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Biological Psychiatry, ISSN 0006-3223, 02/2018, Volume 83, Issue 4, pp. 320 - 327
The genetic evidence implicating amyloid-β in the initial stage of Alzheimer’s disease is unequivocal. However, the long biochemical and cellular prodromal... 
Prevention | Therapy | β-Secretase | Amyloid-β | Alzheimer | γ-Secretase
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2006, Volume 16, Issue 14, pp. 3635 - 3638
A new class of β-secretase inhibitors that incorporate a reduced amide transition state isostere as the key binding element is described. The incorporation of... 
Isostere | β-Secretase | Reduced amide
Journal Article
Journal of Agricultural and Food Chemistry, ISSN 0021-8561, 02/2010, Volume 58, Issue 4, pp. 2230 - 2238
Journal Article
Biomedicine & Pharmacotherapy, ISSN 0753-3322, 05/2018, Volume 101, pp. 379 - 390
Although plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) protects against cerebral ischemia and spinal cord injury-induced oxidative stress and inflammation... 
β-secretase | Trigonelline | Plumbagin | Alzheimer’s disease | Astrocytes | GFAP
Journal Article
Molecules, ISSN 1420-3049, 09/2019, Volume 24, Issue 19, p. 3500
A series of 7-halogeno- (X = F, Cl, Br) and 7-methoxy-substituted acetylated 6-iodo-3-O-flavonol glycosides were prepared, and evaluated for inhibitory effect... 
antioxidant assay | butyrylcholinesterase | molecular docking | 3-O-flavonol glycosides | β-secretase | acetylcholinesterase | X-ray | kinetic studies
Journal Article
Biological Psychiatry, ISSN 0006-3223, 03/2018, Volume 83, Issue 5, pp. 447 - 455
Increased beta-secretase 1 (BACE1) activity has consistently been detected in brain tissue and cerebrospinal fluid of subjects with mild cognitive impairment... 
Alzheimer’s disease dementia | BACE1 | β-secretase | Mild cognitive impairment | Biomarker diagnosis | Prediction
Journal Article
Biological Psychiatry, ISSN 0006-3223, 2017, Volume 83, Issue 5, pp. 447 - 455
Abstract Background Increased β-secretase (BACE1) activity has consistently been detected in the brain tissue and cerebrospinal fluid (CSF) of subjects with... 
Psychiatry | BACE1 | Alzheimer’s disease dementia | β-secretase | prediction | biomarker diagnosis | mild cognitive impairment
Journal Article
Marine Drugs, ISSN 1660-3397, 05/2019, Volume 17, Issue 5, p. 293
Therapeutic options for Alzheimer’s disease, the most common form of dementia, are currently restricted to palliative treatments. The glycosaminoglycan... 
BACE1 | heparin | Portunus pelagicus | Alzheimer’s disease | amyloid-β | β-secretase | heparan sulphate | glycosaminoglycan
Journal Article
Bioorganic Chemistry, ISSN 0045-2068, 10/2017, Volume 74, pp. 126 - 133
Discovering multifunctional agents for the treatment of Alzheimer’s disease (AD) is an attractive therapeutic approach. BACE1 (β-site amyloid precursor protein... 
BACE1 | Schiff base | β-Secretase | Quinazolinone | Hydrazone | Alzheimer’s disease
Journal Article
Journal Article
Current Alzheimer Research, ISSN 1567-2050, 2017, Volume 14, Issue 8, pp. 861 - 869
Journal Article
ChemMedChem, ISSN 1860-7179, 03/2019, Volume 14, Issue 5, pp. 513 - 513
The Cover Feature shows the X‐ray structure of β‐secretase 1 bound to compound 2a (top). The structure was utilized to create an active model of 2a with... 
Tmem27 | type 2 diabetes | BACE2 inhibitors | β-secretase 2 | structure-based design
Journal Article
Current Medicinal Chemistry, ISSN 0929-8673, 01/2015, Volume 22, Issue 3, pp. 373 - 404
Journal Article
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