Therapeutic Drug Monitoring, ISSN 0163-4356, 12/2019, Volume 41, Issue 6, pp. 693 - 695
Journal Article
Journal of Nuclear Medicine, ISSN 0161-5505, 01/2015, Volume 56, Issue 1, pp. 50 - 55
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 05/2015, Volume 33, Issue 15, pp. 527 - 527
Journal Article
Lancet Oncology, The, ISSN 1470-2045, 2013, Volume 14, Issue 11, pp. e465 - e475
Summary Oestrogen receptors are overexpressed in around 70% of all breast cancers, and are a target for endocrine therapy. These receptors can be visualised on...
Hematology, Oncology and Palliative Medicine | FES PET | METABOLIC FLARE | POSITRON-EMISSION-TOMOGRAPHY | ONCOLOGY | FLUORINE-18-LABELED ESTROGENS | TAMOXIFEN | IN-VIVO | ALPHA | HORMONE-BINDING GLOBULIN | UTERINE-TUMORS | BETA | Receptors, Estrogen - metabolism | Animals | Humans | Female | Breast Neoplasms - diagnosis | Positron-Emission Tomography | Breast Neoplasms - metabolism | Pets | Care and treatment | PET imaging | Estrogen | Breast cancer | Metastasis | Tumor proteins
Hematology, Oncology and Palliative Medicine | FES PET | METABOLIC FLARE | POSITRON-EMISSION-TOMOGRAPHY | ONCOLOGY | FLUORINE-18-LABELED ESTROGENS | TAMOXIFEN | IN-VIVO | ALPHA | HORMONE-BINDING GLOBULIN | UTERINE-TUMORS | BETA | Receptors, Estrogen - metabolism | Animals | Humans | Female | Breast Neoplasms - diagnosis | Positron-Emission Tomography | Breast Neoplasms - metabolism | Pets | Care and treatment | PET imaging | Estrogen | Breast cancer | Metastasis | Tumor proteins
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 05/2014, Volume 32, Issue 15, pp. 588 - 588
Journal Article
Journal of Nuclear Medicine, ISSN 0161-5505, 01/2015, Volume 56, Issue 1, pp. 50 - 50
The estrogen receptor (ER) is expressed in approximately 70% of ovarian cancer tumors. PET of tumor ER expression with the tracer 16-18F-fluoro-17-estradiol...
Journal Article
Cancer Research, ISSN 0008-5472, 04/2013, Volume 73, Issue 8 Supplement, pp. 4768 - 4768
Journal Article
ONCOLOGY (United States), ISSN 0890-9091, 05/2014, Volume 28, Issue 5, pp. 434 - 436
Journal Article
Journal of Nuclear Medicine, ISSN 0161-5505, 02/2012, Volume 53, Issue 2, pp. 182 - 190
Journal Article
Journal of Nuclear Medicine, ISSN 0161-5505, 01/2012, Volume 53, Issue 2, pp. 182 - 190
16 alpha -18F-fluoro-17 beta -estradiol (18F-FES) is an estrogen receptor (ER)-specific PET tracer with various potential interesting applications. The precise...
Journal Article
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 08/2018, Volume 59, Issue 8, p. 1212
Heterogeneity of estrogen receptor (ER) expression in breast cancer is recognized. However, knowledge about varying expression across metastases and...
Journal Article
Breast Cancer Research, ISSN 1465-5411, 07/2014, Volume 16, Issue 4, p. 412
DNA methylation and histone modifications are important epigenetic modifications associated with gene (dys) regulation. The epigenetic modifications are...
HDAC INHIBITORS | CELLS | HISTONE DEACETYLASE INHIBITOR | PHASE-II TRIAL | DNA METHYLATION | SOLID TUMORS | ONCOLOGY | SUBEROYLANILIDE HYDROXAMIC ACID | VALPROIC ACID | VORINOSTAT | MODULATION | Epigenomics | Humans | Treatment Outcome | Antineoplastic Agents - therapeutic use | Clinical Trials as Topic | DNA (Cytosine-5-)-Methyltransferases - antagonists & inhibitors | Breast Neoplasms - drug therapy | Breast Neoplasms - metabolism | Animals | Breast Neoplasms - genetics | Female | Histone Deacetylase Inhibitors - pharmacology | Antineoplastic Agents - pharmacology | Epigenesis, Genetic - drug effects | Histone Deacetylase Inhibitors - therapeutic use | Gene Expression Regulation, Neoplastic - drug effects | Histones - metabolism | Drug Evaluation, Preclinical | DNA Methylation - drug effects | Antimitotic agents | Epigenetic inheritance | Care and treatment | Methyltransferases | Genes | Antineoplastic agents | Health aspects | Cancer | Review
HDAC INHIBITORS | CELLS | HISTONE DEACETYLASE INHIBITOR | PHASE-II TRIAL | DNA METHYLATION | SOLID TUMORS | ONCOLOGY | SUBEROYLANILIDE HYDROXAMIC ACID | VALPROIC ACID | VORINOSTAT | MODULATION | Epigenomics | Humans | Treatment Outcome | Antineoplastic Agents - therapeutic use | Clinical Trials as Topic | DNA (Cytosine-5-)-Methyltransferases - antagonists & inhibitors | Breast Neoplasms - drug therapy | Breast Neoplasms - metabolism | Animals | Breast Neoplasms - genetics | Female | Histone Deacetylase Inhibitors - pharmacology | Antineoplastic Agents - pharmacology | Epigenesis, Genetic - drug effects | Histone Deacetylase Inhibitors - therapeutic use | Gene Expression Regulation, Neoplastic - drug effects | Histones - metabolism | Drug Evaluation, Preclinical | DNA Methylation - drug effects | Antimitotic agents | Epigenetic inheritance | Care and treatment | Methyltransferases | Genes | Antineoplastic agents | Health aspects | Cancer | Review
Journal Article
Cancer discovery, ISSN 2159-8274, 01/2015, Volume 5, Issue 1, pp. 72 - 81
It is unknown whether the current dose of fulvestrant, an estrogen receptor (ER) antagonist, is sufficient for maximal ER downregulation in patients with...
TRIAL | DIAGNOSIS | POSTMENOPAUSAL WOMEN | TAMOXIFEN | PET | TISSUE | ONCOLOGY | Estradiol - analogs & derivatives | Estradiol - therapeutic use | Antineoplastic Agents, Hormonal - administration & dosage | Humans | Middle Aged | Estradiol - administration & dosage | Receptors, Estrogen - antagonists & inhibitors | Tomography, X-Ray Computed | Treatment Outcome | Positron-Emission Tomography | Breast Neoplasms - drug therapy | Tamoxifen - administration & dosage | Disease Progression | Antineoplastic Agents, Hormonal - pharmacokinetics | Estradiol - pharmacokinetics | Neoplasm Metastasis | Breast Neoplasms - pathology | Antineoplastic Agents, Hormonal - therapeutic use | Tamoxifen - therapeutic use | Female | Aged | Breast Neoplasms - diagnosis
TRIAL | DIAGNOSIS | POSTMENOPAUSAL WOMEN | TAMOXIFEN | PET | TISSUE | ONCOLOGY | Estradiol - analogs & derivatives | Estradiol - therapeutic use | Antineoplastic Agents, Hormonal - administration & dosage | Humans | Middle Aged | Estradiol - administration & dosage | Receptors, Estrogen - antagonists & inhibitors | Tomography, X-Ray Computed | Treatment Outcome | Positron-Emission Tomography | Breast Neoplasms - drug therapy | Tamoxifen - administration & dosage | Disease Progression | Antineoplastic Agents, Hormonal - pharmacokinetics | Estradiol - pharmacokinetics | Neoplasm Metastasis | Breast Neoplasms - pathology | Antineoplastic Agents, Hormonal - therapeutic use | Tamoxifen - therapeutic use | Female | Aged | Breast Neoplasms - diagnosis
Journal Article
European Journal of Nuclear Medicine and Molecular Imaging, ISSN 1619-7070, 10/2015, Volume 42, Issue 11, pp. 1674 - 1681
Purpose Whereas anti-oestrogen therapy is widely applied to treat oestrogen receptor (ER) positive breast cancer, paradoxically, oestrogens can also induce...
CELLS | APOPTOTIC ACTION | TAMOXIFEN | ENDOCRINE-THERAPY | Breast cancer | Oestrogen receptor | TRIAL | Oestradiol therapy | RECOMMENDATIONS | Imaging | ESTROGEN-RECEPTOR-ALPHA | DIETHYLSTILBESTROL | F-18-FES-PET | BONE | POSTMENOPAUSAL WOMEN | Medicine & Public Health | Orthopedics | Oncology | Nuclear Medicine | Imaging / Radiology | Cardiology | 18 F-FES-PET | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Estradiol - metabolism | Predictive Value of Tests | Estradiol - analogs & derivatives | Estradiol - therapeutic use | Humans | Middle Aged | Drug Resistance, Neoplasm | Male | Treatment Outcome | Positron-Emission Tomography | Breast Neoplasms - drug therapy | Breast Neoplasms - metabolism | Biological Transport | Bone and Bones - metabolism | Biomarkers, Tumor - metabolism | Estradiol - adverse effects | Adult | Female | Aged | Breast Neoplasms - diagnostic imaging | Tomography | Metastasis | Positrons | Emissions | 18F-FES-PET | Original
CELLS | APOPTOTIC ACTION | TAMOXIFEN | ENDOCRINE-THERAPY | Breast cancer | Oestrogen receptor | TRIAL | Oestradiol therapy | RECOMMENDATIONS | Imaging | ESTROGEN-RECEPTOR-ALPHA | DIETHYLSTILBESTROL | F-18-FES-PET | BONE | POSTMENOPAUSAL WOMEN | Medicine & Public Health | Orthopedics | Oncology | Nuclear Medicine | Imaging / Radiology | Cardiology | 18 F-FES-PET | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Estradiol - metabolism | Predictive Value of Tests | Estradiol - analogs & derivatives | Estradiol - therapeutic use | Humans | Middle Aged | Drug Resistance, Neoplasm | Male | Treatment Outcome | Positron-Emission Tomography | Breast Neoplasms - drug therapy | Breast Neoplasms - metabolism | Biological Transport | Bone and Bones - metabolism | Biomarkers, Tumor - metabolism | Estradiol - adverse effects | Adult | Female | Aged | Breast Neoplasms - diagnostic imaging | Tomography | Metastasis | Positrons | Emissions | 18F-FES-PET | Original
Journal Article
Journal of Nuclear Medicine, ISSN 0161-5505, 08/2018, Volume 59, Issue 8, pp. 1212 - 1218
Heterogeneity of estrogen receptor (ER) expression in breast cancer is recognized. However, knowledge about varying expression across metastases and...
PROGESTERONE | estrogen receptor | breast cancer | FUTURE | ESTROGEN-RECEPTOR BINDING | POSITRON-EMISSION-TOMOGRAPHY | THERAPY | EVOLUTION | IN-VIVO | RESISTANCE | ANDROGEN | tumor microenvironment | F-18-fluoroestradiol PET | PET | tumor heterogeneity | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
PROGESTERONE | estrogen receptor | breast cancer | FUTURE | ESTROGEN-RECEPTOR BINDING | POSITRON-EMISSION-TOMOGRAPHY | THERAPY | EVOLUTION | IN-VIVO | RESISTANCE | ANDROGEN | tumor microenvironment | F-18-fluoroestradiol PET | PET | tumor heterogeneity | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Journal Article
Journal of Nuclear Medicine, ISSN 0161-5505, 02/2012, Volume 53, Issue 2, pp. 182 - 190
16 alpha-F-18-fluoro-17 beta-estradiol (F-18-FES) is an estrogen receptor (ER)-specific PET tracer with various potential interesting applications. The precise...
F-18-FES PET | METABOLIC FLARE | EFFICACY | estrogen receptor | breast cancer | imaging | UMCG Approved | HETEROGENEITY | POSITRON-EMISSION-TOMOGRAPHY | THERAPY | ASSAYS | clinical value | EXPRESSION | Clinical value | Estrogen receptor | Breast cancer | F-FES PET | Imaging | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Estradiol - metabolism | Estradiol - analogs & derivatives | Receptors, Estrogen - metabolism | Humans | Middle Aged | Positron-Emission Tomography - methods | Breast Neoplasms - metabolism | Biological Transport | Adult | Female | Aged | Retrospective Studies | Breast Neoplasms - diagnostic imaging | Medicine | Studies | Confidence intervals | Decision making | Biopsy | Oncology | Family medical history | Abdomen
F-18-FES PET | METABOLIC FLARE | EFFICACY | estrogen receptor | breast cancer | imaging | UMCG Approved | HETEROGENEITY | POSITRON-EMISSION-TOMOGRAPHY | THERAPY | ASSAYS | clinical value | EXPRESSION | Clinical value | Estrogen receptor | Breast cancer | F-FES PET | Imaging | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Estradiol - metabolism | Estradiol - analogs & derivatives | Receptors, Estrogen - metabolism | Humans | Middle Aged | Positron-Emission Tomography - methods | Breast Neoplasms - metabolism | Biological Transport | Adult | Female | Aged | Retrospective Studies | Breast Neoplasms - diagnostic imaging | Medicine | Studies | Confidence intervals | Decision making | Biopsy | Oncology | Family medical history | Abdomen
Journal Article
Gynecologic Oncology, ISSN 0090-8258, 2015, Volume 138, Issue 3, pp. 634 - 639
Abstract Objective Androgen receptor (AR), estrogen receptor α and β (ERα, ERβ), and progesterone receptor (PR) are potential therapeutic targets in epithelial...
Hematology, Oncology and Palliative Medicine | Obstetrics and Gynecology | Estrogen receptor | Biomarker | Progesterone receptor | Androgen receptor | Ovarian cancer | TAMOXIFEN | PHASE-II | FLUTAMIDE | CHEMOTHERAPY | BREAST-CANCER | THERAPY | FULVESTRANT | EXPRESSION | CARCINOMA | OBSTETRICS & GYNECOLOGY | ONCOLOGY | LETROZOLE | INHIBITOR | Celecoxib - administration & dosage | Receptors, Estrogen - blood | Prognosis | Prospective Studies | Tissue Array Analysis | Humans | Middle Aged | Neoplasms, Glandular and Epithelial - blood | Receptors, Androgen - biosynthesis | Aged, 80 and over | Adult | Female | Ovarian Neoplasms - drug therapy | Receptors, Androgen - blood | Docetaxel | Carboplatin - administration & dosage | Ovarian Neoplasms - blood | Taxoids - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Neoplasms, Glandular and Epithelial - drug therapy | Survival Analysis | Carcinoma, Ovarian Epithelial | Receptors, Estrogen - biosynthesis | Aged | Receptors, Progesterone - blood | Receptors, Progesterone - biosynthesis | Estrogen | Hormones
Hematology, Oncology and Palliative Medicine | Obstetrics and Gynecology | Estrogen receptor | Biomarker | Progesterone receptor | Androgen receptor | Ovarian cancer | TAMOXIFEN | PHASE-II | FLUTAMIDE | CHEMOTHERAPY | BREAST-CANCER | THERAPY | FULVESTRANT | EXPRESSION | CARCINOMA | OBSTETRICS & GYNECOLOGY | ONCOLOGY | LETROZOLE | INHIBITOR | Celecoxib - administration & dosage | Receptors, Estrogen - blood | Prognosis | Prospective Studies | Tissue Array Analysis | Humans | Middle Aged | Neoplasms, Glandular and Epithelial - blood | Receptors, Androgen - biosynthesis | Aged, 80 and over | Adult | Female | Ovarian Neoplasms - drug therapy | Receptors, Androgen - blood | Docetaxel | Carboplatin - administration & dosage | Ovarian Neoplasms - blood | Taxoids - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Neoplasms, Glandular and Epithelial - drug therapy | Survival Analysis | Carcinoma, Ovarian Epithelial | Receptors, Estrogen - biosynthesis | Aged | Receptors, Progesterone - blood | Receptors, Progesterone - biosynthesis | Estrogen | Hormones
Journal Article
Journal of Nuclear Medicine, ISSN 0161-5505, 01/2015, Volume 56, Issue 1, pp. 50 - 55
The estrogen receptor a (ER alpha) is expressed in approximately 70% of ovarian cancer tumors. PET of tumor ER alpha expression with the tracer 16...
FES PET | RESPONSIVENESS | estrogen receptor | ovarian cancer | TAMOXIFEN | imaging | BETA | BREAST-CANCER | PHASE-II TRIAL | POSITRON-EMISSION-TOMOGRAPHY | THERAPY | LETROZOLE | F-18-FLUOROESTRADIOL | PROGESTERONE-RECEPTOR | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
FES PET | RESPONSIVENESS | estrogen receptor | ovarian cancer | TAMOXIFEN | imaging | BETA | BREAST-CANCER | PHASE-II TRIAL | POSITRON-EMISSION-TOMOGRAPHY | THERAPY | LETROZOLE | F-18-FLUOROESTRADIOL | PROGESTERONE-RECEPTOR | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Journal Article
Pharmacology and Therapeutics, ISSN 0163-7258, 08/2019, Volume 200, pp. 135 - 147
The androgen receptor (AR) is a drug target in breast cancer, and AR-targeted therapies have induced tumor responses in breast cancer patients. In this review,...
AR antagonist | Estrogen receptor | Breast cancer | Human epidermal growth factor receptor 2 | Androgen receptor | Triple-negative breast cancer | PHASE-II | RANDOMIZED-TRIAL | CELL-PROLIFERATION | ADRENAL ANDROGENS | ESTROGEN | ABIRATERONE ACETATE | PHARMACOLOGY & PHARMACY | RESISTANT PROSTATE-CANCER | POSTMENOPAUSAL WOMEN | EXPRESSION | CLINICAL-SIGNIFICANCE | Immunohistochemistry | Medical colleges | Pituitary hormones | RNA | Estrogen | Antibodies | Glycoproteins | Viral antibodies | Androgens | Epidermal growth factor | Analysis | Luteinizing hormone | Progesterone
AR antagonist | Estrogen receptor | Breast cancer | Human epidermal growth factor receptor 2 | Androgen receptor | Triple-negative breast cancer | PHASE-II | RANDOMIZED-TRIAL | CELL-PROLIFERATION | ADRENAL ANDROGENS | ESTROGEN | ABIRATERONE ACETATE | PHARMACOLOGY & PHARMACY | RESISTANT PROSTATE-CANCER | POSTMENOPAUSAL WOMEN | EXPRESSION | CLINICAL-SIGNIFICANCE | Immunohistochemistry | Medical colleges | Pituitary hormones | RNA | Estrogen | Antibodies | Glycoproteins | Viral antibodies | Androgens | Epidermal growth factor | Analysis | Luteinizing hormone | Progesterone
Journal Article
The Journal of Nuclear Medicine, ISSN 0161-5505, 08/2018, Volume 59, Issue 8, p. 1212
Heterogeneity of estrogen receptor (ER) expression in breast cancer is recognized. However, knowledge about varying expression across metastases and...
Cluster analysis | Liver | Estrogens | Estrogen | Estrogen receptors | Metastasis | Estradiol | Subgroups | Lymph nodes | Metastases | Confidence intervals | Heterogeneity | Computed tomography | Bones | Lesions | Medical imaging | Fluorine isotopes | Breast cancer | Patients | Sex hormones | Lungs | Breast | Bone | Tumors | Cancer | Lymph
Cluster analysis | Liver | Estrogens | Estrogen | Estrogen receptors | Metastasis | Estradiol | Subgroups | Lymph nodes | Metastases | Confidence intervals | Heterogeneity | Computed tomography | Bones | Lesions | Medical imaging | Fluorine isotopes | Breast cancer | Patients | Sex hormones | Lungs | Breast | Bone | Tumors | Cancer | Lymph
Journal Article
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