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Journal of Neurochemistry, ISSN 0022-3042, 09/1994, Volume 63, Issue 3, pp. 1077 - 1085
: Competition [3H]RX821002 ([3H]2‐methoxyidazoxan) binding experiments with α2‐adrenoceptor subtype‐specific antagonists—BRL 44408 (α2A selective), ARC 239... 
Human brain | [3H]RX821002 | ARC 239 | α2‐Adrenoceptor subtypes | BRL 44408 | Guanoxabenz | α | H]RX821002 | [ | Adrenoceptor subtypes
Journal Article
BBA - Molecular Cell Research, ISSN 0167-4889, 1995, Volume 1266, Issue 2, pp. 207 - 214
Kinetic, saturation and competition binding assays were employed to optimize and validate radioligand binding methods for characterization of recombinant human... 
Ligand binding | α2-Adrenoceptor subtype | [3H]Atipamezole | [ 3H]RX821002 | [ 3H]Rauwolscine | Recombinant cell line | H]Rauwolscine | H]-Rauwolscine | G]Atipamezole | H]RX821002 | Adrenoceptor subtype
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 1991, Volume 202, Issue 2, pp. 235 - 243
We developed a method for the simultaneous determination of drug affinity constants for rat α - and α -adrenoceptor subtypes by using [ H]RX821002 radioligand... 
Computer modelling | Rat | [ 3H]RX821002 radioligand binding | α2A-Adrenoceptor subtypes | Kidney | Adrenoceptor subtypes | H]RX821002 radioligand binding
Journal Article
Journal of Comparative Neurology, ISSN 0021-9967, 12/2008, Volume 511, Issue 5, pp. 610 - 627
Dopaminergic and adrenergic receptors are G‐protein‐coupled receptors considered to be different based on their pharmacology and signaling pathways. Some... 
binding competition | catecholamines | [3H]RX821002 | autoradiography | bird
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 10/2016, Volume 788, pp. 113 - 121
Kinetic on and off rate constants for many receptor ligands are difficult to determine with regular radioligand binding technique since only few of the ligands... 
Off-rate | [3H]-RX821002 | Kinetics | Residence time | Spiroxatrine | MK912 | Idazoxan - analogs & derivatives | Idazoxan - metabolism | Humans | HEK293 Cells | Radioligand Assay - methods | Receptors, Adrenergic, alpha-2 - metabolism | Protein Binding | Ligands | Recombinant Fusion Proteins - metabolism
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 1994, Volume 252, Issue 1, pp. 43 - 49
The characteristics of [ H]RX821002 binding to the different human α -adrenoceptor subtypes were studied on membranes from COS-7 cells transfected with the... 
α2-Adrenoceptor subtype, human | [ 3H]RX821002, α2-Adrenoceptor antagonist | α | Adrenoceptor subtype, human | [ | H]RX821002, α | Adrenoceptor antagonist
Journal Article
The Journal of comparative neurology, ISSN 0021-9967, 12/2008, Volume 511, Issue 5, pp. 610 - 627
Dopaminergic and adrenergic receptors are G protein-coupled receptors considered to be different based on their pharmacology and signaling pathways. Some... 
binding competition | catecholamines | [3H]RX821002 | autoradiography | bird
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 11/1991, Volume 104, Issue 3, pp. 657 - 664
1 Simultaneous computer modelling of plain and ARC 239‐ and guanoxabenz‐masked [3H]‐RX821002 saturation curves, plain ARC 239 and guanoxabenz competition... 
rat kidney | receptor classification | computer modelling | [3H]‐RX821002 ligand binding | α2‐adrenoceptor subtypes | H]‐RX821002 ligand binding | adrenoceptor subtypes | H]-RX821002 ligand binding
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 1995, Volume 284, Issue 3, pp. 271 - 279
The radioligands [ H]MK912 and [ H]RX821002 were used to label α -, α -, and α -adrenoceptors of the pig cerebellum and kidney cortex. By inclusion of the α... 
[ 3H]MK912 | α2-Adrenoceptor subtype | [ 3H]RX821002 | Pig | H]RX821002 | H]MK912 | Adrenoceptor subtype
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 11/1999, Volume 128, Issue 6, pp. 1215 - 1222
Atipamezole (4‐(2‐ethyl‐2,3‐dihydro‐1H‐inden‐2‐yl)‐1H‐imidazole) was first introduced as a potent and specific α2‐adrenoceptor antagonist, but in some tissues... 
α2‐adrenoceptors | imidazoline receptors | [3H]rauwolscine | rat kidney | receptor autoradiography | non‐adrenergic binding | [3H]atipamezole | [3H]RX821002 | H]atipamezole | Rat kidney | H]RX821002 | Imidazoline receptors | Receptor autoradiography | adrenoceptors | Non-adrenergic binding | H]rauwolscine | non-adrenergic binding | α2-adrenoceptors | Papers
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 10/1999, Volume 128, Issue 3, pp. 515 - 522
The aims of this study were, firstly to use receptor autoradiography to investigate the effect of antisense oligonucleotides to the α2D‐adrenoceptor on... 
UK 14,304 | α2‐adrenoceptors | mydriasis | temperature | Antisense oligonucleotides | receptor autoradiography | behavioural profile | [3H]‐RX821002 | UK 14,304 | α2-adrenoceptors | Papers | [3H]-RX821002
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 02/1995, Volume 114, Issue 3, pp. 678 - 688
1 The aim of this study was to investigate constrictor α‐adrenoceptors in three isolated blood vessles of the pig, the thoracic aorta (TA), the splenic artery... 
contractile responses | radioligand binding | porcine vascular tissue | [3H]‐prazosin | [3H]‐RX821002 | α‐Adrenoceptors | H]‐prazosin | H]‐RX821002 | PORCINE VASCULAR TISSUE | ALPHA-ADRENOCEPTORS | ACTIVATION | RAT | RESISTANCE ARTERIES | BIOCHEMISTRY & MOLECULAR BIOLOGY | ALPHA-1-ADRENOCEPTORS | THORACIC AORTA | RADIOLIGAND BINDING | [H-3] PRAZOSIN | POSTJUNCTIONAL ALPHA-2-ADRENOCEPTORS | SMOOTH-MUSCLE | CONTRACTILE RESPONSES | [H-3] RX821002 | PHARMACOLOGY & PHARMACY | RABBIT | SPLENIC ARTERY | INHIBITOR | Muscle, Smooth, Vascular - metabolism | Veins - ultrastructure | Male | Adrenergic alpha-Antagonists - pharmacology | Structure-Activity Relationship | Yohimbine - pharmacology | Dose-Response Relationship, Drug | Drug Interactions | Receptors, Adrenergic, alpha - drug effects | Dioxanes - metabolism | Prazosin - pharmacology | Swine | Splenic Artery - metabolism | Aorta, Thoracic - drug effects | Radioligand Assay | Cell Membrane - drug effects | Muscle, Smooth, Vascular - drug effects | Binding, Competitive | Idazoxan - analogs & derivatives | Splenic Artery - ultrastructure | Aorta, Thoracic - metabolism | Cell Membrane - ultrastructure | Microscopy, Electron | Aorta, Thoracic - ultrastructure | Veins - drug effects | Splenic Artery - drug effects | Animals | Muscle Contraction - drug effects | Veins - metabolism | Receptors, Adrenergic, alpha - physiology | Ear, External - blood supply | Adrenergic alpha-Agonists - pharmacology | 5'-Nucleotidase - metabolism | Yohimbine - metabolism
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 1989, Volume 167, Issue 1, pp. 95 - 104
Journal Article
Journal of Chemical Neuroanatomy, ISSN 0891-0618, 2002, Volume 23, Issue 4, pp. 269 - 277
In songbirds, song is regulated by a specialized group of brain nuclei known as the song system. Other aspects of courtship, such as male sexual interest in a... 
Sex differences | Catecholamines | Courtship | Norepinephrine | [ 3H] RX821002 | Songbird | Animals | Receptors, Adrenergic, alpha-2 - metabolism | Songbirds - physiology | Vocalization, Animal - physiology | Female | Male | Preoptic Area - metabolism | Sex Characteristics
Journal Article
BBA - Molecular Cell Research, ISSN 0167-4889, 1998, Volume 1448, Issue 1, pp. 135 - 146
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 1993, Volume 243, Issue 3, pp. 305 - 308
The density and affinity states of imidazoline I binding sites as well as the density of α -adrenoceptors were quantitated in the brain of lean and obese... 
Brain | Zucker rat | α 2-Adrenoceptor | [ 3H]RX821002 | Mazindol | Imidazoline I 2 binding sites | [ 3H]Clonidine | [ 3H]Idazoxan
Journal Article