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1. Full Text High dietary glycemic load is associated with higher concentrations of urinary advanced glycation endproducts: the Cohort on Diabetes and Atherosclerosis Maastricht (CODAM) Study
by Maasen, Kim and van Greevenbroek, Marleen M. J and Scheijen, Jean L. J. M and van der Kallen, Carla J. H and Stehouwer, Coen D. A and Schalkwijk, Casper G
American Journal of Clinical Nutrition, ISSN 0002-9165, 08/2019, Volume 110, Issue 2, pp. 358 - 366
Background: Advanced glycation endproducts (AGEs) and their precursors (dicarbonyls) are associated with the progression of diseases such as diabetes and... 
glycemic index | dicarbonyls | glycotoxin | glycemic load | advanced glycation endproducts | cardiovascular complications | DICARBONYL STRESS | glycation | nutrition | type 2 diabetes | PLASMA-LEVELS | INSULIN-RESISTANCE | INFLAMMATION | CARDIOVASCULAR-DISEASE | CANCER-RISK | diet | INDEX | END-PRODUCTS | AGE | FOOD | NUTRITION & DIETETICS | Urine | Plasma | Carbohydrates | Advanced glycosylation end products | Independent variables | Diabetes mellitus | Liquid chromatography | Dietary intake | Glycosylation | Regression analysis | Pentosidine | Diet | Lysine | Dependent variables | Carboxymethyllysine | Human performance | Arteriosclerosis | Atherosclerosis | Diabetes | Cardiovascular diseases | Ornithine | Pyruvaldehyde | Diabetes mellitus (non-insulin dependent) | Age
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2. Full Text Blood pressure variability in individuals with and without (pre)diabetes: the Maastricht Study
by Zhou, Tan Lai and Reesink, Koen and Schram, Miranda and Koster, Annemarie and Schaper, Nicolaas and Dagnelie, Pieter and van der Kallen, Carla and Sep, Simone and Stehouwer, Coen and Henry, Ronald
Journal of Hypertension, ISSN 0263-6352, 02/2018, Volume 36, Issue 2, pp. 259 - 267
Objective: The mechanisms associating (pre)diabetes and cardiovascular disease (CVD) are incompletely understood. We hypothesize that greater blood pressure... 
OBSTRUCTIVE SLEEP-APNEA | average real variability | BAROREFLEX SENSITIVITY | TO-VISIT VARIABILITY | diabetes mellitus | cardiovascular diseases | AMERICAN-HEART-ASSOCIATION | EUROPEAN-SOCIETY | blood pressure variability | DIABETES-MELLITUS | ALL-CAUSE | ARTERIAL STIFFNESS | prediabetic state | PROGNOSTIC-SIGNIFICANCE | HYPERTENSION | MORTALITY | SLEEP-APNEA | PERIPHERAL VASCULAR DISEASE | Control | Blood pressure | Diabetes | Cardiovascular diseases | Risk factors
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3. Full Text Complement C3 and C4, but not their regulators or activated products, are associated with incident metabolic syndrome: the CODAM study
by Xin, Ying and Hertle, Elisabeth and van der Kallen, Carla J. H and Schalkwijk, Casper G and Stehouwer, Coen D. A and van Greevenbroek, Marleen M. J
Endocrine, ISSN 1355-008X, 12/2018, Volume 62, Issue 3, pp. 617 - 627
PurposeWe investigated the associations of components of the alternative (C3, C3a, Bb, factor D [FD], factor H [FH], properdin) and the classical complement... 
Human | REACTIVE PROTEIN | SYSTEM | Longitudinal | ATHEROSCLEROSIS | COMPONENTS | RISK | Metabolic syndrome | Incidence | INFLAMMATORY MARKERS | EFFECTOR | Complement activation | INSULIN-RESISTANCE | ACYLATION-STIMULATING PROTEIN | ADIPOSE-TISSUE | ENDOCRINOLOGY & METABOLISM | Prevalence | Complement C4 - metabolism | Cross-Sectional Studies | Complement C3 - metabolism | Humans | Middle Aged | Male | Complement Factor D - metabolism | Metabolic Syndrome - blood | Complement Factor H - metabolism | Health Surveys | Female | Aged | Metabolic Syndrome - epidemiology | Metabolic diseases | Genetic aspects | Complement (Immunology) | Health aspects | Risk factors | Original
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4. Full Text Subcutaneous Adipose Tissue and Systemic Inflammation are Associated with Peripheral But Not Hepatic Insulin Resistance in Humans
by van der Kolk, Birgitta W and Kalafati, Marianthi and Aiaens, Michiel and van Greevenbroek, Marleen M J and Vogelzangs, Nicole and Saris, Wim H M and Astrup, Arne and Valsesia, Armand and Langin, Dominique and van der Kallen, Carla J H and Eussen, Simone J P M and Schalkwijk, Casper G and Stehouwer, Coen D A and Goossens, Gijs H and Arts, Ilja C W and Jocken, Johan W E and Evelo, Chris T and Blaak, Ellen E
Diabetes, ISSN 0012-1797, 09/2019, Volume 68, Issue 12, pp. 2247 - 2258
Obesity-related insulin resistance (IR) may develop in multiple organs, representing different etiologies towards cardiometabolic diseases. We identified... 
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5. Full Text Uric acid and blood pressure: exploring the role of uric acid production in The Maastricht Study
by Scheepers, Lieke E. J. M and Boonen, Annelies and Dagnelie, Pieter C and Schram, Miranda T and van der Kallen, Carla J. H and Henry, Ronald M. A and Kroon, Abraham A and Stehouwer, Coen D. A and Arts, Ilja C. W
Journal of Hypertension, ISSN 0263-6352, 10/2017, Volume 35, Issue 10, pp. 1968 - 1975
OBJECTIVE:Accumulation of reactive oxygen species by increased uric acid production has been suggested as a possible underlying mechanism for the association... 
blood pressure | pulse pressure | xanthine oxidoreductase | OXIDATIVE STRESS | mean arterial pressure | CORONARY HEART-DISEASE | EUROPEAN-SOCIETY | xanthine dehydrogenase | GENERAL-POPULATION | XANTHINE-OXIDASE | RENIN-ANGIOTENSIN SYSTEM | ARTERIAL STIFFNESS | reactive oxygen species | ABCG2 DYSFUNCTION INCREASES | hypertension | uric acid | xanthine oxidase | INCIDENT HYPERTENSION | RISK-FACTORS | HYPERURICEMIA | METABOLISM | PERIPHERAL VASCULAR DISEASE | ASSOCIATION | Uric Acid - metabolism | Cross-Sectional Studies | Humans | Middle Aged | Risk Factors | Male | Hypertension - metabolism | Hypertension - blood | Female | Aged | Blood Pressure - physiology | Uric Acid - blood | Hypertension - epidemiology
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6. Full Text Distinct Longitudinal Associations of MBL, MASP-1, MASP-2, MASP-3, and MAp44 With Endothelial Dysfunction and Intima-Media Thickness The Cohort on Diabetes and Atherosclerosis Maastricht (CODAM) Study
by Hertle, Elisabeth and Arts, Ilja C. W and van der Kallen, Carla J. H and Feskens, Edith J. M and Schalkwijk, Casper G and Hoffmann-Petersen, Ingeborg T and Thiel, Steffen and Stehouwer, Coen D. A and van Greevenbroek, Marleen M. J
Arteriosclerosis Thrombosis and Vascular Biology, ISSN 1079-5642, 06/2016, Volume 36, Issue 6, pp. 1278 - 1285
OBJECTIVE—Previous studies suggested that the lectin-complement pathway plays a complex role in cardiovascular disease (CVD). To date, no prospective human... 
complement system proteins | lectin-complement pathway | inflammation | carotid intima-media thickness | METABOLIC SYNDROME | MYOCARDIAL-INFARCTION | MANNOSE-BINDING LECTIN | COMPLEMENT ACTIVATION | RISK | INSULIN-RESISTANCE | SERUM-LEVELS | CARDIOVASCULAR-DISEASE | PERIPHERAL VASCULAR DISEASE | LOW-GRADE INFLAMMATION | HEMATOLOGY | CORONARY-ARTERY-DISEASE | Diabetes Mellitus - blood | Predictive Value of Tests | Prognosis | Prospective Studies | Humans | Middle Aged | Netherlands - epidemiology | Carotid Artery Diseases - physiopathology | Male | Mannose-Binding Lectin - genetics | Inflammation - blood | Incidence | Carotid Artery Diseases - diagnostic imaging | Time Factors | Female | Diabetes Mellitus - diagnosis | Inflammation - diagnosis | Mannose-Binding Lectin - blood | Risk Assessment | Carotid Intima-Media Thickness | Risk Factors | Endothelium, Vascular - physiopathology | Carotid Artery Diseases - epidemiology | Genotype | Logistic Models | Biomarkers - blood | Inflammation - epidemiology | Mannose-Binding Protein-Associated Serine Proteases - analysis | Carotid Arteries - diagnostic imaging | Carotid Arteries - physiopathology | Carotid Artery Diseases - blood | Diabetes Mellitus - epidemiology | Aged | Nonlinear Dynamics | Longitudinal Studies
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7. Full Text Protein-Bound Plasma N-epsilon-(Carboxymethyl) lysine Is Inversely Associated With Central Obesity and Inflammation and Significantly Explain a Part of the Central Obesity-Related Increase in Inflammation The Hoorn and CODAM Studies
by Gaens, Katrien H. J and Ferreira, Isabel and van de Waarenburg, Marjo P. H and van Greevenbroek, Marleen M and van der Kallen, Carla J. H and Dekker, Jacqueline M and Nijpels, Giel and Rensen, Sander S and Stehouwer, Coen D. A and Schalkwijk, Casper G
Arteriosclerosis Thrombosis and Vascular Biology, ISSN 1079-5642, 12/2015, Volume 35, Issue 12, pp. 2707 - 2713
OBJECTIVE—Adipose tissue inflammation contributes to the development of complications, such as insulin resistance and type 2 diabetes mellitus. We previously... 
central obesity | epidemiology | advanced glycation endproducts | inflammation | biomarkers | Advanced glycation endproducts | C-REACTIVE PROTEIN | METABOLIC SYNDROME | RECEPTOR | MECHANISMS | INSULIN-RESISTANCE | FAT | PERIPHERAL VASCULAR DISEASE | MICE | HEMATOLOGY | EXPRESSION | GLYCATION END-PRODUCTS | ADIPOSE-TISSUE | Multivariate Analysis | Prospective Studies | Humans | Middle Aged | Netherlands - epidemiology | Obesity, Abdominal - diagnosis | Obesity, Abdominal - physiopathology | Male | Inflammation - blood | Tandem Mass Spectrometry | Obesity, Morbid - physiopathology | Adiposity | Obesity, Abdominal - epidemiology | Chromatography, Liquid | Adult | Female | Inflammation - diagnosis | Lysine - blood | Body Mass Index | Lysine - analogs & derivatives | Cross-Sectional Studies | Risk Factors | Inflammation Mediators - blood | Linear Models | Biomarkers - blood | Inflammation - epidemiology | Absorptiometry, Photon | Obesity, Morbid - diagnosis | Disease Progression | Obesity, Abdominal - blood | Waist Circumference | Aged | Obesity, Morbid - blood | Obesity, Morbid - epidemiology | Index Medicus
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8. Full Text Metabolomics Profile in Depression: A Pooled Analysis of 230 Metabolic Markers in 5283 Cases With Depression and 10,145 Controls
by Bot, Mariska and Milaneschi, Yuri and Al-Shehri, Tahani and Amin, Najaf and Garmaeva, Sanzhima and Onderwater, Gerrit L J and Pool, Rene and Thesing, Carisha S and Vijfhuizen, Lisanne S and Vogelzangs, Nicole and Arts, Ilja C W and Demirkan, Ayse and van Duijn, Cornelia and van Greevenbroek, Marleen and van der Kallen, Carla J H and Köhler, Sebastian and Ligthart, Lannie and van den Maagdenberg, Arn M J M and Mook-Kanamori, Dennis O and de Mutsert, Renée and Tiemeier, Henning and Schram, Miranda T and Stehouwer, Coen D A and Terwindt, Gisela M and Willems van Dijk, Ko and Fu, Jingyuan and Zhernakova, Alexana and Beekman, Marian and Slagboom, P Eline and Boomsma, Dorret I and Penninx, Brenda W J H
Biological Psychiatry, ISSN 0006-3223, 08/2019
BACKGROUND: Depression has been associated with metabolic alterations, which adversely impact cardiometabolic health. Here, a comprehensive set of metabolic... 
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9. Full Text White Matter Connectivity Abnormalities in Prediabetes and Type 2 Diabetes: The Maastricht Study
by Vergoossen, Laura W and Schram, Miranda T and de Jong, Joost J and Stehouwer, Coen D and Schaper, Nicolaas C and Henry, Ronald M and van der Kallen, Carla J and Dagnelie, Pieter C and van Boxtel, Martin P and Eussen, Simone J and Backes, Walter H and Jansen, Jacobus F
Diabetes Care, ISSN 0149-5992, 10/2019, p. dc190762
OBJECTIVE: Prediabetes and type 2 diabetes are associated with structural brain abnormalities, often observed in cognitive disorders. Besides visible lesions,... 
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10. Full Text Prediabetes Is Associated With Structural Brain Abnormalities: The Maastricht Study
by van Agtmaal, Marnix J. M and Houben, Alfons J. H. M and de Wit, Vera and Henry, Ronald M. A and Schaper, Nicolaas C and Dagnelie, Pieter C and van der Kallen, Carla J and Koster, Annemarie and Sep, Simone J and Kroon, Abraham A and Jansen, Jacobus F. A and Hofman, Paul A and Backes, Walter H and Schram, Miranda T and Stehouwer, Coen D. A
Diabetes Care, ISSN 0149-5992, 12/2018, Volume 41, Issue 12, pp. 2535 - 2543
COGNITIVE DYSFUNCTION | VASCULAR DEPRESSION | MICROVASCULAR DYSFUNCTION | SMALL VESSEL DISEASE | GLUCOSE-METABOLISM | ALZHEIMERS-DISEASE | TISSUE SEGMENTATION | WHITE-MATTER HYPERINTENSITIES | LATE-LIFE DEPRESSION | TYPE-2 DIABETES-MELLITUS
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11. Full Text Improved quantification of muscle insulin sensitivity using oral glucose tolerance test data: the MISI Calculator
by O'Donovan, Shauna D and Lenz, Michael and Goossens, Gijs H and van der Kallen, Carla J. H and Eussen, Simone J. M. P and Stehouwer, Coen D. A and van Greevenbroek, Marleen M and Schram, Miranda T and Sep, Simone J and Peeters, Ralf L. M and Blaak, Ellen E and van Riel, Natal A. W and de Kok, Theo M. C. M and Arts, Ilja C. W
Scientific Reports, ISSN 2045-2322, 06/2019, Volume 9
RESISTANCE | METABOLIC SYNDROME | EXERCISE | LIVER | BETA-CELL FUNCTION | INDEXES
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12. Full Text Socially isolated individuals are more prone to have newly diagnosed and prevalent type 2 diabetes mellitus - The Maastricht study - The M
by Brinkhues, Stephanie and Dukers-Muijrers, Nicole H.T.M and Hoebe, Christian J.P.A and Van Der Kallen, Carla J.H and Dagnelie, Pieter C and Koster, Annemarie and Henry, Ronald M.A and Sep, Simone J.S and Schaper, Nicolaas C and Stehouwer, Coen D.A and Bosma, Hans and Savelkoul, Paul H.M and Schram, Miranda T
BMC Public Health, ISSN 1471-2458, 12/2017, Volume 17, Issue 1
Background: Social isolation is associated with type 2 diabetes (T2DM), but it is unclear which elements play a crucial role in this association. Therefore, we... 
Prevention | Type 2 diabetes | Social network | Public Health, Environmental and Occupational Health | Pre-diabetes | Social support
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13. Full Text Adapted dietary inflammatory index and its association with a summary score for low-grade inflammation and markers of glucose metabolism: The cohort study on diabetes and atherosclerosis maastricht (CODAM) and the hoorn study 1-4
by Van Woudenbergh, Geertruida J and Theofylaktopoulou, Despoina and Kuijsten, Anneleen and Ferreira, Isabel and Van Greevenbroek, Marleen M and Van Der Kallen, Carla J and Schalkwijk, Casper G and Stehouwer, Coen D.A and Ocké, Marga C and Nijpels, Giel and Dekker, Jacqueline M and Blaak, Ellen E and Feskens, Edith J.M
American Journal of Clinical Nutrition, ISSN 0002-9165, 12/2013, Volume 98, Issue 6, pp. 1533 - 1542
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14. Full Text Abstract 388: High-density Lipoprotein Cholesterol Efflux Capacity is not associated with Atherosclerosis and Cardiovascular Events: the CODAM Study
by Josefs, Tatjana and Wouters, Kristiaan and Tietge, Uwe J and Dullaart, Robin P and van der Kallen, Carla J and Stehouwer, Coen D and Schalkwijk, Casper G and Goldberg, Ira J and Fisher, Edward A and van Greevenbroek, Marleen M
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 05/2018, Volume 38, Issue Suppl_1
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15. Full Text Social network characteristics are associated with type 2 diabetes complications: The Maastricht study
by Brinkhues, Stephanie and Dukers-Muijrers, Nicole H. T. M and Hoebe, Christian J. P. A and van der Kallen, Carla J. H and Koster, Annemarie and Henry, Ronald M. A and Stehouwer, Coen D. A and Savelkoul, Paul H. M and Schaper, Nicolaas C and Schram, Miranda T
Diabetes Care, ISSN 0149-5992, 2018, Volume 41, Issue 8, pp. 1654 - 1662
OBJECTIVE: The relation between clinical complications and social network characteristics in type 2 diabetes mellitus (T2DM) has hardly been studied.... 
d_article_not_yet_freely_accessible
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16. Full Text Hepatic Fat Content and Liver Enzymes Are Associated with Circulating Free and Protein-Bound Advanced Glycation End Products, Which Are Associated with Low-Grade Inflammation: The CODAM Study
by Bijnen, M and van Greevenbroek, MMJ and van Der Kallen, CJH and Scheijen, JL and van de Waarenburg, MPH and Stehouwer, CDA and Wouters, K and Schallcwijk, CG
JOURNAL OF DIABETES RESEARCH, ISSN 2314-6745, 2019, Volume 2019, pp. 6289831 - 10
Advanced glycation end products (AGEs) accumulate in fatty livers and may contribute to low-grade inflammation (LGI), potentially via their receptor, RAGE. It... 
MEDICINE, RESEARCH & EXPERIMENTAL | ENDOCRINOLOGY & METABOLISM
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17. Full Text Metabolomics profile in depression: a pooled analysis of 230 metabolic markers in 5,283 cases with depression and 10,145 controls
by Bot, Mariska, PhD and Milaneschi, Yuri, PhD and Al-Shehri, Tahani, MSc and Amin, Najaf, PhD and Garmaeva, Sanzhima, MSc and Onderwater, Gerrit L.J., MD and Pool, Rene, PhD and Thesing, Carisha S., MSc and Vijfhuizen, Lisanne S., BSc and Vogelzangs, Nicole, PhD and Arts, Ilja C.W., PhD and Demirkan, Ayse, PhD and van Duijn, Cornelia, PhD and van Greevenbroek, Marleen, PhD and van der Kallen, Carla J.H., PhD and Köhler, Sebastian, PhD and Ligthart, Lannie, PhD and van den Maagdenberg, Arn M.J.M., PhD and Mook-Kanamori, Dennis O., PhD and de Mutsert, Renée, PhD and Tiemeier, Henning, PhD and Schram, Miranda T., PhD and Stehouwer, Coen D.A., PhD and Terwindt, Gisela M., MD, PhD and Willems van Dijk, Ko, PhD and Fu, Jingyuan, PhD and Zhernakova, Alexandra., MD, PhD and Beekman, Marian, PhD and Slagboom, P. Eline, PhD and Boomsma, Dorret I., PhD and Penninx, Brenda W.J.H., PhD
Biological Psychiatry, ISSN 0006-3223, 2019
AbstractBackgroundDepression has been associated with metabolic alterations, which adversely impact cardiometabolic health. Here, a comprehensive set of... 
Psychiatric/Mental Health
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18. Full Text Microvascular endothelial dysfunction is associated with albuminuria: the Maastricht Study
by Martens, Remy J H and Houben, Alfons J H M and Kooman, Jeroen P and Berendschot, Tos T J M and Dagnelie, Pieter C and van der Kallen, Carla J H and Kroon, Abraham A and Leunissen, Karel M L and van der Sande, Frank M and Schaper, Nicolaas C and Schouten, Jan S A G and Schram, Miranda T and Sep, Simone J S and Sörensen, Ben M and Henry, Ronald M A and Stehouwer, Coen D A
Journal of Hypertension, ISSN 0263-6352, 05/2018, Volume 36, Issue 5, pp. 1178 - 1187
cardiovascular disease | endothelium | DEPENDENT DIABETES-MELLITUS | HEART-FAILURE | diabetes mellitus | RENAL-DISEASE | IDDM PATIENTS | endothelial dysfunction | microcirculation | NEPHROPATHY | Journal Article | albuminuria | microalbuminuria | INFLAMMATION | CARDIOVASCULAR-DISEASE | ESCAPE RATE | PROGRESSION
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19. Full Text Validated inference of smoking habits from blood with a finite DNA methylation marker set
by Maas, Silvana C E and Vidaki, Athina and Wilson, Rory and Teumer, Alexander and Liu, Fan and van Meurs, Joyce B J and Uitterlinden, Ané G and Boomsma, Dorret I and de Geus, Eco J C and Willemsen, Gonneke and van Dongen, Jenny and van der Kallen, Carla J H and Slagboom, P Eline and Beekman, Marian and van Heemst, Diana and van den Berg, Leonard H and Duijts, Liesbeth and Jaddoe, Vincent W V and Ladwig, Karl-Heinz and Kunze, Sonja and Peters, Annette and Ikram, M Arfan and Grabe, Hans J and Felix, Janine F and Waldenberger, Melanie and Franco, Oscar H and Ghanbari, Mohsen and Kayser, Manfred
European Journal of Epidemiology, ISSN 0393-2990, 09/2019
Inferring a person's smoking habit and history from blood is relevant for complementing or replacing self-reports in epidemiological and public health... 
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20. Full Text The role of hyperglycemia, insulin resistance, and blood pressure in diabetes-associated differences in cognitive performance - The Maastricht study
by Geijselaers, Stefan L C and Sep, Simone J S and Claessens, Danny and Schram, Miranda T and Van Boxtel, Martin P J and Henry, Ronald M. A and Verhey, Frans R J and Kroon, Abraham A and Dagnelie, Pieter C and Schalkwijk, Casper G and van der Kallen, Carla J H and Biessels, Geert Jan and Stehouwer, Coen D. A
Diabetes Care, ISSN 0149-5992, 11/2017, Volume 40, Issue 11, p. 1537
OBJECTIVE To study to what extent differences in cognitive performance between individuals with different glucose metabolism status are potentially... 
Internal Medicine | Endocrinology, Diabetes and Metabolism | Advanced and Specialised Nursing | Journal Article
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