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Journal of Neuroscience, ISSN 0270-6474, 10/2017, Volume 37, Issue 40, pp. 9617 - 9631
Journal Article
03/2011
α-Synuclein is an abundant nerve terminal protein and a primary component of the Lewy body pathology seen in Parkinson’s disease. While the precise biological... 
Rab3a | α-Synuclein | Parkinson's disease | 0317
Dissertation
BBA - Proteins and Proteomics, ISSN 1570-9639, 10/2019, Volume 1867, Issue 10, pp. 890 - 908
α-Synuclein (α-Syn) has been extensively studied for its structural and biophysical properties owing to its pathophysiological role in Parkinson’s disease... 
Aggregation | α-Synuclein | Amyloid | Parkinson’s disease
Journal Article
Experimental Neurology, ISSN 0014-4886, 09/2016, Volume 283, pp. 213 - 223
Synucleinopathy is characterized by abnormal accumulation of misfolded α-synuclein (α-Syn)-positive cytoplasmic inclusions and by neurodegeneration and... 
α-Synuclein | receptor | Synucleinopathy | Hippocampus | Adenosine A
Journal Article
Acta Neuropathologica, ISSN 0001-6322, 05/2013, Volume 125, Issue 5, pp. 753 - 769
We report a British family with young-onset Parkinson's disease (PD) and a G51D SNCA mutation that segregates with the disease. Family history was consistent... 
Multiple system atrophy | α-Synuclein | Parkinson's disease | SNCA | Atrophy | Ubiquitin | Family | Genetic aspects | Dopa
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 04/2015, Volume 112, Issue 15, pp. E1926 - E1935
Journal Article
Neuropathology and Applied Neurobiology, ISSN 0305-1846, 02/2016, Volume 42, Issue 1, pp. 77 - 94
Journal Article
Journal of Neuroscience Methods, ISSN 0165-0270, 01/2019, Volume 311, pp. 89 - 94
Protein aggregation in neurons is a prominent pathological mark of neurodegeneration. In Parkinson’s disease (PD), inclusions of the α-Synuclein (α-Syn)... 
α-Synuclein | CNS | Neurodegeneration | Drosophila | Parkinson’s disease
Journal Article
Neurobiology of disease, ISSN 0969-9961, 8/2018, Volume 116, pp. 53 - 59
Plasma total and nervous system derived exosomal (NDE) α-synuclein have been determined as potential biomarkers of Parkinson’s disease (PD). To explore the... 
Plasma | α-Synuclein | Risk | Parkinson’s | Prodromal
Journal Article
Biomedicine & Pharmacotherapy, ISSN 0753-3322, 07/2019, Volume 115, p. 108843
Many neurodegenerative diseases are characterized by progressive loss of neurons and abnormal protein accumulation, including amyloid (A)β and tau in... 
α-Synuclein | Monoclonal antibody | Immunotherapy | Parkinson’s disease
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 11/2019, Volume 519, Issue 4, pp. 740 - 746
Microglia-mediated neuroinflammation is critical for the pathogenesis of neurodegenerative diseases, including Parkinson's disease (PD). microRNA-let-7a... 
α-Synuclein | Inflammation | Parkinson's disease | miR-let-7a | STAT3 | Microglia
Journal Article
Analytica Chimica Acta, ISSN 0003-2670, 12/2019, Volume 1089, pp. 32 - 39
Parkinson's disease (PD) is a long-term degenerative disorder that affects predominately dopaminergic neurons in the substantia nigra, which mainly control... 
Nanomaterials | Electrochemical biosensor | Aptamer | α-synuclein | Immunosensor
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 01/2017, Volume 115, Issue 2, pp. 409 - 414
In the neurodegenerative disease multiple system atrophy (MSA), α-synuclein misfolds into a self-templating conformation to become a prion. To compare the... 
Proteinopathy | α-Synuclein | Synucleinopathies | Neurodegeneration | Strains | neurodegeneration | Biological Sciences | proteinopathy | strains | synucleinopathies | α-synuclein
Journal Article
Neurobiology of Disease, ISSN 0969-9961, 12/2019, Volume 132, p. 104582
There are no approved drug therapies that can prevent or slow the progression of Parkinson's disease (PD). Accumulation and aggregation of α-synuclein protein... 
α-Synuclein | Parkinson's | Propagation | Antibody | Immunotherapy | Spreading
Journal Article
Movement Disorders, ISSN 0885-3185, 10/2019, Volume 34, Issue 10, pp. 1452 - 1463
Previous studies that have investigated the potential of in vivo abnormal α‐synuclein deposits as a pathological biomarker for PD included few participants and... 
biopsy | diagnosis | Parkinson's disease | pathology | α‐synuclein
Journal Article
Neuroscience Letters, ISSN 0304-3940, 10/2019, Volume 711, p. 134437
Parkinson’s disease (PD) is characterised pathologically by degeneration of the dopaminergic (DA) neurones of the substantia nigra pars compacta (SNpc) and the... 
Trichloroethylene | α-Synuclein | TaClo | Neurodegeneration | Parkinson’s disease
Journal Article
Biological Psychiatry, ISSN 0006-3223, 05/2019, Volume 85, Issue 9, pp. 769 - 781
Death-associated protein kinase 1 (DAPK1) is a widely distributed serine/threonine kinase that is critical for cell death in multiple neurological disorders,... 
α-Synuclein | miRNA | MPTP | DAPK1 | Peptide | Parkinson’s disease
Journal Article