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1. Hoe pluis is het niet-pluisgevoel?
by Stolper, Erik and van de Wiel, Margje and Van Royen, Paul and Brand, Paul and Jan Dinant, Geert
Huisarts en Wetenschap, ISSN 0018-7070, 04/2015, Volume 58, Issue 4, pp. 192 - 195
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2. Full Text OP21.06: Placental examination during routine ultrasounds in a Dutch academic hospital
: Short oral presentation abstracts
by Schiffer, V and van de Wiel, M and Al Nasiry, S
Ultrasound in Obstetrics & Gynecology, ISSN 0960-7692, 10/2018, Volume 52, pp. 129 - 129
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3. Full Text Identification of FDA-approved drugs targeting the Farnesoid X Receptor
by van de Wiel, Sana M W and Bijsmans, Ingrid T G W and van Mil, Saskia W C and van de Graaf, Stan F J
Scientific Reports, ISSN 2045-2322, 02/2019, Volume 9, Issue 1, pp. 2193 - 11
The farnesoid X receptor (FXR) belongs to the nuclear receptor family and is activated by bile acids. Multiple, chemically rather diverse, FXR agonists have... 
Journal Article | BILE-ACID | FXR | POLYPHARMACOLOGY | OBETICHOLIC ACID | GENE | EFFICACY | NUCLEAR RECEPTORS | MULTIDISCIPLINARY SCIENCES | CHOLESTASIS | GLIQUIDONE | EXPRESSION | Drugs | Flow cytometry | Bile acids | Clinical trials | Confocal microscopy | Drug delivery | Fluticasone | FDA approval | Gene expression | Triclosan | Fluorescence resonance energy transfer | Sensors | Avermectin | Cholestasis | Bile
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4. Full Text EBM and gut feelings
by Stolper, C.F and van de Wiel, M.W.J
Medical Teacher, ISSN 0142-159X, 1/2014, Volume 36, Issue 1, pp. 87 - 88
EDUCATION, SCIENTIFIC DISCIPLINES | HEALTH CARE SCIENCES & SERVICES | General Practitioners - education | Faculty, Medical | Humans | Female | Male | Evidence-Based Medicine | General Practice - education
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5. Full Text Abstract P3-04-01: Manual and digital detection of HER2 status of 2721 circulating tumour cells in patients with metastatic breast cancer
by Brouwer, A and van de Wiel, M and Peeters, B and van Dam, P-J and Vermeulen, P and Peeters, M and Van Laere, S and Peeters, D and Dirix, L
Cancer Research, ISSN 0008-5472, 02/2016, Volume 76, Issue 4 Supplement, pp. P3 - P3-04-01
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6. Full Text Workplace-based assessment: raters' performance theories and constructs
by Govaerts, M.J and Wiel, M.W.J. van de and Schuwirth, L.W and Vleuten, C.P.M. van der and Muijtjens, A.M.M
Advances in Health Sciences Education, ISSN 1382-4996, 2013, Volume 18, Issue 3, pp. 375 - 396
Weaknesses in the nature of rater judgments are generally considered to compromise the utility of workplace-based assessment (WBA). In order to gain insight... 
Clinical education | Competence assessment | Professional judgment | Rater judgments | Education | Performance assessment | Workplace-based assessment | Medical Education | Rating process | Cognition-based assessment models | COMPETENCE | EDUCATION & EDUCATIONAL RESEARCH | PERSPECTIVES | HEALTH CARE SCIENCES & SERVICES | EDUCATION, SCIENTIFIC DISCIPLINES | SCHEMATA | Personnel Evaluation | Trainees | Personality Traits | Netherlands | Evaluators | Protocol Analysis | Foreign Countries | Qualitative Research | Social Cognition | Statistical Analysis | Expertise | Educational Measurement - standards | Educational Measurement - methods | Physicians - standards | Humans | Video Recording | Internship and Residency - standards | Clinical Competence - standards | Medical colleges | Family medicine | Usage | Physicians (General practice) | Cognition | Analysis | Decision making
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7. Full Text PLRS: a flexible tool for the joint analysis of DNA copy number and mRNA expression data
by Leday, G.G.R and van de Wiel, M
Bioinformatics, ISSN 1367-4803, 2013, Volume 29, Issue 8, pp. 1081 - 1082
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8. Full Text MiR-17-92 cluster is associated with 13q gain and c-myc expression during colorectal adenoma to adenocarcinoma progression
by Diosdado Calvo, M.B and van de Wiel, M.A and Terhaar sive ste, J.S and Mongera, S and Postma, C and Meijerink, W.J.H.J and Pinto Morais de Carvalho, B
British Journal of Cancer, ISSN 0007-0920, 2009, Volume 101, Issue 4, pp. 707 - 714
Background:MicroRNAs are small non-coding RNA molecules, which regulate central mechanisms of tumorigenesis. In colorectal tumours, the combination of gain of... 
DNA copy number changes | MiRNA-17-92 cluster expression | Colorectal adenoma to carcinoma progression | ENCODES | DOWN-REGULATION | CANCER | MICRORNA CLUSTER | FAMILY | ONCOLOGY | miRNA-17-92 cluster expression | GENES | colorectal adenoma to carcinoma progression | POLYCISTRON | CELL-CYCLE | MICE | CARCINOMA | Chromosomes, Human, Pair 13 - genetics | Adenocarcinoma - pathology | Adenoma - genetics | Colorectal Neoplasms - genetics | Humans | Middle Aged | Male | Gene Dosage | Reverse Transcriptase Polymerase Chain Reaction | Disease Progression | Proto-Oncogene Proteins c-myc - biosynthesis | Adenoma - pathology | Aged, 80 and over | Female | Adenocarcinoma - genetics | Aged | MicroRNAs - genetics | Colorectal Neoplasms - pathology | Gene Expression Regulation, Neoplastic - genetics | Cluster Analysis | Genetics and Genomics
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9. Full Text Altered microRNA expression associated with chromosomal changes contributes to cervical carcinogenesis
by Wilting, S.M and Snijders, P.J.F and Verlaat, W and Jaspers, A and van de Wiel, M.A and van Wieringen, W.N and Meijer, G.A and Kenter, G.G and Yi, Y and le Sage, C and Agami, R and Meijer, C.J.L.M and Steenbergen, R.D.M
Oncogene, ISSN 0950-9232, 2013, Volume 32, Issue 1, pp. 106 - 116
Little is known about the alterations in microRNA (miRNA) expression patterns during the consecutive stages of cervical cancer development and their... 
hsa-miR-9 | adenocarcinoma | CIN lesion | microRNA | HPV | squamous cell carcinoma | METHYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ORAL-CANCER | OVARIAN-CANCER | HUMAN-PAPILLOMAVIRUS DNA | HUMAN BREAST-CANCER | CELL CARCINOMA | CELL BIOLOGY | MIRNA EXPRESSION | ONCOLOGY | HIGH-RISK | GENETICS & HEREDITY | GENE-EXPRESSION | TUMOR-SUPPRESSIVE MICRORNAS | Cell Transformation, Neoplastic | Humans | Chromosome Aberrations | Female | MicroRNAs - metabolism | Gene Expression Profiling | Uterine Cervical Neoplasms - genetics | MicroRNA | Physiological aspects | Development and progression | Genetic aspects | Research | Carcinogenesis | Risk factors | Cervical cancer | Oncology | Ribonucleic acid--RNA | Gene expression | Index Medicus
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10. Full Text Gut feelings as a third track in general practitioners' diagnostic reasoning
by Stolper, E and Wiel, M. van de and Royen, P. Van and Bokhoven, M. Van and Weijden, G.D.E.M. van der and Dinant, G.J
Journal of General Internal Medicine, ISSN 0884-8734, 2011, Volume 26, Issue 2, pp. 197 - 203
BACKGROUND: General practitioners (GPs) are often faced with complicated, vague problems in situations of uncertainty that they have to solve at short notice.... 
general practitioner | Medicine & Public Health | non-analytical reasoning | dual processes | family physician | Internal Medicine | diagnostic reasoning | intuition | gut feelings | ERRORS | EXPERTISE | EMOTION | MEDICAL-EDUCATION | TACIT KNOWLEDGE | STRATEGIES | STUDENTS | MEDICINE, GENERAL & INTERNAL | JUDGMENT | DECISION-MAKING | HEALTH CARE SCIENCES & SERVICES | Attitude of Health Personnel | General Practitioners - psychology | Humans | General Practice - methods | Intuition | Emotions | Judgment | Neurosciences | Medical errors | Analysis | Family medicine | Physicians (General practice) | Universities and colleges | Public health | Cognition & reasoning | Medical diagnosis | Decision making | Family physicians | Reviews
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11. Full Text Multiple putative oncogenes at the chromosome 20q amplicon contribute to colorectal adenoma to carcinoma progression
by Carvalho, B and Postma, C and Mongera, S and Hopmans, E and Diskin, S and van de Wiel, M A and van Criekinge, W and Thas, O and Matthäi, A and Cuesta, M A and Terhaar sive Droste, J S and Craanen, M and Schröck, E and Ylstra, B and Meijer, G A
Gut, ISSN 0017-5749, 01/2009, Volume 58, Issue 1, pp. 79 - 89
Objective:This study aimed to identify the oncogenes at 20q involved in colorectal adenoma to carcinoma progression by measuring the effect of 20q gain on mRNA... 
COLON-CANCER | BREAST-CANCER | COPY NUMBER | GENE-EXPRESSION PROFILES | CANDIDATE ONCOGENE | COMPARATIVE GENOMIC HYBRIDIZATION | AURORA KINASE | IDENTIFICATION | GASTROENTEROLOGY & HEPATOLOGY | MICROARRAY DATA | CANCER CELL-LINES | Prospective Studies | Oligonucleotide Array Sequence Analysis | Adenoma - genetics | Colorectal Neoplasms - genetics | Humans | Middle Aged | Gene Expression Profiling - methods | Male | Comparative Genomic Hybridization - methods | Neoplasm Proteins - metabolism | Disease Progression | Adenoma - metabolism | Adenocarcinoma - metabolism | Reverse Transcriptase Polymerase Chain Reaction - methods | Chromosome Aberrations | Aged, 80 and over | Female | Adenocarcinoma - genetics | Aged | DNA, Neoplasm - genetics | Neoplasm Proteins - genetics | Colorectal Neoplasms - metabolism | Oncogenes | Chromosomes, Human, Pair 20 - genetics | Development and progression | Genetic markers | Genetic aspects | Research | Adenoma | Colorectal cancer | Studies | Data analysis | Cloning | Cell cycle | Values | Software | Artificial chromosomes | Kinases | Gene expression | Deoxyribonucleic acid--DNA | Tumors | Cancer
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12. Full Text OP21.06: Placental examination during routine ultrasounds in a Dutch academic hospital
by Schiffer, V and Wiel, M and Al Nasiry, S
Ultrasound in Obstetrics & Gynecology, ISSN 0960-7692, 10/2018, Volume 52, Issue S1, pp. 129 - 129
Placenta
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13. Full Text Learning from a lot: Empirical Bayes for high-dimensional model-based prediction
by van de Wiel, Mark A and Te Beest, Dennis E and Münch, Magnus M
Scandinavian Journal of Statistics, ISSN 0303-6898, 03/2019, Volume 46, Issue 1, pp. 2 - 25
Empirical Bayes is a versatile approach to “learn from a lot” in two ways: first, from a large number of variables and, second, from a potentially large amount... 
co-data | marginal likelihood | empirical Bayes | prediction | Statistics and Probability | variable selection | Statistics, Probability and Uncertainty | co‐data | VARIATIONAL INFERENCE | RIDGE-REGRESSION | NEEDLES | STATISTICS & PROBABILITY | VARIABLE-SELECTION | STRAW | CLASSIFIERS | Repositories | Discriminant analysis | Predictions | Mathematical models | Regression analysis | Empirical analysis | Bayesian analysis | Original
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14. Full Text Climate, tectonics or morphology: What signals can we see in drainage basin sediment yields?
by Coulthard, T.J and Van De Wiel, M.J
Earth Surface Dynamics, ISSN 2196-6311, 10/2013, Volume 1, Issue 1, pp. 13 - 27
Sediment yields from river basins are typically considered to be controlled by tectonic and climatic drivers. However, climate and tectonics can operate... 
GEOGRAPHY, PHYSICAL | GEOSCIENCES, MULTIDISCIPLINARY | Basins (Geology) | Climatic changes | Rivers | Sediments (Geology) | Tectonics (Geology)
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15. Full Text Genome-wide DNA copy number alterations in head and neck squamous cell carcinomas with or without oncogene-expressing human papillomavirus
by Smeets, S.J and Braakhuis, B.J.M and Abbas, S and Snijders, P.J.F and Ylstra, B and Wiel, van de, M.A and Meijer, G.A and Leemans, C.R and Brakenhoff, R.H
Oncogene, ISSN 0950-9232, 2006, Volume 25, Issue 17, pp. 2558 - 2564
Oncogene-expressing human papillomavirus type 16 (HPV16) is found in a subset of head and neck squamous cell carcinomas (HNSCC). HPV16 drives carcinogenesis by... 
Journal Article | Comparative Study | Cancer genetics | Head and neck cancer | Human papillomavirus | Array CGH | Multi-step carcinogenesis | CANCER PATIENTS | head and neck cancer | array CGH | BIOCHEMISTRY & MOLECULAR BIOLOGY | ORAL-CANCER | TUMOR-SUPPRESSOR GENE | RISK | HYBRIDIZATION DATA | CELL BIOLOGY | multi-step carcinogenesis | EPITHELIAL DYSPLASIA | cancer genetics | ONCOLOGY | human papillomavirus | GENETICS & HEREDITY | CLINICAL-IMPLICATIONS | ALLELIC LOSS | PROGRESSION MODEL | GENETICALLY ALTERED FIELDS | Nucleic Acid Hybridization | Papillomavirus Infections - complications | Head and Neck Neoplasms - virology | Signal Transduction | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - virology | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Tumor Suppressor Protein p53 - metabolism | Male | Papillomavirus E7 Proteins | Gene Dosage | Papillomaviridae - isolation & purification | Papillomaviridae - genetics | Microarray Analysis | Adult | Female | Head and Neck Neoplasms - genetics | Papillomavirus Infections - virology | Aged | Genome | Repressor Proteins - metabolism | Oncogene Proteins, Viral - metabolism | Head | Deoxyribonucleic acid | DNA | Genomics | Viruses | Neck | Gene expression | Cancer
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16. Nucleic acid detection using BRET-beacons based on bioluminescent protein-DNA hybrids
by Engelen, Wouter and van de Wiel, Kayleigh M and Meijer, Lenny HH and Saha, Bedabrata and Merkx, Maarten
Chemical Communications: Chem Comm, ISSN 1359-7345, 03/2017, Volume 53, Issue 19, pp. 2862 - 2865
Bioluminescent molecular beacons have been developed using a modular design approach that relies on BRET between the bright luciferase NanoLuc and a Cy3... 
Modular design | Beacons | Scattering | Fluorescence | Complex media | Nanostructure | Nucleic acids
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17. Tbc: Van gedwongen opname tot gedwongen behandeling
by Drijver-Messelink, Marieke T and Drijver-Messelink, Marieke T and Kerstjens, Huib A M and Kerstjens, Huib A.M and De Lange, Wiel C.M and de Lange, Wiel C M and De Vries, Jan and de Vries, Jan and van der Werf, Tjip S and Van Der Werf, Tjip S and Akkerman, Onno W and Akkerman, Onno W
Nederlands Tijdschrift voor Geneeskunde, ISSN 0028-2162, 2018, Volume 162, Issue 33
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