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NeuroImage, ISSN 1053-8119, 01/2018, Volume 165, pp. 83 - 91
PET imaging of the 18 kDa translocator protein (TSPO), a biomarker of microglial activity, receives growing interest in clinical and preclinical applications... 
Myocardium | Small animal PET | TSPO | Brain uptake normalization | [18F]GE180 | F]GE180 | MICROGLIAL ACTIVATION | AMYLOID DEPOSITION | PS2APP TRANSGENIC MICE | ALZHEIMERS-DISEASE | 18 KDA | NEUROSCIENCES | NEUROIMAGING | [F-18]GE180 | POSITRON-EMISSION-TOMOGRAPHY | NEUROINFLAMMATION | INFLAMMATION | MOUSE MODEL | TRANSLOCATOR PROTEIN TSPO | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Neuroimaging - methods | Brain - diagnostic imaging | Mice, Inbred C57BL | Molecular Imaging - methods | Image Processing, Computer-Assisted - methods | Positron-Emission Tomography - methods | Heart - diagnostic imaging | Animals | Radionuclide Imaging - methods | Female | Mice | Alzheimer Disease - diagnostic imaging | Fluorine Radioisotopes | Radiopharmaceuticals | Receptors, GABA - analysis | Physiological aspects | Pets | Cardiology | Analysis | Neuroimaging | Brain | Multiple sclerosis | Stabilization | Body weight | Quantitation | Proteins | Regression models | Transgenic animals | Rodents | Tomography | Physiology | Bioindicators | Alzheimer's disease | Age | Radioactivity | Quantitative analysis | Medical imaging | Neurodegenerative diseases | Cardiac muscle | Positron emission | Feasibility studies | Muscles | Data processing | Histology | Inflammation | Regression analysis | Skeletal muscle | Studies | Musculoskeletal system | Biomarkers | Ligands | Scaling | Alzheimers disease | Positron emission tomography
Journal Article
eBook
Journal Article
2007, 1 Auflage., ISBN 3865732623
Book
Journal Article
FRONTIERS IN AGING NEUROSCIENCE, ISSN 1663-4365, 06/2018, Volume 10
Positron-emission-tomography (PET) imaging of tau pathology has facilitated development of anti-tau therapies. While members of the arylquinoline and... 
TOMOGRAPHY | PROTEIN | small animal PET | ASTROCYTOSIS | ALZHEIMERS-DISEASE | F-18-T807 | tau | NEUROSCIENCES | GERIATRICS & GERONTOLOGY | F-18-AV-1451 | transgenic mice | IN-VIVO | DERIVATIVES | F-18-THK5117 | PROGRESSIVE SUPRANUCLEAR PALSY | PARADIGM
Journal Article
JOURNAL OF NEUROINFLAMMATION, ISSN 1742-2094, 11/2018, Volume 15, Issue 1
BackgroundCausal associations between microglia activation and -amyloid (A) accumulation during the progression of Alzheimer's disease (AD) remain a matter of... 
ACTIVATION | BRAIN-INJURY | ALZHEIMERS-DISEASE | MACROPHAGES | TSPO PET | Neuroinflammation | IMMUNOLOGY | NEUROSCIENCES | Microglia | POSITRON-EMISSION-TOMOGRAPHY | PROTEIN 18 KDA | TRANSLOCATOR PROTEIN | Amyloid PET | MOUSE MODEL | Aging | Alzheimer's disease | PROGRESSION
Journal Article
Data in Brief, ISSN 2352-3409, 08/2018, Volume 19, pp. 331 - 336
Data in this article show radioligand uptake (to gamma counter and positron-emission-tomography) as well as polymerase chain reaction analyses of 18 kDa... 
Journal Article
Frontiers in Aging Neuroscience, ISSN 1663-4365, 06/2018, Volume 10
Positron-emission-tomography (PET) imaging of tau pathology has facilitated development of anti-tau therapies. While members of the arylquinoline and... 
Small animal PET | Tau | F-T807 | Transgenic mice | F-THK5117 | Immunohistochemistry | Nuclear medicine | Disease | Brain stem | Radioisotopes | Pathology | Neurofibrillary tangles | Brain research | Tau protein | Transgenic animals | Rodents | Ligands | Positron emission tomography | Age | Dementia | Tracers | tau | 18F-T807 | transgenic mice | small animal PET | 18F-THK5117
Journal Article
Alzheimer's Research & Therapy, ISSN 1758-9193, 12/2019, Volume 11, Issue 1, pp. 1 - 11
Abstract Background Augmenting the brain clearance of toxic oligomers with small molecule modulators constitutes a promising therapeutic concept against tau... 
Neuronal injury | Small animal PET | Tau | Late-stage | Anle138b
Journal Article
ALZHEIMERS RESEARCH & THERAPY, ISSN 1758-9193, 08/2019, Volume 11, Issue 1, p. 67
BackgroundAugmenting the brain clearance of toxic oligomers with small molecule modulators constitutes a promising therapeutic concept against tau deposition.... 
FDG-PET | Small animal PET | ACTIVATION | Neuronal injury | Tau | TAUOPATHY | NEUROSCIENCES | CLINICAL NEUROLOGY | BETA | OLIGOMER MODULATOR | INHIBITION | GLUCOSE-METABOLISM | Late-stage | Anle138b | HYPERPHOSPHORYLATION | BRAIN | PROGRESSION | Usage | Care and treatment | PET imaging | Alzheimer's disease
Journal Article
Respiratory Research, ISSN 1465-9921, 12/2011, Volume 12, Issue 1, pp. 1 - 8
The development of bronchial hyperreactivity (BHR) subsequent to precapillary pulmonary hypertension (PHT) was prevented by acting on the major signalling... 
Medicine & Public Health | Pneumology/Respiratory System | PARENCHYMAL MECHANICS | LUNG | METHACHOLINE-INDUCED BRONCHOCONSTRICTION | AIRWAY | THERAPY | VASOACTIVE-INTESTINAL-PEPTIDE | RESPIRATORY SYSTEM | ARTERIAL-HYPERTENSION | INHALATION | NITRIC-OXIDE | VIP | Antihypertensive Agents - pharmacology | Tetrazoles - pharmacology | Airway Resistance - drug effects | Iloprost - pharmacology | Bronchial Provocation Tests | Antihypertensive Agents - administration & dosage | Hypertension, Pulmonary - physiopathology | Male | Endothelins - metabolism | Sulfones - pharmacology | Lung Volume Measurements | Sildenafil Citrate | Time Factors | Vasoactive Intestinal Peptide - pharmacology | Bronchoconstriction - drug effects | Bronchial Hyperreactivity - physiopathology | Bronchial Hyperreactivity - metabolism | Blood Pressure - drug effects | Hypertension, Pulmonary - drug therapy | Lung - metabolism | Phosphodiesterase 5 Inhibitors - pharmacology | Endothelin Receptor Antagonists | Disease Models, Animal | Bronchial Hyperreactivity - etiology | Prostaglandins I - metabolism | Bronchial Hyperreactivity - therapy | Infusion Pumps, Implantable | Vasodilator Agents - pharmacology | Administration, Oral | Purines - pharmacology | Receptors, Endothelin - metabolism | Infusions, Parenteral | Rats | Hypertension, Pulmonary - metabolism | Lung - physiopathology | Piperazines - pharmacology | Rats, Sprague-Dawley | Animals | Analysis of Variance | Signal Transduction - drug effects | Lung - drug effects | Pyridines - pharmacology | Lung - blood supply | Nitric Oxide - metabolism | Vasodilator Agents - administration & dosage | Hypertension, Pulmonary - complications | Bronchi | Physiological aspects | Development and progression | Respiratory agents | Research | Drug therapy | Health aspects | Pulmonary hypertension | Prevention | Nitric oxide
Journal Article