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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2016, Volume 113, Issue 16, pp. 4476 - 4481
Inhibition of the vascular endothelial growth factor (VEGF) pathway has failed to improve overall survival of patients with glioblastoma (GBM). We previously... 
Anti-angiogenic therapy | Macrophage polarization | Tumor microenvironment | Microglia reprogramming | Anti-tumor immunity | anti-angiogenic therapy | BEVACIZUMAB | MULTIDISCIPLINARY SCIENCES | macrophage polarization | RANDOMIZED-TRIAL | ANGIOPOIETIN-2 | CANCER | THERAPY | microglia reprogramming | TIE2-EXPRESSING MONOCYTES | BLOOD-VESSELS | TUMOR-ASSOCIATED MACROPHAGES | tumor microenvironment | NORMALIZATION | anti-tumor immunity | ENDOTHELIAL GROWTH-FACTOR | Macrophages - pathology | Antibodies, Bispecific - pharmacology | Vesicular Transport Proteins - metabolism | Humans | Neoplasm Proteins - antagonists & inhibitors | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Neoplasm Proteins - metabolism | Neoplasms, Experimental - pathology | Xenograft Model Antitumor Assays | Macrophages - metabolism | Vesicular Transport Proteins - antagonists & inhibitors | Animals | Antibodies, Neoplasm - pharmacology | Ribonuclease, Pancreatic - metabolism | Glioblastoma - pathology | Cell Line, Tumor | Glioblastoma - metabolism | Antineoplastic Agents - pharmacology | Mice | Neoplasms, Experimental - metabolism | Glioblastoma - drug therapy | Ribonuclease, Pancreatic - antagonists & inhibitors | Neoplasms, Experimental - drug therapy | Viral antibodies | Care and treatment | Antibodies | Physiological aspects | Models | Macrophages | Vascular endothelial growth factor | Health aspects | Glioblastoma multiforme | Genotype & phenotype | Survival analysis | Protein expression | Cells | Tumors | Cancer | Index Medicus | Biological Sciences
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2016, Volume 113, Issue 16, pp. 4470 - 4475
Glioblastomas (GBMs) rapidly become refractory to anti-VEGF therapies. We previously demonstrated that ectopic overexpression of angiopoietin-2 (Ang-2)... 
Anti-angiogenic therapy | Colony-stimulating factor 1 | Tumor immunity | Tumor microenvironment | Macrophage | anti-angiogenic therapy | ANGIOPOIETIN-2 FUNCTIONS | ANGIOGENESIS | MULTIDISCIPLINARY SCIENCES | macrophage | BEVACIZUMAB PLUS IRINOTECAN | RANDOMIZED-TRIAL | ANTIBODY | tumor immunity | KINASE INHIBITOR | ANTIANGIOGENIC THERAPY | PHASE-II TRIAL | colony-stimulating factor 1 | tumor microenvironment | EXPRESSION | ENDOTHELIAL GROWTH-FACTOR | Macrophages - pathology | Neoplasm Proteins - antagonists & inhibitors | Neoplasm Proteins - metabolism | Neovascularization, Pathologic - pathology | Neoplasms, Experimental - pathology | Macrophages - metabolism | Animals | Antibodies, Neoplasm - pharmacology | Receptors, Vascular Endothelial Growth Factor - metabolism | Ribonuclease, Pancreatic - metabolism | Neovascularization, Pathologic - drug therapy | Glioblastoma - pathology | Cell Line, Tumor | Receptors, Vascular Endothelial Growth Factor - antagonists & inhibitors | Glioblastoma - metabolism | Mice | Neovascularization, Pathologic - metabolism | Neoplasms, Experimental - metabolism | Glioblastoma - drug therapy | Quinazolines - pharmacology | Ribonuclease, Pancreatic - antagonists & inhibitors | Neoplasms, Experimental - drug therapy | Drug Screening Assays, Antitumor | Survival analysis | Gene expression | Kinases | Cells | Tumors | Cancer | Index Medicus | Biological Sciences
Journal Article
CANCER RESEARCH, ISSN 0008-5472, 05/2019, Volume 79, Issue 9, pp. 2104 - 2106
The limited efficacy of current antiangiogenic therapies calls for a better understanding of the specific resistance mechanisms in glioblastoma (GBM) and the... 
ANGIOGENESIS | ONCOLOGY | IMMUNOTHERAPY | Index Medicus
Journal Article
Journal of Immunology, ISSN 0022-1767, 04/2018, Volume 200, Issue 8, pp. 3000 - 3007
Coinhibitory receptors, such as CTLA-4 and PD-1, play a critical role in maintaining immune homeostasis by dampening T cell responses. Recently, they have... 
CD226 | DISEASES | IMMUNOLOGY | RECEPTORS | T-CELLS | GLY307SER | Immunoglobulins | Immune response | PD-1 protein | Therapeutic applications | Antibodies | Homeostasis | T cell receptors | Lymphocytes T | Regression analysis | Immunity | Receptors | CTLA-4 protein | Molecular modelling | Lymphocytes | In vivo methods and tests | Cancer | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
Materials Science & Engineering C, ISSN 0928-4931, 05/2016, Volume 62, pp. 897 - 907
Journal Article
Journal Article
Journal Article