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Toxicon, ISSN 0041-0101, 08/2016, Volume 118, pp. 36 - 42
Disintegrins are small peptides produced in viper venom that act as integrin antagonists. When bound to integrins, disintegrins induce altered cellular... 
Cell proliferation | Melanoma cell line | αvβ3 integrin | Recombinant RGD disintegrin | αv knockdown | rac-1 expression | Apoptosis induction | Cell migration | MIGRATION | ANGIOGENESIS | INTEGRIN | ECHISTATIN | alpha v knockdown | MELANOMA | alpha v beta 3 integrin | DISINTEGRIN | IN-VIVO | PHARMACOLOGY & PHARMACY | TOXICOLOGY | EXPRESSION | Integrin alphaV - chemistry | Reptilian Proteins - genetics | Apoptosis - drug effects | Humans | Peptide Fragments - pharmacology | Disintegrins - genetics | Mutant Proteins - pharmacology | Reptilian Proteins - pharmacology | Antineoplastic Agents - metabolism | RNA Interference | Drug Design | Antineoplastic Agents - pharmacology | Integrin alpha Chains - antagonists & inhibitors | Integrin alphaV - genetics | Peptide Fragments - genetics | Integrin alphaV - metabolism | Recombinant Proteins - metabolism | Peptide Fragments - metabolism | Disintegrins - metabolism | Mutant Proteins - genetics | Recombinant Proteins - chemistry | Mutant Proteins - metabolism | Integrin alpha Chains - metabolism | Recombinant Proteins - genetics | Recombinant Proteins - pharmacology | Antineoplastic Agents - chemistry | Amino Acid Motifs | Viper Venoms - chemistry | Cell Movement - drug effects | Animals | Peptide Fragments - antagonists & inhibitors | Melanoma - drug therapy | Mutant Proteins - chemistry | rac1 GTP-Binding Protein - antagonists & inhibitors | Cell Line, Tumor | Cell Proliferation - drug effects | Aspartic Acid - chemistry | Enzyme Repression - drug effects | Reptilian Proteins - antagonists & inhibitors | Integrin alpha Chains - genetics | rac1 GTP-Binding Protein - metabolism | Disintegrins - pharmacology | Reptilian Proteins - metabolism | rac1 GTP-Binding Protein - genetics | Aspartate | Peptides | RNA | Integrins | Apoptosis | Index Medicus | Biotechnology | Migration | Amino acids | Aspartates | Gene expression | Recombinant | melanoma cell line | cell proliferation | apoptosis induction | recombinant RGD disintegrin | cell migration
Journal Article
Journal Article
Journal of Endodontics, ISSN 0099-2399, 2014, Volume 40, Issue 11, pp. 1802 - 1809
Journal Article
Cell Biochemistry and Function, ISSN 0263-6484, 12/2012, Volume 30, Issue 8, pp. 687 - 695
CYR61 is one of the six proteins of the CCN family of proteins known to play diverse roles in angiogenesis, cellular proliferation, survival, migration and... 
stable knockdown | β | 5 | v | integrin α | migration | CYR61 | stable overexpression | Stable overexpression | Stable knockdown | Integrin α | Migration | stable knock down | integrin αvβ5 | stable over-expression
Journal Article
Biomaterials, ISSN 0142-9612, 2013, Volume 34, Issue 17, pp. 4223 - 4234
Abstract Interactions between blood vessels and osteoblasts—bone-forming cells—are critical for successful bone development. We therefore investigated the... 
Advanced Basic Science | Dentistry | FOXC2 | Extracellular matrix | Integrin αvβ3/CD61 | Bone | Endothelial differentiation | Mesenchymal stem cells | TRANSCRIPTION FACTORS | MULTIPOTENT CELLS | MATERIALS SCIENCE, BIOMATERIALS | OSTEOBLAST DIFFERENTIATION | HUMAN OSTEOPROGENITORS | ANGIOGENESIS | ENGINEERING, BIOMEDICAL | MESENCHYMAL STEM-CELLS | TRABECULAR BONE | IN-VITRO | GROWTH-FACTOR | Integrin alpha v beta 3/CD61 | MARROW STROMAL CELLS | Human Umbilical Vein Endothelial Cells - metabolism | Humans | Extracellular Matrix - metabolism | Gene Knockdown Techniques | Cell Differentiation - genetics | Mesenchymal Stromal Cells - cytology | Forkhead Transcription Factors - metabolism | Human Umbilical Vein Endothelial Cells - cytology | Adult | Osteoblasts - cytology | Stem Cell Niche - genetics | Extracellular Matrix Proteins - metabolism | Biomarkers - metabolism | Adult Stem Cells - cytology | Bone Marrow Cells - cytology | Neovascularization, Physiologic - genetics | Mesenchymal Stromal Cells - metabolism | Up-Regulation - genetics | Chick Embryo | Fetus - cytology | Transcription Factors - metabolism | Adult Stem Cells - metabolism | Animals | Laminin - metabolism | Osteoblasts - metabolism | Bone Marrow Cells - metabolism | Proteins | Medical colleges | Blood lipids | Stem cells | Endothelium | Index Medicus
Journal Article
Oncotarget, ISSN 1949-2553, 2017, Volume 8, Issue 17, pp. 27754 - 27771
Integrins have been suggested as possible targets in anticancer therapy. Here we show that knockdown of integrins αVβ3, αVβ5, α3β1 and α4β1 and pharmacological... 
Homologous recombination repair | Rad51 | Malignant gliomas | Temozolomide | Integrin αVβ3 silencing | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Phosphorylation | Receptors, Vitronectin - antagonists & inhibitors | Apoptosis - drug effects | Dacarbazine - therapeutic use | Humans | Brain Neoplasms - pathology | Antineoplastic Agents, Alkylating - pharmacology | Peptides, Cyclic - pharmacology | Integrin alphaVbeta3 - metabolism | Gene Knockdown Techniques | Flow Cytometry | Neoplasm Grading | DNA Breaks, Double-Stranded - drug effects | Glioblastoma - genetics | Integrin alphaVbeta3 - genetics | RNA Interference | Dacarbazine - pharmacology | Dacarbazine - analogs & derivatives | Integrin beta3 - genetics | Receptors, Vitronectin - genetics | Receptors, Vitronectin - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Integrin alphaVbeta3 - antagonists & inhibitors | Rad51 Recombinase - metabolism | Recombinational DNA Repair | Rad51 Recombinase - genetics | Signal Transduction | Down-Regulation | Brain Neoplasms - genetics | Brain Neoplasms - drug therapy | Apoptosis Regulatory Proteins - metabolism | Antineoplastic Agents, Alkylating - therapeutic use | Xenograft Model Antitumor Assays | Drug Resistance, Neoplasm - genetics | Integrin beta3 - metabolism | Animals | Mice, Nude | Glioblastoma - pathology | NF-KappaB Inhibitor alpha - metabolism | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Mice, Inbred BALB C | Glioblastoma - drug therapy | RNA, Small Interfering - metabolism | Index Medicus
Journal Article
International Journal of Oncology, ISSN 1019-6439, 4/2013, Volume 42, Issue 4, pp. 1279 - 1288
Journal Article
Thrombosis and Haemostasis, ISSN 0340-6245, 11/2009, Volume 102, Issue 5, pp. 975 - 982
Integrins αvβ3 and αvβ5 have been long considered as proangiogenic receptors, yet genetic ablation studies demonstrated enhanced angiogenesis in mice lacking... 
siRNA | αv suppression | αvβ3 and αvβ5 integrins | αvβ3 and αvβ5 inhibitors | angiogenesis | Endothelium and Vascular Development | Angiogenesis | TRANSCRIPTION FACTORS | alpha v suppression | alpha v beta 3 and alpha v beta 5 inhibitors | alpha v beta 3 and alpha v beta 5 integrins | MICE LACKING | CEREBRAL-HEMORRHAGE | ALPHA(V)BETA | INTEGRINS | ALPHA-V-BETA-3 | BLOOD-VESSELS | GROWTH-FACTOR RECEPTOR-2 | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | TUMOR-GROWTH | Humans | Integrin alphaV - physiology | Sp1 Transcription Factor - metabolism | Gene Knockdown Techniques | Vascular Endothelial Growth Factor Receptor-2 - genetics | RNA, Messenger - biosynthesis | Flow Cytometry | Polymerase Chain Reaction | Receptors, Vitronectin - physiology | Vascular Endothelial Growth Factor Receptor-2 - biosynthesis | Integrin alphaV - genetics | Umbilical Veins - cytology | Vascular Endothelial Growth Factor A - pharmacology | Promoter Regions, Genetic | Cells, Cultured - drug effects | Endothelial Cells - metabolism | RNA, Messenger - genetics | RNA, Small Interfering - pharmacology | Gene Expression Regulation - physiology | Organ Specificity | Cell Division - drug effects | E-Box Elements | Gene Expression Regulation - drug effects | Capillaries - cytology | Integrin alphaVbeta3 - physiology | Cells, Cultured - metabolism | Endothelial Cells - drug effects
Journal Article
Experimental Cell Research, ISSN 0014-4827, 01/2019, Volume 374, Issue 1, pp. 128 - 139
Vang-like 2 (VANGL2) is a four-pass transmembrane protein required for a variety of polarized cell behaviors underlying embryonic development. Recent data show... 
Protein stability | Extracellular matrix | VANGL2 | Integrin αv | Adhesion | WNT/PLANAR CELL POLARITY | GASTRULATION MOVEMENTS | LIGAND-BINDING | TISSUE POLARITY | NEURAL-TUBE DEFECTS | Integrin alpha v | STRABISMUS | CELL BIOLOGY | ONCOLOGY | FIBRONECTIN | MUTATIONS | PLANAR POLARITY
Journal Article
Cancers, ISSN 2072-6694, 06/2013, Volume 5, Issue 2, pp. 617 - 638
Osteopontin and MMP9 are implicated in angiogenesis and cancer progression. The objective of this study is to gain insight into the molecular mechanisms... 
Osteopontin | Angiogenesis | Curcumin | Integrin avß3 | MMP9 | VEGF | Chemotherapy | Vascular endothelial growth factor | Prostate cancer | Cells | integrin αvβ3 | osteopontin | angiogenesis | curcumin
Journal Article