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1. Trends on the role of PET in drug development
by Elsinga, Philip H and Van Waarde, Aren and Paans, Anne M. J and Dierckx, Rudi A. J. O
2011, ISBN 981431773X, 600
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2. Full Text In Vivo Quantification of ERb Expression by Pharmacokinetic Modeling: Studies with 18F-FHNP PET
by Antunes, Ines F and Willemsen, Antoon T. M and Sijbesma, Jurgen W. A and Boerema, Ate S and van Waarde, Aren and Glaudemans, Andor W. J. M and Dierckx, Rudi A. J. O and de Vries, Elisabeth G. E and Hospers, Geke A. P and de Vries, Erik F. J
Journal of Nuclear Medicine, ISSN 0161-5505, 11/2017, Volume 58, Issue 11, pp. 1743 - 1748
The estrogen receptor (ER) is a target for endocrine therapy in breast cancer patients. Individual quantification of ER alpha and ER beta expression, rather... 
ESTROGEN-RECEPTOR-BETA | SELECTIVE RADIOLIGAND | quantification | THERAPY | FES | 16-ALPHA-F-18-FLUORO-17-BETA-ESTRADIOL | pharmacokinetics | EARLY BREAST-CANCER | estrogen receptors | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | PET | oncology
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3. Full Text In vivo quantification of ERb expression by pharmacokinetic modeling: Studies with18F-FHNP PET
by Antunes, Inês F and Willemsen, Antoon T.M and Sijbesma, Jurgen W.A and Boerema, Ate S and Van Waarde, Aren and Glaudemans, Andor W.J.M and Dierckx, Rudi A.J.O and De Vries, Elisabeth G.E and Hospers, Geke A.P and De Vries, Erik F.J
Journal of Nuclear Medicine, ISSN 0161-5505, 11/2017, Volume 58, Issue 11, pp. 1743 - 1748
Estrogen receptors | Oncology | Quantification | Pharmacokinetics | PET
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4. Full Text Selectivity of F-18-FLT and F-18-FDG for differentiating tumor from inflammation in a rodent model
by van Waarde, Aren and Cobben, David C P and Suurmeijer, Albert J H and Maas, Bram and Vaalburg, Willem and de Vries, Erik and Jager, Pieter L and Hoekstra, Harald J and Elsinga, Philippus
Journal of Nuclear Medicine, ISSN 0161-5505, 04/2004, Volume 45, Issue 4, pp. 695 - 700
Increased glucose metabolism of inflammatory tissues is the main source of false-positive F-18-FDG PET findings in oncology. It has been suggested that... 
GRANULATION TISSUES | POSITRON-EMISSION-TOMOGRAPHY | THYMIDINE KINASE-1 | IN-VIVO | KINETIC-ANALYSIS | HIGH ACCUMULATION | IMAGING PROLIFERATION | CELL-LINES | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | FLT UPTAKE | FLUORINE-18-FLUORODEOXYGLUCOSE
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5. Full Text Synthesis and evaluation of the estrogen receptor β-selective radioligand 2-18F-fluoro-6-(6-hydroxynaphthalen-2-yl) pyridin-3-ol: Comparison with 16α-18F-fluoro-17β-estradiol
by Antunes, Inês F and Van Waarde, Aren and Dierckx, Rudi A.J.O and De Vries, Elisabeth G.E and Hospers, Geke A.P and De Vries, Erik F.J
Journal of Nuclear Medicine, ISSN 0161-5505, 04/2017, Volume 58, Issue 4, pp. 554 - 559
Estrogen receptors (ERs) are targets for endocrine treatment of estrogen-dependent cancers. The ER consists of 2 isoforms, ERα and ERβ, which have distinct... 
Estrogen receptors | Hormones | Imaging | PET | Cancer | Cell proliferation | Ovarian carcinoma | Estrogens | Genistein | Estrogen | 17β-Estradiol | Selectivity | Receptors | Cell activation | Synthesis | Radiochemistry | Xenografts | Tomography | Binding | Evaluation | Medical imaging | Cell survival | Medical treatment | Organs | Positron emission | Sex hormones | Isoforms | Affinity | Mice | Fluorination | Apoptosis | Index Medicus
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6. Full Text PET Imaging with S-[11C]Methyl-L-Cysteine and L-[Methyl-11C]Methionine in Rat Models of Glioma, Glioma Radiotherapy, and Neuroinflammation
by Parente, Andrea and van Waarde, Aren and Shoji, Alexandre and de Paula Faria, Daniele and Maas, Bram and Zijlma, Rolf and Dierckx, Rudi A. J. O and Langendijk, Johannes A and de Vries, Erik F.J and Doorduin, Janine
Molecular Imaging and Biology, ISSN 1536-1632, 6/2018, Volume 20, Issue 3, pp. 465 - 472
S-[11C]-methyl-L-cysteine ([11C]MCYS) has been claimed to offer higher tumor selectivity than L-[methyl- 11C]methionine ([11C]MET). We examined this claim in... 
Brain | Small animal imaging | Medicine & Public Health | Brain tumors | Amino acids | Inflammation | Imaging / Radiology | Positron emission tomography | TUMOR | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Cysteine - analogs & derivatives | Inflammation - pathology | Brain - diagnostic imaging | Rats, Wistar | Male | Positron-Emission Tomography | Cysteine - chemistry | Tumor Burden | Glioma - radiotherapy | Animals | Glioma - diagnostic imaging | Methionine - analogs & derivatives | Methionine - chemistry | Methionine - pharmacokinetics | Brain - pathology | Cysteine - pharmacokinetics | Inflammation - diagnostic imaging | Kinetics | Disease Models, Animal | Neuroimaging | Cysteine | Animal models | Irradiated | Accumulation | Lipopolysaccharides | Rodents | Neostriatum | Tomography | Wound healing | Salivary glands | Positron emission | Methionine | Rats | Salivary gland | Radiation therapy | Epithelium | Glioma | Irradiation | Tumors | Tracers | Index Medicus
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7. Full Text Preclinical evaluation and quantification of 18F-Fluoroethyl and 18F-Fluoropropyl Analogs of SCH442416 as radioligands for PET imaging of the adenosine a2a receptor in rat brain
by Khanapur, Shivashankar and Van Waarde, Aren and Dierckx, Rudi A.J.O and Elsinga, Philip H and Koole, Michel J.B
Journal of Nuclear Medicine, ISSN 0161-5505, 03/2017, Volume 58, Issue 3, pp. 466 - 472
The cerebral adenosine A2A receptor is an attractive therapeutic target for neuropsychiatric disorders. 18F-fluoroethyl and 18F-fluoropropyl analogs of... 
F-SCH442416 analogs | Kinetic analysis | Cerebral adenosine A2A receptor | Preclinical positron emission tomography (μPET) | Rat brain | Index Medicus
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8. Full Text Test-Retest Stability of Cerebral 2-Deoxy-2-[18F]Fluoro-D-Glucose ([18F]FDG) Positron Emission Tomography (PET) in Male and Female Rats
by Sijbesma, Jürgen W. A and van Waarde, Aren and Vállez García, David and Boersma, Hendrikus H and Slart, Riemer H. J. A and Dierckx, Rudi A. J. O and Doorduin, Janine
Molecular Imaging and Biology, ISSN 1536-1632, 4/2019, Volume 21, Issue 2, pp. 240 - 248
An important issue in rodent imaging is the question whether a mixed population of male and female animals can be used rather than animals of a single sex. For... 
Small animal imaging | Medicine & Public Health | Estrogens | Regional cerebral metabolic rate of glucose | Gender differences | Imaging / Radiology | Test-retest stability | SMALL-ANIMAL PET | GRAPHICAL EVALUATION | IN-VIVO | BRAIN TRANSFER CONSTANTS | GLUCOSE METABOLIC-RATES | SEX-DIFFERENCES | GENDER-DIFFERENCES | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Neuroimaging | Metabolic rate | Brain | Emission analysis | Correlation coefficients | Glucose | Estrus cycle | Gender | Males | Blood | Blood plasma | Rodents | Tomography | Anesthesia | Radioactivity | Estrus | Stability | Medical imaging | Body temperature | Positron emission | Rats | Sex differences | Fluorine isotopes | Metabolism | Isoflurane | Emissions | Heart rate | Population (statistical) | Animals | Females | Oxygenation | Positron emission tomography
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9. Full Text Potential Therapeutic Applications of Adenosine A2A Receptor Ligands and Opportunities for A2A Receptor Imaging
: ADENOSINE A2A RECEPTOR LIGANDS
by van Waarde, Aren and Dierckx, Rudi A. J. O and Zhou, Xiaoyun and Khanapur, Shivashankar and Tsukada, Hideo and Ishiwata, Kiichi and Luurtsema, Gert and de Vries, Erik F. J and Elsinga, Philip H
Medicinal Research Reviews, ISSN 0198-6325, 01/2018, Volume 38, Issue 1, pp. 5 - 56
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10. Full Text Preclinical Evaluation and Quantification of F-18-Fluoroethyl and F-18-Fluoropropyl Analogs of SCH442416 as Radioligands for PET Imaging of the Adenosine A(2A) Receptor in Rat Brain
by Khanapur, Shivashankar and van Waarde, Aren and Dierckx, Rudi A. J. O and Elsinga, Philip H and Koole, Michel J. B
Journal of Nuclear Medicine, ISSN 0161-5505, 03/2017, Volume 58, Issue 3, pp. 466 - 472
The cerebral adenosine A(2A) receptor is an attractive therapeutic target for neuropsychiatric disorders. F-18-fluoroethyl and F-18-fluoropropyl analogs of... 
TEST-RETEST | kinetic analysis | BASAL GANGLIA | rat brain | HUMANS | preclinical positron emission tomography (mu PET) | POSITRON-EMISSION-TOMOGRAPHY | cerebral adenosine A(2A) receptor | DISEASE | LIGAND | F-18-SCH442416 analogs | BINDING | VIOLATIONS | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
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11. Full Text C-11-Hydroxytryptophan Uptake and Metabolism in Endocrine and Exocrine Pancreas
by Di Gialleonardo, Valentina and Signore, Alberto and Scheerstra, Ena A and Visser, Anniek K. D and van Waarde, Aren and Dierckx, Rudi A. J. O and de Vries, Erik F. J
Journal of Nuclear Medicine, ISSN 0161-5505, 11/2012, Volume 53, Issue 11, pp. 1755 - 1763
Determination of the residual beta-cell mass using noninvasive tools might help to follow up the efficacy of new treatments in both type 1 (insulin-dependent)... 
STORAGE | POSITRON-EMISSION-TOMOGRAPHY | PET imaging | 5-HYDROXYTRYPTAMINE | serotonin pathway | MONOAMINE-OXIDASE ACTIVITY | BETA-CELLS | [C-11]HTP | exocrine pancreas | TUMORS | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | beta cells
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12. Full Text Acute social defeat does not alter cerebral 5-HT2A receptor binding in male Wistar rats
by Visser, Anniek K. D and Meerlo, Peter and Ettrup, Anders and Knudsen, Gitte M and Bosker, Fokko J and den Boer, Johan A and Dierckx, Rudi A. J. O and van Waarde, Aren
Synapse, ISSN 0887-4476, 2014, Volume 68, Issue 9, pp. 379 - 386
It has been hypothesized that effects of uncontrollable stress on serotonin receptor expression contribute to the etiology of stress-related disorders like... 
stress | anxiety | serotonin | depression | positron emission tomography | Depression | Anxiety | Serotonin | Positron emission tomography | Stress | SEROTONIN METABOLISM | SINGLE | POSITRON EMISSION | SUICIDE VICTIMS | NEUROSCIENCES | ANXIETY-LIKE BEHAVIORS | LEARNED HELPLESSNESS | EXPRESSION | BRAIN | Rats, Wistar | Anxiety - physiopathology | Fluorobenzenes | Male | Positron-Emission Tomography | Cerebral Cortex - diagnostic imaging | Cerebral Cortex - metabolism | Hippocampus - diagnostic imaging | Exploratory Behavior - physiology | Hippocampus - metabolism | Dominance-Subordination | Animals | Time Factors | Piperidines | Growth and Development | Radiopharmaceuticals | Receptor, Serotonin, 5-HT2A - metabolism | Stress, Psychological - diagnostic imaging | Carbon Radioisotopes | Stress, Psychological - physiopathology | Depression, Mental | Index Medicus
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13. Full Text Test-Retest Stability of Cerebral 2-Deoxy-2[-[.sup.18]F]Fluoro-D-Glucose [ Positron Emission Tomography in Male and Female Rats
by Sijbesma, Jurgen W. A and van Waarde, Aren and Vallez Garcia, David and Boersma, Hendrikus H and Slart, Riemer H. J. A and Dierckx, Rudi A. J. O and Doorduin, Janine
Molecular Imaging and Biology, ISSN 1536-1632, 04/2019, Volume 21, Issue 2, p. 240
An important issue in rodent imaging is the question whether a mixed population of male and female animals can be used rather than animals of a single sex. For... 
Glucose metabolism | Medical examination | Heart beat | PET imaging | Estrogen | Sport-utility vehicles | Glucose | Blood | Dextrose
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14. Full Text PET imaging of adenosine A(1) receptor occupancy
by Paul, Soumen and Khanapur, Shivashankar and Elsinga, Philip H and Ishiwata, Kiichi and Meerlo, Peter and Dierckx, Rudi and van Waarde, Aren
Journal of Nuclear Medicine, ISSN 0161-5505, 2014, Volume 55, Issue 11, pp. 1918 - 1918
HIGH-AFFINITY | RADIOLIGAND | ANTAGONISTS | AGONISTS | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | BRAIN
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15. Full Text PET imaging of adenosine A1 receptor occupancy
by Paul, Soumen and Khanapur, Shivashankar and Elsinga, Philip H and Ishiwata, Kiichi and Meerlo, Peter and Dierckx, Rudi and Van Waarde, Aren
Journal of Nuclear Medicine, ISSN 0161-5505, 11/2014, Volume 55, Issue 11, pp. 1918 - 1918
Xanthines - chemistry | Carbon Radioisotopes - chemistry | Animals | Nuclear Medicine - methods | Humans | Rodentia | Positron-Emission Tomography | Receptor, Adenosine A1 - chemistry | Kinetics | Nuclear Medicine - trends | Index Medicus
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16. Full Text Comparison of in vitro assays in selecting radiotracers for in vivo P-glycoprotein PET imaging
by Raaphorst, Renske M and Savolainen, Heli and Cantore, Mariangela and van de Steeg, Evita and van Waarde, Aren and Colabufo, Nicola A and Elsinga, Philip H and Lammertsma, Aiaan A and Windhorst, Albert D and Luurtsema, Geert
Pharmaceuticals, ISSN 1424-8247, 09/2017, Volume 10, Issue 3, p. 76
Positron emission tomography (PET) imaging of P-glycoprotein (P-gp) in the blood-brain barrier can be important in neurological diseases where P-gp is... 
Bidirectional transport | Tritium labeling | Blood-brain barrier | Apical and basolateral membrane | Calcein-AM | Glycoproteins | Medical imaging | blood-brain barrier | calcein-AM | tritium labeling | bidirectional transport | apical and basolateral membrane
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17. Full Text Cerebral adenosine A1receptors are upregulated in rodent encephalitis
by Soumen Paul and Shivashankar Khanapur and Wytske Boersma and Jurgen W Sijbesma and Kiichi Ishiwata and Philip H Elsinga and Peter Meerlo and Janine Doorduin and Rudi A Dierckx and Aren van Waarde
NeuroImage, ISSN 1053-8119, 05/2014, Volume 92, p. 83
  Adenosine A1receptors (A1Rs) are implied in the modulation of neuroinflammation. Activation of cerebral A1Rs acts as a brake on the microglial response after... 
Studies | Pets | Brain damage | Rodents
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18. Full Text Comparison of Sigma-Ligands and Metabolic PET Tracers for Differentiating Tumor from Inflammation
by van Waarde, Aren and Jager, Pieter L and Ishiwata, Kiichi and Dierckx, Rudi A and Elsinga, Philip H
The Journal of Nuclear Medicine, ISSN 0161-5505, 01/2006, Volume 47, Issue 1, pp. 150 - 154
Novel radiopharmaceuticals for the detection of tumors and their metastases may be of clinical interest if they are more tumor selective than F-18-FDG.... 
Tumor | Inflammation | Sigma-ligands | Choline | Methionine | CELL-LINES | C-11-CHOLINE PET | BRAIN-TUMORS | BREAST-CANCER | choline | F-18-FDG PET | POSITRON-EMISSION-TOMOGRAPHY | sigma-ligands | inflammation | methionine | tumor | AMINO-ACIDS | RECEPTOR LIGANDS | PROSTATE-CANCER | HIGH ACCUMULATION | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Diagnosis, Differential | Reproducibility of Results | Radiopharmaceuticals - pharmacokinetics | Rats, Wistar | Rats | Male | Metabolic Clearance Rate | Positron-Emission Tomography - methods | Organ Specificity | Glioma - metabolism | Tissue Distribution | Inflammation - metabolism | Animals | Glioma - diagnostic imaging | Sensitivity and Specificity | Inflammation - diagnostic imaging | Receptors, sigma - metabolism | Index Medicus
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