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aldosterone/metabolism; animals; body weight; colon/metabolism; diet; eating; epithelial sodium channels/biosynthesis; epithelial sodium channels/genetics; female; kidney tubules, collecting/metabolism; kidney tubules, collecting/pathology; male; mice; mice, knockout; phosphorylation; potassium/blood; potassium/metabolism; pseudohypoaldosteronism/genetics; pseudohypoaldosteronism/metabolism; sodium/blood; sodium/metabolism; solute carrier family 12, member 1/biosynthesis; solute carrier family 12, member 1/genetics; solute carrier family 12, member 3/biosynthesis; solute carrier family 12, member 3/genetics (1) 1
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FRONTIERS IN PHARMACOLOGY, ISSN 1663-9812, 04/2018, Volume 9, p. 178
The role of epithelial sodium channel (ENaC) activity in the regulation of endothelial function is not clear. Here, we analyze the role of ENaC in the... 
endothelium | endothelial barrier integrity | CELLS | PERMEABILITY | MRI | ATHEROSCLEROSIS | alpha ENaC | VASCULAR ENDOTHELIUM | LPS | PHARMACOLOGY & PHARMACY | ALDOSTERONE | MICE | endothelial-induced vasodilation | DYSFUNCTION | EXCHANGER | αENaC
Journal Article
Clinical Science, ISSN 0143-5221, 02/2013, Volume 124, Issue 3, pp. 153 - 164
Sirtuins are members of the Sir2 (silent information regulator 2) family, a group of class III deacetylases. Mammals have seven different sirtuins,... 
SIRT1 (sirtuin 1) | Aging | Diabetic nephropathy | Sirtuin | MEDICINE, RESEARCH & EXPERIMENTAL | HYPOXIA-INDUCIBLE FACTOR | LIFE-SPAN | LIPID-METABOLISM | B-DEPENDENT TRANSCRIPTION | SIRT1 DEACETYLASE | CELL-SURVIVAL | SIRT1(sirtuin 1) | sirtuin | STRESS-RESPONSIVE DEACETYLASE | GENE-EXPRESSION | aging | CHRONIC KIDNEY-DISEASE | diabetic nephropathy | CALORIE RESTRICTION | Sirtuin 1 - metabolism | Animals | Sirtuin 3 - metabolism | Caloric Restriction | Diabetic Nephropathies - metabolism | Humans | Sirtuins - metabolism | Aging - metabolism | Kidney Diseases - metabolism | Atg, autophagy-related gene | Idh2, isocitrate dehydrogenase 2 | WFR, Wistar fatty diabetic rat | adenovirus E1V 19-kDa interacting protein 3 | PGC-1α, PPAR-γ co-activator-1α | LC3, light chain 3 | PTP1B, protein tyrosine phosphatase 1B | TNF-α, tumour necrosis factor α | ICAM-1, intercellular adhesion molecule 1 | IGF, insulin-like growth factor | mTOR, mammalian target of rapamycin | CKD, chronic kidney disease | RAS, renin–angiotensin system | FOXO, forkhead box O | H3K9, histone H3 Lys9 | eNOS, endothelial NO synthase | PER2, Period 2 | PPAR, peroxisome-proliferator-activated receptor | HIF, hypoxia-inducible factor | UUO, unilateral ureteral obstruction | Mn-SOD, manganese superoxide dismutase | Bnip3, BCL2 | LXR, liver X receptor | CRP, C-reactive protein | AGE, advanced glycation end-product | PARP, poly(ADP-ribose) polymerase | IRS, insulin receptor substrate | CR, calorie restriction | AMPK, AMP-activated protein kinase | Review | VCAM-1, vascular cell adhesion protein 1 | SREBP, sterol-regulatory-element-binding protein | BMAL1, brain and muscle ARNT (aryl hydrocarbon receptor nuclear translocator)-like 1 | TGF, transforming growth factor | ROS, reactive oxygen species | AT1R, angiotensin type 1 receptor | SIRT1 etc., sirtuin 1 etc., SNP, single nucleotide polymorphism | H3K9me3, H3K9 trimethylation | COX2, cyclo-oxygenase 2 | FXR, farnesoid X receptor | PKC, protein kinase C | α-ENaC, epithelial Na+ channel α-subunit | Sir2, silent information regulator 2 | NF-κB, nuclear factor-κB | AngII, angiotensin II | ER, endoplasmic reticulum | MCP-1, monocyte chemotactic protein-1
Journal Article
Autonomic Neuroscience: Basic and Clinical, ISSN 1566-0702, 03/2018, Volume 210, pp. 34 - 43
In peripheral tissues, aldosterone alters expression of multiple genes, including the clock gene Period 1 (Per1), 11 beta-hydroxysteroid dehydrogenase-2... 
α-ENAC | mRNA | 11-HSD2 | Period 1 | Blood pressure and DOCA/salt hypertension | Orexin | alpha-ENAC | SODIUM-CHANNELS | 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-2 | HEART-FAILURE | NEUROSCIENCES | ALDOSTERONE-SENSITIVE NEURONS | BLOOD-PRESSURE | CIRCADIAN CLOCK | SALT | MICE | STRESS | BRAIN
Journal Article
Shock, ISSN 1073-2322, 01/2013, Volume 39, Issue 2, pp. 1 - 196
Acute lung injury (ALI) is a clinical syndrome characterized by hypoxia which is caused by the breakdown of the alveolar capillary barrier. IL-1β a cytokine... 
αENaC | p38 MAP Kinase | IRAK-1 | TAK-1 | Stress Protein Response | Lung
Journal Article
American Journal of Physiology - Renal Physiology, ISSN 0363-6127, 02/2016, Volume 310, Issue 4, pp. F300 - F310
Journal Article
Cellular Immunology, ISSN 0008-8749, 07/2017, Volume 317, pp. 18 - 25
Journal Article
BBA - Biomembranes, ISSN 0005-2736, 07/2012, Volume 1818, Issue 7, pp. 1682 - 1690
Active Na absorption by alveolar ENaC is the main driving force of liquid clearance at birth and lung edema resorption in adulthood. We have demonstrated... 
kATP channels | α-ENaC | Alveolar cells | KvLQT1 channels | MAPK | Fluid clearance | channels | BIOPHYSICAL PROPERTIES | ACTIVATED PROTEIN-KINASE | COLLECTING DUCT CELLS | alpha-ENaC | BIOCHEMISTRY & MOLECULAR BIOLOGY | SENSITIVE POTASSIUM CHANNEL | SODIUM-CHANNEL | BIOPHYSICS | NA+ CHANNEL | LUNG LIQUID CLEARANCE | DECREASES EXPRESSION | II CELLS | k(ATP) channels
Journal Article
Journal Article
Clinical Medicine Insights: Cardiology, ISSN 1179-5468, 08/2010, Volume 2010, Issue 4, pp. 73 - 75
Marlene F. ShehataDepartment of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada. AbstractThe epithelial sodium... 
Salt-sensitive hypertension | α ENaC-b | Western analysis | Dahl rats
Journal Article
Comptes Rendus - Biologies, ISSN 1631-0691, 07/2003, Volume 326, Issue 6, pp. 615 - 624
Journal Article
Biochemistry Insights, ISSN 1178-6264, 01/2009, Volume 2, pp. 21 - 27
Introduction: In Dahl rats’ kidney cortex, the alternatively spliced form of the epithelial sodium channel α subunit (α ENaC-b) is the most abundant mRNA... 
α ENaC-wt | expression | dose-dependent response | salt-sensitive hypertension | Dahl rats | transfection | binding | α ENaC-b | COS7 cells
Journal Article
Journal of Steroid Biochemistry and Molecular Biology, ISSN 0960-0760, 2004, Volume 88, Issue 3, pp. 305 - 310
The epithelial amiloride-sensitive sodium channel (ENaC) plays a central role in sodium homeostasis and blood pressure control. The molecular effect of high... 
Sodium chloride | αENaC | Protein Biosynthesis | Sodium Chloride - pharmacology | Rats | DNA Primers | Rats, Sprague-Dawley | Cycloheximide - pharmacology | Gene Expression Regulation - drug effects | Epithelial Sodium Channels | Animals | Base Sequence | Female | Sodium Channels - genetics | Protein Synthesis Inhibitors - pharmacology
Journal Article
Biochemistry Insights, ISSN 1178-6264, 04/2009, Volume 2009, Issue 2, p. BCI.S880
Marlene F. ShehataDepartment of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa ON, Canada.AbstractIntroduction: In Dahl... 
Journal Article
Comptes rendus - Biologies, ISSN 1631-0691, 2003, Volume 326, Issue 7, pp. 615 - 624
Journal Article