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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2012, Volume 109, Issue 8, pp. 2724 - 2729
Journal Article
Arteriosclerosis, thrombosis, and vascular biology, ISSN 1079-5642, 1/2015, Volume 35, Issue 1, pp. 30 - 39
The last five years have witnessed a significant expansion in our understanding of VEGF signaling. In particular, the process of canonical activation of VEGFR... 
Journal Article
Genes and Cancer, ISSN 1947-6019, 12/2011, Volume 2, Issue 12, pp. 1085 - 1096
Tumors have been recently recognized as aberrant organs composed of a complex mixture of highly interactive cells that in addition to the cancer cell include... 
endothelial cells | Ephrin | Slit | angiopoietins | VEGF | neovascularization | Notch | Robo | Tie | Delta | tumor angiogenesis | VEGFR | Jagged | Eph | Monographs
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2015, Volume 10, Issue 7, pp. e0133219 - e0133219
We report here on experimental and theoretical efforts to determine how best to combine drugs that inhibit HER2 and AKT in HER2+ breast cancers. We... 
LAPATINIB | ACTIVATION | THERAPY | TRASTUZUMAB | PIK3CA | MULTIDISCIPLINARY SCIENCES | METASTATIC BREAST-CANCER | RESISTANCE | KINASE INHIBITOR | CELL-LINES | CHEMOTHERAPY | Epithelial Cells - metabolism | Receptor, ErbB-2 - genetics | Epithelial Cells - drug effects | Humans | Gene Expression Regulation, Neoplastic | Receptor, ErbB-2 - metabolism | Gene Expression Profiling | Phosphatidylinositol 3-Kinases - metabolism | Proto-Oncogene Proteins c-akt - genetics | Mammary Glands, Human | Oxadiazoles - pharmacology | Female | Antineoplastic Agents - pharmacology | Receptor, ErbB-2 - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - metabolism | Pyrazoles - pharmacology | Signal Transduction | Epithelial Cells - pathology | Ribosomal Protein S6 - genetics | Phosphatidylinositol 3-Kinases - genetics | Drug Resistance, Neoplasm - genetics | Class I Phosphatidylinositol 3-Kinases | Ribosomal Protein S6 - metabolism | Cell Line, Tumor | Diamines - pharmacology | Protein Kinase Inhibitors - pharmacology | Mutation | Quinazolines - pharmacology | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Breast cancer | Genetic aspects | Drugs | Health sciences | Biotechnology | Laboratories | Downstream effects | AKT protein | Biochemistry | Biology | Genomes | Kinases | Cancer therapies | Proteins | Life sciences | Light levels | Biomedical engineering | Electrical engineering | Tumor cell lines | ErbB-2 protein | 1-Phosphatidylinositol 3-kinase | Signaling | Decoupling | Cell lines | Differential equations | Breast | Combinatorial analysis | Cancer | Tumors | Index Medicus | cancer treatment | drug therapy | drug interactions | signal inhibition | AKT signaling cascade | breast cancer | confidence intervals | 60 APPLIED LIFE SCIENCES | MAPK signaling cascades
Journal Article
Science Signaling, ISSN 1945-0877, 01/2014, Volume 7, Issue 307, pp. ra1 - ra1
Although vascular complications are a hallmark of diabetes, the molecular mechanisms that underlie endothelial dysfunction are unclear. We showed that reactive... 
INACTIVATION | OXIDATIVE STRESS | ACTIVATION | PROTEIN | TYROSINE KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | NITRIC-OXIDE | MECHANISMS | GOLGI | EXPRESSION | ENDOTHELIAL GROWTH-FACTOR | CELL BIOLOGY | Free Radical Scavengers - pharmacology | Reactive Oxygen Species - metabolism | Human Umbilical Vein Endothelial Cells - metabolism | Blood Vessels - metabolism | Golgi Apparatus - drug effects | Humans | Diabetes Mellitus, Experimental - genetics | Endothelium, Vascular - drug effects | Immunoblotting | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - genetics | Vascular Endothelial Growth Factor Receptor-2 - genetics | Blood Vessels - physiopathology | Dose-Response Relationship, Drug | Phosphorylation - drug effects | Diabetes Mellitus, Experimental - metabolism | Vascular Endothelial Growth Factor A - pharmacology | Diabetes Mellitus, Experimental - physiopathology | Human Umbilical Vein Endothelial Cells - drug effects | Cells, Cultured | Endothelium, Vascular - physiopathology | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Mice, Transgenic | Glucose - pharmacology | Signal Transduction - genetics | Reverse Transcriptase Polymerase Chain Reaction | Mice, Knockout | Cell Movement - drug effects | Animals | Signal Transduction - drug effects | Endothelium, Vascular - metabolism | Acetylcysteine - pharmacology | Golgi Apparatus - metabolism | Ligands | Mice, Obese | Signal Transduction - physiology | Mice | Index Medicus
Journal Article
Journal of Cell Science, ISSN 0021-9533, 2015, Volume 128, Issue 12, pp. 2236 - 2248
Journal Article
Journal Article
01/2015, ISBN 9781339091303
The purpose of the vascular system is to distribute oxygen rich blood to all organs and extremities, to mediate the transport of nutrients and waste, and to... 
Cellular biology | Biology | Molecular biology
Dissertation
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 11/2016, Volume 36, Issue 11, pp. 2203 - 2212
Journal Article
Journal Article