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Nature Communications, ISSN 2041-1723, 2019, Volume 10, Issue 1
Predicting longer-term mortality risk requires collection of clinical data, which is often cumbersome. Therefore, we use a well-standardized metabolomics... 
Journal Article
Nature Communications, ISSN 2041-1723, 2019, Volume 10, Issue 1
Sleep is an essential human function but its regulation is poorly understood. Using accelerometer data from 85,670 UK Biobank participants, we perform a... 
Journal Article
Journal Article
Frontiers in Aging Neuroscience, ISSN 1663-4365, 2019, Volume 10, Issue FEB
Background: Alterations in insulin-like growth factor I (IGF-I) signaling have been associated with dementia and Alzheimer's disease (AD). Studies on the... 
Journal Article
Kidney International, ISSN 0085-2538, 07/2011, Volume 80, Issue 2, pp. 208 - 217
Journal Article
Nature, ISSN 0028-0836, 07/2015, Volume 523, Issue 7561, pp. 459 - U176
Homozygosity has long been associated with rare, often devastating, Mendelian disorders(1), and Darwin was one of the first to recognize that inbreeding... 
INTELLIGENCE | HOMOZYGOSITY | PATHWAYS | ASSOCIATION ANALYSIS | QUANTITATIVE TRAITS | INBREEDING DEPRESSION | DISEASE | ARCHITECTURE | GENETIC-VARIANTS | BLOOD-PRESSURE | MULTIDISCIPLINARY SCIENCES | TRAITS | ASSOCIATION | Studies | Cognition & reasoning | Disease | Genomics | Cognitive ability | Genomes | Educational attainment
Journal Article
Journal Article
by Joshi, Peter and Pirastu, Nicola and Kentistou, K.A and Fischer, Krista and Hofer, Edith and Schraut, K.E and Clark, D.W and Nutile, T and Barnes, C.L.K and Timmers, P.R.H.J and Shen, X and Gandin, Ilaria and McDaid, A.F and Hansen, T.F and Gordon, Scott D and Giulianini, Franco and Boutin, Thibaud and Abdellaoui, Abdel and Zhao, Wei and Medina-Gomez, Carolina and Bartz, Traci M and Trompet, Stella and Lange, Leslie and Raffield, L and Spek, Ashley and Galesloot, Tessel and Proitsi, P and Yanek, Lisa and Bielak, Lawrence F and Payton, Antony and Murgia, Daniela and Concas, Maria Pina and Biino, Ginevra and Tajuddin, S.M and Seppälä, Ilkka and Amin, N and Boerwinkle, E and Børglum, A.D and Campbell, Archie and Demerath, Ellen and Demuth, Ilja and Faul, Jessica D and Ford, Ian and Gialluisi, A and Gögele, Martin and Graff, Maud J.L and Hingorani, Aroon and Hottenga, Jouke Jan and Hougaard, David and Hurme, M.A and Ikram, Kamran and Jylhä, M and Kuh, D and Ligthart, Lannie and Lill, Christina and Lindenberger, Ulman and Lumley, Thomas and Mägi, Reedik and Marques-Vidal, Peo and Medland, Sarah Elizabeth and Milani, Lili and Nagy, R and Ollier, William and Peyser, Patricia A and Pramstaller, Peter Paul and Ridker, Paul and Rivadeneira, F and Ruggiero, D and Saba, Yasaman and Schmidt, Reinhold and Schmidt, Helena and Slagboom, Eline and Smith, B.H and Smith, Jennifer A and Sotoodehnia, Nona and Steinhagen-Thiessen, Elisabeth and Rooij, Frank and Verbeek, A.L.M and Vermeulen, Sita and Vollenweider, Peter and Wang, Y and Werge, Thomas and Whitfield, John B and Zonderman, A.B and Lehtimäki, Terho and Evans, Michele and Pirastu, Mario and Fuchsberger, Christian and Bertram, Lars and Pendleton, Neil and Kardia, S.L.R and Ciullo, M and Becker, Diane and Wong, A and Psaty, Bruce M and Duijn, Cornelia and Wilson, James and Jukema, Jan Wouter and Kiemeney, Bart and Uitterlinden, Ané and ...
Nature Communications, ISSN 2041-1723, 12/2017, Volume 8, Issue 1, pp. 910 - 13
Journal Article
by Deelen, Joris and Evans, Daniel and Arking, Dan and Tesi, N and Nygaard, M and Liu, X and Wojczynski, Mary and Biggs, M and Spek, Ashley and Atzmon, Gil and Ware, Erin B and Sarnowski, C and Smith, Albert and Seppälä, Ilkka and Cordell, Heather and Dose, J and Amin, N and Arnold, Alice and Ayers, Kristin and Barzilai, Ari and Becker, E.J and Beekman, M and Blanché, Hélène and Christensen, Kaare and Christiansen, L and Collerton, Joanna and Cubaynes, S and Cummings, S and Davies, Karen and Debrabant, B and Deleuze, Jean-François and Duncan, R and Faul, J.D and Franceschi, Claudio and Galan, Pilar and Gudnason, V and Harris, Tamara and Huisman, Martijn and Hurme, Mikko and Jagger, Carol and Jansen, Iris and Jylhä, M and Kähönen, M and Karasik, David and Kardia, Sharon and Kingston, A and Kirkwood, John and Launer, Lenore and Lehtimäki, Terho and Lieb, Wolfgang and Lyytikäinen, L.-P and Martin-Ruiz, Carmen and Min, J and Nebel, Almut and Newman, Anne B and Nie, C and Nohr, Christian and Orwoll, Eric and Perls, Thomas T and Province, Mike and Psaty, B.M and Raitakari, Olli and Reinders, Marcel and Robine, Jean-Marie and Rotter, Jerome I and Sebastiani, Paola and Smith, Jennifer A and Sørensen, Thorkild and Taylor, Kent and Uitterlinden, Ané and Flier, Wiesje and Lee, Sven and Duijn, Cornelia and Heemst, Diana and Vaupel, James and Weir, D and Ye, K and Zeng, Y and Zheng, W and Holstege, Henne and Kiel, Douglas P and Lunetta, Kathryn and Slagboom, Eline and Murabito, Joanne
Nature Communications, ISSN 2041-1723, 12/2019, Volume 10, Issue 1, pp. 3669 - 14
textabstractHuman longevity is heritable, but genome-wide association (GWA) studies have had limited success. Here, we perform two meta-analyses of GWA studies... 
SURVIVAL | LIFE-SPAN | GWAS | CONFIRMS APOE | MULTIDISCIPLINARY SCIENCES | HEALTH | PREVALENCE | LD SCORE REGRESSION | LOCUS | HERITABILITY | AGE | Phenotypes | Apolipoprotein E | Genes | Association analysis | Genomes | Longevity | Gene expression | Survival | Age
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2019, Volume 9, Issue 1, pp. 11623 - 12
Journal Article