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1. Full Text SPIO labeling of endothelial cells using ultrasound and targeted microbubbles at diagnostic pressures
by Skachkov, Ilya and Luan, Ying and Van Tiel, Sandra T and Van Der Steen, Antonius F.W and De Jong, Nico and Bernsen, Monique R and Kooiman, Klazina
PLoS ONE, ISSN 1932-6203, 09/2018, Volume 13, Issue 9, pp. e0204354 - e0204354
In vivo cell tracking of therapeutic, tumor, and endothelial cells is an emerging field and a promising technique for imaging cardiovascular disease and cancer... 
IRON-OXIDE NANOPARTICLES | BREAST-CANCER CELLS | APOPTOSIS | COATED MICROBUBBLES | SONOPORATION | MEDIATED DRUG-DELIVERY | SINGLE CELLS | CONTRAST AGENTS | MRI | MULTIDISCIPLINARY SCIENCES | IN-VIVO | Glycocalyx | Usage | Safety and security measures | Magnetic resonance imaging | Ultrasonic waves | Labels | Diagnosis | Research | Cardiovascular diseases | Index Medicus
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2. Full Text Acoustic Characterization of the CLINIcell for Ultrasound Contrast Agent Studies
by Beekers, Ines and van Rooij, Tom and van der Steen, Antonius F. W and de Jong, Nico and Verweij, Martin D and Kooiman, Klazina
IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, ISSN 0885-3010, 01/2019, Volume 66, Issue 1, pp. 244 - 246
Ultrasound contrast agents consist of gas-filled coated microbubbles that oscillate upon ultrasound insonification. Their characteristic oscillatory response... 
Integrated optics | Acoustic characterization | Ultrasonic imaging | Biomedical optical imaging | ultrahigh-speed imaging | Optical variables control | Acoustics | Drug delivery | ultrasound contrast agents (UCAs) | Optical sensors | Ultrahigh-speed imaging | Ultrasound contrast agents (UCAs) | ACOUSTICS | BEHAVIOR | drug delivery | MICROBUBBLES | NONLINEAR RESPONSE | ENGINEERING, ELECTRICAL & ELECTRONIC | Contrast agents | Cell culture | Biotechnology | Drug delivery systems | Amplitudes
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3. Full Text Contrast-enhanced ultrasound imaging of the vasa vasorum: From early atherosclerosis to the identification of unstable plaques
by Staub, Daniel and Schinkel, Arend F.L and Coll, Blai and Coli, Stefano and Van Der Steen, Antonius F.W and Reed, Jess D and Krueger, Christian and Thomenius, Kai E and Adam, Dan and Sijbrands, Eric J and Ten Cate, Folkert J and Feinstein, Steven B
JACC: Cardiovascular Imaging, ISSN 1936-878X, 2010, Volume 3, Issue 7, pp. 761 - 771
Proliferation of the adventitial vasa vasorum (VV) is inherently linked with early atherosclerotic plaque development and vulnerability. Recently, direct... 
atherosclerosis | surrogate marker | contrast-enhanced ultrasound | vasa vasorum | Coronary Vessels - diagnostic imaging | Connective Tissue - diagnostic imaging | Predictive Value of Tests | Humans | Disease Progression | Neovascularization, Pathologic - diagnostic imaging | Animals | Atherosclerosis - diagnostic imaging | Carotid Arteries - diagnostic imaging | Contrast Media | Time Factors | Ultrasonography | Rupture, Spontaneous | Connective Tissue - blood supply | Disease Models, Animal
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4. Full Text A 2-D Ultrasound Transducer With Front-End ASIC and Low Cable Count for 3-D Forward-Looking Intravascular Imaging: Performance and Characterization
by Janjic, Jovana and Tan, Mingliang and Daeichin, Verya and Noothout, Emile and Chen, Chao and Chen, Zhao and Chang, Zu-Yao and Beurskens, Robert H. S. H and van Soest, Gijs and van der Steen, Antonius F. W and Verweij, Martin D and Pertijs, Michiel A.P and de Jong, Nico
IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, ISSN 0885-3010, 10/2018, Volume 65, Issue 10, pp. 1832 - 1844
Intravascular ultrasound (IVUS) is an imaging modality used to visualize atherosclerosis from within the inner lumen of human arteries. Complex lesions like... 
front-end application-specific integrated circuit (ASIC) | Transducers | Ultrasonic imaging | intravascular ultrasound (IVUS) | Two dimensional displays | Imaging | Forward looking (FL) | piezoelectrical transducer | Acoustics | Finite element analysis | Catheters | ATHEROSCLEROSIS | IVUS | ICE | CORONARY-ARTERIES | ABLATION CATHETER | ENGINEERING, ELECTRICAL & ELECTRONIC | ACOUSTICS | CHIP | FABRICATION | ECHOCARDIOGRAPHY | PHASED-ARRAY | PROBE | Circuit design | Computer simulation | Zirconium titanates | Arteries | Image acquisition | Cables | Finite element method | Integrated circuits | Application specific integrated circuits | Beamforming | Sensitivity | Reflectors | Atherosclerosis | Lesions
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5. Full Text Vibrational Responses of Bound and Nonbound Targeted Lipid-Coated Single Microbubbles
by van Rooij, Tom and Beekers, Ines and Lattwein, Kirby R and van der Steen, Antonius F. W and de Jong, Nico and Kooiman, Klazina
IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, ISSN 0885-3010, 05/2017, Volume 64, Issue 5, pp. 785 - 797
One of the main challenges for ultrasound molecular imaging is acoustically distinguishing nonbound microbubbles from those bound to their molecular target. In... 
Biological system modeling | lipid-coating | nonlinear behavior | targeted microbubbles | Lipidomics | Acoustics | Biotin-streptavidin | molecular imaging | Frequency control | Ultrasonic imaging | ultrasound contrast agents | Resonant frequency | Biomembranes | ultrahigh-speed optical imaging | DSPC | BEHAVIOR | BUBBLES | ENGINEERING, ELECTRICAL & ELECTRONIC | ACOUSTICS | SPECTROSCOPY | IN-VIVO | ENHANCEMENT | ADHERENT | BINDING | ENCAPSULATED MICROBUBBLES | Biotin - chemistry | Optical Imaging | Lipids - chemistry | Biotinylation | Vibration | Streptavidin | Microbubbles | Contrast Media - chemistry | Molecular Imaging - methods | Molecular biology | Research
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6. Full Text On the dynamics of StemBells: Microbubble-conjugated stem cells for ultrasound-controlled delivery
by Kokhuis, Tom J.A and Naaijkens, Benno A and Juffermans, Lynda J. M and Kamp, Otto and van der Steen, Antonius F.W and Versluis, Michel and de Jong, Nico
Applied physics letters, ISSN 0003-6951, 07/2017, Volume 111, Issue 2, p. 23701
The use of stem cells for regenerative tissue repair is promising but hampered by the low number of cells delivered to the site of injury. To increase the... 
TARGETED MICROBUBBLES | PHYSICS, APPLIED | CONTRAST AGENTS | AMPLITUDE | ACOUSTIC RADIATION FORCE | OSCILLATIONS | CARDIAC REPAIR | BUBBLES
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7. Full Text Carotid Plaque Morphological Classification Compared With Biomechanical Cap Stress: Implications for a Magnetic Resonance Imaging–Based Assessment
by Gijsen, Frank J.H and Nieuwstadt, Harm A and Wentzel, Jolanda J and Verhagen, Hence J.M and van der Lugt, Aad and van der Steen, Antonius F.W
Stroke, ISSN 0039-2499, 08/2015, Volume 46, Issue 8, pp. 2124 - 2128
BACKGROUND AND PURPOSE—Two approaches to target plaque vulnerability—a histopathologic classification scheme and a biomechanical analysis—were compared and the... 
carotid artery plaque | magnetic resonance imaging | mechanics | risk assesment | histology | stroke | ATHEROSCLEROTIC LESIONS | MRI | MODEL | CLINICAL NEUROLOGY | RUPTURE | PERIPHERAL VASCULAR DISEASE | SIMULATIONS | CIRCUMFERENTIAL STRESS | VULNERABLE PLAQUE | THICKNESS | Endarterectomy, Carotid | Carotid Stenosis - classification | Magnetic Resonance Imaging - classification | Carotid Stenosis - diagnosis | Humans | Magnetic Resonance Imaging - methods | Stress, Mechanical | Female | Male | Carotid Stenosis - surgery
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8. Full Text Autofluorescence: A New NIR on the Block
by van Soest, Gijs and van der Steen, Antonius F.W and Regar, Evelyn
JACC: Cardiovascular Imaging, ISSN 1936-878X, 11/2016, Volume 9, Issue 11, pp. 1315 - 1317
coronary artery disease | autofluorescence imaging | first-in-human | optical coherence tomography | multimodality optical coherence tomography | OCT | CARDIAC & CARDIOVASCULAR SYSTEMS | PLAQUES | PERCUTANEOUS CORONARY INTERVENTION | ARTERIES | PERIPROCEDURAL MYOCARDIAL-INFARCTION | OUTCOMES | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
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9. Full Text Autofluorescence: A New NIR on the Block.sup.
by Van Soest, Gijs and Van der Steen, Antonius F.W and Regar, Evelyn
JACC: Cardiovascular Imaging, ISSN 1936-878X, 11/2016, Volume 9, Issue 11, p. 1315
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10. Full Text Variation in Coronary Atherosclerosis Severity Related to a Distinct LDL (Low-Density Lipoprotein) Profile: Findings From a Familial Hypercholesterolemia Pig Model
by Hoogendoorn, Ayla and den Hoedt, Sandra and Hartman, Eline M.J and Krabbendam-Peters, Ilona and te Lintel Hekkert, Maaike and van der Zee-van Vark, Leonie and van Gaalen, Kim and Witberg, Karen Th and Dorst, Kristien and Ligthart, Jurgen M.R and Drouet, Ludovic and Van der Heiden, Kim and van Lennep, Jeanine Roeters and van der Steen, Antonius F.W and Duncker, Dirk J and Mulder, Monique T and Wentzel, Jolanda J
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 09/2019
OBJECTIVE:In an adult porcine model of familial hypercholesterolemia (FH), coronary plaque development was characterized. To elucidate the underlying... 
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11. Full Text Autofluorescence
by van Soest, Gijs, PhD and van der Steen, Antonius F.W., PhD and Regar, Evelyn, MD, PhD
JACC: Cardiovascular Imaging, ISSN 1936-878X, 2016
Cardiovascular
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12. Full Text Sonoporation of endothelial cells by vibrating targeted microbubbles
by Kooiman, Klazina and Foppen-Harteveld, Miranda and der Steen, Antonius F.W. van and de Jong, Nico
Journal of Controlled Release, ISSN 0168-3659, 2011, Volume 154, Issue 1, pp. 35 - 41
Molecular imaging using ultrasound makes use of targeted microbubbles. In this study we investigated whether these microbubbles could also be used to induce... 
Drug delivery | Ultrasound | Sonoporation | Targeted microbubble | Endothelial cells | PECAM-1 | ULTRASOUND CONTRAST AGENTS | DRUG-DELIVERY | TUMOR ANGIOGENESIS | PLASMA-MEMBRANE | CHEMISTRY, MULTIDISCIPLINARY | ADHESION MOLECULE-1 | ACOUSTIC CAVITATION | INERTIAL CAVITATION | P-SELECTIN | PHARMACOLOGY & PHARMACY | ECHOCARDIOGRAPHY | Human Umbilical Vein Endothelial Cells | Sonication - methods | Vibration | Propidium - administration & dosage | Endothelial Cells - metabolism | Phonophoresis - methods | Platelet Endothelial Cell Adhesion Molecule-1 - metabolism | Humans | Microbubbles | Cell Culture Techniques | Drug Delivery Systems - methods | Microscopy, Fluorescence | Drugs | Drug delivery systems | Vehicles | Endothelium
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13. Full Text Intravascular Photoacoustic Imaging: A New Tool for Vulnerable Plaque Identification
by Jansen, Krista and van Soest, Gijs and van der Steen, Antonius F.W
Ultrasound in Medicine & Biology, ISSN 0301-5629, 2014, Volume 40, Issue 6, pp. 1037 - 1048
Abstract The vulnerable atherosclerotic plaque is believed to be at the root of the majority of acute coronary events. Even though the exact origins of plaque... 
Radiology | Vulnerable plaque | Photoacoustic imaging | Intravascular ultrasound | Tissue characterization | Atherosclerosis | CORE | OPTICAL COHERENCE TOMOGRAPHY | CLASSIFICATION | MICROSCOPY | ACOUSTICS | CAP | ULTRASOUND | CORONARY ATHEROSCLEROSIS | NEAR-INFRARED SPECTROSCOPY | VIRTUAL HISTOLOGY | CATHETER | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Photoacoustic Techniques - methods | Plaque, Atherosclerotic - diagnosis | Ultrasonography, Interventional - methods | Animals | Humans | Lipids | Biomedical engineering
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14. Full Text Young's modulus reconstruction of vulnerable atherosclerotic plaque components using deformable curves
by Baldewsing, Radj A and Mastik, Frits and Schaar, Johannes A and Serruys, Patrick W and Van Der Steen, Antonius F. W
Ultrasound in Medicine and Biology, ISSN 0301-5629, 02/2006, Volume 32, Issue 2, pp. 201 - 210
Rupture, with subsequent thrombosis, of thin-cap fibroatheromas (TCFAs) is a major cause of myocardial infarction. A TCFA has two main components: these are a... 
Finite element method | Inverse elasticity problem | Young's modulus | Vulnerable plaque | Deformable curves | Atherosclerosis | Intravascular ultrasound elastography | Tissue characterization | Strain | atherosclerosis | strain | CORONARY-ARTERY DISEASE | ENDOVASCULAR ELASTOGRAPHY | MODEL | IDENTIFICATION | ACOUSTICS | intravascular ultrasound elastography | finite element method | vulnerable plaque | IMAGES | deformable curves | IN-VIVO | tissue characterization | inverse elasticity problem | STRESS | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Ultrasonography, Interventional - methods | Models, Cardiovascular | Humans | Elasticity | Stress, Mechanical | Image Processing, Computer-Assisted - methods | Algorithms | Atherosclerosis - diagnostic imaging | Computer Simulation | Finite Element Analysis | Arteries - diagnostic imaging | Image Enhancement - methods | Phantoms, Imaging | Medical equipment | Usage | Atherosclerotic plaque | Analysis | Physiological apparatus
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15. Full Text Hybrid intravascular imaging: Recent advances, technical considerations, and current applications in the study of plaque pathophysiology
by Bourantas, Christos V and Jaffer, Farouc A and Gijsen, Frank J and Van Soest, Gijs and Madden, Sean P and Courtney, Brian K and Fard, Ali M and Tenekecioglu, Erhan and Zeng, Yaping and Van Der Steen, Antonius F. W and Emelianov, Stanislav and Muller, James and Stone, Peter H and Marcu, Laura and Tearney, Guillermo J and Serruys, Patrick W
European Heart Journal, ISSN 0195-668X, 02/2017, Volume 38, Issue 6, pp. 400 - 412b
Cumulative evidence from histology-based studies demonstrate that the currently available intravascular imaging techniques have fundamental limitations that do... 
Coronary atherosclerosis | Intravascular imaging | Hybrid imaging | CARDIAC & CARDIOVASCULAR SYSTEMS | ATHEROSCLEROTIC PLAQUES | OPTICAL COHERENCE TOMOGRAPHY | CORONARY-ARTERIES | COMPUTED-TOMOGRAPHY | STENT IMPLANTATION | IN-VIVO VALIDATION | NEAR-INFRARED SPECTROSCOPY | EX-VIVO | VULNERABLE PLAQUES | ENDOTHELIAL SHEAR-STRESS | Computed Tomography Angiography - trends | Plaque, Atherosclerotic - diagnostic imaging | Spectroscopy, Near-Infrared - trends | Coronary Artery Disease - diagnostic imaging | Fluorescein Angiography - trends | Cardiac Imaging Techniques - trends | Multimodal Imaging - trends | Humans | Ultrasonography, Interventional - trends | Photoacoustic Techniques - trends | Coronary Angiography - trends | Tomography, Optical Coherence - trends | Review
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16. Full Text Carotid intima-media thickness for cardiovascular risk assessment: Systematic review and meta-analysis
by van den Oord, Stijn C.H and Sijbrands, Eric J.G and ten Kate, Gerrit L and van Klaveren, David and van Domburg, Ron T and van der Steen, Antonius F.W and Schinkel, Arend F.L
Atherosclerosis, ISSN 0021-9150, 2013, Volume 228, Issue 1, pp. 1 - 11
Abstract Objective B-mode ultrasound measurement of the carotid intima-media thickness (CIMT) is a widely used marker for atherosclerosis and is associated... 
Cardiovascular | Intima-media thickness | Risk prediction | Carotid ultrasound | Atherosclerosis | CARDIAC & CARDIOVASCULAR SYSTEMS | MYOCARDIAL-INFARCTION | ROC CURVE | B-MODE ULTRASOUND | SUBCLINICAL ATHEROSCLEROSIS | ARTERIAL-WALL THICKNESS | ATHEROSCLEROSIS RISK | ALL-CAUSE | TASK-FORCE | PERIPHERAL VASCULAR DISEASE | ELDERLY-MEN | CORONARY-HEART-DISEASE | Cardiovascular Diseases - epidemiology | Risk Assessment - methods | Carotid Intima-Media Thickness | Humans | Risk Factors | Cardiovascular Diseases - diagnostic imaging | Cardiovascular diseases | Risk assessment | Biomedical engineering
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17. Full Text Attenuation and Size Distribution Measurements of Definity™ and Manipulated Definity™ Populations
by Goertz, David E and de Jong, Nico and van der Steen, Antonius F.W
Ultrasound in Medicine & Biology, ISSN 0301-5629, 2007, Volume 33, Issue 9, pp. 1376 - 1388
Abstract The contrast agent Definity™ has recently been shown to have substantial nonlinear activity at high ultrasound frequencies (>10 MHz). In this study,... 
Radiology | Contrast agents | Microcirculation | Mouse imaging | High frequency ultrasound | Microbubbles | Vasa vasorum | Intravascular ultrasound | intravascular ultrasound | ULTRASOUND CONTRAST AGENTS | contrast agents | microcirculation | MULTIPLE-SCATTERING | MONOLAYERS | BUBBLY LIQUIDS | ACOUSTICS | mouse imaging | IN-VITRO | microbubbles | GAS-BUBBLES | INTERFACE | vasa vasorum | FREQUENCY | high frequency ultrasound | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Fluorocarbons - chemistry | Models, Theoretical | Particle Size | Transducers | Chemical Phenomena | Chemistry, Physical | Equipment Design | Microscopy, Acoustic - methods | Ultrasonics | Ultrasonography - methods
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