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1. Full Text Safety and efficacy of ombitasvir/paritaprevir/ritonavir/dasabuvir plus ribavirin in patients over 65 years with HCV genotype 1 cirrhosis
by Ascione, Antonio and De Luca, Massimo and Melazzini, Mario and Montilla, Simona and Trotta, Maria Paola and Petta, Salvatore and Puoti, Massimo and Sangiovanni, Vincenzo and Messina, Vincenzo and Bruno, Savino and Izzi, Antonio and Villa, Erica and Aghemo, Alessio and Zignego, Anna Linda and Orlandini, Alessandra and Fontanella, Luca and Gasbarrini, Antonio and Marzioni, Marco and Giannini, Edoardo G and Craxì, Antonio and ABACUS Study Group and For the ABACUS Study Group
Infection, ISSN 0300-8126, 10/2018, Volume 46, Issue 5, pp. 607 - 615
To analyse safety and efficacy of treatment based on ombitasvir/paritaprevir/ritonavir/dasabuvir plus ribavirin in the sub-group of GT1 patients older than... 
Cirrhosis | Ombitasvir | Medicine & Public Health | General Practice / Family Medicine | Infectious Diseases | Internal Medicine | Paritaprevir | Elderly | Dasabuvir | Humans | Hepacivirus - genetics | Hepatitis C, Chronic - virology | Male | Carbamates - administration & dosage | Hepatitis C, Chronic - complications | Uracil - administration & dosage | Ribavirin - administration & dosage | Aged, 80 and over | Female | Drug Therapy, Combination | Liver Cirrhosis - etiology | Liver Cirrhosis - diagnosis | Ritonavir - administration & dosage | Antiviral Agents - therapeutic use | Genotype | Treatment Outcome | Hepatitis C, Chronic - diagnosis | Hepatitis C, Chronic - drug therapy | Antiviral Agents - administration & dosage | Anilides - administration & dosage | Antiviral Agents - adverse effects | Biomarkers | Aged | Macrocyclic Compounds - administration & dosage | Sulfonamides - administration & dosage | Uracil - analogs & derivatives | Complications and side effects | Research | Hepatitis C | Drug therapy | Liver cirrhosis | Risk factors | Hypertension | Effectiveness | Liver diseases | Ritonavir | Health risks | Viruses | Pharmacology | Bilirubin | Multivariate analysis | Ribonucleic acid--RNA | Patients | Ribavirin | Hepatitis | Patient safety | Safety | Hepatitis C virus | Genotypes
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2. Full Text Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis
by Liu, Xiangdong and Invernizzi, Pietro and Lu, Yue and Kosoy, Roman and Lu, Yan and Bianchi, Ilaria and Podda, Mauro and Xu, Chun and Xie, Gang and MacCiardi, Fabio and Selmi, Carlo and Lupoli, Sara and Shigeta, Russell and Ransom, Michael and Lleo, Ana and Lee, Annette T and Mason, Andrew L and Myers, Robert P and Peltekian, Kevork M and Ghent, Cameron N and Bernuzzi, Francesca and Zuin, Massimo and Rosina, Floriano and Borghesio, Elisabetta and Floreani, Annarosa and Lazzari, Roberta and Niro, Grazia and Andriulli, Angelo and Muratori, Luigi and Muratori, Paolo and Almasio, Piero L and Andreone, Pietro and Margotti, Marzia and Brunetto, Maurizia and Coco, Barbara and Alvaro, Domenico and Bragazzi, Maria C and Marra, Fabio and Pisano, Alessandro and Rigamonti, Cristina and Colombo, Massimo and Marzioni, Marco and Benedetti, Antonio and Fabris, Luca and Strazzabosco, Mario and Portincasa, Piero and Palmieri, Vincenzo O and Tiribelli, Claudio and Croce, Lory and Bruno, Savino and Rossi, Sonia and Vinci, Maria and Prisco, Cleofe and Mattalia, Alberto and Toniutto, Pierluigi and Picciotto, Antonio and Galli, Andrea and Ferrari, Carlo and Colombo, Silvia and Casella, Giovanni and Morini, Lorenzo and Caporaso, Nicola and Colli, Agostino and Spinzi, Giancarlo and Montanari, Renzo and Gregersen, Peter K and Heathcote, E Jenny and Hirschfield, Gideon M and Siminovitch, Katherine A and Amos, Christopher I and Gershwin, M Eric and Seldin, Michael F
Nature Genetics, ISSN 1061-4036, 08/2010, Volume 42, Issue 8, pp. 658 - 660
A genome-wide association screen for primary biliary cirrhosis risk alleles was performed in an Italian cohort. The results from the Italian cohort replicated... 
SYSTEMIC-LUPUS-ERYTHEMATOSUS | VARIANTS | SPI-B | TRANSCRIPTION | GENETICS & HEREDITY | RISK | ASTHMA | CELL | EXPRESSION | Canada | Interferon Regulatory Factors | European Continental Ancestry Group - genetics | Genome-Wide Association Study | Meta-Analysis as Topic | Humans | Alleles | Liver Cirrhosis, Biliary | Genome | Odds Ratio | Autoimmunity | Chromosome mapping | Autoantibodies | Genomics | Development and progression | Genetic aspects | Biliary cirrhosis | Research | Properties | Methods | Celiac disease | Medical research | Disease | Autoimmune diseases
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3. Full Text Effect of Thalidomide on Clinical Remission in Children and Adolescents With Refractory Crohn Disease: A Randomized Clinical Trial
by Lazzerini, Marzia and Martelossi, Stefano and Magazzù, Giuseppe and Pellegrino, Salvatore and Lucanto, Maria Cristina and Barabino, Arrigo and Calvi, Angela and Arrigo, Serena and Lionetti, Paolo and Lorusso, Monica and Mangiantini, Francesca and Fontana, Massimo and Zuin, Giovanna and Palla, Gabriella and Maggiore, Giuseppe and Bramuzzo, Matteo and Pellegrin, Maria Chiara and Maschio, Massimo and Villanacci, Vincenzo and Manenti, Stefania and Decorti, Giuliana and De Iudicibus, Sara and Paparazzo, Rossella and Montico, Marcella and Ventura, Alessandro
JAMA, ISSN 0098-7484, 11/2013, Volume 310, Issue 20, pp. 2164 - 2173
IMPORTANCE Pediatric-onset Crohn disease is more aggressive than adult-onset disease, has high rates of resistance to existing drugs, and can lead to permanent... 
YOUNG-ADULTS | MEDICINE, GENERAL & INTERNAL | INFLAMMATORY-BOWEL-DISEASE | THERAPY | EFFICACY | SAFETY | PEDIATRIC-PATIENTS | THROMBOEMBOLIC EVENTS | OPEN-LABEL | ACTIVITY INDEX | INFLIXIMAB | Severity of Illness Index | Thalidomide - adverse effects | Double-Blind Method | Humans | Immunosuppressive Agents - therapeutic use | Male | Treatment Outcome | Remission Induction | Crohn Disease - pathology | Crohn Disease - drug therapy | Adolescent | Age of Onset | Female | Immunosuppressive Agents - adverse effects | Thalidomide - therapeutic use | Child | Crohn's disease | Dosage and administration | Research | Drug therapy | Thalidomide | Clinical trials | Prescription drugs | Pediatrics | Childrens health | Crohns disease
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4. Full Text Modeling cost‐effectiveness and health gains of a “universal” versus “prioritized” hepatitis C virus treatment policy in a real‐life cohort
by Kondili, Loreta A and Romano, Federica and Rolli, Francesca Romana and Ruggeri, Matteo and Rosato, Stefano and Brunetto, Maurizia Rossana and Zignego, Anna Linda and Ciancio, Alessia and Di Leo, Alfredo and Raimondo, Giovanni and Ferrari, Carlo and Taliani, Gloria and Borgia, Guglielmo and Santantonio, Teresa Antonia and Blanc, Pierluigi and Gaeta, Giovanni Battista and Gasbarrini, Antonio and Chessa, Luchino and Erne, Elke Maria and Villa, Erica and Ieluzzi, Donatella and Russo, Francesco Paolo and Andreone, Pietro and Vinci, Maria and Coppola, Carmine and Chemello, Liliana and Madonia, Salvatore and Verucchi, Gabriella and Persico, Marcello and Zuin, Massimo and Puoti, Massimo and Alberti, Alfredo and Nardone, Gerardo and Massari, Marco and Montalto, Giuseppe and Foti, Giuseppe and Rumi, Maria Grazia and Quaranta, Maria Giovanna and Cicchetti, Americo and Craxì, Antonio and Vella, Stefano and on behalf of the PITER Collaborating Group
Hepatology, ISSN 0270-9139, 12/2017, Volume 66, Issue 6, pp. 1814 - 1825
We evaluated the cost‐effectiveness of two alternative direct‐acting antiviral (DAA) treatment policies in a real‐life cohort of hepatitis C virus–infected... 
Hepatitis | Population studies | Liver diseases | Hepatitis C | Cost analysis | Fibrosis | Original
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5. Full Text Forecasting Hepatitis C liver disease burden on real‐life data. Does the hidden iceberg matter to reach the elimination goals?
by Kondili, Loreta A and Robbins, Sarah and Blach, Sarah and Gamkrelidze, Ivane and Zignego, Anna L and Brunetto, Maurizia R and Raimondo, Giovanni and Taliani, Gloria and Iannone, Andrea and Russo, Francesco P and Santantonio, Teresa A and Zuin, Massimo and Chessa, Luchino and Blanc, Pierluigi and Puoti, Massimo and Vinci, Maria and Erne, Elke M and Strazzabosco, Mario and Massari, Marco and Lampertico, Pietro and Rumi, Maria G and Federico, Alessandro and Orlandini, Alessandra and Ciancio, Alessia and Borgia, Guglielmo and Andreone, Pietro and Caporaso, Nicola and Persico, Marcello and Ieluzzi, Donatella and Madonia, Salvatore and Gori, Andrea and Gasbarrini, Antonio and Coppola, Carmine and Brancaccio, Giuseppina and Andriulli, Angelo and Quaranta, Maria G and Montilla, Simona and Razavi, Homie and Melazzini, Mario and Vella, Stefano and Craxì, Antonio and PITER Collaborating Grp and PITER Collaborating Group
Liver International, ISSN 1478-3223, 12/2018, Volume 38, Issue 12, pp. 2190 - 2198
Background & Aims Advances in direct‐acting antiviral treatment of HCV have reinvigorated public health initiatives aimed at identifying affected individuals.... 
HCV | chronic infection | linkage to care | WHO | VIRUS-INFECTION | RISK-FACTORS | NATIONAL PROGRESS | UNIVERSAL | PREVALENCE | GENERAL-POPULATION | INJECT DRUGS | PEOPLE | GASTROENTEROLOGY & HEPATOLOGY | EPIDEMIOLOGY | HCV-INFECTION | Antiviral agents | Evaluation | Hepatitis C virus | Hepatitis C | Analysis | Hepatitis | Screening | Liver diseases | Liver | Strategy | Birth | Icebergs | Patients | Public health | Viral Hepatitis
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6. Full Text Hemostatic balance in patients with liver cirrhosis: Report of a consensus conference
by Andriulli, Angelo and Tripodi, Armando and Angeli, Paolo and Senzolo, Marco and Primignani, Massimo and Giannini, Edoardo G and Riggio, Oliviero and Colli, Agostino and Prati, Daniele and Sacerdoti, David and Merkel, Carlo and Basili, Stefania and Ferro, Domenico and Villa, Erica and Di Minno, Giovanni and Caraceni, Paolo and Marzioni, Marco and Mannucci, Pier Mannuccio and Violi, Francesco and Piscaglia, Fabio and Calvaruso, Vincenza and De Pietri, Lesley and Falcone, Marco and Feltracco, Paolo and Grandone, Elvira and La Mura, Vincenzo and Licata, Anna and Lucidi, Cristina and Maimone, Sergio and Marietta, Marco and Morisco, Filomena and Napoleone, Laura and Piano, Salvatore and Raparelli, Valeria and Rebulla, Paolo and Ribero, Dario and Sartori, Maria Teresa and Scalera, Antonella and Schepis, Filippo and Siciliano, Massimo and Baroni, Gianluca Svegliati and Tufano, Antonella and Vitale, Alessandro and Zuin, Massimo and Under the auspices of the Italian Association for the Study of Liver Diseases (AISF) and the Italian Society of Internal Medicine (SIMI)
Digestive and Liver Disease, ISSN 1590-8658, 2016, Volume 48, Issue 5, pp. 455 - 467
Abstract Patients with cirrhosis present with hemostatic alterations secondary to reduced availability of pro-coagulant and anti-coagulant factors. The net... 
Gastroenterology and Hepatology | Cirrhosis | Hemostasis | Thrombosis | Bleeding | PORTAL-VEIN THROMBOSIS | ACUTE VARICEAL HEMORRHAGE | RECOMBINANT FACTOR VIIA | RANDOMIZED CONTROLLED-TRIAL | VON-WILLEBRAND-FACTOR | ACTIVATED FACTOR-VII | DEEP VENOUS THROMBOSIS | MOLECULAR-WEIGHT HEPARIN | INTERNATIONAL NORMALIZED RATIO | GASTROENTEROLOGY & HEPATOLOGY | FRESH-FROZEN PLASMA | Coagulants - therapeutic use | Gastrointestinal Hemorrhage - prevention & control | Liver Cirrhosis - complications | Postoperative Hemorrhage - prevention & control | Humans | Blood Coagulation Tests | Anticoagulants - therapeutic use | Esophageal and Gastric Varices - etiology | Liver Cirrhosis - physiopathology | Thrombosis - prevention & control | Drug Monitoring | Care and treatment | Conferences, meetings and seminars | Conferences and conventions | Liver cirrhosis
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7. Full Text Individualized treatment of genotype 1 Naïve patients: An Italian multicenter field practice experience
by Mangia, Alessandra and Cenderello, Giovanni and Orlandini, Alessandra and Piazzolla, Valeria and Picciotto, Antonio and Zuin, Massimo and Ciancio, Alessia and Brancaccio, Giuseppina and Forte, Paolo and Carretta, Vito and Zignego, Anna Linda and Minerva, Nicola and Brindicci, Gaetano and Marignani, Massimo and Baroni, Gianluca Svegliati and Bertino, Gaetano and Cuccorese, Giuseppe and Mottola, Leonardo and Ripoli, Maria and Pirisi, Mario
PLoS ONE, ISSN 1932-6203, 10/2014, Volume 9, Issue 10, p. e110284
Background: Triple therapy including Telaprevir or Boceprevir still represents in many European countries the standard of care for patients with Hepatitis C... 
TELAPREVIR TVR | TRIAL | IL28B POLYMORPHISM | PLUS RIBAVIRIN | VIRUS-INFECTION | MULTIDISCIPLINARY SCIENCES | CHRONIC HEPATITIS-C | TRIPLE-THERAPY | BOCEPREVIR | INTERIM ANALYSIS | Decision Making | Genetic Association Studies | Proline - analogs & derivatives | Humans | Middle Aged | Hepacivirus - genetics | Hepatitis C, Chronic - virology | Genotype | Male | Treatment Outcome | Hepatitis C, Chronic - drug therapy | Oligopeptides - therapeutic use | Interleukins - genetics | Proline - therapeutic use | Female | Italy | Drug Therapy, Combination | Hepatitis C, Chronic - genetics | Precision Medicine | Therapy | Liver diseases | Internal medicine | Anemia | Liver | Medical services | Viruses | Infections | Patients | Medicine | Hepatitis | Body mass index | Genotype & phenotype | Infectious diseases | Hospitals | Body mass | Hepatology | Body size | Gastroenterology | Interferon | Hepatitis C virus | Hepatitis C | Genotypes
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8. Full Text Pathway-based analysis of primary biliary cirrhosis genome-wide association studies
by Kar, S.P and Seldin, M.F and Chen, W and Lu, E and Hirschfield, G.M and Invernizzi, P and Heathcote, J and Cusi, D and Almasio, Piero L and Alvaro, Domenico and Andreone, Pietro and Andriulli, Angelo and Barlassina, Cristina and Benedetti, Antonio and Bernuzzi, Francesca and Bianchi, Ilaria and Bragazzi, MariaConsiglia and Brunetto, Maurizia and Bruno, Savino and Caliari, Lisa and Casella, Giovanni and Coco, Barbara and Colli, Agostino and Colombo, Massimo and Colombo, Silvia and Cursaro, Carmela and Croce, Lory Saveria and Crosignani, Andrea and Donato, Francesca and Elia, Gianfranco and Fabris, Luca and Floreani, Annarosa and Galli, Andrea and Grattagliano, Ignazio and Lazzari, Roberta and Lleo, Ana and Macaluso, Fabio and Marra, Fabio and Marzioni, Marco and Mascia, Elisabetta and Mattalia, Alberto and Montanari, Renzo and Morini, Lorenzo and Morisco, Filomena and Muratori, Luigi and Muratori, Paolo and Niro, Grazia and Picciotto, Antonio and Podda, Mauro and Portincasa, Piero and Prati, Daniele and Raggi, Chiara and Rosina, Floriano and Rossi, Sonia and Sogno, Ilaria and Spinzi, Giancarlo and Strazzabosco, Mario and Tarallo, Sonia and Tarocchi, Mirko and Tiribelli, Claudio and Toniutto, Pierluigi and Vinci, Maria and Zuin, Massimo and Gershwin, M.E and Siminovitch, K.A and Amos, C.I and Italian PBC Genetics Study Grp and Italian PBC Genetics Study Group and the Italian PBC Genetics Study Group
Genes and Immunity, ISSN 1466-4879, 05/2013, Volume 14, Issue 3, pp. 179 - 186
Genome-wide association studies (GWAS) have successfully identified several loci associated with primary biliary cirrhosis (PBC) risk. Pathway analysis... 
autoimmune disease | hedgehog signaling | linear combination test | phosphatidylinositol signaling | CELLS | ACTIVATION | VARIANTS | IMMUNOLOGY | IDENTIFICATION | SENSORS | EPITHELIAL-MESENCHYMAL TRANSITION | RESPONSES | DISEASES | GENE | GENETICS & HEREDITY | TRAITS | Genetic Predisposition to Disease - genetics | Meta-Analysis as Topic | Gene Frequency | Humans | Middle Aged | Databases, Genetic | Genotype | Male | Signal Transduction - genetics | Liver Cirrhosis, Biliary - genetics | Linkage Disequilibrium | Canada | Algorithms | Female | Italy | Polymorphism, Single Nucleotide | Genome-Wide Association Study - methods | Cohort Studies | Quantitative trait loci | Physiological aspects | Development and progression | Genetic aspects | Biliary cirrhosis | Research | Hedgehog proteins
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9. Full Text ABCB4 mutations in adult patients with cholestatic liver disease: impact and phenotypic expression
by Degiorgio, Dario and Degiorgio, Dario and Crosignani, Andrea and Crosignani, Andrea and Colombo, Carla and Colombo, Carla and Bordo, Domenico and Bordo, Domenico and Zuin, Massimo and Zuin, Massimo and Vassallo, Emanuela and Vassallo, Emanuela and Syrén, Marie-Louise and Syrén, Marie-Louise and Coviello, Domenico A and Coviello, Domenico A and Battezzati, Pier Maria and Battezzati, Pier Maria
Journal of Gastroenterology, ISSN 0944-1174, 3/2016, Volume 51, Issue 3, pp. 271 - 280
The ABCB4 gene encodes the MDR3 protein. Mutations of this gene cause progressive familial intrahepatic cholestasis type 3 (PFIC3) in children, but their... 
Primary biliary cirrhosis | Medicine & Public Health | Colorectal Surgery | Hepatology | ABCB4 | Gastroenterology | Abdominal Surgery | Primary sclerosing cholangitis | MDR3 protein | Idiopathic chronic cholestasis | Surgical Oncology | Cholangiocarcinoma | GENE-MUTATIONS | TYPE-3 | CLINICAL-FEATURES | CHOLELITHIASIS | VARIANT | SCLEROSING CHOLANGITIS | PRIMARY BILIARY-CIRRHOSIS | SPECTRUM | GASTROENTEROLOGY & HEPATOLOGY | BILE | Amino Acid Sequence | Cholestasis - genetics | Cholestasis, Intrahepatic - genetics | ATP Binding Cassette Transporter, Sub-Family B - deficiency | Humans | Middle Aged | Cholangitis, Sclerosing - genetics | Male | Liver Cirrhosis, Biliary - genetics | Case-Control Studies | Young Adult | Phenotype | Sequence Alignment | Adolescent | Age of Onset | Pregnancy Complications - genetics | Adult | Female | Aged | Mutation | ATP Binding Cassette Transporter, Sub-Family B - genetics | Child | Chronic Disease | Proteins | Genetic research | Genetic aspects | Adults | Liver cirrhosis
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