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Nature chemical biology, ISSN 1552-4469, 2015, Volume 11, Issue 8, pp. 611 - 617
The current predominant therapeutic paradigm is based on maximizing drug-receptor occupancy to achieve clinical benefit. This strategy, however, generally... 
CHIMERIC MOLECULES | CHEMICAL PROTEOMICS | STRUCTURAL BASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESTROGEN-RECEPTOR-ALPHA | KINASE INHIBITORS | CARD15 MUTATIONS | BLAU-SYNDROME | ABSOLUTE QUANTIFICATION | LIGASE COMPLEX | CELL-DEATH | Neoplasm Transplantation | Small Molecule Libraries - pharmacology | Receptors, Estrogen - metabolism | Humans | Ubiquitin - metabolism | Neoplasm Proteins - antagonists & inhibitors | Molecular Targeted Therapy | Neoplasm Proteins - metabolism | Receptor-Interacting Protein Serine-Threonine Kinase 2 - genetics | Breast Neoplasms - metabolism | Receptor-Interacting Protein Serine-Threonine Kinase 2 - metabolism | Ubiquitination | MCF-7 Cells | Proteolysis | Female | Antineoplastic Agents - pharmacology | Von Hippel-Lindau Tumor Suppressor Protein - genetics | Neoplasm Proteins - genetics | Binding Sites | Von Hippel-Lindau Tumor Suppressor Protein - metabolism | Receptor-Interacting Protein Serine-Threonine Kinase 2 - antagonists & inhibitors | Biocatalysis | Receptors, Estrogen - genetics | Models, Molecular | Receptors, Estrogen - antagonists & inhibitors | Ubiquitin - genetics | Breast Neoplasms - drug therapy | Animals | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Protein Binding | Mice | Proteasome Endopeptidase Complex - metabolism | Proteins | Molecular biology | Biocatalysts
Journal Article
Nature communications, ISSN 2041-1723, 2019, Volume 10, Issue 1, pp. 6 - 16
Journal Article
Physical review letters, ISSN 1079-7114, 2019, Volume 122, Issue 7, p. 078001
Molecular exchange processes are important equilibration and transport mechanisms in both synthetic and biological self-assembled systems such as micelles,... 
MIXTURES | PHYSICS, MULTIDISCIPLINARY | COPOLYMER MICELLES | NORMAL-ALKANES | KINETICS | CHAIN EXCHANGE | Exchanging | Self assembly | Molecular diffusion | Enthalpy | Crystallinity | Melting points | Binary mixtures | Microprocessors | Micelles | Ethylene oxide | Ethers | Activation energy | Crystal structure
Journal Article
Amino Acids, ISSN 0939-4451, 7/2011, Volume 41, Issue 2, pp. 311 - 320
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2015, Volume 290, Issue 7, pp. 4178 - 4191
Journal Article
Physical review letters, ISSN 0031-9007, 2019
Molecular exchange processes are important equilibration and transport mechanisms in both synthetic and biological self-assembled systems such as micelles,... 
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 07/2018, Volume 9, Issue 7, pp. 623 - 628
Abdominal pain and abnormal bowel habits represent major symptoms for irritable bowel syndrome (IBS) patients that are not adequately managed. Although the... 
genotoxicity | RET kinase | IBS | AMES | gut restricted | CHEMISTRY, MEDICINAL | DISORDERS | MECHANISMS | HIRSCHSPRUNGS-DISEASE | FAMILY | GDNF | GROWTH | NEURONS | EXPRESSION | IRRITABLE-BOWEL-SYNDROME | HYPERSENSITIVITY
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 08/2016, Volume 7, Issue 8, pp. 768 - 773
CZ415, a potent ATP-competitive mTOR inhibitor with unprecedented selectivity over any other kinase is described. In addition to a comprehensive... 
mTOR | kinase inhibitor | inflammation | collagen induced arthritis model | RAPAMYCIN | VITRO | CHEMISTRY, MEDICINAL | KINASE INHIBITORS | CANCER | POTENT | COMPETITIVE MAMMALIAN TARGET | PATHWAY | CHEMICAL PROBES | DIFFERENTIATION | T-CELLS
Journal Article
Analytical Chemistry, ISSN 0003-2700, 12/2011, Volume 83, Issue 23, pp. 8959 - 8967
Fragmentation of multiple peptides in a single tandem mass scan impairs accuracy of isobaric mass tag based quantification. Consequently, practitioners aim at... 
MIXTURES | CHEMISTRY, ANALYTICAL | PEPTIDES | DISSOCIATION |