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1. Full Text Human coronaviruses: What do they cause?
by Van Der Hoek, Lia
Antiviral Therapy, ISSN 1359-6535, 2007, Volume 12, Issue 4 B, pp. 651 - 658
SARS-CoV human coronavirus NL63 (HCoV-NL63) and HCoV-HKU1 were first described in 2003, 2004 and 2005 respectively. Nevertheless, discovery of three new human... 
INFECTIOUS DISEASES | SARS CORONAVIRUS | FREQUENT DETECTION | ACUTE RESPIRATORY SYNDROME | TRACT INFECTIONS | KAWASAKI-DISEASE | VIROLOGY | MULTIPLE-SCLEROSIS | NEW-HAVEN CORONAVIRUS | NL63 INFECTION | PHARMACOLOGY & PHARMACY | SYNCYTIAL VIRUS | YOUNG-CHILDREN | Coronavirus - classification | Coronavirus - pathogenicity | Severe Acute Respiratory Syndrome - virology | Humans | Child, Preschool | Coronavirus Infections - physiopathology | Coronavirus OC43, Human - pathogenicity | Severe Acute Respiratory Syndrome - physiopathology | Infant | Male | SARS Virus - pathogenicity | Coronavirus 229E, Human - pathogenicity | Coronavirus Infections - virology | Adult | Aged | Respiratory Tract Infections - virology | Respiratory Tract Infections - physiopathology | Child
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2. Full Text Enhanced bioinformatic profiling of VIDISCA libraries for virus detection and discovery
by Kinsella, Cormac M and Deijs, Martin and van der Hoek, Lia
Virus research, 12/2018, Volume 263, p. 21
VIDISCA is a next-generation sequencing (NGS) library preparation method designed to enrich viral nucleic acids from samples before highly-multiplexed low... 
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3. Full Text Human Bocavirus Can Be Cultured in Differentiated Human Airway Epithelial Cells
by Ronald Dijkman and Sylvie M. Koekkoek and Richard Molenkamp and Oliver Schildgen and Lia van der Hoek
Journal of Virology, ISSN 0022-538X, 08/2009, Volume 83, Issue 15, pp. 7739 - 7748
Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley... 
VIRUS | REPLICATION | VIROLOGY | RNA | INFECTION | CLEAVAGE SITES | PARVOVIRUS | CILIATED CELLS | CULTIVATION | EPIDEMIOLOGIC PROFILE | CHILDREN | Parvoviridae Infections - virology | Humans | Cells, Cultured | Molecular Sequence Data | Infant | Bocavirus - isolation & purification | Respiratory System - virology | Virus Replication | Base Sequence | Epithelial Cells - virology | Virus Cultivation | Bocavirus - genetics | Bocavirus - physiology | Cellular Response to Infection
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4. Full Text The novel human coronaviruses NL63 and HKU1
by Pyrc, Krzysztof and Berkhout, Ben and Van Der Hoek, Lia
Journal of Virology, ISSN 0022-538X, 04/2007, Volume 81, Issue 7, pp. 3051 - 3057
ANGIOTENSIN-CONVERTING ENZYME-2 | KAWASAKI-DISEASE | VIROLOGY | MOUSE HEPATITIS-VIRUS | SARS CORONAVIRUS | SPIKE PROTEIN | AMINOPEPTIDASE-N | CLEAVAGE SITES | ACUTE RESPIRATORY SYNDROME | FUNCTIONAL RECEPTOR | TRACT INFECTIONS | Tropism | Coronavirus - classification | Viral Envelope Proteins - genetics | Membrane Glycoproteins - metabolism | Genome, Viral - genetics | Humans | Recombinant Fusion Proteins - metabolism | Membrane Glycoproteins - genetics | Spike Glycoprotein, Coronavirus | Animals | Viral Envelope Proteins - metabolism | Recombinant Fusion Proteins - genetics | Genetic Variation - genetics | Coronavirus - physiology | Minireview
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5. Full Text Absence of accessory genes in a divergent simian T-lymphotropic virus type 1 isolated from a bonnet macaque (Macaca radiata)
by Afonso, PV and Fagrouch, Z and Deijs, M and Niphuis, H and Bogers, W and Gessain, A and van der Hoek, L and Verschoor, EJ
PLOS NEGLECTED TROPICAL DISEASES, ISSN 1935-2735, 07/2019, Volume 13, Issue 7, p. e0007521
Background Primate T-lymphotropic viruses type 1 (PTLV-1) are complex retroviruses infecting both human (HTLV-1) and simian (STLV-1) hosts. They share common... 
STRAINS | IN-VITRO | TRANSMISSION | BINDING MOTIF | NONHUMAN PRIMATE | SEQUENCES | PDZ DOMAIN | DISTINCT | CELL LEUKEMIA | IDENTIFICATION | PARASITOLOGY | TROPICAL MEDICINE | Proteins | Analysis | Genes | Genomics | Genetic research | Monkeys | Phylogeny | Epidemiology | Strain analysis | Nucleotide sequence | Laboratories | Leukemia | Viruses | Genomes | Biology | Monkeys & apes | Virology | Persistence | Databases | Gag protein | Strains | Phylogenetics | Primates | In vivo methods and tests | Open reading frames | Taxation | Background radiation | Viral infections | Life Sciences | Microbiology and Parasitology | Populations and Evolution | Biodiversity | Systematics, Phylogenetics and taxonomy
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6. Full Text Enhanced bioinformatic profiling of VIDISCA libraries for virus detection and discovery
by Kinsella, Cormac M and Deijs, Martin and van der Hoek, Lia
Virus Research, ISSN 0168-1702, 04/2019, Volume 263, pp. 21 - 26
VIDISCA is a next-generation sequencing (NGS) library preparation method designed to enrich viral nucleic acids from samples before highly-multiplexed low... 
Virus discovery | Cluster-profiling | VIDISCA | Bioinformatics | VIROLOGY | METAGENOMICS | CLASSIFICATION | Enzymes | Microbiology | Ribosomal RNA | Swine | Analysis | Genomics | Libraries | HIV (Viruses)
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7. Full Text Virus discovery reveals frequent infection by diverse novel members of the Flaviviridae in wild lemurs
by Canuti, Marta and Williams, Cathy V and Sagan, Selena M and Oude Munnink, Bas B and Gadi, Sashi and Verhoeven, Joost T. P and Kellam, Paul and Cotten, Matthew and Lang, Andrew S and Junge, Randall E and Cullen, John M and van der Hoek, Lia
Archives of Virology, ISSN 0304-8608, 02/2019, Volume 164, Issue 2, pp. 509 - 522
Lemurs are highly endangered mammals inhabiting the forests of Madagascar. In this study, we performed virus discovery on serum samples collected from 84 wild... 
NUCLEOTIDE SUBSTITUTIONS | TAXONOMY | MADAGASCAR | TRANSMISSION | NUMBER | PROTEIN | SERIES | VIROLOGY | HEPACIVIRUS | MULTIPLE SEQUENCE ALIGNMENT | SOFTWARE | Lemurs | Analysis | Genomics | Resveratrol | Phylogeny | Hepatitis C virus | Health aspects | Viruses | Endangered species | Genotypes
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8. Full Text Isolation and Characterization of Current Human Coronavirus Strains in Primary Human Epithelial Cell Cultures Reveal Differences in Target Cell Tropism
by Ronald Dijkman and Maarten F. Jebbink and Sylvie M. Koekkoek and Martin Deijs and Hulda R. Jónsdóttir and Richard Molenkamp and Margareta Ieven and Herman Goossens and Volker Thiel and Lia van der Hoek
Journal of Virology, ISSN 0022-538X, 06/2013, Volume 87, Issue 11, pp. 6081 - 6090
Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley... 
ACUTE-RESPIRATORY-SYNDROME | NATURAL RECOMBINATION | ORGAN CULTURES | COMMON-COLD | IN-VITRO | GENOME SEQUENCE | VIRUS-INFECTION | VIROLOGY | AIRWAY EPITHELIA | CILIATED CELLS | REAL-TIME | Coronavirus - classification | Humans | Middle Aged | Cells, Cultured | Male | Respiratory System - cytology | Young Adult | Respiratory System - virology | Coronavirus Infections - virology | Virus Replication | Epithelial Cells - virology | Coronavirus - genetics | Adult | Female | Respiratory Tract Infections - virology | Viral Tropism | Coronavirus - physiology | Coronavirus - isolation & purification | Virus-Cell Interactions
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9. Full Text Virus discovery: are we scientists or genome collectors?
by Canuti, Marta and van der Hoek, Lia
Trends in Microbiology, ISSN 0966-842X, 2014, Volume 22, Issue 5, pp. 229 - 231
Some scientists now proclaim that future pandemics can be successfully forecasted, allowing the planning of useful intervention strategies for pandemic... 
Internal Medicine | virus discovery | next generation sequencing | pandemic preparedness | Next generation sequencing | Pandemic preparedness | Virus discovery | METAGENOMICS | BIOCHEMISTRY & MOLECULAR BIOLOGY | PERSPECTIVES | SEQUENCE | MICROBIOLOGY | Genetic Variation | Viruses - classification | Genome, Viral | Viruses - isolation & purification | Virus Diseases - epidemiology | Viruses - genetics | Virus Diseases - virology | Molecular Epidemiology - methods
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10. Full Text Simultaneous Treatment of Human Bronchial Epithelial Cells with Serine and Cysteine Protease Inhibitors Prevents Severe Acute Respiratory Syndrome Coronavirus Entry
by Miyuki Kawase and Kazuya Shirato and Lia van der Hoek and Fumihiro Taguchi and Shutoku Matsuyama
Journal of Virology, ISSN 0022-538X, 06/2012, Volume 86, Issue 12, pp. 6537 - 6545
Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley... 
FUSION | VIROLOGY | CATHEPSIN-L | PROTEOLYTIC ACTIVATION | TRANSMEMBRANE | TRYPSIN | TMPRSS2 | CLEAVAGE | SPIKE-PROTEIN | SARS-CORONAVIRUS | INFLUENZA-VIRUS HEMAGGLUTININ | Bronchi - virology | Severe Acute Respiratory Syndrome - virology | Epithelial Cells - drug effects | Humans | SARS Virus - drug effects | Down-Regulation - drug effects | Severe Acute Respiratory Syndrome - drug therapy | Virus Internalization - drug effects | Cysteine Proteinase Inhibitors - pharmacology | Epithelial Cells - virology | SARS Virus - physiology | Bronchi - cytology | Serine Proteinase Inhibitors - pharmacology | Virus-Cell Interactions
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11. Full Text Viral Metagenomics on Cerebrospinal Fluid
by Edridge, Arthur W D and Deijs, Martin and van Zeggeren, Ingeborg E and Kinsella, Cormac M and Jebbink, Maarten F and Bakker, Margreet and van de Beek, Diederik and Brouwer, Matthijs C and van der Hoek, Lia
Genes, ISSN 2073-4425, 04/2019, Volume 10, Issue 5, p. 332
Identifying the causative pathogen in central nervous system (CNS) infections is crucial for patient management and prognosis. Many viruses can cause CNS... 
metaviromics | next-generation sequencing | encephalitis | metagenomics | cerebrospinal fluid | VIDISCA-NGS | CNS infection | viromics | virus
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12. Full Text Identification of a new human coronavirus
by van der Hoek, Lia and Pyrc, Krzysztof and Jebbink, Maarten F and Vermeulen-Oost, Wilma and Berkhout, Ron J. M and Wolthers, Katja C and Wertheim-van Dillen, Pauline M. E and Kaandorp, Jos and Spaargaren, Joke and Berkhout, Ben
Nature medicine, ISSN 1078-8956, 2004, Volume 10, Issue 4, pp. 368 - 373
Three human coronaviruses are known to exist: human coronavirus 229E (HCoV-229E), HCoV-OC43 and severe acute respiratory syndrome (SARS)-associated coronavirus... 
MEDICINE, RESEARCH & EXPERIMENTAL | VIRUS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ACUTE RESPIRATORY SYNDROME | GENOME | CELL BIOLOGY | ORGAN CULTURES | S-GENE | DISEASE | OC43 | SPIKE PROTEIN | RECEPTOR-BINDING | SARS-CORONAVIRUS | Genome, Viral | Coronavirus - classification | Humans | Middle Aged | Molecular Sequence Data | Infant | DNA Primers | Reverse Transcriptase Polymerase Chain Reaction | Base Sequence | Coronavirus - genetics | Adult | Aged | Coronavirus - isolation & purification
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13. Full Text Human Coronavirus NL63 Employs the Severe Acute Respiratory Syndrome Coronavirus Receptor for Cellular Entry
by Heike Hofmann and Krzysztof Pyrc and Lia van der Hoek and Martina Geier and Ben Berkhout and Stefan Pöhlmann and Diane E. Griffin
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2005, Volume 102, Issue 22, pp. 7988 - 7993
Coronavirus (CoV) infection of humans is usually not associated with severe disease. However, discovery of the severe acute respiratory syndrome (SARS) CoV... 
Proteins | Biological Sciences | Receptors | Plasmids | Cell lines | Antibodies | Viruses | Infections | Glycoproteins | SARS virus | Human coronavirus NL63 | ANGIOTENSIN-CONVERTING ENZYME-2 | TRACT DISEASE | MULTIDISCIPLINARY SCIENCES | SARS CORONAVIRUS | AMINOPEPTIDASE-N | S-PROTEIN | REVERSE GENETICS | FUNCTIONAL RECEPTOR | YOUNG-CHILDREN | VIRAL ENTRY | SPIKE GLYCOPROTEIN | Cell Line | Membrane Glycoproteins - metabolism | Species Specificity | Receptors, Virus - metabolism | Humans | Neutralization Tests | Peptidyl-Dipeptidase A | Coronavirus 229E, Human - metabolism | SARS Virus - metabolism | Spike Glycoprotein, Coronavirus | Coronavirus Infections - metabolism | Flow Cytometry | Plasmids - genetics | Viral Envelope Proteins - metabolism | Carboxypeptidases - metabolism | Respiratory Tract Diseases - virology | Research | Coronaviruses | Microbiology | Severe acute respiratory syndrome
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14. Full Text Full genome virus detection in fecal samples using sensitive nucleic acid preparation, deep sequencing, and a novel iterative sequence classification algorithm
by Cotten, Matthew and Oude Munnink, Bas and Canuti, Marta and Deijs, Martin and Watson, Simon J and Kellam, Paul and van der Hoek, Lia
PLoS ONE, ISSN 1932-6203, 2014, Volume 9, Issue 4, p. e93269
We have developed a full genome virus detection process that combines sensitive nucleic acid preparation optimised for virus identification in fecal material... 
GENOTYPES | VIROME | DIARRHEA | B-ASSOCIATED SUBSTANCE | VIDISCA-454 | IMMUNODEFICIENCY-VIRUS | MULTIDISCIPLINARY SCIENCES | DIVERSITY | HEPATITIS NON-A | IDENTIFICATION | METAGENOMIC ANALYSIS | Algorithms | Feces - chemistry | Genome, Viral - genetics | HIV Infections - diagnosis | HIV Infections - genetics | Humans | Adolescent | Nucleic Acids - genetics | HIV-1 - genetics | High-Throughput Nucleotide Sequencing - methods | DNA Barcoding, Taxonomic - methods | Sequence Analysis, DNA - methods | Virus diseases | Care and treatment | DNA | Analysis | Development and progression | Diagnosis | Nucleic acids | Health aspects | Laboratories | Pathogenesis | Viruses | Homology | Infections | Identification | Genomes | Gene sequencing | Hepatitis | Acquired immune deficiency syndrome--AIDS | Human immunodeficiency virus--HIV | Bacteria | Feces | Plant viruses | Bioinformatics | Assembly | Deoxyribonucleic acid--DNA | Pathogens | Nucleotide sequence | Genetic diversity | Virology | Acids | Adults | DNA sequencing | Acquired immune deficiency syndrome | Deoxyribonucleic acid | AIDS | HIV | Human immunodeficiency virus
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15. Full Text The dominance of human coronavirus OC43 and NL63 infections in infants
by Dijkman, Ronald and Jebbink, Maarten F and Gaunt, Eleanor and Rossen, John W. A and Templeton, Kate E and Kuijpers, Taco W and van der Hoek, Lia
Journal of Clinical Virology, ISSN 1386-6532, 02/2012, Volume 53, Issue 2, pp. 135 - 139
Background: It is unknown to what extent the human coronaviruses (HCoVs) OC43, HKU1, 229E and NL63 infect healthy children. Frequencies of infections are only... 
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16. Full Text Viruses causing gastroenteritis: The known, the new and those beyond
by Oude Munnink, Bas B and van der Hoek, Lia
Viruses, ISSN 1999-4915, 02/2016, Volume 8, Issue 2, p. 42
The list of recently discovered gastrointestinal viruses is expanding rapidly. Whether these agents are actually involved in a disease such as diarrhea is the... 
Gastroenteritis | Virus discovery | Next-generation sequencing | VA-CLADE | next-generation sequencing | FECAL SAMPLES | MLB-CLADE | STL POLYOMAVIRUS | CHILDREN | VIROLOGY | EPITHELIAL-CELLS | gastroenteritis | VIRAL GASTROENTERITIS | virus discovery | AICHI VIRUS | COMPLETE GENOME | STOOL SAMPLES | Viruses - classification | Viruses - isolation & purification | Animals | Viruses - genetics | Humans | Virus Diseases - virology | Gastroenteritis - virology | Virus Physiological Phenomena
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