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Cell Stem Cell, ISSN 1934-5909, 06/2019, Volume 24, Issue 6, pp. 927 - 943.e6
The deubiquitinating enzyme BAP1 is a tumor suppressor, among others involved in cholangiocarcinoma. BAP1 has many proposed molecular targets, while its... 
tumor modeling | genome editing | CRISPR/Cas9 | liver | cancer | cholangiocarcinoma | BAP1 | epigenetics | human organoids
Journal Article
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, ISSN 1940-087X, 07/2019, Issue 149
Hematopoietic stem and progenitor cells (HSPCs) gradually accumulate DNA mutations during a lifespan, which can contribute to age-associated diseases such as... 
leukemia | development | SIGNATURES | MULTIDISCIPLINARY SCIENCES | lineage tracing | somatic mutations | hematopoiesis | Issue 149 | clonality | mutational signatures | ADULT STEM-CELLS | Genetics | ACCUMULATION
Journal Article
Blood, ISSN 0006-4971, 10/2015, Volume 126, Issue 18, pp. 2098 - 2109
textabstractExpression of the for khead transcription factor FOXP1 is essential for early B-cell development, whereas down regulation ofFOXP1at the germinal... 
Journal Article
Blood, ISSN 0006-4971, 10/2015, Volume 126, Issue 18, p. 2098
Expression of the for khead transcription factor FOXP1 is essential for early B-cell development, whereas down regulation ofFOXP1at the germinal center (GC)... 
Journal Article
Proceedings of the National Academy of Sciences, USA, ISSN 0027-8424, 03/2017, Volume 114, Issue 12, pp. E2357 - E2357
In the adenoma-carcinoma sequence, it is proposed that intestinal polyps evolve through a set of defined mutations toward metastatic colorectal cancer (CRC).... 
Journal Article
BMC Genomics, ISSN 1471-2164, 05/2015, Volume 16
Background: Since the completion of the rat reference genome in 2003, whole-genome sequencing data from more than 40 rat strains have become available. These... 
Journal Article
Nature, ISSN 0028-0836, 05/2015, Volume 521, Issue 7550, pp. 43 - 7
Crypt stem cells represent the cells of origin for intestinal neoplasia. Both mouse and human intestinal stem cells can be cultured in medium containing the... 
Journal Article
Nature, ISSN 0028-0836, 05/2015, Volume 521, Issue 7550, p. 43
Crypt stem cells represent the cells of origin for intestinal neoplasia. Both mouse and human intestinal stem cells can be cultured in medium containing the... 
Journal Article
Cell, ISSN 0092-8674, 01/2015, Volume 160, Issue 1-2, pp. 299 - 312
textabstractDespite the enormous replication potential of the human liver, there are currently no culture systems available that sustain hepatocyte replication... 
Journal Article
Nature, ISSN 0028-0836, 10/2016, Volume 538, Issue 7624, pp. 260 - 264
Journal Article
BMC Genomics, ISSN 1471-2164, 05/2015, Volume 16
Background: Since the completion of the rat reference genome in 2003, whole-genome sequencing data from more than 40 rat strains have become available. These... 
Journal Article
Journal Article
Nature, ISSN 0028-0836, 2015, Volume 521, Issue 7550, pp. 43 - 37
Journal Article
Methods in Molecular Biology, ISSN 1064-3745, 2010, Volume 597, pp. 151 - 167
The rat is one of the most preferred model organisms in biomedical research and has been extremely useful for linking physiology and pathology to the genome.... 
DNA - genetics | Ethylnitrosourea - administration & dosage | DNA - isolation & purification | Animals | Mutagenesis | Animals, Genetically Modified - genetics | Female | Male | Mutation | Rats - genetics | Ethylnitrosourea - pharmacology
Journal Article
Methods in Molecular Biology, ISSN 1064-3745, 2011, Volume 693, pp. 295 - 308
The generation of genetically modified animals using N-ethyl-N-nitrosourea (ENU) mutagenesis is a fast and highly effective method. The technique is based on... 
Animals | Animals, Genetically Modified | Mutagenesis - genetics | Rats | Female | Genotype | Male | Mice | Mutagenesis - drug effects | Ethylnitrosourea - pharmacology
Journal Article
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