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FEBS Letters, ISSN 0014-5793, 2010, Volume 584, Issue 9, pp. 1748 - 1759
Simple sphingolipids such as ceramide and sphingomyelin (SM) as well as more complex glycosphingolipids play very important roles in cell function under... 
Ganglioside | Neurodegeneration | Sphingolipid | Ceramide | Sphingomyelin | Membrane | Huntington’s disease | Alzheimer | Parkinson | interleukin 1β | APP | JNK | sodium–calcium exchanger | platelet-derived growth factor | contactin-associated protein | Trk | fibroblast growth factor | PI3K | acidic sphingomyelinase | glycosphingolipids | mTOR | Src-family kinase | TAG-1 | TRPC5 | FGF | aSMase | IL1β | PKC | NGF | SERCA | sarcoplasmic/endoplasmic reticulum Ca2+-ATPase | neurofascin-155 | neutral sphingomyelinase | GSLs | PAG-N | caspr | ROS | epidermal growth factor | phosphoinositide 3-kinase | transient receptor potential cation channel subfamily C member 5 | nSMase | NCX | phosphoprotein associated with glycospingolipid-enriched microdomains | N-acetyl-α-neuraminidase 3 | NT-3 | N-methyl-d-aspartate | Neu3 | mammalian target of rapamycin | SBD | amyloid precursor protein | nerve growth factor | reactive oxygen species | NMDA | SFK | c-Jun-N-terminal kinase | transient-axonal glycoprotein 1 | protein kinase C | neurotrophin 3 | EGF | β-site APP-cleavage enzyme | sphingolipid-binding domain | Huntington's disease | NF-155 | PDGF | sphingomyelin | tropomyosin-receptor kinase | BACE | PROTEIN | GM1 GANGLIOSIDE | ALZHEIMERS-DISEASE | PHOSPHATIDYLINOSITOL 3-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | NECROSIS-FACTOR-ALPHA | CELL-ADHESION | CELL BIOLOGY | GROWTH-FACTOR RECEPTOR | BIOPHYSICS | METABOLISM | LIPIDOMIC ANALYSIS | Sphingolipids - chemistry | Intracellular Membranes - physiology | Humans | Nervous System - metabolism | Organelles - physiology | Nerve Degeneration - physiopathology | Sphingolipids - physiology | Cell Membrane - physiology | Nerve Degeneration - metabolism | Membrane Proteins - physiology | Gangliosides - metabolism | Nervous System Physiological Phenomena | Cell Membrane - pathology | Gangliosides - physiology | Membrane Proteins - metabolism | Nervous System Diseases - physiopathology | Gangliosides - chemistry | Nervous System Diseases - pathology | Organelles - pathology | Sphingolipids - metabolism | Nerve Degeneration - pathology | Aging - pathology | Animals | Aging - physiology | Models, Biological | Organelles - metabolism | Intracellular Membranes - metabolism | Aging - metabolism
Journal Article
EBioMedicine, ISSN 2352-3964, 07/2019, Volume 45, pp. 393 - 407
Journal Article
Neuron, ISSN 0896-6273, 08/2013, Volume 79, Issue 3, pp. 447 - 460
The convergence of APP (substrate) and BACE-1 (enzyme) is a rate-limiting, obligatory event triggering the amyloidogenic pathway—a key step in Alzheimer’s... 
RECYCLING ENDOSOMES | SYNAPTIC FUNCTION | AMPA RECEPTORS | ALZHEIMERS-DISEASE | IN-VIVO | TRAFFICKING | AXONAL-TRANSPORT | AMYLOID PRECURSOR PROTEIN | NEUROSCIENCES | CULTURED HIPPOCAMPAL-NEURONS | BETA | Amyloid Precursor Protein Secretases - genetics | Membrane Microdomains - metabolism | Protein Transport - physiology | Aspartic Acid Endopeptidases - genetics | rab5 GTP-Binding Proteins - metabolism | Case-Control Studies | Alzheimer Disease - pathology | Brain - metabolism | Neurons - ultrastructure | Amyloid beta-Protein Precursor - metabolism | Organ Culture Techniques | Animals, Newborn | Enzyme Inhibitors - pharmacology | Clathrin - genetics | Clathrin-Coated Vesicles - drug effects | Excitatory Amino Acid Antagonists - pharmacology | Hippocampus - cytology | Nerve Tissue Proteins - genetics | Clathrin - metabolism | Endocytosis - physiology | GABA Antagonists - pharmacology | Nerve Tissue Proteins - metabolism | Amyloid Precursor Protein Secretases - metabolism | Animals | Glycine - pharmacology | Aspartic Acid Endopeptidases - metabolism | Brain - pathology | Picrotoxin - pharmacology | Signal Transduction - physiology | Mice | Clathrin-Coated Vesicles - physiology | Hydrogen-Ion Concentration | Enzymes | Clathrin | Neurosciences | Amyloidosis | Alzheimer's disease | Amyloid beta-protein | Proteins | Brain research | Sucrose | Neurons | Colleges & universities | Biosynthesis | Alzheimers disease | Convergence | recycling endosomes | β-site APP cleaving enzyme (BACE-1) | amyloid precursor protein (APP) | neuronal activity | vesicle trafficking
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 07/2010, Volume 114, Issue 2, pp. 374 - 385
Journal Article
Journal of Pineal Research, ISSN 0742-3098, 10/2015, Volume 59, Issue 3, pp. 308 - 320
Journal Article
Nature neuroscience, ISSN 1097-6256, 1/2016, Volume 19, Issue 1, pp. 55 - 64
Cleavage of APP (amyloid precursor protein) by BACE-1 (β-site APP cleaving enzyme-1) is the rate-limiting step in amyloid-beta (Aβ) production and a... 
recycling endosomes | β-site APP cleaving enzyme (BACE-1) | amyloid precursor protein (APP) | Bimolecular fluorescence complementation | Alzheimer's disease | vesicle trafficking
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 02/2007, Volume 100, Issue 3, pp. 802 - 809
Generation and deposition of the amyloid β (Aβ) peptide following proteolytic processing of the amyloid precursor protein (APP) by BACE‐1 and γ‐secretase is... 
secretase | p‐glycoprotein | TASTPM | amyloid precursor protein | Alzheimer's disease | β‐site amyloid precursor protein cleaving enzyme 1 | β-site amyloid precursor protein cleaving enzyme 1 | p-glycoprotein | Amyloid precursor protein | Secretase | SITE | ASPARTYL PROTEASE | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | IDENTIFICATION | NEUROSCIENCES | beta-site amyloid precursor protein cleaving enzyme 1 | SECRETASE ACTIVITY | PURIFICATION | MICE | BRAIN | STRUCTURE-BASED DESIGN | Thiazines - therapeutic use | Amyloid beta-Protein Precursor - chemistry | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Male | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Enzyme Inhibitors - chemical synthesis | Brain - metabolism | Peptides - metabolism | Amyloid beta-Protein Precursor - metabolism | Thiazines - pharmacology | Disease Models, Animal | Alzheimer Disease - physiopathology | Administration, Oral | Aspartic Acid Endopeptidases - antagonists & inhibitors | Amyloid beta-Peptides - biosynthesis | Brain - physiopathology | Enzyme Inhibitors - pharmacology | Alzheimer Disease - drug therapy | Mice, Transgenic | Treatment Outcome | Down-Regulation - drug effects | Enzyme Inhibitors - therapeutic use | Thiazines - chemical synthesis | Brain - drug effects | Down-Regulation - physiology | Amyloid Precursor Protein Secretases - metabolism | Animals | Aspartic Acid Endopeptidases - metabolism | Alzheimer Disease - metabolism | Cell Line, Tumor | Mice | Amyloid Precursor Protein Secretases - antagonists & inhibitors
Journal Article