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Immunity, ISSN 1074-7613, 07/2018, Volume 49, Issue 1, pp. 14 - 15
The HIV-1 fusion peptide is a target for broadly neutralizing antibodies. In a recent issue of Nature Medicine, Xu et al. (2018) provide proof-of-concept that... 
INFECTION | FUSION PEPTIDE | IMMUNOLOGY | NEUTRALIZING ANTIBODY | VACCINE DESIGN | Antibodies, Neutralizing | HIV Infections | HIV-1 - immunology | Animals | Peptides | HIV Antibodies | AIDS Vaccines | Epitopes | Viral antibodies | Biological products | Analysis | Vaccination | Antibodies | HIV (Viruses)
Journal Article
Immunity, ISSN 1074-7613, 07/2018, Volume 49, Issue 1, pp. 14 - 15
The HIV-1 fusion peptide is a target for broadly neutralizing antibodies. In a recent issue of , provide proof-of-concept that vaccination with fusion peptide... 
Studies | Pathogens | Animal models | Immunoglobulins | Vaccination | Human immunodeficiency virus--HIV | Glycoprotein | Antibodies | Viruses | Infections | Trimers | Vaccines
Journal Article
Trends in Microbiology, ISSN 0966-842X, 2014, Volume 22, Issue 10, pp. 550 - 551
Passive immunization studies, including a recent one by Pegu et al. , have repeatedly shown that HIV-specific broadly neutralizing antibodies (bnAbs) protect... 
Internal Medicine | MICROBIOLOGY | BIOCHEMISTRY & MOLECULAR BIOLOGY | VACCINE | HIV Infections - prevention & control | Antibodies, Neutralizing - immunology | HIV-1 - immunology | Animals | HIV Antibodies - immunology | Humans | AIDS Vaccines - immunology | Immunization, Passive | Macaca mulatta | HIV antibodies | HIV (Viruses) | AIDS vaccines
Journal Article
Virology, ISSN 0042-6822, 01/2013, Volume 435, Issue 1, pp. 46 - 56
The need for an effective vaccine to prevent the global spread of human immunodeficiency virus type 1 (HIV-1) is well recognized. Passive immunization and... 
Infection | Envelopes | Reviews | Antibodies | Glycoproteins | Epitopes | Immunization (passive) | Vaccines
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 515, Issue 7525, pp. 138 - 142
The isolation of human monoclonal antibodies is providing important insights into the specificities that underlie broad neutralization of HIV-1 (reviewed in... 
B-CELLS | SPECIFICITIES | MULTIDISCIPLINARY SCIENCES | SERA | IMMUNODEFICIENCY-VIRUS TYPE-1 | ENV TRIMERS | VULNERABILITY | GP120 | HUMAN MONOCLONAL-ANTIBODIES | CLEAVAGE | DEPENDENT EPITOPE | Immunoglobulin Fab Fragments - ultrastructure | Antibody Specificity | Epitope Mapping | HIV Envelope Protein gp41 - immunology | Humans | AIDS Vaccines - immunology | Molecular Sequence Data | Leukocytes, Mononuclear | HIV Envelope Protein gp41 - chemistry | Virus Internalization - drug effects | Epitopes - immunology | HIV Envelope Protein gp120 - immunology | Antibodies, Neutralizing - immunology | Receptors, CCR5 - metabolism | HIV Antibodies - immunology | Conserved Sequence | Inhibitory Concentration 50 | HIV Envelope Protein gp120 - chemistry | HIV Antibodies - pharmacology | Antibodies, Monoclonal - chemistry | Antibodies, Monoclonal - immunology | Cell Line | Immunoglobulin Fab Fragments - genetics | HIV-1 - drug effects | Antibodies, Monoclonal - pharmacology | Models, Molecular | Antibodies, Neutralizing - pharmacology | Antibody Affinity | Antibodies, Neutralizing - genetics | HIV Antibodies - chemistry | AIDS Vaccines - chemistry | Antibodies, Monoclonal - genetics | HIV-1 - immunology | Antibodies, Neutralizing - chemistry | Immunoglobulin Fab Fragments - chemistry | Cell Membrane - virology | Epitopes - chemistry | HIV Antibodies - genetics | Immunoglobulin Fab Fragments - immunology | CD4 Antigens - metabolism | Viral antibodies | Care and treatment | Antibodies | Physiological aspects | Genetic aspects | Research | HIV infection | Antigenic determinants | Amino acids | Mutation | Vaccines | Human immunodeficiency virus--HIV | Binding sites | Index Medicus
Journal Article
PLoS pathogens, ISSN 1553-7366, 2013, Volume 9, Issue 9, p. e1003618
A desirable but as yet unachieved property of a human immunodeficiency virus type 1 (HIV-1) vaccine candidate is the ability to induce broadly neutralizing... 
ENVELOPE GLYCOPROTEIN TRIMERS | PROTEIN | VACCINE | GP41 | MICROBIOLOGY | GP120 | CONFORMATIONAL EPITOPE | POTENT | VIROLOGY | IMMUNODEFICIENCY-VIRUS TYPE-1 | BINDING-SITE | MONOCLONAL-ANTIBODIES | PARASITOLOGY | Protein Aggregates | Antibody Specificity | HIV Infections - prevention & control | Molecular Weight | Humans | Antibodies, Neutralizing - metabolism | env Gene Products, Human Immunodeficiency Virus - metabolism | AIDS Vaccines - therapeutic use | HIV Infections - immunology | env Gene Products, Human Immunodeficiency Virus - genetics | Immunoglobulin Fab Fragments - metabolism | env Gene Products, Human Immunodeficiency Virus - antagonists & inhibitors | Protein Stability | Mutant Proteins - antagonists & inhibitors | Peptide Fragments - genetics | env Gene Products, Human Immunodeficiency Virus - chemistry | HIV Antibodies - metabolism | Peptide Fragments - metabolism | Solubility | Antibody Affinity | Mutant Proteins - metabolism | Epitopes | Recombinant Fusion Proteins - chemistry | HIV-1 - immunology | Peptide Fragments - chemistry | Peptide Fragments - antagonists & inhibitors | Mutant Proteins - chemistry | Antibodies, Monoclonal - metabolism | Amino Acid Substitution | Physiological aspects | Genetic aspects | Research | Nucleotide sequencing | HIV (Viruses) | Gene expression | Health aspects | DNA sequencing | Medical research | AIDS | Human immunodeficiency virus | Vaccines | HIV | Acquired immune deficiency syndrome
Journal Article
Current Opinion in Virology, ISSN 1879-6257, 10/2019, Volume 38, pp. 70 - 80
Broadly neutralizing antibodies (bnAbs) are currently under investigation as a therapy for HIV-1 infection and recent clinical trials have shown prolonged... 
Journal Article
Journal of biological chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 35, pp. 14718 - 14719
Bispecific antibodies show great promise as intrinsic combination therapies, but often suffer from poor physiochemical properties, many times related to poor... 
BIOCHEMISTRY & MOLECULAR BIOLOGY | Antibodies, Bispecific - genetics | Neoplasms - immunology | Dimerization | Protein Engineering | Editors' Picks Highlights
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2014, Volume 111, Issue 49, pp. 17624 - 17629
Journal Article
Immunity, ISSN 1074-7613, 05/2014, Volume 40, Issue 5, pp. 657 - 668
Journal Article