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Biochemical Journal, ISSN 0264-6021, 05/2015, Volume 467, Issue 3, pp. 365 - 386
In the last decade, the ubiquitin-proteasome system has emerged as a valid target for the development of novel therapeutics. E3 ubiquitin ligases are... 
Ubiquitin | Ubiquitination | Small molecule | Structure | Structure-based design | Assembly | small molecule | ANAPHASE-PROMOTING COMPLEX | SOCS-BOX | BIOCHEMISTRY & MOLECULAR BIOLOGY | F-BOX PROTEINS | KAPPA-B-ALPHA | structure | structure-based design | ubiquitin | CANCER-THERAPY | ubiquitination | COP9 SIGNALOSOME | assembly | TUMOR-SUPPRESSOR PROTEIN | SUBSTRATE-ASSISTED INHIBITION | CELL-CYCLE | PROTEASOME SYSTEM | Protein Structure, Tertiary | Protein Subunits | Cullin Proteins - antagonists & inhibitors | Proteasome Inhibitors - pharmacology | Humans | Models, Molecular | Proteasome Inhibitors - chemistry | Drug Discovery - methods | Cullin Proteins - chemistry | Cullin Proteins - genetics | Drug Design | Protein Structure, Quaternary | Molecular Structure | MEL26, maternal effect lethal 26 | HECT, homologous with E6-associated protein C-terminus | DCAF, DDB1–Cul4A-associated factor | CPH, conserved within Cul7, PARC and HERC2 | CSA, Cockayne syndrome A | NAE, NEDD8-activating enzyme | Rbx1, RING-box protein 1 | PPI, protein–protein interaction | C, anaphase-promoting complex | SV5, simian virus 5 | Fbxw, F-box | Skp2, S-phase kinase-associated protein 2 | IAA, indole-3-acetic acid | Cpd, compound | Fbw | SMER3, small-molecule enhancer of rapamycin 3 | mTOR, mammalian target of rapamycin | HERC2, HECT domain- and RLD (regulator of chromosome condensation 1 protein-like domain) domain-containing E3 ubiquitin protein ligase 2 | IκB, inhibitor of NF-κB | UPS, ubiquitin–proteasome system | Nrf2, nuclear factor-erythroid 2-related factor 2 | Protac, proteolysis-targeting chimaeric molecule | WD repeat-containing protein | ZIM (zinc finger expressed in inflorescence) domain protein 1 | NF-κB, nuclear factor κB | leucine-rich motif-containing protein | CTD, C-terminal domain | Ub, ubiquitin | Vif, virion infectivity factor | NTD, N-terminal domain | GHR, growth hormone receptor | CRBN, cereblon | HIF-1α, hypoxia-inducible factor 1α | SH2, Src homology 2 | BP, β-propeller | UBL, ubiquitin-like protein | FP, fluorescence polarization | Cks1, cyclin-dependent protein kinase regulatory subunit 1 | CSN, COP9 (constitutive photomorphogenesis 9) signalosome complex | ITC, isothermal titration calorimetry | RING, really interesting new gene | Ubc12, ubiquitin-conjugating enzyme 12 | KLHL, Kelch-like protein | Review | VPRBP, Vpr-binding protein | SCF, Skp1–Cdc53–F-box Cdc4 | POZ, pox virus and zinc finger | JAZ1, jasmonate | Keap1, Kelch-like enoyl-CoA hydratase-associated protein 1 | PARC, p53-associated parkin-like cytoplasmic protein | DDB, damage-specific DNA-binding protein | JA-Ile, jasmonoyl-isoleucine | Fbxl, F-box | MATH, meprin and TRAF (tumour necrosis factor receptor-associated factor) homology | CRL, Cullin–RING E3 ubiquitin ligase | other domain-containing protein | COI1, coronatine-insensitive protein 1 | EloBC, ElonginB–ElonginC complex | broad complex | VHL, von Hippel–Lindau | Vpr, viral protein R | Aux, auxin | STAT, signal transducer and activator of transcription | CAND1, Cullin-associated NEDD8-dissociated protein 1 | Fbxo, F-box | TIR1, transport inhibitor response 1 | CBFβ, core binding factor β | BCR, BTB–Cul3–Rbx1 | cyclosome | SOCS, suppressor of cytokine signalling | NEDD, neural-precursor-cell-expressed developmentally down-regulated | BTB, bric-a-brac | APC | Cdc, cell division cycle | Cul, Cullin | SPOP, speckle-type POZ protein | β-TrCP, β-transducin repeat-containing protein | tramtrack | ASB, ankyrin repeat and SOCS-box
Journal Article
Biochemical Society Transactions, ISSN 0300-5127, 08/2015, Volume 43, Issue 4, pp. 611 - 620
Journal Article
Biochemical Journal, ISSN 0264-6021, 09/2004, Volume 382, Issue 2, pp. 393 - 409
Two members of the NF-kappaB (nuclear factor kappaB)/Rel transcription factor family, NF-kappaB1 and NF-kappaB2, are produced as precursor proteins, NF-kappaB1... 
IκB kinase (IKK) | p100 | Tumour progression locus-2 (TPL-2) | Nuclear factor κB (NF-κB) | p105 | Toll-like receptor (TLR) | nuclear factor kappa B (NF-kappa B) | TRCP UBIQUITIN LIGASE | I kappa B kinase (IKK) | BIOCHEMISTRY & MOLECULAR BIOLOGY | P105 REQUIRES PHOSPHORYLATION | ALLERGIC AIRWAY INFLAMMATION | KINASE KINASE KINASE | P50 SUBUNIT | GLYCINE-RICH REGION | TUMOR-NECROSIS-FACTOR | TOLL-LIKE RECEPTORS | tumour progression locus-2 (TPL-2) | NF-KAPPA-B | SIGNAL-TRANSDUCTION PATHWAY | TNF, tumour necrosis factor | GC, germinal centre | NEMO, nuclear factor κB essential modulator | MAP 3-kinase, MAP kinase kinase kinase | BAFF, B-cell activating factor | ERK, extracellular-signal-regulated kinase | Fn14, fibroblast-growth-factor-inducible 14 | ABIN, A20-binding inhibitor of nuclear factor κB | GM-CSF, granulocyte–macrophage colony-stimulating factor | GSK, glycogen synthase kinase | Dif, Dorsal-related immunity factor | EBNA1, EBV nuclear antigen 1 | BMDM, bone-marrow-derived macrophage | NF-κB, nuclear factor κB | SCF, Skp1 | Imd, immune deficiency | F-box | IL, interleukin | MAP kinase, mitogen-activated protein kinase | EBV, Epstein–Barr virus | LPS, lipopolysaccharide | IFNβ, interferon-β | IκB, inhibitor of nuclear factor κB | TRAF, TNF-receptor-associated factor | TLR, Toll-like receptor | DC, dendritic cell | IKK, IκB kinase | GRR, glycine-rich region | Review | JNK, c-Jun N-terminal kinase | PGRP-LC, peptidoglycan recognition protein LC | ERK kinase | RANKL, receptor activator of NF-κB ligand | LTβR, lymphotoxin-β receptor | MIP, macrophage inflammatory protein | DD, death domain | HTLV-1, human T-cell leukaemia virus type 1 | MEK, MAP kinase | COX-2, cyclo-oxygenase-2 | TH2, T-helper 2 | TH1, T-helper 1 | LMP1, latent membrane protein 1 | TPL-2, tumour progression locus-2 | TWEAK, TNF-like weak inducer of apoptosis | Cul1 | PEST region, polypeptide sequence enriched in proline (P), glutamic acid (E), serine (S) and threonine (T) | RHD, Rel homology domain | nuclear factor κB (NF-κB) | NIK, NF-κB-inducing kinase | MEF, mouse embryo fibroblast | βTrCP, β-transducin repeat-containing protein
Journal Article
Bioscience Reports, ISSN 0144-8463, 12/2012, Volume 32, Issue 6, pp. 597 - 608
NOD1 {nucleotide-binding oligomerization domain 1; NLRC [NOD-LRR (leucine-rich repeat) family with CARD (caspase recruitment domain) 1]} and NOD2 (NLRC2) are... 
Inflammation | Nuclear factor-κB (NF-κB) | Nucleotide-binding oligomerization domain 2 (NOD2) | Nucleotide-binding oligomerization domain 1 (NOD1) | Nucleotide-binding oligomerization domain (NOD) leucine-rich repeat (NLR) | CROHNS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | NUCLEOTIDE-BINDING | DIAMINOPIMELIC ACID | INTESTINAL EPITHELIAL-CELLS | CELL BIOLOGY | nucleotide-binding oligomerization domain 1 (NOD1) | nucleotide-binding oligomerization domain (NOD) leucine-rich repeat (NLR) | FAMILY-MEMBER | nucleotide-binding oligomerization domain 2 (NOD2) | inflammation | MURAMYL DIPEPTIDE | nuclear factor-kappa B (NF-kappa B) | TOLL-LIKE RECEPTORS | BACTERIAL-INFECTION | NF-KAPPA-B | PATTERN-RECOGNITION RECEPTORS | Immunity, Innate - drug effects | Anti-Inflammatory Agents - pharmacology | Bacterial Infections - drug therapy | Humans | Gene Expression Regulation | Nod2 Signaling Adaptor Protein - immunology | Bacterial Physiological Phenomena | Nod2 Signaling Adaptor Protein - genetics | Inflammation - immunology | Nod1 Signaling Adaptor Protein - immunology | Host-Pathogen Interactions | Bacterial Infections - genetics | Animals | Bacterial Infections - immunology | Inflammation - drug therapy | Nod2 Signaling Adaptor Protein - antagonists & inhibitors | Inflammation - genetics | Nod1 Signaling Adaptor Protein - antagonists & inhibitors | Nod1 Signaling Adaptor Protein - genetics | IRF, interferon regulatory factor | TRAF, tumour-necrosis-factor-receptor-associated factor | NEMO, NF-κB essential modulator | TLR, Toll-like receptor | DC, dendritic cell | CARD, caspase recruitment domain | IL-6, interleukin 6 | Review | JNK, c-Jun N-terminal kinase | MDP, muramyl dipeptide | SCF, stem cell factor | IAP, inhibitor of apoptosis protein | AP-1, activator protein 1 | ERK, extracellular-signal-regulated kinase | RIP2, receptor-interacting protein 2 | BMT, bone marrow transplant | HFD, high-fat diet | LUBAC, linear ubiquitin chain assembly complex | IFN, interferon | DAP, L-Ala-γ-D-Glu-m-diaminopimelic acid | NLR, NOD-LRR | NLRC, NOD-LRR family with CARD | c-IAP1, cellular IAP1 | LRR, leucine-rich repeat | MAVS, mitochondrial antiviral signalling | MKK, MAPK kinase | PG, peptidoglycan | nuclear factor-κB (NF-κB) | NOD, nucleotide-binding oligomerization domain | IKK, inhibitory κB kinase | KO, knockout | TBK1, TRAF-associated nuclear factor-κB activator-binding kinase 1 | IBD, inflammatory bowel disease | β-TrCP, β-transducin repeat-containing protein | BIR, baculovirus IAP repeat | XIAP, X-linked IAP | MAPK, mitogen-activated protein kinase | EAE, experimental autoimmune encephalomyelitis | TAB, TGF (transforming growth factor)-β-activated kinase-binding protein
Journal Article