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1. Full Text The authors reply
by Angus, Derek C and Van Der Poll, Tom
New England Journal of Medicine, ISSN 0028-4793, 2013, Volume 369, Issue 21, p. 2063
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2. Full Text Recombinant Human Soluble Thrombomodulin in Patients With Sepsis-Associated Coagulopathy Another Negative Sepsis Trial?
by van der Poll, T
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, ISSN 0098-7484, 05/2019, Volume 321, Issue 20, pp. 1978 - 1980
The article discusses the findings of a study to evaluate the effect of human soluble thrombomodulin on 28-day all-cause mortality in patients with... 
DOUBLE-BLIND | MEDICINE, GENERAL & INTERNAL | EFFICACY | SAFETY | DISSEMINATED INTRAVASCULAR COAGULATION | ART-123 | Sepsis | Anticoagulants (Medicine) | Research | Patient outcomes | Anticoagulants | Coagulation | Tissue factor | Clinical trials | Disseminated intravascular coagulation | Activation | Inflammation | Activated protein C | Thrombosis | Hemorrhage | Antithrombin | Clotting | Microvasculature | Thrombomodulin | Thromboembolism | Platelets | Recombinant
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3. Full Text Correction to: What's new in immunostimulating strategies in the ICU
by Pickkers, Peter and van der Poll, Tom
Intensive Care Medicine, ISSN 0342-4642, 1/2019, Volume 45, Issue 1, pp. 137 - 137
The original version of this article unfortunately contained two mistakes 
Pediatrics | Pain Medicine | Emergency Medicine | Pneumology/Respiratory System | Medicine & Public Health | Intensive / Critical Care Medicine | Anesthesiology
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4. Full Text What’s new?
: Immunostimulating strategies in the ICU
by Pickkers, Peter and van der Poll, Tom
Intensive Care Medicine, ISSN 0342-4642, 1/2019, Volume 45, Issue 1, pp. 110 - 112
Pediatrics | Pain Medicine | Emergency Medicine | Pneumology/Respiratory System | Medicine & Public Health | Intensive / Critical Care Medicine | Anesthesiology
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5. Full Text Leukocyte transcriptional signatures dependent on LPS dosage in human endotoxemia
by Khan, Hina N and Perlee, Desiree and Schoenmaker, Lieke and van der Meer, Anne-Jan and Franitza, Marek and Toliat, Mohammad Reza and Nürnberg, Peter and Zwinderman, Aeilko H and van der Poll, Tom and Scicluna, Brendon P
Journal of leukocyte biology, ISSN 0741-5400, 07/2019
The host immune response is characterized by a complex interplay of signal-specific cellular transcriptional responses. The magnitude of the immune response is... 
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6. Full Text "What's new?": Immunostimulating strategies in the ICU
by Pickkers, P and van der Poll, T
INTENSIVE CARE MEDICINE, ISSN 0342-4642, 01/2019, Volume 45, Issue 1, pp. 110 - 112
MORTALITY | SEPSIS | PHASE-III | CRITICAL CARE MEDICINE
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7. Full Text Severe Sepsis and Septic Shock
by Angus, Derek C and van der Poll, Tom
The New England Journal of Medicine, ISSN 0028-4793, 08/2013, Volume 369, Issue 9, pp. 840 - 851
Sepsis, a complex physiological and metabolic response to infection, is a common reason for admission to an intensive care unit. This review examines the... 
UNITED-STATES | MORTALITY | RESPONSES | MEDICINE, GENERAL & INTERNAL | THERAPY | ACTIVATED PROTEIN-C | ORGAN DYSFUNCTION | SURVIVING SEPSIS | INFECTION | INTENSIVE-CARE | EPIDEMIOLOGY | Sepsis - etiology | Sepsis - immunology | Shock, Septic - etiology | Humans | Risk Factors | Shock, Septic - physiopathology | Shock, Septic - diagnosis | Shock, Septic - therapy | Resuscitation | Incidence | Causes of | Sepsis | Care and treatment | Diagnosis | Research | Studies | Intensive care | Pathogenesis | Gram-positive bacteria | Septic shock | Metabolic response | Streptococcus infections
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8. Full Text Reply: Are histones real pathogenic agents in sepsis?
by Van Der Poll, Tom and Van De Veerdonk, Frank L and Scicluna, Brendon P and Netea, Mihai G
Nature Reviews Immunology, ISSN 1474-1733, 02/2018, Volume 18, Issue 2, p. 148
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9. Full Text Local stimulation of alpha 7 cholinergic receptors inhibits LPS-induced TNF-alpha release in the mouse lung
by Giebelen, Ida A. J and van Westerloo, David J and Larosa, Gregory J and de Vos, Alex F and van der Poll, Tom
Shock (Augusta, Ga.), ISSN 1073-2322, 2007, Volume 28, Issue 6, pp. 700 - 703
The cholinergic nervous system can inhibit the release of proinflammatory cytokines such as TNF-alpha from LPS-stimulated macrophages. Acetylcholine, the... 
SURGERY | RECRUITMENT | ACTIVATION | NICOTINE | GTS-21 | chemokines | mice | AGONISTS | vagus nerve | PATHWAY | INFLAMMATION | LIPOPOLYSACCHARIDE | PERIPHERAL VASCULAR DISEASE | cytokines | HEMATOLOGY | endotoxin | CRITICAL CARE MEDICINE
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10. Full Text Epithelial Myeloid-Differentiation Factor 88 Is Dispensable during Klebsiella Pneumonia
by Anas, Adam A and Claushuis, Theodora A. M and Mohan, Rajiv A and Christoffels, Vincent M and Aidinis, Vassilis and Florquin, Sanine and van't Veer, Cornelis and Hou, Baidong and de Vos, Alex F and van der Poll, Tom
American journal of respiratory cell and molecular biology, ISSN 1044-1549, 2017, Volume 56, Issue 5, pp. 648 - 656
Klebsiella pneumoniae is a common cause of pneumonia. Previous studies have documented an important role for Toll-like receptors (TLRs) expressed by myeloid... 
Klebsiella | Pneumonia | Lung epithelial | Myeloid-differentiation factor 88 | Toll-like receptor | ACTIVATION | lung epithelial | BIOCHEMISTRY & MOLECULAR BIOLOGY | INNATE IMMUNE-RESPONSE | CELL BIOLOGY | CLARA CELLS | pneumonia | RESPIRATORY SYSTEM | TOLL-LIKE RECEPTORS | HOST-DEFENSE | BACTERIAL-INFECTION | HEALTH | NF-KAPPA-B | myeloid-differentiation factor 88 | LUNG INFLAMMATION | EPIDEMIOLOGY | Inflammation - pathology | Pneumonia, Bacterial - microbiology | Epithelial Cells - metabolism | Klebsiella Infections - pathology | Klebsiella Infections - metabolism | Pulmonary Surfactant-Associated Protein C - metabolism | Epithelial Cells - pathology | Bronchioles - pathology | Klebsiella Infections - microbiology | Microbial Viability | Pneumonia, Bacterial - metabolism | Uteroglobin - metabolism | Animals | Epithelial Cells - microbiology | Klebsiella pneumoniae - physiology | Integrases - metabolism | Mice | Myeloid Differentiation Factor 88 - metabolism | Pneumonia, Bacterial - pathology | Cell culture | Mucosa | Infections | Defense mechanisms | Colony-forming cells | Drug resistance | Experiments | Blood transfusion | Interleukin 6 | Clonal deletion | Granulocyte colony-stimulating factor | Intestine | Rodents | American Type Culture Collection | Respiratory tract diseases | Colony-stimulating factor | Alveoli | Medical research | Pathogens | Immune response | Bronchus | Inflammation | Thorax | Surfactants | Anatomy | Epithelium | Defense | Cre recombinase | Studies | Lungs | Ligands | Adapter proteins | Chemokines
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11. Full Text Systemic Inflammation Induces Release of Cell-Free DNA from Hematopoietic and Parenchymal Cells in Mice and Human
by Kroeze, Anna and van der Meer, Anne Jan and Hoogendijk, Arie J and Ait Soussan, Aicha and van der Schoot, C. Ellen and Wuillemin, Walter A and Voermans, Carlijn and van der Poll, Tom and Zeerleder, Sacha S
Blood, ISSN 0006-4971, 11/2018, Volume 132, Issue Supplement 1, pp. 1107 - 1107
Abstract Cell-free DNA (cfDNA) and DNA binding proteins are released in the circulation upon systemic inflammation, the extent of which is proportional to the... 
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12. Full Text Inflammation and coagulation
by Levi, Marcel and van der Poll, Tom
Critical Care Medicine, ISSN 0090-3493, 02/2010, Volume 38 Suppl, Thrombosis and Critical Illness: Bench to Bedside, Issue 2, pp. S26 - S34
In the pathogenesis of sepsis, inflammation and coagulation play a pivotal role. Increasing evidence points to an extensive cross-talk between these two... 
Fibrin | Glycocalyx | Inflammation | Fibrinolysis | Coagulation | glycocalyx | ACTIVATED PROTEIN-C | ESCHERICHIA-COLI | INNATE IMMUNE-RESPONSE | COLI SEPTIC SHOCK | coagulation | TISSUE FACTOR EXPRESSION | fibrinolysis | TUMOR-NECROSIS-FACTOR | inflammation | DISSEMINATED INTRAVASCULAR COAGULATION | ANTITHROMBIN-III | fibrin | CRITICALLY-ILL PATIENTS | SEVERE SEPSIS | CRITICAL CARE MEDICINE | Fibrin - physiology | Protein C - physiology | Blood Coagulation Disorders - etiology | Humans | Thrombin - physiology | Blood Platelets - physiology | Fibrinolysin - physiology | Plasminogen - physiology | Lipoproteins - physiology | Inflammation - blood | Down-Regulation - physiology | Receptors, Proteinase-Activated - physiology | Inflammation - complications | Blood Coagulation Disorders - immunology | Antithrombins - physiology | Blood Coagulation - physiology | Fibrinolysis - physiology | Blood Coagulation Disorders - physiopathology | Inflammation - physiopathology
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13. Full Text Severe Sepsis and Septic Shock
by Angus, Derek C and van der Poll, Tom
The New England Journal of Medicine, ISSN 0028-4793, 11/2013, Volume 369, Issue 21, pp. 2069 - 2069
Severe Sepsis and Septic Shock Review Article, N Engl J Med 2013;369:840-851. In Table 2 (page 846), the grade given for “Continue fluid-challenge technique as... 
Septic shock | Sepsis
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14. Full Text Reply
by Scicluna, Brendon P and Klouwenberg, Peter M. C. Klein and Van Der Poll, Tom
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 11/2015, Volume 192, Issue 10, pp. 1261 - 1262
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15. Full Text Tumor Necrosis Factor Inhibition in Severe Sepsis: A Promise Not Fulfilled
by van der Poll, Tom
Critical care medicine, ISSN 0090-3493, 2014, Volume 42, Issue 3, pp. 724 - 725
clinical trial | editorial | tumor necrosis factor | sepsis | SAFETY | CACHECTIN | SEPTIC SHOCK | CRITICAL CARE MEDICINE | Sepsis - drug therapy | Female | Male | Immunoglobulin Fab Fragments - administration & dosage | Humans | Tumor Necrosis Factor-alpha - antagonists & inhibitors
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16. Full Text Reply
by Scicluna, Brendon P and Van Vught, Lonneke A and Van Der Poll, Tom and Klouwenberg, Peter M.C. Klein and Cremer, Olaf L
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 01/2016, Volume 193, Issue 1, pp. 102 - 103
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17. Full Text Eosinophilic inflammation amplifies the prednisolone-induced prothrombotic state in asthma
by Majoor, Christof J and Sneeboer, Marlous S and de Kievit, Anne and Meijers, Joost C.M and van der Poll, Tom and Lutter, Rene and Kamphuisen, Pieter Willem and Bel, Elisabeth H
European Respiratory Journal, ISSN 0903-1936, 09/2016, Volume 48, Issue suppl 60, p. OA493
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18. Full Text Secondary Infection in Patients With Sepsis—Reply
by van Vught, Lonneke A and Klein Klouwenberg, Peter MC and van der Poll, Tom
JAMA, ISSN 0098-7484, 08/2016, Volume 316, Issue 7, pp. 772 - 772
MEDICINE, GENERAL & INTERNAL | Sepsis | Humans | Coinfection
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19. Full Text Comprehensive Validation of the FAIM3:PLAC8 Ratio in Time-matched Public Gene Expression Data Reply
by Scicluna, Brendon P and Klein Klouwenberg, Peter M. C and van der Poll, Tom
American journal of respiratory and critical care medicine, ISSN 1073-449X, 2015, Volume 192, Issue 10, pp. 1261 - 1262
RESPIRATORY SYSTEM | COMMUNITY-ACQUIRED PNEUMONIA | CRITICAL CARE MEDICINE
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20. Full Text Pathogenesis, treatment, and prevention of pneumococcal pneumonia
by van der Poll, Tom, Prof and Opal, Steven M, Prof
Lancet, The, ISSN 0140-6736, 2009, Volume 374, Issue 9700, pp. 1543 - 1556
Summary Pneumococcus remains the most common cause of community-acquired pneumonia worldwide. Streptococcus pneumoniae is well adapted to people, and is a... 
Internal Medicine | C-REACTIVE PROTEIN | MEDICINE, GENERAL & INTERNAL | COMMUNITY-ACQUIRED PNEUMONIA | STREPTOCOCCUS-PNEUMONIAE | VIRULENCE FACTORS | HOST-DEFENSE | ALVEOLAR MACROPHAGE APOPTOSIS | HIV-INFECTED ADULTS | MARGINAL ZONE MACROPHAGES | T-CELLS | INNATE IMMUNITY | Humans | Vaccination | Carrier State - microbiology | Cost of Illness | Pneumonia, Pneumococcal - diagnosis | Genome, Bacterial - physiology | Host-Pathogen Interactions - immunology | Incidence | Pneumococcal Vaccines | Streptococcus pneumoniae - immunology | Streptococcus pneumoniae - pathogenicity | Pneumonia, Pneumococcal - epidemiology | Penicillin Resistance | Streptococcus pneumoniae - genetics | Adult | Child | Multifactorial Inheritance - genetics | Primary Prevention | Global Health | Penicillins - therapeutic use | Pneumonia, Pneumococcal - etiology | Carrier State - therapy | Genome, Bacterial - genetics | DNA, Bacterial - genetics | Carrier State - diagnosis | Pneumonia, Pneumococcal - therapy | Causality | Prevention | Causes of | Pneumonia, Pneumococcal | Drug therapy | Bacteria | Pneumonia | Vaccines | Streptococcus infections | Respiratory tract | Pathogens | Molecular modelling | Antibiotics | Virulence | Genomes
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