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International Journal of Cancer, ISSN 0020-7136, 05/2008, Volume 122, Issue 9, pp. 1987 - 1998
Abrogation of apoptosis to sustain cell survival is an essential step in development of cancer. Aberrant activation of signal transcription factors NF‐κB or... 
BAX | NF‐κB | BCL‐XL | HNSCC | STAT3 | p53 | NF-κB | BCL-XL | CANCER-CELLS | TRANSCRIPTION FACTORS | CONSTITUTIVE ACTIVATION | BCL-2 FAMILY PROTEINS | TUMOR-SUPPRESSOR P53 | CISPLATIN SENSITIVITY | GROWTH-FACTOR RECEPTOR | NF-kappa B | ONCOLOGY | IN-VIVO | THERAPEUTIC TARGET | PROTEASOME INHIBITOR BORTEZOMIB
Journal Article
Pharmaceutical Research, ISSN 0724-8741, 12/2011, Volume 28, Issue 12, pp. 3256 - 3264
We have demonstrated that (-)-gossypol-enriched cottonseed oil [(-)-GPCSO] can down-regulate Bcl-2 expression in MCF-7 and primary cultured human breast cancer... 
Biomedical Engineering | Biochemistry, general | Bcl-2 | (-)-gossypol | Bcl-xL | chemoresistance | Biomedicine | liposomes | Pharmacy | Medical Law | Pharmacology/Toxicology | APOPTOSIS | DOXORUBICIN | INDUCTION | ANTITUMOR | CHEMISTRY, MULTIDISCIPLINARY | CHEMOTHERAPY | DELIVERY | FAMILY | RESISTANCE | PHARMACOLOGY & PHARMACY | GOSSYPOL ENANTIOMERS | COLON-CARCINOMA | Cottonseed Oil - administration & dosage | Gossypol - therapeutic use | Paclitaxel - pharmacology | Humans | bcl-X Protein - genetics | Breast - metabolism | Antineoplastic Agents, Phytogenic - administration & dosage | Female | Gene Expression Regulation, Neoplastic - drug effects | Tumor Cells, Cultured | Antineoplastic Agents, Phytogenic - therapeutic use | Breast - pathology | Cell Survival - drug effects | Breast Neoplasms - drug therapy | Cottonseed Oil - pharmacology | Gossypol - pharmacology | Animals | Breast Neoplasms - genetics | Breast - drug effects | Breast Neoplasms - pathology | Mice, Nude | Cell Line, Tumor | Mice | Liposomes | Antineoplastic Agents, Phytogenic - pharmacology | Gossypol - administration & dosage | Proto-Oncogene Proteins c-bcl-2 - genetics | Cottonseed Oil - therapeutic use | Care and treatment | Messenger RNA | Analysis | Breast cancer | Drug resistance | Gossypol | Nanotechnology | Cancer | Vegetable oils | Lipids | Gene expression | Pharmaceutical sciences | (−)-gossypol
Journal Article
Aging, ISSN 1945-4589, 2012, Volume 4, Issue 3, pp. 187 - 201
Central nervous system microglia promote neuronal regeneration and sequester toxic beta-amyloid (A beta) deposition during Alzheimer's disease. We show that... 
mTOR | Amyloid | Erythropoietin | Wnt | Alzheimer's disease | Microglia | MAMMALIAN TARGET | OXIDATIVE STRESS | PROTEIN-KINASE-B | OXIDANT STRESS | ALZHEIMERS-DISEASE | CELLULAR TARGETS | CELL BIOLOGY | GERIATRICS & GERONTOLOGY | amyloid | SIGNALING PATHWAY | VASCULAR INTEGRITY | PHOSPHATIDYLSERINE EXPOSURE | microglia | NF-KAPPA-B | erythropoietin | Erythropoietin - pharmacology | Mitochondria - enzymology | Wnt1 Protein - genetics | Phosphorylation | TOR Serine-Threonine Kinases - metabolism | Apoptosis - drug effects | Peptide Fragments - toxicity | Phosphatidylinositol 3-Kinase - antagonists & inhibitors | Humans | bcl-X Protein - genetics | Wnt1 Protein - metabolism | Membrane Potential, Mitochondrial - drug effects | Alzheimer Disease - pathology | Dose-Response Relationship, Drug | TOR Serine-Threonine Kinases - antagonists & inhibitors | Caspases - metabolism | Neuroprotective Agents - pharmacology | Transfection | RNA Interference | Time Factors | Microglia - pathology | bcl-Associated Death Protein - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Phosphatidylinositol 3-Kinase - metabolism | Cytoprotection | Cell Line | Microglia - drug effects | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Amyloid beta-Peptides - toxicity | Alzheimer Disease - drug therapy | Microglia - enzymology | Alzheimer Disease - enzymology | Mitochondria - drug effects | Mitochondria - pathology | Recombinant Proteins - pharmacology | Signal Transduction - drug effects | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | bcl-X Protein - metabolism
Journal Article
Journal Article
Journal Article
Journal of Cerebral Blood Flow & Metabolism, ISSN 0271-678X, 3/2003, Volume 23, Issue 3, pp. 320 - 330
Erythropoietin (EPO) plays a prominent role in the regulation of the hematopoietic system, but the potential function of this trophic factor as a... 
Apoptosorne | Caspase-3 | Apoptosis | Bcl-2 family | Mitochondrial membrane potential | Phosphatidylserine exposure
Journal Article
Clinical and Experimental Pharmacology and Physiology, ISSN 0305-1870, 05/2007, Volume 34, Issue 5, pp. 450 - 456
SUMMARY • The aim of the present study was to investigate the changes in chemotherapeutic drug sensitivity of HepG2 cells transfected with Bcl-2 and Bcl-xl... 
5-fluorouracil | Bcl-2 | Bcl-xl | HepG2 cells | RNA interference | 10-hydroxycamptothecin | 10‐hydroxycamptothecin | Bcl‐2 | 5‐fluorouracil | Bcl‐xl | PHYSIOLOGY | PROTEIN | CANCER CELLS | INDUCED APOPTOSIS | INVOLVEMENT | MECHANISMS | CYTOCHROME-C | CAMPTOTHECIN | BAX | DEGRADATION | PHARMACOLOGY & PHARMACY | INHIBITOR | RNA, Small Interfering - genetics | Apoptosis - drug effects | Humans | Caspase 3 - metabolism | bcl-X Protein - genetics | Cell Survival - genetics | Apoptosis - genetics | RNA, Messenger - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Flow Cytometry | Transfection | Time Factors | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Camptothecin - analogs & derivatives | Cell Survival - drug effects | RNA, Messenger - genetics | Gene Silencing | Down-Regulation - drug effects | Cell Line, Tumor | Fluorouracil - pharmacology | bcl-X Protein - metabolism | Camptothecin - pharmacology | Proto-Oncogene Proteins c-bcl-2 - genetics | Microscopy, Fluorescence | Drug Resistance, Neoplasm - drug effects | Cell Survival, drug effects | Drug Resistance, Neoplasm, drug effects | Camptothecin, pharmacology | Apoptosis, drug effects | Fluorouracil, pharmacology | bcl-X Protein, genetics | Down-Regulation, drug effects | Caspase 3, metabolism | RNA, Messenger, genetics | Camptothecin, analogs and derivatives | RNA, Messenger, metabolism | bcl-X Protein, metabolism | RNA, Small Interfering, genetics | Proto-Oncogene Proteins c-bcl-2, genetics | Antineoplastic Agents, pharmacology | Apoptosis, genetics | Cell Survival, genetics | Proto-Oncogene Proteins c-bcl-2, metabolism | Gene Expression Regulation, Neoplastic, drug effects | Liver cancer | Chemotherapy | Genetic engineering | Cancer
Journal Article
Oncogene, ISSN 0950-9232, 11/2003, Volume 22, Issue 54, pp. 8758 - 8773
Subtraction hybridization identified melanoma differentiation associated gene-7, mda-7, in the context of terminally differentiated human melanoma cells. Based... 
mda-7/IL-24 | Bcl-2 protein family | Prostate cancer | Apoptosis | Cancer gene therapy
Journal Article
Drug Development and Industrial Pharmacy, ISSN 0363-9045, 01/2016, Volume 42, Issue 1, pp. 12 - 18
Journal Article
Experimental Cell Research, ISSN 0014-4827, 06/2004, Volume 296, Issue 2, pp. 196 - 207
Protein kinase B (Akt1) holds a central role for cellular growth, development, and survival, but the cellular pathways of Akt1 that prevent inflammatory demise... 
Cysteine proteases | Cytochrome c | Protein kinase B | Phosphatidylserine | Endothelial cells | Mitochondrial membrane potential
Journal Article
Cancer Biology & Therapy, ISSN 1538-4047, 01/2008, Volume 7, Issue 1, pp. 51 - 60
Journal Article