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1. Full Text A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals
by Deelen, Joris and Kettunen, Johannes and Fischer, Krista and van der Spek, Ashley and Trompet, Stella and Kastenmueller, Gabi and Boyd, Andy and Zierer, Jonas and van den Akker, Erik B and Ala-Korpela, Mika and Amin, Najaf and Demirkan, Ayse and Ghanbari, Mohsen and van Heemst, Diana and Ikram, M. Arfan and van Klinken, Jan Bert and Mooijaart, Simon P and Peters, Annette and Salomaa, Veikko and Sattar, Naveed and Spector, Tim D and Tiemeier, Henning and Verhoeven, Aswin and Waldenberger, Melanie and Wurtz, Peter and Smith, George Davey and Metspalu, Anes and Perola, Markus and Menni, Cristina and Geleijnse, Johanna M and nos, Fotios and Beekman, Marian and Jukema, J. Wouter and van Duijn, Cornelia M and Slagboom, P. Eline
Nature Communications, ISSN 2041-1723, 08/2019, Volume 10
Predicting longer-term mortality risk requires collection of clinical data, which is often cumbersome. Therefore, we use a well-standardized metabolomics... 
MAGNETIC-RESONANCE METABOLOMICS | HYPERGLYCEMIA | ASSOCIATION | AMINO-ACIDS | EPIDEMIOLOGY
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2. Full Text A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals
by Deelen, Joris and Kettunen, Johannes and Fischer, Krista and van der Spek, Ashley and Trompet, Stella and Boyd, Andy and Zierer, Jonas and van den Akker, E.B and Ala-Korpela, Mika
Nature Communications, ISSN 2041-1723, 2019, Volume 10, Issue 1
Predicting longer-term mortality risk requires collection of clinical data, which is often cumbersome. Therefore, we use a well-standardized metabolomics... 
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3. Full Text Genetic studies of accelerometer-based sleep measures yield new insights into human sleep behaviour
by Jones, Samuel E and van Hees, Vincent T and Mazzotti, Diego R and Marques-Vidal, Peo and Sabia, S. verine and van der Spek, Ashley and Dashti, Hassan S and Engmann, Jorgen and Kocevska, Desana and Tyrrell, Jessica and Beaumont, Robin N and Hillsdon, Melvyn and Ruth, Katherine S and Tuke, Marcus A and Yaghootkar, Hanieh and Sharp, Seth A and Ji, Yingjie and Harrison, Jamie W and Freathy, Rachel M and Murray, Anna and Luik, Annemarie I and Amin, Najaf and Lane, Jacqueline M and Saxena, Richa and Rutter, Martin K and Tiemeier, Henning and Kutalik, Zoltán and Kumari, Meena and Frayling, Timothy M and Weedon, Michael N and Gehrman, Philip R and Wood, Anew R
Nature Communications, ISSN 2041-1723, 2019, Volume 10, Issue 1
Sleep is an essential human function but its regulation is poorly understood. Using accelerometer data from 85,670 UK Biobank participants, we perform a... 
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4. Full Text Revisiting the Role of Insulin-Like Growth Factor-I Receptor Stimulating Activity and the Apolipoprotein E in Alzheimer’s Disease
by Galle, Sara A and van der Spek, Ashley and Drent, Madeleine L and Brugts, Michael P and Scherder, Erik J. A and Janssen, Joseph A. M. J. L and Ikram, M. Arfan and van Duijn, Cornelia M
Frontiers in Aging Neuroscience, ISSN 1663-4365, 02/2019, Volume 11
Background: Alterations in Insulin-Like Growth Factor I (IGF-I) signaling have been associated with dementia and Alzheimer’s disease. Studies on the... 
Insulin-like growth factor I | Heterozygotes | Insulin-like growth factors | Epidemiology | Insulin | Serum levels | Homozygotes | Apolipoprotein E | Cattle | Alleles | Dementia disorders | Physical growth | Geriatrics | apolipoprotein E | dementia | KIRA assay | Alzheimer’s disease | insulin-like growth factor I | genetic epidemiology
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5. Full Text Metabolomics reveals a link between homocysteine and lipid metabolism and leukocyte telomere length: the ENGAGE consortium
by van der Spek, Ashley and Broer, Linda and isma, Harmen H M and Pool, René and Albrecht, Eva and Beekman, Marian and Mangino, Massimo and Raag, Mait and Nyholt, Dale R and Dharuri, Harish K and Codd, Veryan and Amin, Najaf and de Geus, Eco J C and Deelen, Joris and Demirkan, Ayse and Yet, Idil and Fischer, Krista and Haller, Toomas and Henders, Anjali K and Isaacs, Aaron and Medland, Sarah E and Montgomery, Grant W and Mooijaart, Simon P and Strauch, Konstantin and Suchiman, H Eka D and Vaarhorst, Anika A M and van Heemst, Diana and Wang-Sattler, Rui and Whitfield, John B and Willemsen, Gonneke and Wright, Margaret J and Martin, Nicholas G and Samani, Nilesh J and Metspalu, Anes and Eline Slagboom, P and Spector, Tim D and Boomsma, D.I and van Duijn, Cornelia M and Gieger, Christian
Scientific Reports, ISSN 2045-2322, 08/2019, Volume 9, Issue 1
Telomere shortening has been associated with multiple age-related diseases such as cardiovascular disease, diabetes, and dementia. However, the biological... 
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6. Full Text Directional dominance on stature and cognition in diverse human populations
by Joshi, Peter K and Esko, Tonu and Mattsson, Hannele and Eklund, Niina and Gandin, Ilaria and Nutile, Teresa and Jackson, Anne U and Schurmann, Claudia and Smith, Albert V and Zhang, Weihua and Okada, Yukinori and Stancakova, Alena and Faul, Jessica D and Zhao, Wei and Bartz, Traci M and Concas, Maria Pina and Franceschini, Nora and Enroth, Stefan and Vitart, Veronique and Trompet, Stella and Guo, Xiuqing and Chasman, Daniel I and O'Connel, Jeffrey R and Corre, Tanguy and Nongmaithem, Suraj S and Chen, Yuning and Mangino, Massimo and Ruggiero, Daniela and Traglia, Michela and Farmaki, Aliki-Eleni and Kacprowski, Tim and Bjonnes, Anew and van der Spek, Ashley and Wu, Ying and Giri, Anil K and Yanek, Lisa R and Wang, Lihua and Hofer, Edith and Rietveld, Cornelius A and McLeod, Olga and Cornelis, Marilyn C and Pattaro, Cristian and Verweij, Niek and Baumbach, Clemens and Abdellaoui, Abdel and Warren, Helen R and van der Laan, Sander W and Asselbergs, Folkert W and van Setten, Jessica and Pasterkamp, Gerard
Nature, ISSN 0028-0836, 07/2015, Volume 523, Issue 7561, p. 459
Homozygosity has long been associated with rare, often devastating, Mendelian disorders(1), and Darwin was one of the first to recognize that inbreeding... 
PATHWAYS | ASSOCIATION ANALYSIS | Meta-Analysis | QUANTITATIVE TRAITS | GENETIC-VARIANTS | BLOOD-PRESSURE | Journal Article | INTELLIGENCE | HOMOZYGOSITY | Research Support, Non-U.S. Gov't | INBREEDING DEPRESSION | DISEASE | ARCHITECTURE
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7. Full Text Revisiting the role of insulin-like growth factor-I receptor stimulating activity and the apolipoprotein E in Alzheimer's disease
by Galle, Sara A and van der Spek, Ashley and nt, Madeleine L and Brugts, Michael P and Scherder, Erik J. A and Janssen, Joseph A. M. J. L and Arfan Ikram, M and van Duijn, Cornelia M
Frontiers in Aging Neuroscience, ISSN 1663-4365, 2019, Volume 10, Issue FEB
Background: Alterations in insulin-like growth factor I (IGF-I) signaling have been associated with dementia and Alzheimer's disease (AD). Studies on the... 
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8. Full Text Premature aging of circulating T cells in patients with end-stage renal disease
by Betjes, Michiel G.H and Langerak, Anton W and van der Spek, Ashley and de Wit, Elly A and Litjens, Nicolle H.R
Kidney International, ISSN 0085-2538, 07/2011, Volume 80, Issue 2, pp. 208 - 217
Progressive loss of renal function is associated with a dysregulation of circulating T cells that may underlie their impaired T-cell immunity. Here we tested... 
chronic kidney disease | lymphocytes | aging | clinical immunology | telomeres | HOMEOSTASIS | MEMORY-LIKE PHENOTYPE | DENDRITIC CELLS | LYMPHOCYTE SUBSETS | INCREASES | HUMANS | PROLIFERATION | NAIVE | IMMUNE | HEMODIALYSIS-PATIENTS | UROLOGY & NEPHROLOGY | Thymus Gland | Blood Cells | Kidney Failure, Chronic - immunology | Age Factors | Humans | Middle Aged | CD4 Lymphocyte Count | Case-Control Studies | Cellular Senescence - immunology | Apoptosis - immunology | Aged, 80 and over | Adult | Aged | T-Lymphocytes - pathology
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9. Full Text Directional dominance on stature and cognition in diverse human populations
by Joshi, Peter K and Esko, Tonu and Mattsson, Hannele and Eklund, Niina and Gandin, Ilaria and Nutile, Teresa and Jackson, Anne U and Schurmann, Claudia and Smith, Albert V and Zhang, Weihua and Okada, Yukinori and Stancakova, Alena and Faul, Jessica D and Zhao, Wei and Bartz, Traci M and Concas, Maria Pina and Franceschini, Nora and Enroth, Stefan and Vitart, Veronique and Trompet, Stella and Guo, Xiuqing and Chasman, Daniel I and O'Connel, Jeffrey R and Corre, Tanguy and Nongmaithem, Suraj S and Chen, Yuning and Mangino, Massimo and Ruggiero, Daniela and Traglia, Michela and Farmaki, Aliki-Eleni and Kacprowski, Tim and Bjonnes, Anew and van der Spek, Ashley and Wu, Ying and Giri, Anil K and Yanek, Lisa R and Wang, Lihua and Hofer, Edith and Rietveld, Cornelius A and McLeod, Olga and Cornelis, Marilyn C and Pattaro, Cristian and Verweij, Niek and Baumbach, Clemens and van der Most, Peter J and Asselbergs, Folkert W and Bakker, Stephan J. L and Nolte, Ilja M and Oldehinkel, Albertine J and van der Harst, Pim and BioBank Japan Project and The BioBank Japan Project
Nature, ISSN 0028-0836, 07/2015, Volume 523, Issue 7561, pp. 459 - U176
Homozygosity has long been associated with rare, often devastating, Mendelian disorders(1), and Darwin was one of the first to recognize that inbreeding... 
INTELLIGENCE | HOMOZYGOSITY | PATHWAYS | ASSOCIATION ANALYSIS | QUANTITATIVE TRAITS | INBREEDING DEPRESSION | DISEASE | ARCHITECTURE | GENETIC-VARIANTS | BLOOD-PRESSURE | MULTIDISCIPLINARY SCIENCES | TRAITS | ASSOCIATION | Studies | Cognition & reasoning | Disease | Genomics | Cognitive ability | Genomes | Educational attainment
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10. Full Text Genetic studies of accelerometer-based sleep measures yield new insights into human sleep behaviour
by Jones, S and van Hees, V.T and Mazzotti, D.R and Marques-Vidal, Peo and Sabia, S and Spek, Ashley and Dashti, HS and Engmann, J and Kocevska, Desana and Tyrrell, A.W.R and Beaumont, RN and Hillsdon, M and Ruth, KS and Tuke, MA and Yaghootkar, Hanieh and Sharp, S.A and Ji, Y.J and Harrison, J.W and Freathy, Rachel and Murray, Anna and Luik, Annemarie and Amin, Najaf and Lane, J.M and Saxena, Richa and Rutter, M.K and Tiemeier, Henning and Kutalik, Zoltán and Kumari, Meena and Frayling, Timothy and Weedo, Michael and Gehrman, Philip and Wood, Anew
Nature Communications, ISSN 2041-1723, 01/2019, Volume 10, Issue 1, pp. 1585 - 12
textabstractSleep is an essential human function but its regulation is poorly understood. Using accelerometer data from 85,670 UK Biobank participants, we... 
INDIVIDUALS | RISK LOCI | OBESITY | SEDENTARY BEHAVIOR | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | PHYSICAL-ACTIVITY | LD SCORE REGRESSION | DISTURBANCE | DURATION | GENOME-WIDE ASSOCIATION | Polysomnography - methods | Serotonin - genetics | Humans | Serotonin - metabolism | Sleep Wake Disorders - diagnosis | Accelerometry - methods | Polymorphism, Single Nucleotide | Sleep - genetics | Circadian Rhythm | Waist-Hip Ratio | Sleep Wake Disorders - genetics | Accelerometers | Legs | Restless legs syndrome | Sleep | Serotonin | Genomes | Human behavior | Sleep deprivation | Leg | Index Medicus
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11. Full Text Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity
by Joshi, Peter and Pirastu, Nicola and Kentistou, K.A and Fischer, Krista and Hofer, Edith and Schraut, K.E and Clark, D.W and Nutile, T and Barnes, C.L.K and Timmers, P.R.H.J and Shen, X and Gandin, Ilaria and McDaid, A.F and Hansen, T.F and Gordon, Scott D and Giulianini, Franco and Boutin, Thibaud and Abdellaoui, Abdel and Zhao, Wei and Medina-Gomez, Carolina and Bartz, Traci M and Trompet, Stella and Lange, Leslie and Raffield, L and Spek, Ashley and Galesloot, Tessel and Proitsi, P and Yanek, Lisa and Bielak, Lawrence F and Payton, Antony and Murgia, Daniela and Concas, Maria Pina and Biino, Ginevra and Tajuddin, S.M and Seppälä, Ilkka and Amin, N and Boerwinkle, E and Børglum, A.D and Campbell, Archie and Demerath, Ellen and Demuth, Ilja and Faul, Jessica D and Ford, Ian and Gialluisi, A and Gögele, Martin and Graff, Maud J.L and Hingorani, Aroon and Hottenga, Jouke Jan and Hougaard, David and Hurme, M.A and Ikram, Kamran and Jylhä, M and Kuh, D and Ligthart, Lannie and Lill, Christina and Lindenberger, Ulman and Lumley, Thomas and Mägi, Reedik and Marques-Vidal, Peo and Medland, Sarah Elizabeth and Milani, Lili and Nagy, R and Ollier, William and Peyser, Patricia A and Pramstaller, Peter Paul and Ridker, Paul and Rivadeneira, F and Ruggiero, D and Saba, Yasaman and Schmidt, Reinhold and Schmidt, Helena and Slagboom, Eline and Smith, B.H and Smith, Jennifer A and Sotoodehnia, Nona and Steinhagen-Thiessen, Elisabeth and Rooij, Frank and Verbeek, A.L.M and Vermeulen, Sita and Vollenweider, Peter and Wang, Y and Werge, Thomas and Whitfield, John B and Zonderman, A.B and Lehtimäki, Terho and Evans, Michele and Pirastu, Mario and Fuchsberger, Christian and Bertram, Lars and Pendleton, Neil and Kardia, S.L.R and Ciullo, M and Becker, Diane and Wong, A and Psaty, Bruce M and Duijn, Cornelia and Wilson, James and Jukema, Jan Wouter and Kiemeney, Bart and Uitterlinden, Ané and ...
Nature Communications, ISSN 2041-1723, 12/2017, Volume 8, Issue 1, pp. 910 - 13
textabstractGenomic analysis of longevity offers the potential to illuminate the biology of human aging. Here, using genome-wide association meta-analysis of... 
SURVIVAL | INDIVIDUALS | POPULATION | MULTIDISCIPLINARY SCIENCES | DISEASE | SUSCEPTIBILITY LOCI | RISK | GENETIC-VARIANTS | APOE | BLOOD-PRESSURE | AGE | Body Mass Index | Lung Neoplasms - genetics | Smoking - adverse effects | Coronary Disease - blood | Genetic Predisposition to Disease - genetics | Genome-Wide Association Study | Life Style | HLA-DRB1 Chains - genetics | Lipoproteins, HDL - blood | Obesity - complications | Humans | Coronary Disease - etiology | Longevity - genetics | HLA-DQ alpha-Chains - genetics | Obesity - genetics | Socioeconomic Factors | Education | Alleles | Insulin Resistance - genetics | Lung Neoplasms - blood | Polymorphism, Single Nucleotide | Lipoprotein(a) - genetics | Body fat | DQA1 protein | Lung cancer | Parents | Cardiovascular disease | Genomes | Body mass index | Apolipoprotein E | Drb1 protein | Aging | Heart diseases | Lipoproteins (high density) | FOXO3 protein | Genomic analysis | Coronary artery | Longevity | Cigarettes | Cigarette smoking | Insulin | Coronary artery disease | Cholesterol | Educational attainment | Genetic variance | Life span | Body mass | Histocompatibility antigen HLA | Smoking
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12. Full Text A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals
by Deelen, Joris and Kettunen, J and Fischer, Krista and Spek, Ashley and Trompet, Stella and Kastenmuller, Gabi and Boyd, A and Zierer, J and Akker, Erik and Ala-Korpela, Mika and Amin, N and Demirkan, A and Ghanbari, Mohsen and Heemst, Diana and Ikram, Arfan and Klinken, Jan Bert and Mooijaart, Simon and Peters, Annette and Salomaa, Veikko and Sattar, Naveed and Spector, Timothy and Tiemeier, Henning and Verhoeven, Aswin and Waldenberger, M and Würtz, Peter and Davey Smith, G and Metspalu, Anes and Perola, Markus and Menni, Cristina and Geleijnse, J.M and nos, F and Beekman, M and Jukema, Jan Wouter and Duijn, Cornelia and Slagboom, Eline
Nature Communications, ISSN 2041-1723, 08/2019, Volume 10, Issue 1, pp. 3346 - 8
textabstractPredicting longer-term mortality risk requires collection of clinical data, which is often cumbersome. Therefore, we use a well-standardized... 
MAGNETIC-RESONANCE METABOLOMICS | HYPERGLYCEMIA | ASSOCIATION | AMINO-ACIDS | MULTIDISCIPLINARY SCIENCES | EPIDEMIOLOGY | Metabolomics | Mortality | Men | Predictions | Biomarkers | Health risk assessment | Metabolism | Risk analysis | Risk factors
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13. Full Text Metabolomics based markers predict type 2 diabetes in a 14-year follow-up study
by Liu, J and Semiz, S and Lee, Sven and Spek, Ashley and Verhoeven, Aswin and Klinken, Jan Bert and Sijbrands, Eric and Harms, Amy and Hankemeier, Thomas and Willems van Dijk, Ko and Duijn, Cornelia and Demirkan, Ayşe
Metabolomics, ISSN 1573-3882, 09/2017, Volume 13, Issue 9, pp. 1 - 11
textabstractBackground: The growing field of metabolomics has opened up new opportunities for prediction of type 2 diabetes (T2D) going beyond the classical... 
Type 2 diabetes | Metabolomics | Metabolites | Early biomarkers | Prospective study | Prediction | Life Sciences | Biochemistry, general | Biomedicine, general | Molecular Medicine | Developmental Biology | Cell Biology | LIFE-STYLE INTERVENTION | POPULATION | ADULTS | RISK | FASTING GLUCOSE | MODELS | INSULIN-RESISTANCE | ENDOCRINOLOGY & METABOLISM | IMPROVEMENT | ASSOCIATION | Nuclear magnetic resonance spectroscopy | Analysis | Fasting | Nuclear magnetic resonance--NMR | Diabetes mellitus | Markers | Performance prediction | Amino acids | Mass spectroscopy | Triglycerides | Shrinkage | Glucose | Regression analysis | Metabolism | Risk analysis | Density | Risk factors | Incidence | Magnetic resonance spectroscopy | Body mass | Mathematical models | Diabetes | Mass spectrometry | Original
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14. Full Text A meta-analysis of genome-wide association studies identifies multiple longevity genes
by Deelen, Joris and Evans, Daniel and Arking, Dan and Tesi, N and Nygaard, M and Liu, X and Wojczynski, Mary and Biggs, M and Spek, Ashley and Atzmon, Gil and Ware, Erin B and Sarnowski, C and Smith, Albert and Seppälä, Ilkka and Cordell, Heather and Dose, J and Amin, N and Arnold, Alice and Ayers, Kristin and Barzilai, Ari and Becker, E.J and Beekman, M and Blanché, Hélène and Christensen, Kaare and Christiansen, L and Collerton, Joanna and Cubaynes, S and Cummings, S and Davies, Karen and Debrabant, B and Deleuze, Jean-François and Duncan, R and Faul, J.D and Franceschi, Claudio and Galan, Pilar and Gudnason, V and Harris, Tamara and Huisman, Martijn and Hurme, Mikko and Jagger, Carol and Jansen, Iris and Jylhä, M and Kähönen, M and Karasik, David and Kardia, Sharon and Kingston, A and Kirkwood, John and Launer, Lenore and Lehtimäki, Terho and Lieb, Wolfgang and Lyytikäinen, L.-P and Martin-Ruiz, Carmen and Min, J and Nebel, Almut and Newman, Anne B and Nie, C and Nohr, Christian and Orwoll, Eric and Perls, Thomas T and Province, Mike and Psaty, B.M and Raitakari, Olli and Reinders, Marcel and Robine, Jean-Marie and Rotter, Jerome I and Sebastiani, Paola and Smith, Jennifer A and Sørensen, Thorkild and Taylor, Kent and Uitterlinden, Ané and Flier, Wiesje and Lee, Sven and Duijn, Cornelia and Heemst, Diana and Vaupel, James and Weir, D and Ye, K and Zeng, Y and Zheng, W and Holstege, Henne and Kiel, Douglas P and Lunetta, Kathryn and Slagboom, Eline and Murabito, Joanne
Nature Communications, ISSN 2041-1723, 12/2019, Volume 10, Issue 1, pp. 3669 - 14
textabstractHuman longevity is heritable, but genome-wide association (GWA) studies have had limited success. Here, we perform two meta-analyses of GWA studies... 
SURVIVAL | LIFE-SPAN | GWAS | CONFIRMS APOE | MULTIDISCIPLINARY SCIENCES | HEALTH | PREVALENCE | LD SCORE REGRESSION | LOCUS | HERITABILITY | AGE | Phenotypes | Apolipoprotein E | Genes | Association analysis | Genomes | Longevity | Gene expression | Survival | Age
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15. Full Text Non-additive genome-wide association scan reveals a new gene associated with habitual coffee consumption
by Pirastu, Nicola and Kooyman, Maarten and Robino, Antonietta and Van Der Spek, Ashley and Navarini, Luciano and Amin, Najaf and Karssen, Lennart C and Van Duijn, Cornelia M and Gasparini, Paolo
Scientific Reports, ISSN 2045-2322, 08/2016, Volume 6, Issue 1, p. 31590
Coffee is one of the most consumed beverages world-wide and one of the primary sources of caffeine intake. Given its important health and economic impact, the... 
POPULATION | MULTIDISCIPLINARY SCIENCES | DISEASE | CAFFEINE | RISK | PDSS2 MUTANT MICE | TYPE-2 DIABETES-MELLITUS | MAP | DEFICIENCY | Caffeine - metabolism | Caffeine - administration & dosage | Humans | Middle Aged | Alkyl and Aryl Transferases - metabolism | Genotype | Male | Gene Expression Profiling | Coffee | Drinking Behavior | Alkyl and Aryl Transferases - genetics | Adult | Female | Polymorphism, Single Nucleotide | Genome-Wide Association Study - methods | Cohort Studies | Enhancers | Population studies | Genomes | Single-nucleotide polymorphism | Beverages | Gene expression | Health risk assessment | Metabolism | Bioinformatics | Caffeine
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16. Full Text Metabolomics reveals a link between homocysteine and lipid metabolism and leukocyte telomere length: the ENGAGE consortium
by Spek, Ashley and Boer, Linda and isma, Gerrit and Pool, Reńe and Albrecht, Eva and Beekman, M and Mangino, Massimo and Raag, M and Nyholt, D.R and Dharuri, Harish and Codd, V and Amin, Najaf and de Geus, E.J.C and Deelen, Joris and Demirkan, Ayşe and Yet, Idil and Fischer, Krista and Haller, T and Henders, A.K and Isaacs, A and Medland, S.E and Montgomery, G.W and Mooijaart, Simon and Strauch, Konstantin and Suchiman, H.E.D and Vaarhorst, Anika and Heemst, Diana and Wang-Sattler, R and Whitfield, John and Willemsen, G and Wright, M.J and Martin, Nicholas and Samani, N.J and Metspalu, A and Eline Slagboom, P and Spector, T.D and Boomsma, D.I and Duijn, Cornelia and Gieger, C
Scientific Reports, ISSN 2045-2322, 12/2019, Volume 9, Issue 1, pp. 11623 - 12
textabstractTelomere shortening has been associated with multiple age-related diseases such as cardiovascular disease, diabetes, and dementia. However, the... 
MORTALITY | LIFE-SPAN | METHIONINE RESTRICTION | PLASMA TOTAL HOMOCYSTEINE | HEART-DISEASE | MULTIDISCIPLINARY SCIENCES | ENDOTHELIAL-CELLS | LOW-DENSITY-LIPOPROTEIN | CARDIOVASCULAR-DISEASE | WHITE BLOOD-CELLS | FAMILIAL LONGEVITY | Tyrosine | Oxidative stress | Metabolomics | Lecithin | Oxidative metabolism | Diabetes mellitus | Methionine | Cardiovascular disease | Mass spectroscopy | Metabolism | Lysophosphatidylcholine | Morbidity | Polymerase chain reaction | Metabolites | Correlation analysis | Dementia disorders | Diabetes | Lipid metabolism | Cardiovascular diseases | Homocysteine | Age
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