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中国药理学报:英文版, ISSN 1671-4083, 2017, Volume 38, Issue 10, pp. 1317 - 1328
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model remains the most commonly used animal model of Parkinson's disease (PD). There are three... 
小鼠模型 | 评价 | 动物模型 | α-突触核蛋白 | 帕金森病 | 治疗方案 | MPTP | 亚急性
Journal Article
中国神经再生研究:英文版, ISSN 1673-5374, 2017, Volume 12, Issue 3, pp. 380 - 384
Gaucher disease(GD),the commonest lysosomal storage disorder,results from the lack or functional deficiency of glucocerebrosidase(GCase) secondary to mutations... 
帕金森氏病 | 溶酶体 | 自噬 | α-突触核蛋白 | 功能缺陷 | 功能障碍 | 神经退行性疾病 | 基因突变 | Glucocerebrosidase | Gaucher disease | Drosophila | GBA | Lysosome | Autophagy | Parkinson’s disease
Journal Article
法医学杂志, ISSN 1004-5619, 2016, Volume 32, Issue 6, pp. 406 - 409
目的 观察急性乙醇中毒大鼠脑皮质α-突触核蛋白(α-synuclein,α-syn)表达及神经细胞凋亡的变化,探讨乙醇对神经细胞损害的机制。方法 用50%乙醇溶液灌胃方法制作大鼠急性乙醇中毒模型。采用免疫组织化学染色技术和图像分析方法观察大鼠急性乙醇中毒后1 h、3 h、6 h、12... 
法医毒理学 | 细胞凋亡 | 大鼠 | 脑皮质 | 急性乙醇中毒 | α突触核蛋白 | 法医病理学 | caspase-3
Journal Article
中国校外教育:下旬, ISSN 1004-8502, 2014, Issue 9, pp. 109 - 110
目前研究表明,α-突触核蛋白功能异常会导致路易小体疾病,以及体的产生。路易小体的产生,被认为是帕金森病( Parkinson disease, PD)的主要病因,而路易小体相关轴退变被认为是阿尔兹海默病(Alzheimer’s disease,... 
抗体治疗 | 阿尔兹海默病 | α-突触核蛋白 | 帕金森病
Journal Article
神经科学通报:英文版, ISSN 1673-7067, 2010, Issue 3, pp. 205 - 210
目的帕金森氏病的一个重要标志是胞浆内路易小体的形成。路易小体的主要成分是α-突触核蛋白的聚集体,它和铁的积聚一同存在于黒质区。本实验旨在研究铁和α-突触核蛋白聚集的关系。方法... 
帕金森氏病 | α-突触核蛋白 | 枸橼酸铁胺
Journal Article
神经科学通报:英文版, ISSN 1673-7067, 2017, Volume 33, Issue 3, pp. 331 - 338
Exosomes, nano-sized extracellular vesicles secreted by most cell types, are found in all kinds of biological fluids and tissues, including the central nervous... 
帕金森氏病 | α-突触核蛋白 | 生物标志物 | 中枢神经系统 | 生物体液 | 细胞信号转导 | 过氧化氢酶 | 神经保护作用 | Pathology | Therapy | Biomarker | Exosomes | Parkinson’s disease
Journal Article
纳米研究:英文版, ISSN 1998-0124, 2017, Volume 10, Issue 10, pp. 3496 - 3508
Alpha-synuclein (a-syn) deposition in Lewy bodies (LB) is one of the main neuropathological hallmarks of Parkinson's disease (PD). LB accumulation is... 
RNA干扰 | 疗效评价 | α-突触核蛋白 | 原代细胞 | 基因敲除 | siRNA | 皮层神经元 | 核糖核酸
Journal Article
蛋白质与细胞:英文版, ISSN 1674-800X, 2017, Volume 8, Issue 9, pp. 696 - 700
Dear Editor. Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder affecting about 1% of the worldwide population over the age of 60... 
诊断 | 脑脊液 | α-突触核蛋白 | 检测 | 帕金森病 | 应用 | Life Sciences | Biochemistry, general | Protein Science | Stem Cells | Human Genetics | Developmental Biology | Cell Biology | Letter
Journal Article
神经科学通报:英文版, ISSN 1673-7067, 2017, Volume 33, Issue 5, pp. 526 - 534
Typical Parkinsonian symptoms consist of bradykinesia plus rigidity and/or resting tremor. Some time later postural instability occurs. Pre-motor symptoms such... 
不稳定 | 运动障碍 | 症状 | 诊断 | α-突触核蛋白 | 帕金森病 | 睡眠行为 | 生物标记物 | Neurosciences | Human Physiology | Premotor symptoms | Anatomy | REM sleep behavior disorder | Neurology | Pain Medicine | Biomedicine | Gut-brain-axis | Hyposmia | Anesthesiology | Constipation | Parkinson’s disease
Journal Article
中国神经再生研究:英文版, ISSN 1673-5374, 2017, Volume 12, Issue 9, pp. 1435 - 1436
Parkinson's disease (PD) is a progressive neurodegenerative disease, which is generally considered a multifactorial disorder that arises owing to a combination... 
靶点 | 运动障碍 | 神经变性疾病 | 体功能 | α-突触核蛋白 | 帕金森病 | 组织 | 对症治疗
Journal Article
中国神经再生研究:英文版, ISSN 1673-5374, 2017, Volume 12, Issue 6, pp. 897 - 901
For 50 years ago was introduced L-3,4-dihydroxyphenylalanine(L-dopa) in Parkinson's disease treatment and during this significant advances has been done but... 
内源性 | 谷胱甘肽转移酶 | α-突触核蛋白 | 帕金森病 | L-DOPA | 神经毒素 | 多巴胺能神经元 | 神经保护作用 | Aminochrome | Dopamine | Monoamine oxidase | VMAT-2 | L-dopa | 3,4-Dihydroxyphenylacetaldehyde | 3,4-dihydroxyphenylacetic acid | Neuromelanin
Journal Article
中国药理学报:英文版, ISSN 1671-4083, 2013, Volume 34, Issue 5, pp. 674 - 680
A growing body of evidence suggests that α-synuclein accumulation may play an important role in the pathogenesis of Parkinson's disease. The aim of this study... 
自噬 | α-突触核蛋白 | PC12细胞 | 蛋白酶活性 | 雷帕霉素 | 间隙 | 串扰 | 蛋白酶体抑制剂
Journal Article
中国神经再生研究:英文版, ISSN 1673-5374, 2017, Volume 12, Issue 2, pp. 207 - 209
Targeting early steps in amyloid-beta production:Alzheimer’s disease(AD)has a long history as the"amyloid deposit"disorder.Many disorders are now known to be... 
穿梭 | 淀粉样前体蛋白 | α-突触核蛋白 | 帕金森病 | 阿尔茨海默病 | β淀粉样蛋白 | 错误折叠 | 加工 | PLAQUES | NEUROSCIENCES | ALZHEIMERS-DISEASE | PEPTIDE | CELL BIOLOGY | Alzheimer's disease | Prions | Analysis | Amyloid beta-protein | Proteins | Brain | Enzymes | Neurotoxicity | Clinical trials | Mutation | Alzheimers disease | Cholesterol
Journal Article
中国神经再生研究:英文版, ISSN 1673-5374, 2015, Volume 10, Issue 5, pp. 704 - 706
Parkinson's disease (PD) is a slowly progressing neuro- degenerative disorder clinically defined by key symptoms like bradykinesia, rigidity, resting tremor,... 
神经再生 | 内源性 | α-突触核蛋白 | 帕金森病 | 神经退行性疾病 | 免疫系统 | 多巴胺能神经元 | 小胶质细胞 | Signal transduction | Genotype & phenotype | Dopamine | Brain research | Cytokines | Pathogenesis | Aging | Tumor necrosis factor-TNF | Gene expression | Growth factors | Neurogenesis
Journal Article
中国神经再生研究:英文版, ISSN 1673-5374, 2016, Volume 11, Issue 6, pp. 910 - 911
Formation of Lewy body inclusions(LBs)in the substantia nigra(SN)is a very well-characterized pathological hallmark of Parkinson’s disease(PD).LBs are... 
结合蛋白 | α-突触核蛋白 | 帕金森病 | 泛素-蛋白酶体系统 | 夹杂物 | 结构要素 | LBS | 生物活性 | COMPLEX | NRF2 | UBIQUITIN LIGASE | SUBSTRATE | MITOPHAGY | NEUROSCIENCES | PARKINSONS-DISEASE | CELL BIOLOGY | Proteins | Signal transduction | Pathology | Mitochondria | Dopamine | Neurons | Cell cycle | Homeostasis | Biosynthesis | Metabolism
Journal Article
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