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Nature Protocols, ISSN 1754-2189, 02/2016, Volume 11, Issue 2, pp. 347 - 58
This protocol describes a strategy for the generation of 3D prostate organoid cultures from healthy mouse and human prostate cells (either bulk or FACS-sorted... 
PROGENITOR CELLS | MURINE PROSTATE | STEM-CELLS | IN-VITRO | VIVO | REGENERATION | EXPANSION | BIOCHEMICAL RESEARCH METHODS | Epithelial Cells - physiology | Organ Culture Techniques - methods | Animals | Organoids - growth & development | Humans | Cells, Cultured | Culture Media, Serum-Free | Male | Mice | Time | Prostate - physiology | Cell culture | Care and treatment | Prostate cancer | Methods | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 2015, Volume 521, Issue 7550, pp. 43 - 37
Journal Article
Molecular Cell, ISSN 1097-2765, 08/2016, Volume 63, Issue 3, pp. 352 - 4
Intratumor heterogeneity is thought to be the driving force of tumor evolution and therapy resistance. Yet tools to study these processes are limited. In this... 
STEM-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENOME | INTRATUMOR HETEROGENEITY | CELL BIOLOGY | Mutation | Humans | Oncogenes | Clustered Regularly Interspaced Short Palindromic Repeats | Genetic aspects | Genes | Bar codes | Cancer | Index Medicus
Journal Article
Methods in Molecular Biology, ISSN 1064-3745, 2016, Volume 1481, pp. 141 - 59
We established an in vitro culture model in which intestinal epithelial stem cells can grow into three-dimensional, ever-expanding epithelial organoids that... 
Wnt signaling | CRISPR/Cas9 | Organoids | Intestine | Lentivirus | Cell Differentiation - genetics | Animals | Wnt Signaling Pathway - genetics | Humans | Organoids - metabolism | Organoids - cytology | Clustered Regularly Interspaced Short Palindromic Repeats - genetics | Mice | Genetic Vectors | Cell Culture Techniques - methods | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 03/2017, Volume 114, Issue 12, pp. E2357 - E2364
Journal Article
Molecular Cell, ISSN 1097-2765, 08/2016, Volume 63, Issue 3, p. 352
Intratumor heterogeneity is thought to be the driving force of tumor evolution and therapy resistance. Yet tools to study these processes are limited. In this... 
Journal Article
Journal Article
Nature Protocols, ISSN 1754-2189, 02/2016, Volume 11, Issue 2, p. 347
This protocol describes a strategy for the generation of 3D prostate organoid cultures from healthy mouse and human prostate cells (either bulk or FACS-sorted... 
Journal Article
eLife, ISSN 2050-084X, 11/2016, Volume 5
Colorectal cancer (CRC) organoids can be derived from almost all CRC patients and therefore capture the genetic diversity of this disease. We assembled a panel... 
Journal Article
Nature, ISSN 0028-0836, 05/2015, Volume 521, Issue 7550, pp. 43 - 7
Crypt stem cells represent the cells of origin for intestinal neoplasia. Both mouse and human intestinal stem cells can be cultured in medium containing the... 
Journal Article
Nature, ISSN 0028-0836, 05/2015, Volume 521, Issue 7550, p. 43
Crypt stem cells represent the cells of origin for intestinal neoplasia. Both mouse and human intestinal stem cells can be cultured in medium containing the... 
Journal Article
Embo Molecular Medicine, ISSN 1757-4676, 07/2016, Volume 8, Issue 7, p. 745
The heterogeneous nature of colorectal cancer (CRC) complicates prognosis and is suggested to be a determining factor in the efficacy of adjuvant therapy for... 
Journal Article
EMBO Molecular Medicine, ISSN 1757-4676, 2016, Volume 8, Issue 7, pp. 745 - 60
The heterogeneous nature of colorectal cancer (CRC) complicates prognosis and is suggested to be a determining factor in the efficacy of adjuvant therapy for... 
Journal Article
by Kaukonen, Kirsi-Maija and Vaara, Suvi T and Pettilä, Ville and Bellomo, Rinaldo and Tuimala, Jarno and Cooper, David J and Krusius, Tom and Kuitunen, Anne and Reinikainen, Matti and Koskenkari, Juha and Uusaro, Ari and Laru-Sompa, Raili and Pulkkinen, Anni and Saarelainen, Minna and Reilama, Mikko and Tolmunen, Sinikka and Rantalainen, Ulla and Miettinen, Marja and Suvela, Markku and Pesola, Katrine and Saastamoinen, Pekka and Kauppinen, Sirpa and Korhonen, Anna-Maija and Nisula, Sara and Vaara, Suvi and Suojaranta-Ylinen, Raili and Mildh, Leena and Haapio, Mikko and Nurminen, Laura and Sutinen, Sari and Pettilä, Leena and Laitinen, Helinä and Syrjä, Heidi and Henttonen, Kirsi and Lappi, Elina and Boman, Hillevi and Varpula, Tero and Porkka, Päivi and Mira Rahkonen, Mirka Sivula and Tsurkka, Anne and Nieminen, Taina and Prittinen, Niina and Alaspää, Ari and Salanto, Ville and Juntunen, Hanna and Sanisalo, Teija and Parviainen, Ilkka and Ruokonen, Esko and Bendel, Stepani and Rissanen, Niina and Lång, Maarit and Rahikainen, Sari and Rissanen, Saija and Ahonen, Merja and Halonen, Elina and Vaskelainen, Eija and Poukkanen, Meri and Lintula, Esa and Suominen, Sirpa and Heikkinen, Jorma and Lavander, Timo and Heinonen, Kirsi and Juopperi, Anne-Mari and Kaminski, Tadeusz and Gäddnäs, Fiia and Kuusela, Tuija and Roiko, Jane and Karlsson, Sari and Surakka, Tero and Jyrkönen, Helena and Eiserbeck, Tanja and Kallinen, Jaana and Lund, Vesa and Tuominen, Päivi and Perkola, Pauliina and Tuominen, Riikka and Hietaranta, Marika and Johansson, Satu and Hovilehto, Seppo and Kirsi, Anne and Tiainen, Pekka and Myllärinen, Tuija and Leino, Pirjo and Toropainen, Anne and Leppänen, Ilona and Levoranta, Markus and Hoppu, Sanna and Sauranen, Jukka and Tenhunen, Jyrki and Kukkurainen, Atte and Kortelainen, Samuli and Varila, Simo and Inkinen, Outi and Koivuviita, Niina and Kotamäki, Jutta and Laine, Anu and Ala-Kokko, Tero and Laurila, Jouko and Sälkiö, Sinikka and Koivisto, Simo-Pekka and ... and FINNAKI Study Grp and FINNAKI study group and The FINNAKI study group
Critical Care, ISSN 1364-8535, 10/2013, Volume 17, Issue 5, pp. R222 - R222
Journal Article
Development (Cambridge, England), ISSN 0950-1991, 03/2017, Volume 144, Issue 6, pp. 968 - 975
Journal Article
MALARIA JOURNAL, ISSN 1475-2875, 02/2015, Volume 14
Background: The malaria vaccine RTS,S induces antibodies against the Plasmodium falciparum circumsporozoite protein (CSP) and the concentration of... 
Plasmodium falciparum | INFECTIOUS DISEASES | RTS,S | Malaria | Antibody | SAFETY | Avidity | EXPANDED-PROGRAM | Vaccine | Correlate of protection | PARASITOLOGY | TROPICAL MEDICINE
Journal Article