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SCIENTIFIC REPORTS, ISSN 2045-2322, 07/2019, Volume 9, Issue 1, pp. 1 - 9
Development of an efficient and scalable synthesis of 6-formylindolo[3,2-b]carbazole (FICZ), a naturally-occurring aryl hydrocarbon receptor (AhR) ligand,... 
METABOLISM | QUINONES | MULTIDISCIPLINARY SCIENCES | LIGHT | HIGH-AFFINITY | AH RECEPTOR | CELL-DIFFERENTIATION | IDENTIFICATION | Hydrocarbons | Ligands | Carbazole | Quinone | Biological activity
Journal Article
Nature Reviews Drug Discovery, ISSN 1474-1776, 07/2019, Volume 18, Issue 8, pp. 574 - 574
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 07/2019, Volume 29, Issue 14, pp. 1727 - 1731
We demonstrate an innovative approach for optimization of kinase inhibitor potency and selectivity utilising kinase mini-panels and kinome-wide panels. We... 
Kinome selectivity | 4-anilinoquinoline | 4-Anilinoquinazoline | Mini-kinome panel | Cyclin G associated kinase (GAK) | MULTIPLE ROLES | CHEMISTRY, MEDICINAL | CHEMISTRY, ORGANIC | IDENTIFICATION | Case studies | Drugstores | Quinoline | Medical colleges | Pharmacy
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 07/2015, Volume 11, Issue 8, pp. 536 - 541
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2017, Volume 12, Issue 8, pp. e0181585 - e0181585
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2011, Volume 108, Issue 45, pp. 18348 - 18353
Journal Article
Cancer cell, ISSN 1535-6108, 10/2011, Volume 20, Issue 4, pp. 500 - 510
A genomic signature designed to assess the activity of the estrogen-related receptor alpha (ERRα) was used to profile more than eight hundred breast tumors,... 
Journal Article
Journal Article
The Journal of Pathology, ISSN 0022-3417, 07/2016, Volume 239, Issue 3, pp. 320 - 334
Journal Article
Nature Communications, ISSN 2041-1723, 12/2019, Volume 10, Issue 1, pp. 2450 - 16
Tumor-associated myeloid cells regulate tumor growth and metastasis, and their accumulation is a negative prognostic factor for breast cancer. Here we find... 
Immunohistochemistry | Cell Proliferation | Tumor Escape - genetics | Breast Neoplasms - immunology | Humans | Breast Neoplasms - metabolism | Triple Negative Breast Neoplasms - immunology | Calcium-Calmodulin-Dependent Protein Kinase Kinase - immunology | Myeloid Cells - immunology | Female | Macrophages - immunology | Chemokines - immunology | Mammary Neoplasms, Animal - genetics | Tumor Escape - immunology | Mammary Neoplasms, Animal - immunology | Carcinoma - immunology | Mice, Transgenic | Calcium-Calmodulin-Dependent Protein Kinase Kinase - genetics | Mice, Knockout | Tumor Microenvironment - immunology | Macrophages - metabolism | Animals | Breast Neoplasms - genetics | Triple Negative Breast Neoplasms - genetics | Triple Negative Breast Neoplasms - metabolism | Calcium-Calmodulin-Dependent Protein Kinase Kinase - antagonists & inhibitors | Mammary Neoplasms, Animal - metabolism | Calcium-Calmodulin-Dependent Protein Kinase Kinase - metabolism | Myeloid Cells - metabolism | Carcinoma - genetics | Mice | Carcinoma - metabolism | CD8-Positive T-Lymphocytes - immunology | In Vitro Techniques | Cell proliferation | Animal models | Myeloid cells | Calcium | CD8 antigen | Effector cells | Breast cancer | Lymphocytes T | Kinases | Macrophages | Accumulation | Metastases | Immune systems | Lymphocytes | Immunotherapy | Calcium-binding protein | Breast | Inhibition | Calmodulin | Chemokines | Tumors | Index Medicus
Journal Article