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apoptosis (102) 102
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Cell Death and Differentiation, ISSN 1350-9047, 10/2010, Volume 17, Issue 10, pp. 1540 - 1550
We have previously analysed the bioenergetic consequences of activating J774.A1 macrophages (MU) with interferon-gamma (IFN-gamma) and lipopolysaccharide (LPS)... 
apoptosis | macrophage activation | oxidative phosphorylation | caspase activation | glycolysis | EARLY EVENTS | INNER MEMBRANE | STAUROSPORINE | BIOCHEMISTRY & MOLECULAR BIOLOGY | INTRACELLULAR PH | NECROSIS-FACTOR-ALPHA | DEATH | Delta Psi(m) | CELL BIOLOGY | T-CELL-ACTIVATION | NITRIC-OXIDE | HYPERPOLARIZATION | CYTOCHROME-C RELEASE
Journal Article
Journal Article
Biochemical Journal, ISSN 0264-6021, 04/2011, Volume 435, Issue 2, pp. 297 - 312
Assessing mitochondrial dysfunction requires definition of the dysfunction to be investigated. Usually, it is the ability of the mitochondria to make ATP... 
Mitochondrion | Membrane potential | Respiration | Respiratory control | Mitochondrial function | respiratory control | CEREBELLAR GRANULE NEURONS | SPARE RESPIRATORY CAPACITY | BROWN-ADIPOSE-TISSUE | mitochondrial function | ELECTROCHEMICAL POTENTIAL GRADIENT | BIOCHEMISTRY & MOLECULAR BIOLOGY | respiration | DOWN ELASTICITY ANALYSIS | RAT-LIVER MITOCHONDRIA | mitochondrion | SKELETAL-MUSCLE MITOCHONDRIA | INS-1E INSULINOMA CELLS | membrane potential | PANCREATIC BETA-CELLS | METABOLIC CONTROL-THEORY | Mitochondrial Diseases - pathology | Protons | Clinical Laboratory Techniques | Humans | Mitochondrial Diseases - metabolism | Cells - ultrastructure | Mitochondria - metabolism | Mitochondria - pathology | Cells - pathology | Animals | Energy Metabolism | Models, Biological | Cells - metabolism | Electron Transport - physiology | Mitochondria - physiology | Mitochondrial Diseases - physiopathology | Mitochondrial Diseases - diagnosis | FCCP, carbonyl cyanide p-trifluoromethoxyphenylhydrazone | state 4o, state 4oligomycin | TPMP, triphenylmethylphosphonium | TMRM, tetramethylrhodamine methyl ester | PMPI, plasma membrane potential indicator | UQ, ubiquinone | Review | pmf, protonmotive force | state 4 | Δψm, mitochondrial membrane potential | state 3u, uncoupled state | Δψp, plasma membrane potential | TPP, tetraphenylphosphonium | ΔpH, pH gradient | RCR, respiratory control ratio (state 3 | R123, rhodamine 123
Journal Article
Journal Article
FEBS Letters, ISSN 0014-5793, 1997, Volume 415, Issue 1, pp. 21 - 24
Mitochondrial depolarisation has been reported to enhance the generation of superoxide anion (O⋅− 2) in a number of cell preparations while an inhibition has... 
Mitochondrion | Reactive oxygen species | Superoxide | Neuron | Mitochondrial membrane potential | Δψm | HET | hydroethidine
Journal Article
Journal of Molecular and Cellular Cardiology, ISSN 0022-2828, 2014, Volume 78, pp. 100 - 106
Abstract The mitochondrial permeability transition (PT) – an abrupt increase permeability of the inner membrane to solutes – is a causative event in... 
Cardiovascular | Mitochondria | Ischemia–reperfusion injury | Permeability transition pore | Ischemia-reperfusion injury | DEPENDENT ANION CHANNEL | CARDIAC & CARDIOVASCULAR SYSTEMS | CA-2&-INDUCED MEMBRANE TRANSITION | CELL BIOLOGY | CYCLOPHILIN-D | CYCLOSPORINE-A | MYOCARDIAL INFARCT SIZE | ATP SYNTHASE | PERIPHERAL BENZODIAZEPINE-RECEPTOR | ADRENAL-CORTEX MITOCHONDRIA | MALIC ENZYME-ACTIVITY | Mitochondrial Membranes - drug effects | Mitochondrial Membrane Transport Proteins - metabolism | Permeability - drug effects | Animals | Mitochondria, Heart - metabolism | Cyclosporine - pharmacology | Humans | Cyclophilins - metabolism | Cardiotonic Agents - pharmacology | Mitochondria, Heart - drug effects | Mitochondrial Proton-Translocating ATPases - metabolism | Mitochondrial Membranes - metabolism | Mitochondrial DNA | Permeability | OMM, outer mitochondrial membrane | PTP, permeability transition pore | PKG, cyclic GMP-dependent protein kinase | PT, permeability transition | IMM, inner mitochondrial membrane | PKA, cyclic AMP-dependent protein kinase | Drp1, dynamin-related protein 1 | CsA, cyclosporin A | PPIase, peptidylprolyl cis-trans isomerase | ERK, extracellular signal regulated kinase | CyP, cyclophilin | ANT, adenine nucleotide translocase | R, ischemia–reperfusion | Review | TSPO, transport protein of 18 kDa | MMC, mitochondrial megachannel | Δψm, mitochondrial membrane potential | VDAC, voltage-dependent anion channel | GSK, glycogen synthase kinase | ROS, reactive oxygen species
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2015, Volume 136, Issue 3, pp. 769 - 780
Background Inflammation and oxidative stress play critical roles in patients with chronic obstructive pulmonary disease (COPD). Mitochondrial oxidative stress... 
Allergy and Immunology | airway hyperresponsiveness | antioxidant | proliferation | MitoQ | inflammation | mitochondria | airway smooth muscle | Ozone | oxidative stress | chronic obstructive pulmonary disease | ASTHMA FEATURES | MECHANISMS | IMMUNOLOGY | FRAGMENTATION | HYPERRESPONSIVENESS | BETA | RESPONSES | ALLERGY | ENERGY-METABOLISM | EXPRESSION | COPD | Respiratory System - pathology | Reactive Oxygen Species - metabolism | Humans | Middle Aged | Male | Pulmonary Disease, Chronic Obstructive - pathology | Bronchial Hyperreactivity - genetics | Ubiquinone - pharmacology | Muscle, Smooth - drug effects | Smoking - physiopathology | Organophosphorus Compounds - pharmacology | Myocytes, Smooth Muscle - drug effects | Pneumonia - genetics | Pulmonary Disease, Chronic Obstructive - genetics | Bronchial Hyperreactivity - chemically induced | Signal Transduction | Mitochondria - pathology | Smoking - metabolism | Bronchial Hyperreactivity - pathology | Reactive Oxygen Species - antagonists & inhibitors | Electron Transport Chain Complex Proteins - metabolism | Pulmonary Disease, Chronic Obstructive - chemically induced | Respiratory System - drug effects | Airway Remodeling - genetics | Mice | Oxidative Stress - drug effects | Bronchial Hyperreactivity - drug therapy | Myocytes, Smooth Muscle - pathology | Pneumonia - pathology | Membrane Potential, Mitochondrial - drug effects | Pneumonia - chemically induced | Adult | Female | Pulmonary Disease, Chronic Obstructive - metabolism | Myocytes, Smooth Muscle - metabolism | Ubiquinone - analogs & derivatives | Gene Expression Regulation | Hydrogen Peroxide - pharmacology | Electron Transport Chain Complex Proteins - genetics | Mitochondria - metabolism | Antioxidants - pharmacology | Mitochondria - drug effects | Muscle, Smooth - metabolism | Animals | Pneumonia - drug therapy | Respiratory System - metabolism | Aged | Muscle, Smooth - pathology | Oxidative stress | Care and treatment | Lung diseases, Obstructive | Inflammation | Pharmaceutical industry | Biomedical research | Disease | Laboratories | Mortality | Colleges & universities | Smooth muscle | Mitochondrial DNA | Metabolism | Defects | Antioxidants | Mitochondria | Hospitals | Biopsy | Chronic obstructive pulmonary disease | Apoptosis | Smoking | NO, Nitric oxide | ΔΨm, Mitochondrial membrane potential | ASM, Airway smooth muscle | NAC, N-acetylcysteine | RL, Lung resistance | BAL, Bronchoalveolar lavage | OCR, Oxygen consumption rate | dTPP, Decyltriphenylphosphonium bromide | AHR, Airway hyperresponsiveness | logPC100, Concentration of acetylcholine that increased lung resistance by 100 | GOLD, Global Initiative for Chronic Obstructive Lung Disease | ATP, Adenosine triphosphate | KC, Keratinocyte-derived cytokine | JC-1, 5,5′,6,6′-Tetrachloro-1,1′,3,3′-tetraethylbenzimidazolylcarbocyanine iodide | COPD, Chronic obstructive pulmonary disease | ROS, Reactive oxygen species | Mechanisms of Allergy and Clinical Immunology
Journal Article
Journal Article
Hepatology Research, ISSN 1386-6346, 01/2007, Volume 37, Issue 1, pp. 68 - 76
Flavonoids exist extensively in plants, and several biological effects of them have been demonstrated. Wogonin is an important flavonoid compound. In this... 
human hepatoma cell | ΔΨm | cytochrome c | wogonin | caspase‐9 | ROS | Cytochromec | Δψm | Wogonin | Human hepatoma cell | Caspase-9 | PROTEOLYTIC CLEAVAGE | ACTIVATION | PROTEIN | CARCINOMA CELLS | caspase-9 | INDUCED APOPTOSIS | HL-60 CELLS | KINASE C-DELTA | INDUCTION | PERMEABILITY TRANS