort of 50 patients with ROS1 -rearranged... 
ANAPLASTIC LYMPHOMA KINASE | RESISTANT | MEDICINE, GENERAL & INTERNAL | SAFETY | INHIBITORS | FUSIONS | ROS GENE | PROTEINS | TUMORS | Lung Neoplasms - drug therapy | Pyrazoles - therapeutic use | Humans | Middle Aged | Male | Protein Kinase Inhibitors - adverse effects | Protein-Tyrosine Kinases - genetics | Pyridines - adverse effects | Vision Disorders - chemically induced | Adult | Female | Pyrazoles - adverse effects | Pyridines - therapeutic use | Lung Neoplasms - genetics | Administration, Oral | Carcinoma, Non-Small-Cell Lung - genetics | Kaplan-Meier Estimate | In Situ Hybridization, Fluorescence | Proto-Oncogene Proteins - genetics | Treatment Outcome | Disease-Free Survival | Protein Kinase Inhibitors - therapeutic use | Gene Rearrangement | Aged | Carcinoma, Non-Small-Cell Lung - drug therapy | Tyrosine | Inhibitor drugs | Biomedical research | Lung cancer | Non-small cell lung carcinoma | Chromosome rearrangements | Kinases | Lymphoma | c-Met protein | Protein-tyrosine kinase receptors | Antitumor activity | Pharmacokinetics | Binding sites | Tumors
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7. Full Text Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility
by Yu, Min and Bardia, Aditya and Aceto, Nicola and Bersani, Francesca and Madden, Marissa W and Donaldson, Maria C and Desai, Rushil and Zhu, Huili and Comaills, Valentine and Zheng, Zongli and Wittner, Ben S and Stojanov, Petar and Brachtel, Elena and Sgroi, Dennis and Kapur, Ravi and Shioda, Toshihiro and Ting, David T and Ramaswamy, Sridhar and Getz, Gad and Iafrate, A. John and Benes, Cyril and Toner, Mehmet and Maheswaran, Shyamala and Haber, Daniel A
Science, ISSN 0036-8075, 2014, Volume 345, Issue 6193, pp. 216 - 220
Circulating tumor cells (CTCs) are present at low concentrations in the peripheral blood of patients with solid tumors. It has been proposed that the... 
POTENT | DOMAIN | MULTIDISCIPLINARY SCIENCES | ALPHA | MUTATIONS | INHIBITOR | IDENTIFICATION | CANCER | DISCOVERY | FAMILY | Oncology, Experimental | Cancer cells | Breast cancer | Research | Drug therapy | Drug allergy | Cancer | Cell culture | Tumors | Drugs | Mutations | Blood circulation | Breast | Patients | Blood | Culture
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8. Full Text East Asian summer monsoon precipitation variability since the last deglaciation
by Chen, Fahu and Xu, Qinghai and Chen, Jianhui and Birks, H. John B and Liu, Jianbao and Zhang, Shengrui and Jin, Liya and An, Chengbang and Telford, Richard J and Cao, Xianyong and Wang, Zongli and Zhang, Xiaojian and Selvaraj, Kandasamy and Lu, Houyuan and Li, Yuecong and Zheng, Zhuo and Wang, Haipeng and Zhou, Aifeng and Dong, Guanghui and Zhang, Jiawu and Huang, Xiaozhong and Bloemendal, Jan and Rao, Zhiguo
Scientific Reports, ISSN 2045-2322, 06/2015, Volume 5, Issue 1, p. 11186
The lack of a precisely-dated, unequivocal climate proxy from northern China, where precipitation variability is traditionally considered as an East Asian... 
ICE-AGE | MULTIDISCIPLINARY SCIENCES | HIGH-RESOLUTION | OXYGEN ISOTOPES | RECORD | INDIAN MONSOON | COLD EVENT | HOLOCENE | CHINESE LOESS PLATEAU | LAKE AREA | CLIMATE | Wind | Climate change | Climate | Precipitation | Temperature effects | Feedback
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9. Full Text Incidence of gastric cancer among patients with gastric precancerous lesions: observational cohort study in a low risk Western population
by Song, Huan and Ekheden, Isabella Guncha and Zheng, Zongli and Ericsson, Jan and Nyrén, Olof and Ye, Weimin
BMJ : British Medical Journal, ISSN 0959-8138, 7/2015, Volume 351, p. h3867
Objective To accurately measure the incidence of gastric cancer among patients with gastric precancerous lesions, and to quantify the excess incidence in... 
RESEARCH | DIAGNOSIS | MEDICINE, GENERAL & INTERNAL | INTESTINAL METAPLASIA | HELICOBACTER-PYLORI INFECTION | ATYPIA | ADENOCARCINOMA | DYSPLASIA | FOLLOW-UP | GASTROINTESTINAL ENDOSCOPY | ERADICATION | CARCINOMA
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10. Full Text Recurrent and functional regulatory mutations in breast cancer
by Rheinbay, Esther and Parasuraman, Prasanna and Grimsby, Jonna and Tiao, Grace and Engreitz, Jesse M and Kim, Jaegil and Lawrence, Michael S and Taylor-Weiner, Amaro and Rodriguez-Cuevas, Sergio and Rosenberg, Mara and Hess, Julian and Stewart, Chip and Maruvka, Yosef E and Stojanov, Petar and Cortes, Maria L and Seepo, Sara and Cibulskis, Carrie and Tracy, Adam and Pugh, Trevor J and Lee, Jesse and Zheng, Zongli and Ellisen, Leif W and Iafrate, A. John and Boehm, Jesse S and Gabriel, Stacey B and Meyerson, Matthew and Golub, Todd R and Baselga, Jose and Hidalgo-Miranda, Alfredo and Shioda, Toshi and Bernards, Andre and Lander, Eric S and Getz, Gad
Nature, ISSN 0028-0836, 07/2017, Volume 547, Issue 7661, pp. 55 - 60
Genomic analysis of tumours has led to the identification of hundreds of cancer genes on the basis of the presence of mutations in protein-coding regions. By... 
LUMINAL SUBTYPE | FOXA1 | TERT PROMOTER MUTATIONS | PROTEIN | LANDSCAPE | MULTIDISCIPLINARY SCIENCES | GENOME-WIDE ANALYSIS | EXPRESSION | SOMATIC MUTATIONS | DISCOVERY | ESTROGEN-RECEPTOR BINDING | Protein Binding - genetics | Humans | Receptors, Estrogen - antagonists & inhibitors | Hepatocyte Nuclear Factor 3-alpha - genetics | RNA, Long Noncoding - genetics | Promoter Regions, Genetic - genetics | E2F Transcription Factors - metabolism | Hepatocyte Nuclear Factor 3-alpha - metabolism | Exome - genetics | Breast Neoplasms - genetics | High-Throughput Nucleotide Sequencing | Mutation | Gene Expression Regulation, Neoplastic - genetics | Cohort Studies | Breast cancer | Genetic aspects | Research | Oncology, Experimental | Tumors | Cancer | Binding | Transcription factors | Genomic analysis | Genes | Genomics | Genomes | Patients | Proteins | E2F protein | Ribonucleic acids | Breast | Non-coding RNA | Apoptosis
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11. Full Text Elevated Blood Lead Levels of Children in Guiyu, an Electronic Waste Recycling Town in China
by Xia Huo and Lin Peng and Xijin Xu and Liangkai Zheng and Bo Qiu and Zongli Qi and Bao Zhang and Dai Han and Zhongxian Piao
Environmental Health Perspectives, ISSN 0091-6765, 7/2007, Volume 115, Issue 7, pp. 1113 - 1117
Background: Electronic waste (e-waste) recycling has remained primitive in Guiyu, China, and thus may contribute to the elevation of blood lead levels (BLLs)... 
Chemical hazards | International cooperation | Toxicity | Environmental health | Lead | Circuit boards | Children | Recycling | Ewaste | Blood | Children's Health | e-waste | Guiyu | Environmental | China | ENVIRONMENTAL SCIENCES | IMPACT | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | environmental | children | INTELLECTUAL IMPAIRMENT | E-JUNK | lead | EXPOSURE | Lead - blood | Humans | Child, Preschool | Electronics | Female | Infant | Male | Environmental Exposure | Child | Industrial Waste | Electronic waste | Lead in the body | Environmental aspects | Research | Health aspects
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12. Full Text Facile fabrication and enhanced microwave absorption properties of reduced graphene oxide/tin dioxide binary nanocomposites in the X-band
by Zhang, Jiabin and Shu, Ruiwen and Wu, Yue and Wan, Zongli and Zheng, Mingdong
Synthetic Metals, ISSN 0379-6779, 11/2019, Volume 257, p. 116157
Herein, reduced graphene oxide/tin dioxide (RGO/SnO ) binary nanocomposites were synthesized through a facile one-pot hydrothermal route by using graphene... 
Din dioxide | Microwave absorption | Reduced graphene oxide | Nanocomposites | Filler loading
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