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analogs (1) 1
binding sites (1) 1
brucei phosphodiesterases (1) 1
catechols - chemical synthesis (1) 1
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1. Full Text Catechol Pyrazolinones as Trypanocidals: Fragment-Based Design, Synthesis, and Pharmacological Evaluation of Nanomolar Inhibitors of Trypanosomal Phosphodiesterase B1
by Orrling, Kristina M and Jansen, Chimed and Vu, Xuan Lan and Balmer, Vreni and Bregy, Patrick and Shanmugham, Anitha and England, Paul and Bailey, David and Cos, Paul and Maes, Louis and Adams, Emily and van den Bogaart, Erika and Chatelain, Eric and Ioset, Jean-Robert and van de Stolpe, Andrea and Zorg, Stèphanie and Veerman, Johan and Seebeck, Thomas and Sterk, Geert Jan and de Esch, Iwan J. P and Leurs, Rob
Journal of Medicinal Chemistry, ISSN 0022-2623, 10/2012, Volume 55, Issue 20, pp. 8745 - 8756
Trypanosomal phosphodiesterases B1 and B2 (TbrPDEB1 and TbrPDEB2) play an important role in the life cycle of Trypanosoma brucei, the causative parasite of... 
SELECTIVE PDE4 INHIBITORS | DRUG | IN-VITRO | CHEMISTRY, MEDICINAL | HUMAN AFRICAN TRYPANOSOMIASIS | ANALOGS | BRUCEI PHOSPHODIESTERASES | SLEEPING SICKNESS | CIS-HEXAHYDROPHTHALAZINONES | PARASITE | CULTIVATION | Catechols - chemical synthesis | Tetrazoles - pharmacology | Cyclic Nucleotide Phosphodiesterases, Type 1 - chemistry | Pyrazoles - chemical synthesis | Catechols - chemistry | Trypanocidal Agents - chemistry | Structure-Activity Relationship | Trypanosoma brucei brucei - enzymology | Cyclic Nucleotide Phosphodiesterases, Type 1 - antagonists & inhibitors | Pyrazoles - chemistry | Tetrazoles - chemistry | Drug Design | Catechols - pharmacology | Binding Sites | Cyclic AMP - metabolism | Pyrazoles - pharmacology | Pyrazolones - chemical synthesis | Pyrazolones - chemistry | Tetrazoles - chemical synthesis | Trypanosoma brucei brucei - drug effects | Trypanocidal Agents - pharmacology | Pyrazolones - pharmacology | Trypanocidal Agents - chemical synthesis | Molecular Docking Simulation | Trypanosoma brucei rhodesiense - drug effects | Trypanosoma brucei rhodesiense - enzymology
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