2014, ISBN 1625645856, xvii, 419 pages
Book
Nature, ISSN 0028-0836, 08/2016, Volume 537, Issue 7622, pp. 680 - 684
Thirst motivates animals to drink in order to maintain fluid balance. Thirst has conventionally been viewed as a homeostatic response to changes in blood...
Water-Electrolyte Balance - physiology | Calcium - metabolism | Drinking - physiology | Homeostasis | Male | Optogenetics | Neural Pathways | Blood | Eating - physiology | Thirst - physiology | Feedback, Physiological | Animals | Time Factors | Subfornical Organ - physiology | Mouth - physiology | Subfornical Organ - cytology | Mouth - innervation | Neurons - physiology | Female | Mice | Physiological aspects | Drinking (Physiology) | Eating (Physiology) | Research | Neurological research | Neurons | Studies | Water | Rodents | Physiology
Water-Electrolyte Balance - physiology | Calcium - metabolism | Drinking - physiology | Homeostasis | Male | Optogenetics | Neural Pathways | Blood | Eating - physiology | Thirst - physiology | Feedback, Physiological | Animals | Time Factors | Subfornical Organ - physiology | Mouth - physiology | Subfornical Organ - cytology | Mouth - innervation | Neurons - physiology | Female | Mice | Physiological aspects | Drinking (Physiology) | Eating (Physiology) | Research | Neurological research | Neurons | Studies | Water | Rodents | Physiology
Journal Article
2010, New problems of philosophy., ISBN 0415485541, x, 246
How do we know right from wrong? Do we even have moral knowledge? Moral epistemology studies these and related questions about our understanding of virtue and...
Ethics | Knowledge, Theory of | Philosophy | Epistemology | Ethics Philosophy
Ethics | Knowledge, Theory of | Philosophy | Epistemology | Ethics Philosophy
Book
Nature Reviews Neuroscience, ISSN 1471-003X, 08/2017, Volume 18, Issue 8, pp. 459 - 469
Thirst motivates animals to find and consume water. More than 40 years ago, a set of interconnected brain structures known as the lamina terminalis was shown...
BETA-ADRENERGIC STIMULATION | VASOPRESSIN SECRETION | SENSORY CIRCUMVENTRICULAR ORGANS | MEDIAN PREOPTIC NUCLEUS | SUBFORNICAL ORGAN NEURONS | WATER-INTAKE | SALT APPETITE | NEUROSCIENCES | ALDOSTERONE-SENSITIVE NEURONS | PLASMA ANGIOTENSIN-II | BODY-FLUID | Thirst - physiology | Brain - cytology | Animals | Hypothalamus - physiology | Homeostasis - physiology | Humans | Drinking Behavior - physiology | Brain - physiology | Neural Pathways - physiology | Physiological aspects | Homeostasis | Neural circuitry | Thirst | Health aspects | Analysis | Drinking behavior | Neural networks
BETA-ADRENERGIC STIMULATION | VASOPRESSIN SECRETION | SENSORY CIRCUMVENTRICULAR ORGANS | MEDIAN PREOPTIC NUCLEUS | SUBFORNICAL ORGAN NEURONS | WATER-INTAKE | SALT APPETITE | NEUROSCIENCES | ALDOSTERONE-SENSITIVE NEURONS | PLASMA ANGIOTENSIN-II | BODY-FLUID | Thirst - physiology | Brain - cytology | Animals | Hypothalamus - physiology | Homeostasis - physiology | Humans | Drinking Behavior - physiology | Brain - physiology | Neural Pathways - physiology | Physiological aspects | Homeostasis | Neural circuitry | Thirst | Health aspects | Analysis | Drinking behavior | Neural networks
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 03/2017, Volume 376, Issue 9, pp. 836 - 847
Among adults with relapsed or refractory B-cell precursor acute lymphoblastic leukemia, treatment with the bispecific anti-CD19 and anti-CD3 monoclonal...
ADULT PATIENTS | MEDICINE, GENERAL & INTERNAL | HYPER-CVAD | INOTUZUMAB OZOGAMICIN | ACUTE LYMPHOCYTIC-LEUKEMIA | SALVAGE THERAPY | MONOCLONAL-ANTIBODY | PROGNOSTIC-SIGNIFICANCE | STEM-CELL TRANSPLANTATION | T-CELLS | CHAIN ANTIBODY CONSTRUCT | Humans | Middle Aged | Male | Antineoplastic Agents - therapeutic use | Combined Modality Therapy | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - therapy | Transplantation, Homologous | Stem Cell Transplantation | Young Adult | Antibodies, Bispecific - therapeutic use | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Antibodies, Bispecific - adverse effects | Sepsis - chemically induced | Antineoplastic Agents - adverse effects | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - mortality | Adolescent | Survival Analysis | Aged, 80 and over | Adult | Female | Aged | Chemotherapy | Usage | Care and treatment | Acute lymphocytic leukemia | Diagnosis | Comparative analysis | Patients | Cancer | CD19 antigen | Acute lymphatic leukemia | Cell survival | Writers | Clinical trials | Stem cell transplantation | Lymphocytes T | CD3 antigen | Lymphatic leukemia | Lymphocytes B | Medical prognosis | Monoclonal antibodies | Remission | Index Medicus | Abridged Index Medicus
ADULT PATIENTS | MEDICINE, GENERAL & INTERNAL | HYPER-CVAD | INOTUZUMAB OZOGAMICIN | ACUTE LYMPHOCYTIC-LEUKEMIA | SALVAGE THERAPY | MONOCLONAL-ANTIBODY | PROGNOSTIC-SIGNIFICANCE | STEM-CELL TRANSPLANTATION | T-CELLS | CHAIN ANTIBODY CONSTRUCT | Humans | Middle Aged | Male | Antineoplastic Agents - therapeutic use | Combined Modality Therapy | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - therapy | Transplantation, Homologous | Stem Cell Transplantation | Young Adult | Antibodies, Bispecific - therapeutic use | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Antibodies, Bispecific - adverse effects | Sepsis - chemically induced | Antineoplastic Agents - adverse effects | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - mortality | Adolescent | Survival Analysis | Aged, 80 and over | Adult | Female | Aged | Chemotherapy | Usage | Care and treatment | Acute lymphocytic leukemia | Diagnosis | Comparative analysis | Patients | Cancer | CD19 antigen | Acute lymphatic leukemia | Cell survival | Writers | Clinical trials | Stem cell transplantation | Lymphocytes T | CD3 antigen | Lymphatic leukemia | Lymphocytes B | Medical prognosis | Monoclonal antibodies | Remission | Index Medicus | Abridged Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2013, Volume 8, Issue 7, p. e69593
While the TRAIL pathway represents a promising therapeutic target in melanoma, resistance to TRAIL-mediated apoptosis remains a barrier to its successful...
AXIN | INHIBITION | WNT | EXPRESSION | MULTIDISCIPLINARY SCIENCES | NEGATIVE REGULATOR | Melanoma - metabolism | Proto-Oncogene Proteins - metabolism | Glycogen Synthase Kinase 3 - antagonists & inhibitors | Humans | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | Axin Protein - antagonists & inhibitors | Melanoma - pathology | TNF-Related Apoptosis-Inducing Ligand - metabolism | beta Catenin - metabolism | Apoptosis Regulatory Proteins - metabolism | Wnt3A Protein - pharmacology | Culture Media, Conditioned | TNF-Related Apoptosis-Inducing Ligand - pharmacology | Bcl-2-Like Protein 11 | RNA Interference | Cell Line, Tumor | Membrane Proteins - metabolism | Protein Kinase Inhibitors - pharmacology | Cell Culture Techniques | TNF-Related Apoptosis-Inducing Ligand - genetics | Wnt Signaling Pathway | Apoptosis | Phosphorylation | Wnt protein | Pathogenesis | Intracellular signalling | Kinases | Cancer therapies | Proteins | β-catenin | Signal transduction | Conditioning | Drug dosages | Recombinant | Melanoma | Abundance | siRNA | Mcl-1 protein | Medicine | Sensitivity | Medical prognosis | Cell lines | Ligands | Sensitivity enhancement | Adapter proteins | Tumors
AXIN | INHIBITION | WNT | EXPRESSION | MULTIDISCIPLINARY SCIENCES | NEGATIVE REGULATOR | Melanoma - metabolism | Proto-Oncogene Proteins - metabolism | Glycogen Synthase Kinase 3 - antagonists & inhibitors | Humans | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | Axin Protein - antagonists & inhibitors | Melanoma - pathology | TNF-Related Apoptosis-Inducing Ligand - metabolism | beta Catenin - metabolism | Apoptosis Regulatory Proteins - metabolism | Wnt3A Protein - pharmacology | Culture Media, Conditioned | TNF-Related Apoptosis-Inducing Ligand - pharmacology | Bcl-2-Like Protein 11 | RNA Interference | Cell Line, Tumor | Membrane Proteins - metabolism | Protein Kinase Inhibitors - pharmacology | Cell Culture Techniques | TNF-Related Apoptosis-Inducing Ligand - genetics | Wnt Signaling Pathway | Apoptosis | Phosphorylation | Wnt protein | Pathogenesis | Intracellular signalling | Kinases | Cancer therapies | Proteins | β-catenin | Signal transduction | Conditioning | Drug dosages | Recombinant | Melanoma | Abundance | siRNA | Mcl-1 protein | Medicine | Sensitivity | Medical prognosis | Cell lines | Ligands | Sensitivity enhancement | Adapter proteins | Tumors
Journal Article
International Immunology, ISSN 0953-8178, 01/2015, Volume 27, Issue 1, pp. 31 - 37
Multi-agent chemotherapy is the standard treatment for most B cell malignancies. Since chemotherapy can be associated with significant toxicity and since...
bi-specific antibody | Lymphoma | Immunotherapy | Leukemia | BiTE | BISPECIFIC ANTIBODIES | leukemia | ACTIVATION | lymphoma | SINGLE-CHAIN ANTIBODY | LYSIS | IMMUNOLOGY | RELAPSE | immunotherapy | ACUTE LYMPHOBLASTIC-LEUKEMIA | BiTE (R) | MINIMAL RESIDUAL DISEASE | MRD | REMISSION | T-Lymphocytes, Cytotoxic - immunology | Immunotherapy - methods | Antigens, Neoplasm - immunology | Humans | Lymphoma, B-Cell - therapy | Clinical Trials as Topic | Molecular Targeted Therapy | Antibodies, Bispecific - therapeutic use | Animals | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Lymphocyte Activation - drug effects | CD3 Complex - immunology | Lymphoma, B-Cell - immunology | Drug Evaluation, Preclinical | Cytotoxicity, Immunologic - drug effects | Antigens, CD19 - immunology | Index Medicus
bi-specific antibody | Lymphoma | Immunotherapy | Leukemia | BiTE | BISPECIFIC ANTIBODIES | leukemia | ACTIVATION | lymphoma | SINGLE-CHAIN ANTIBODY | LYSIS | IMMUNOLOGY | RELAPSE | immunotherapy | ACUTE LYMPHOBLASTIC-LEUKEMIA | BiTE (R) | MINIMAL RESIDUAL DISEASE | MRD | REMISSION | T-Lymphocytes, Cytotoxic - immunology | Immunotherapy - methods | Antigens, Neoplasm - immunology | Humans | Lymphoma, B-Cell - therapy | Clinical Trials as Topic | Molecular Targeted Therapy | Antibodies, Bispecific - therapeutic use | Animals | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Lymphocyte Activation - drug effects | CD3 Complex - immunology | Lymphoma, B-Cell - immunology | Drug Evaluation, Preclinical | Cytotoxicity, Immunologic - drug effects | Antigens, CD19 - immunology | Index Medicus
Journal Article
Endocrine Practice, ISSN 1530-891X, 07/2015, Volume 21, pp. 1 - 87
The American Association of Clinical Endocrinologists/American College of Endocrinology Medical Guidelines for Clinical Practice are systematically developed...
MULTIPLE DAILY INJECTIONS | OBSTRUCTIVE SLEEP-APNEA | LIFE-STYLE INTERVENTION | ENDOCRINOLOGY & METABOLISM | SUBCUTANEOUS INSULIN INFUSION | IMPAIRED GLUCOSE-TOLERANCE | ALPHA-LIPOIC ACID | POSITIVE AIRWAY PRESSURE | RANDOMIZED CONTROLLED-TRIAL | CORONARY-HEART-DISEASE | CARDIOVASCULAR RISK-FACTORS
MULTIPLE DAILY INJECTIONS | OBSTRUCTIVE SLEEP-APNEA | LIFE-STYLE INTERVENTION | ENDOCRINOLOGY & METABOLISM | SUBCUTANEOUS INSULIN INFUSION | IMPAIRED GLUCOSE-TOLERANCE | ALPHA-LIPOIC ACID | POSITIVE AIRWAY PRESSURE | RANDOMIZED CONTROLLED-TRIAL | CORONARY-HEART-DISEASE | CARDIOVASCULAR RISK-FACTORS
Journal Article
Molecular Physics, ISSN 0026-8976, 01/2015, Volume 113, Issue 2, pp. 184 - 215
A summary of the technical advances that are incorporated in the fourth major release of the Q-Chem quantum chemistry program is provided, covering...
software | density functional theory | quantum chemistry | electronic structure theory | computational modelling | Q-Chem | electron correlation | Q-CHEM | PLESSET PERTURBATION-THEORY | PHYSICS, ATOMIC, MOLECULAR & CHEMICAL | CHEMISTRY, PHYSICAL | FRAGMENT POTENTIAL METHOD | ELECTRONIC-STRUCTURE CALCULATIONS | REACTION FIELD TREATMENT | EXCITATION-ENERGY TRANSFER | GENERALIZED GRADIENT APPROXIMATION | MATRIX RENORMALIZATION-GROUP | BENCHMARK INTERACTION ENERGIES | SPIN-COUPLING-CONSTANTS | DENSITY-FUNCTIONAL THEORY | Accuracy | Algorithms | Quantum chemistry | Benchmarks | Excitation | Nuclear magnetic resonance | Density | Computer programs | or physical chemistry | Chemical Sciences | Theoretical and
software | density functional theory | quantum chemistry | electronic structure theory | computational modelling | Q-Chem | electron correlation | Q-CHEM | PLESSET PERTURBATION-THEORY | PHYSICS, ATOMIC, MOLECULAR & CHEMICAL | CHEMISTRY, PHYSICAL | FRAGMENT POTENTIAL METHOD | ELECTRONIC-STRUCTURE CALCULATIONS | REACTION FIELD TREATMENT | EXCITATION-ENERGY TRANSFER | GENERALIZED GRADIENT APPROXIMATION | MATRIX RENORMALIZATION-GROUP | BENCHMARK INTERACTION ENERGIES | SPIN-COUPLING-CONSTANTS | DENSITY-FUNCTIONAL THEORY | Accuracy | Algorithms | Quantum chemistry | Benchmarks | Excitation | Nuclear magnetic resonance | Density | Computer programs | or physical chemistry | Chemical Sciences | Theoretical and
Journal Article
eLife, ISSN 2050-084X, 08/2016, Volume 5, Issue AUGUST
The neural mechanisms underlying hunger are poorly understood. AgRP neurons are activated by energy deficit and promote voracious food consumption, suggesting...
AGOUTI-RELATED PROTEIN | STIMULATION | ENERGY HOMEOSTASIS | FOOD-INTAKE | BIOLOGY | MICE | AGRP | ARCUATE NUCLEUS | BRAIN | NEUROPEPTIDE-Y | CIRCUIT | Action Potentials | Hunger | Animals | Neurons - chemistry | Neurons - physiology | Agouti-Related Protein - analysis | Feeding Behavior | Mice | Optogenetics | Physiological aspects | Neural circuitry | Potentiation | Medical research | Neurosciences | Statistical analysis | Neurons | Hormones | Experiments | Feeding | Food availability | Reinforcement | Behavior | Protocol | Food consumption | Food
AGOUTI-RELATED PROTEIN | STIMULATION | ENERGY HOMEOSTASIS | FOOD-INTAKE | BIOLOGY | MICE | AGRP | ARCUATE NUCLEUS | BRAIN | NEUROPEPTIDE-Y | CIRCUIT | Action Potentials | Hunger | Animals | Neurons - chemistry | Neurons - physiology | Agouti-Related Protein - analysis | Feeding Behavior | Mice | Optogenetics | Physiological aspects | Neural circuitry | Potentiation | Medical research | Neurosciences | Statistical analysis | Neurons | Hormones | Experiments | Feeding | Food availability | Reinforcement | Behavior | Protocol | Food consumption | Food
Journal Article
11/2018, 1, Routledge handbooks in philosophy, ISBN 1138816124, 578
The Routledge Handbook of Moral Epistemology brings together philosophers, cognitive scientists, developmental and evolutionary psychologists, animal...
Ethics | Epistemology | Behavioral Psychology | Sociology of Knowledge | Ethics Philosophy | Moral Theory | Social Psychology | Philosophy of Education | Criminal Justice - Criminology | Knowledge, Theory of-Handbooks, manuals, etc | Ethics-Handbooks, manuals, etc | Knowledge, Theory of
Ethics | Epistemology | Behavioral Psychology | Sociology of Knowledge | Ethics Philosophy | Moral Theory | Social Psychology | Philosophy of Education | Criminal Justice - Criminology | Knowledge, Theory of-Handbooks, manuals, etc | Ethics-Handbooks, manuals, etc | Knowledge, Theory of
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