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alzheimer's disease (5) 5
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Neurodegenerative Diseases, ISSN 1660-2854, 02/2010, Volume 6, Issue 5-6, pp. 230 - 239
Journal Article
Acta Pharmaceutica Sinica B, ISSN 2211-3835, 11/2015, Volume 5, Issue 6, pp. 506 - 519
Cysteine proteases continue to provide validated targets for treatment of human diseases. In neurodegenerative disorders, multiple cysteine proteases provide... 
Calpain | Cathepsin | Enzyme inhibitors | Cysteine protease | Neurodegeneration | Alzheimer's disease | BETA-SECRETASE | ALZHEIMERS-DISEASE | FOCAL CEREBRAL-ISCHEMIA | AMYLOID PRECURSOR PROTEIN | TRAUMATIC BRAIN-INJURY | PEPTIDE-BIPHENYL HYBRIDS | AFFINITY LABEL CONCEPT | IN-VIVO | PHARMACOLOGY & PHARMACY | SPINAL-CORD-INJURY | TRANSGENIC MOUSE MODEL | APP | AppLon, London familial amyloid precursor protein mutation, APP (V717I) | NFT, neurofibrilliary tangles | Ile, isoleucine | Arg, arginine | Lys, lysine | Gln, glutamine | Thr, threonine | AppSwe, Swedish amyloid precursor protein mutation, APP (K670N | Gly, glutamine | ERK1 | PD, Parkinson׳s disease | MMP-9, matrix metalloproteinase 9 | Tyr, tyrosine | WT, wildtype | WRX, Trp-Arg containing epoxysuccinate cysteine protease inhibitor | TNF, tumor necrosis factor | SP, senile plaques | Alzheimer׳s disease | PS1, Aβ overexpressing mice APP (K670N | EGFR, epidermal growth factor receptor | pGlu, pyroglutamate | p35, activator of cyclin-dependent kinase 5 | AD, Alzheimer׳s disease | CaMKII, Ca2 | KO, knockout | PK, pharmacokinetic | Phe, phenylalanine | Aβ, amyloid β | TBI, traumatic brain injury | calmodulin-dependent protein kinases II | DTT, dithioerythritol | APP, amyloid precursor protein | isoAsp, isoaspartate | Glu, glutamic acid | Leu, leucine | GSH, glutathione | PTP1B, protein-tyrosine phosphatase 1B | Review | ALS, amyotrophic lateral sclerosis | CREB, cyclic adenosine monophosphate response element binding protein | 2, extracellular signal-regulated kinase 1 | MAP-2, microtubule-associated protein 2 | M671L) and PS1 (M146L) mutants | Nle, norleucine | CANP, calcium-activated neutral protease | Hsp70.1, heat shock protein 70.1 | Met, methionine | BACE-1, β-amyloid cleaving enzyme | M671L | Aβ1-42, amyloid β, 42 amino acid protein | PKC, protein kinase C | BBB, blood–brain barrier | Pro, proline | CNS, central nervous system | Val, valine | Cdk5 | pyroGluAβ, pyroglutamate-amyloid β | Ala, alanine
Journal Article
Expert Opinion on Therapeutic Patents, ISSN 1354-3776, 06/2007, Volume 17, Issue 6, pp. 737 - 740
This application describes the further evolution of non-peptidic inhibitors of β-amyloid cleaving enzyme (BACE1) for the treatment of Alzheimer's disease.... 
β-secretase | aspartyl protease inhibitors | Alzheimer's disease | β-amyloid cleaving enzyme (BACE1) | Aspartyl protease inhibitors
Journal Article
Expert Opinion on Therapeutic Patents, ISSN 1354-3776, 06/2007, Volume 17, Issue 6, pp. 737 - 740
This application describes the further evolution of non-peptidic inhibitors of β-amyloid cleaving enzyme (BACE1) for the treatment of Alzheimer's disease.... 
β-secretase | aspartyl protease inhibitors | Alzheimer's disease | β-amyloid cleaving enzyme (BACE1) | PHARMACOLOGY & PHARMACY | beta-amyloid cleaving enzyme (BACE1) | MEDICINE, LEGAL | beta-secretase
Journal Article
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