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1. Full Text Letter by Cattaneo and von Kügelgen Regarding Article, “International Expert Consensus on Switching Platelet P2Y12 Receptor-Inhibiting Therapies”
by Cattaneo, Marco and von Kügelgen, Ivar
Circulation, ISSN 0009-7322, 05/2018, Volume 137, Issue 21, pp. 2309 - 2309
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2. Full Text Letter by Cattaneo and von Kügelgen Regarding Article, “International Expert Consensus on Switching Platelet P2Y 12 Receptor-Inhibiting Therapies”
by Cattaneo, Marco and von Kügelgen, Ivar
Circulation, ISSN 0009-7322, 05/2018, Volume 137, Issue 21, pp. 2309 - 2309
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3. Full Text Letter by Cattaneo and von Kügelgen Regarding Article, "International Expert Consensus on Switching Platelet P2Y 12 Receptor-Inhibiting Therapies"
by Cattaneo, Marco and von Kügelgen, Ivar
Circulation, 05/2018, Volume 137, Issue 21, p. 2309
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4. Structure, pharmacology and roles in physiology of the P2Y12 receptor
by von Kügelgen, Ivar
Advances in Experimental Medicine and Biology, ISSN 0065-2598, 2017, Volume 1051, pp. 123 - 138
Atherogenesis | receptor | Adenine nucleotides | P2Y | Microglial cells | Inflammation | Platelet aggregation | Receptor ligands | Crystal structure
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5. Structure, Pharmacology and Roles in Physiology of the P2Y 12 Receptor
by von Kügelgen, Ivar
Advances in experimental medicine and biology, ISSN 0065-2598, 2017, Volume 1051, p. 123
P2Y receptors are G-protein-coupled receptors (GPCRs) for extracellular nucleotides. The platelet ADP-receptor which has been denominated P2Y receptor is an... 
Blood Platelets - pathology | Asthma - metabolism | Muscle, Smooth, Vascular - metabolism | Atherosclerosis - genetics | Humans | GTP-Binding Protein alpha Subunit, Gi2 - metabolism | Structure-Activity Relationship | Brain Injuries - metabolism | Alzheimer Disease - pathology | GTP-Binding Protein alpha Subunit, Gi2 - genetics | rap GTP-Binding Proteins - genetics | Protein Domains | Receptors, Purinergic P2Y12 - metabolism | Receptors, Purinergic P2Y12 - genetics | Atherosclerosis - pathology | Brain Injuries - genetics | Asthma - genetics | Atherosclerosis - metabolism | Platelet Aggregation | Receptors, Purinergic P2Y12 - chemistry | Muscle, Smooth, Vascular - pathology | Animals | Blood Platelets - metabolism | Alzheimer Disease - metabolism | Alzheimer Disease - genetics | rap GTP-Binding Proteins - metabolism | Asthma - pathology | Brain Injuries - pathology
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6. Full Text Pharmacological profiles of cloned mammalian P2Y-receptor subtypes
by von Kügelgen, Ivar
Pharmacology and Therapeutics, ISSN 0163-7258, 2006, Volume 110, Issue 3, pp. 415 - 432
Membrane-bound P2-receptors mediate the actions of extracellular nucleotides in cell-to-cell signalling. P2X-receptors are ligand-gated ion channels, whereas... 
Prasugrel | MRS2567 | Cangrelor | P2Y receptor | MRS2279 | Subtype-selective antagonists | MRS2179 | Clopidogrel | clopidogrel | PLATELET ADP RECEPTOR | URIDINE NUCLEOTIDE RECEPTOR | prasugrel | DEOXYADENOSINE BISPHOSPHATE DERIVATIVES | cangrelor | HUMAN P2Y RECEPTOR | SITE-DIRECTED MUTAGENESIS | P2 RECEPTORS | PROTEIN-COUPLED RECEPTOR | FUNCTIONAL EXPRESSION | PHARMACOLOGY & PHARMACY | SMOOTH-MUSCLE-CELLS | subtype-selective antagonists | HUMAN MAST-CELLS | Amino Acid Sequence | Receptors, Purinergic P2 - chemistry | Animals | Signal Transduction | Species Specificity | Humans | Cloning, Molecular | Molecular Sequence Data | Purinergic P2 Receptor Antagonists | Ligands | Receptors, Purinergic P2 - physiology | Purinergic P2 Receptor Agonists | Adenylate cyclase | Coenzymes | RNA | Heterocyclic compounds | Cloning | Angiotensin | Cellulose | Physiological aspects | Nucleosides | Nucleotides | Peptide hormones
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7. Full Text Key Determinants of Nucleotide-Activated G Protein-Coupled P2Y2 Receptor Function Revealed by Chemical and Pharmacological Experiments, Mutagenesis and Homology Modeling
by Hillmann, Petra and Ko, Geun-Yung and Spinrath, Andreas and Raulf, Alexandra and von Kügelgen, Ivar and Wolff, Samuel C and Nicholas, Robert A and Kostenis, Evi and Höltje, Hans-Dieter and Müller, Christa E
Journal of Medicinal Chemistry, ISSN 0022-2623, 05/2009, Volume 52, Issue 9, pp. 2762 - 2775
The P2Y2 receptor, which is activated by UTP, ATP, and dinucleotides, was studied as a prototypical nucleotide-activated GPCR. A combination of receptor... 
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8. Full Text Pharmacology and structure of P2Y receptors
by von Kügelgen, Ivar and Hoffmann, Kristina
Neuropharmacology, ISSN 0028-3908, 05/2016, Volume 104, pp. 50 - 61
P2Y receptors are G-protein-coupled receptors (GPCRs) for extracellular nucleotides. There are eight mammalian P2Y receptor subtypes (P2Y , P2Y , P2Y , P2Y ,... 
Uracil nucleotides | Adenine nucleotides | P2Y receptors | Platelet aggregation | Inflammation | Receptor ligands | Neuromodulation | Crystal structure | PLATELET ADP RECEPTOR | ATP RECEPTOR | HUMAN P2Y RECEPTOR | NEUROSCIENCES | PROTEIN-COUPLED RECEPTOR | REVERSE CHOLESTEROL TRANSPORT | ADENYLYL-CYCLASE | PHARMACOLOGY & PHARMACY | MOLECULAR-CLONING | PURINERGIC RECEPTOR | HUMAN MAST-CELLS | URACIL NUCLEOTIDE DERIVATIVES | Purinergic P2Y Receptor Antagonists - pharmacology | Microglia - metabolism | Receptors, Purinergic P2Y - chemistry | Uridine Triphosphate - metabolism | Cardiovascular Diseases - metabolism | Humans | Receptors, Purinergic P2Y - metabolism | Neurodegenerative Diseases - metabolism | Receptors, Purinergic P2Y - physiology | Purinergic P2Y Receptor Agonists - pharmacology | Brain - metabolism | Platelet Aggregation | Animals | Adenosine Triphosphate - metabolism | Neurons - metabolism | Adenosine Diphosphate - metabolism | Physiological aspects | Purines | Pharmacology | Nucleotides | Structure | Crystals | Pyrimidines
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9. Full Text Multiple novel alterations in Kit tyrosine kinase in patients with gastrointestinally pronounced systemic mast cell activation disorder
by Molderings, Gerhard J and Kolck, Ulrich W and Scheurlen, Christian and Brüss, Michael and Homann, Jürgen and Von Kügelgen, Ivar
Scandinavian Journal of Gastroenterology, ISSN 0036-5521, 2007, Volume 42, Issue 9, pp. 1045 - 1053
Objective. Sequencing efforts to discover mutations in the tyrosine kinase Kit related to systemic mast cell disorders have so far been focused mainly on only... 
Gastrointestinal stromal cell tumor | mast cell activation disorder | Kit tyrosine kinase | mast cell mediator syndrome | irritable bowel disease | Mast cell mediator syndrome | Irritable bowel disease | Mast cell activation disorder | GENE-MUTATIONS | SITE | ISOFORMS | C-KIT | ACUTE MYELOID-LEUKEMIA | STROMAL TUMORS | gastrointestinal stromal cell tumor | RECEPTOR DIMERIZATION | MASTOCYTOSIS | IMATINIB | GASTROENTEROLOGY & HEPATOLOGY | EXPRESSION | Mastocytosis - diagnosis | Humans | Middle Aged | Male | Mastocytosis - genetics | Syndrome | Point Mutation - genetics | Gastrointestinal Diseases - genetics | RNA Splicing - genetics | Adult | Female | Proto-Oncogene Proteins c-kit - genetics | Aged
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10. Full Text Adenosine activates brown adipose tissue and recruits beige adipocytes via A2A receptors
by Gnad, Thorsten and Gnad, Thorsten and Scheibler, Saskia and Kugelgen, Ivar Von and Scheele, Camilla and Kilic, Ana and Glode, Anja and Hoffmann, Linda S and Reverte-Salisa, Laia and Horn, Philipp and Mutlu, Samet and El-Tayeb, Ali and Kranz, Mathias and Deuther-Conrad, Winnie and Brust, Peter and Lidell, Martin E and Betz, Matthias J and Enerback, Sven and Schrader, Jurgen and Yegutkin, Gennady G and Muller, Christa E and Pfeifer, Alexander
Nature, ISSN 0028-0836, 12/2014, Volume 516, Issue 7531, pp. 395 - 399
Brown adipose tissue (BAT) is specialized in energy expenditure, making it a potential target for anti-obesity therapies. Following exposure to cold, BAT is... 
Cricetinae | Phenethylamines - pharmacology | Humans | Mice, Inbred C57BL | Cells, Cultured | Male | Adenosine - pharmacology | Receptor, Adenosine A2A - metabolism | Animals | Adenosine A2 Receptor Agonists - pharmacology | Diet | Adenosine - analogs & derivatives | Adipocytes - metabolism | Mesocricetus | Adenosine - metabolism | Adipose Tissue, Brown - drug effects | Adipose Tissue, Brown - metabolism | Mice | Brown adipose tissue | Adenosine | Research | Health aspects | Rodents | Index Medicus
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11. Full Text An Agonist Radioligand for the Proinflammatory Lipid-Activated G Protein-Coupled Receptor GPR84 Providing Structural Insights
by Köse, Meryem and Pillaiyar, Thanigaimalai and Namasivayam, Vigneshwaran and De Filippo, Elisabetta and Sylvester, Katharina and Ulven, Trond and von Kügelgen, Ivar and Müller, Christa E
Journal of Medicinal Chemistry, ISSN 0022-2623, 11/2019
Index Medicus
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12. Full Text Pharmacology of P2Y receptors
by von Kügelgen, Ivar
Brain Research Bulletin, ISSN 0361-9230, 09/2019, Volume 151, pp. 12 - 24
P2Y receptors are G-protein-coupled receptors (GPCRs) for extracellular nucleotides. There are eight mammalian P2Y receptor subtypes divided into two subgroups... 
Uracil nucleotides | P2Y receptors | Receptor ligands | Adenine nucleotides | Crystal structure | PLATELET ADP RECEPTOR | PHOSPHOLIPASE-C | HIGH-AFFINITY | HUMAN P2Y RECEPTOR | SITE-DIRECTED MUTAGENESIS | NEUROSCIENCES | PROTEIN-COUPLED RECEPTOR | SMOOTH-MUSCLE-CELLS | MOLECULAR-CLONING | PURINERGIC RECEPTOR | URACIL NUCLEOTIDE DERIVATIVES | Aggregation | Pyrimidines | Metabolites | Blood platelets | Analysis | Crystals | Physiological aspects | Cellular signal transduction | Pharmacology | Inflammation | Nucleotides | Structure
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13. Full Text A2B receptors mediate the induction of early genes and inhibition of arterial smooth muscle cell proliferation via Epac
by Mayer, Peter and Hinze, Annette Viktoria and Harst, Anja and Von Kügelgen, Ivar
Cardiovascular Research, ISSN 0008-6363, 04/2011, Volume 90, Issue 1, pp. 148 - 156
Extracellular adenosine and adenine nucleotides play important roles in the regulation of the blood vessel tonus and platelet aggregation. Less is known about... 
receptor | Arterial smooth muscle cell | Proliferation | Exchange protein activated by cAMP | Nuclear factor NR4A1 | Adenosine A | Immunohistochemistry | Up-Regulation | Muscle, Smooth, Vascular - metabolism | Oligonucleotide Array Sequence Analysis | Humans | Middle Aged | Coronary Vessels - metabolism | Dose-Response Relationship, Drug | Transfection | Adenosine A2 Receptor Agonists - pharmacology | RNA Interference | Time Factors | Guanine Nucleotide Exchange Factors - metabolism | Receptor, Adenosine A2B - drug effects | Adult | Female | Myocytes, Smooth Muscle - drug effects | Cyclic AMP - metabolism | Myocytes, Smooth Muscle - metabolism | Muscle, Smooth, Vascular - drug effects | Nuclear Receptor Subfamily 4, Group A, Member 1 - genetics | Signal Transduction | Cells, Cultured | Gene Expression Profiling - methods | Reverse Transcriptase Polymerase Chain Reaction | Receptor, Adenosine A2B - metabolism | Adenosine A2 Receptor Antagonists - pharmacology | Adenosine - metabolism | Nuclear Receptor Subfamily 4, Group A, Member 1 - metabolism | Aged | Cell Proliferation - drug effects
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14. Full Text Diindolylmethane Derivatives: Potent Agonists of the Immunostimulatory Orphan G Protein-Coupled Receptor GPR84
by Pillaiyar, Thanigaimalai and Köse, Meryem and Sylvester, Katharina and Weighardt, Heike and Thimm, Dominik and Borges, Gleice and Förster, Irmgard and von Kügelgen, Ivar and Müller, Christa E
Journal of Medicinal Chemistry, ISSN 0022-2623, 05/2017, Volume 60, Issue 9, pp. 3636 - 3655
The Gi protein-coupled receptor GPR84, which is activated by (hydroxy)­fatty acids, is highly expressed on immune cells. Recently, 3,3′-diindolylmethane was... 
BREAST-CANCER CELLS | 3,3'-DIINDOLYLMETHANE DERIVATIVES | CHEMISTRY, MEDICINAL | SOLVENT-FREE CONDITIONS | CHAIN FATTY-ACIDS | CATALYZED-REACTIONS | PROSTATE-CANCER | EFFICIENT SYNTHESIS | CARBONYL-COMPOUNDS | FUNCTIONAL-CHARACTERIZATION | REDUCTIVE C-ALKYLATION | C