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δnp63 (76) 76
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Biochemical and Biophysical Research Communications, ISSN 0006-291X, 07/2019, Volume 515, Issue 2, pp. 310 - 317
The cutaneous squamous cell carcinoma (cSCC) originates from epithelial stem cells through the dysregulation of self-renewal and differentiation. Recent... 
m6A modification | ΔNp63 | Cutaneous squamous cell carcinoma | METTL3
Journal Article
Oncogene, ISSN 0950-9232, 11/2016, Volume 35, Issue 44, pp. 5781 - 5794
The Cancer Genome Atlas (TCGA) network study of 12 cancer types (PanCancer 12) revealed frequent mutation of TP53, and amplification and expression of related... 
cRel | ΔNp63α | ChIP-seq | TAp73 | TNF-alpha
Journal Article
International Journal of Biochemistry and Cell Biology, ISSN 1357-2725, 2013, Volume 45, Issue 8, pp. 1568 - 1576
Several lines of evidence suggest that specific transcriptional events are involved in cell cycle, prolifera-tion and differentiation processes; however, their... 
ΔNp63 | Colon cancer | Cell cycle | EVI1 | P21
Journal Article
Oncotarget, ISSN 1949-2553, 06/2018, Volume 9, Issue 49, p. 29220
encodes TAp63, which is functionally similar to the tumor suppressor , and ΔNp63, which lacks the transcription-activating domain of TAp63 and appears potently... 
Journal Article
International journal of medical sciences, ISSN 1449-1907, 2019, Volume 16, Issue 5, pp. 766 - 773
Yes-associated protein (YAP) is a candidate oncogene in various human cancers, and recently, it has been reported that YAP expression and its activity was... 
Journal Article
FEBS Letters, ISSN 0014-5793, 07/2018, Volume 592, Issue 13, pp. 2334 - 2340
Potassium channel tetramerization domain containing 5 (KCTD5) was previously documented as a component of the Cullin3‐RING ligase (CRL3). It has been reported... 
ΔNp63α | Cullin3 | ubiquitination | KCTD5 | transactivity | proproliferation | ISOFORMS | BIOCHEMISTRY & MOLECULAR BIOLOGY | COMPLEXES | P63 | CELL BIOLOGY | BIOPHYSICS | LIGASES | DEGRADATION | Delta Np63 alpha | PROMOTE
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 05/2017, Volume 114, Issue 20, pp. E3964 - E3973
Activation of phosphatidylinositol 3 kinase (PI3K), Ras, and Her2 signaling plays a critical role in cancer development. Hotspot constitutive activating... 
ΔNp63α | Cancer metastasis | PIK3CA | Ras | Her2 | SIGNALING PATHWAYS | PIK3CA MUTATIONS | CANCER CELLS | MULTIDISCIPLINARY SCIENCES | P63 | COMPREHENSIVE GENOMIC CHARACTERIZATION | LUNG-CANCER | PHOSPHATIDYLINOSITOL 3-KINASES | PI3K PATHWAY | PHOSPHOINOSITIDE 3-KINASES | Delta Np63 alpha | EXPRESSION | cancer metastasis | Biological Sciences | PNAS Plus
Journal Article
Experimental Cell Research, ISSN 0014-4827, 09/2019, Volume 382, Issue 2, p. 111481
Most recently, mounting evidence has shown that cancer cells can invade as a cohesive and multicellular group with coordinated movement, which is called... 
Dll4 | Leader cell | Δ;Np63α | Cysteine protease cathepsin B | Collective invasion | K14 | CARCINOMA-CELLS | MIGRATION | LUNG | CANCER | INHIBITS TUMOR-GROWTH | CELL BIOLOGY | EPITHELIAL-MESENCHYMAL TRANSITION | EXPRESSION PATTERNS | MICROENVIRONMENT | ONCOLOGY | Delta;Np63 alpha | EXTRACELLULAR-MATRIX | CATHEPSIN-B
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 2008, Volume 369, Issue 4, pp. 994 - 1000
is expressed as multiple variants including TA and ΔN forms. Since -deficient mice displayed profound defects of stratified epithelia, p63 is an essential... 
BMP-7 | Keratinocyte | ΔNp63 | Wound healing | Matrilin-2 | Migration
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 02/2019, Volume 509, Issue 3, pp. 784 - 789
p53-related p63 plays a critical role in regulation of cell proliferation, survival and cell differentiation. Dysregulation of p63 functions results in a... 
ΔNp63α | Cell cycle arrest | MKP3 | p38MAPK | APOPTOSIS | ACTIVATION | P53 PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | P63 | DIFFERENTIAL REGULATION | PROTEIN-KINASES | BIOPHYSICS | PATHWAY | Delta Np63 alpha | TUMORIGENESIS | PHOSPHATASES MKPS | ERK
Journal Article
International Journal of Molecular Sciences, ISSN 1661-6596, 03/2019, Volume 20, Issue 5, p. 1161
Cell⁻cell adhesion plays an important role in regulation of cell proliferation, migration, survival, and drug sensitivity. Metformin, a first line drug for... 
ΔNp63α | Anoikis | Integrin β1 | Metformin | Cell adhesion | integrin β1 | anoikis | metformin | cell adhesion
Journal Article
Toxicology in Vitro, ISSN 0887-2333, 12/2018, Volume 53, pp. 57 - 66
Arsenic is known to perturb epidermal homeostasis and induce abnormal keratinocyte proliferation, leading to skin carcinogenesis. P63 and its isoforms are... 
Keratinocytes | Bowen's disease | ΔNp63 | Abnormal proliferation | Arsenic | INDUCED BOWENS-DISEASE | PROTEIN | Delta Np63 | RECEPTOR EXPRESSION | CELL-PROLIFERATION | P53 HOMOLOG | P63 | CARCINOGENESIS | DEGRADATION | TOXICOLOGY | DIFFERENTIATION | Index Medicus
Journal Article
Redox Biology, ISSN 2213-2317, 09/2019, Volume 26, p. 101233
Reactive oxygen species (ROS) are key regulators in cell proliferation, survival, tumor initiation and development. However, the role of ROS in tumor... 
ΔNp63α | Cell-matrix adhesion | Cell-cell junction | Metastasis | Hippo kinase
Journal Article
Journal of Cellular Physiology, ISSN 0021-9541, 10/2018, Volume 233, Issue 10, pp. 6565 - 6577
We previously revealed that epithelial‐to‐mesenchymal transition (EMT) was mediated by ΔNp63β, a splicing variant of ΔNp63, in oral squamous cell carcinoma... 
OSCC | ΔNp63β | miRNA | cancer | EMT | Squamous cell carcinoma | Phenotypes | Mesenchyme | Splicing | Markers | MiRNA | Oral squamous cell carcinoma | Zinc | Homeobox | Transfection | Lymphocytes B | Ribonucleic acids | Inhibition | Tumors | Cancer | Original | Original s
Journal Article
Developmental Biology, ISSN 0012-1606, 07/2015, Volume 403, Issue 2, pp. 150 - 161
The epithelial compartment of the breast contains two lineages, the luminal- and the myoepithelial cells. D492 is a breast epithelial cell line with stem cell... 
MiR-200c-141 | Breast cancer | Breast morphogenesis | EMT | Stem cells | δNp63 | TARGET | STEM-CELLS | Delta Np63 | DEVELOPMENTAL BIOLOGY | MESENCHYMAL TRANSITION | P63 | CANCER | FAMILY | MIR-200 | BIOLOGY | GENES | EXPRESSION
Journal Article
Molecular cancer research : MCR, ISSN 1541-7786, 4/2015, Volume 13, Issue 4, pp. 732 - 742
The transforming growth factor beta (TGFβ) superfamily regulates a broad range of cellular processes including proliferation, cell-fate specification,... 
TGFβ | ΔNp63α | Epithelial to Mesenchymal Transition | BMP | p53
Journal Article
Oncotarget, 2017, Volume 8, Issue 43, pp. 73407 - 73418
Epidermal squamous cell carcinoma (SCC) is among the most common cancers. SCC can be treated by surgical excision, but recurrence of therapy-resistant disease... 
ΔNp63α | YAP | Hippo signaling | TAZ | Sulforaphane | sulforaphane | TRANSGLUTAMINASE | HIPPO PATHWAY | POLYCOMB GROUP PROTEIN | AIRBORNE POLLUTANTS | P53 HOMOLOG | P63 | CELL BIOLOGY | GROWTH | MICE | SKIN | DIFFERENTIATION | Delta Np63 alpha | hippo signaling
Journal Article