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Journal of Neurochemistry, ISSN 0022-3042, 07/2010, Volume 114, Issue 2, pp. 374 - 385
Journal Article
American Journal of Physiology - Endocrinology And Metabolism, ISSN 0193-1849, 12/2010, Volume 299, Issue 6, pp. 1087 - 1095
Journal Article
International Journal of Molecular Medicine, ISSN 1107-3756, 7/2014, Volume 34, Issue 1, pp. 160 - 166
Amyloid precursor protein (APP) and β-site APP cleaving enzyme (BACE-1) play important roles in the pathogenesis of Alzheimer's disease (AD). In this study,... 
β-site amyloid precursor protein cleaving enzyme | microRNA | amyloid precursor protein | Alzheimer's disease | MicroRNA | Amyloid precursor protein | BACE1 | MEDICINE, RESEARCH & EXPERIMENTAL | APP | MICE | CEREBROSPINAL-FLUID | beta-site amyloid precursor protein cleaving enzyme | CANCER
Journal Article
FEBS Journal, ISSN 1742-464X, 03/2010, Volume 277, Issue 6, pp. 1503 - 1518
Journal Article
Journal of International Pharmaceutical Research, ISSN 1674-0440, 08/2014, Volume 41, Issue 4, pp. 400 - 406
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 06/2002, Volume 81, Issue 5, pp. 1011 - 1020
Journal Article
The International Journal of Neuropsychopharmacology, ISSN 1461-1457, 2/2012, Volume 15, Issue 1, pp. 77 - 90
Journal Article
Neuroscience Letters, ISSN 0304-3940, 02/2018, Volume 665, pp. 80 - 85
Amyloid precursor protein (APP) proteolysis is essential for the production of β-amyloid peptides (Aβ) that form senile plaques in Alzheimer’s disease (AD)... 
Chitosan oligosaccharides | β-Site amyloid precursor protein cleaving enzyme 1 (BACE1) | Alzheimer's disease | β-Amyloid peptide | ACID | REDUCTION | beta-Amyloid peptide | enzyme 1 (BACE1) | beta-Site amyloid precursor protein cleaving | PATHOLOGY | TRANSGENIC MOUSE MODEL | PLAQUE | NEUROSCIENCES | IMPAIRMENT | Index Medicus
Journal Article
Biochemical Journal, ISSN 0264-6021, 01/2012, Volume 441, Issue 1, pp. 285 - 295
Insulin resistance and impaired glucose homoeostasis are important indicators of Type 2 diabetes and are early risk factors of AD (Alzheimer's disease). An... 
β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) | Glucose uptake | Uncoupling protein (UCP) | Insulin sensitivity | Liver | Skeletal muscle | BETA-SECRETASE ACTIVITY | HIGH-FAT-DIET | beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1) | liver | ALZHEIMERS-DISEASE | FOOD-INTAKE | BIOCHEMISTRY & MOLECULAR BIOLOGY | AMYLOID PRECURSOR PROTEIN | BROWN ADIPOSE-TISSUE | KNOCKOUT MICE | insulin sensitivity | glucose uptake | RESISTANCE | UNCOUPLING PROTEIN-3 | skeletal muscle | uncoupling protein (UCP) | GROWTH-FACTOR EXPRESSION | Amyloid Precursor Protein Secretases - genetics | Cell Line | Dietary Fats - adverse effects | Obesity - chemically induced | Ion Channels | Insulin Resistance | Gene Expression Regulation - physiology | Blood Glucose | Glucose - genetics | Aspartic Acid Endopeptidases - genetics | Mitochondrial Proteins | Obesity - genetics | Mice, Knockout | Obesity - metabolism | Amyloid Precursor Protein Secretases - metabolism | Myoblasts - metabolism | Animals | Adiposity | Diet | Aspartic Acid Endopeptidases - metabolism | Dietary Fats - administration & dosage | Glucose - metabolism | Mice | Uncoupling Protein 1 | Index Medicus | WT, wild-type | AMPK, AMP-activated protein kinase | FFA, free fatty acid | HBS, Hepes-buffered saline | PKB, protein kinase B | Aβ, β-amyloid peptide | DMEM, Dulbecco's modified Eagle's medium | HFD, high-fat diet | ITT, insulin tolerance test | OGTT, oral glucose tolerance test | qRT-PCR, quantitative real-time PCR | IGTT, intraperitoneal glucose tolerance test | RMR, resting metabolic rate | BAT, brown adipose tissue | FBS, fetal bovine serum | RQ, respiratory quotient | T4, thyroxine | WAT, white adipose tissue | AD, Alzheimer's disease | TG, triacylglycerol | qMR, quantitative magnetic resonance | PDK, phosphoinositide-dependent kinase | UCP, uncoupling protein | ADDL, Aβ-derived diffusible ligands | BACE1, β-site amyloid precursor protein-cleaving enzyme 1 | APP, amyloid precursor protein | IRS, insulin receptor substrate
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 02/2007, Volume 100, Issue 3, pp. 802 - 809
Generation and deposition of the amyloid β (Aβ) peptide following proteolytic processing of the amyloid precursor protein (APP) by BACE‐1 and γ‐secretase is... 
secretase | TASTPM | glycoprotein | amyloid precursor protein | Alzheimer's disease | β‐site amyloid precursor protein cleaving enzyme 1 | β-site amyloid precursor protein cleaving enzyme 1 | p-glycoprotein | Amyloid precursor protein | Secretase | SITE | ASPARTYL PROTEASE | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | IDENTIFICATION | NEUROSCIENCES | beta-site amyloid precursor protein cleaving enzyme 1 | SECRETASE ACTIVITY | PURIFICATION | MICE | BRAIN | STRUCTURE-BASED DESIGN | Thiazines - therapeutic use | Amyloid beta-Protein Precursor - chemistry | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Male | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Enzyme Inhibitors - chemical synthesis | Brain - metabolism | Peptides - metabolism | Amyloid beta-Protein Precursor - metabolism | Thiazines - pharmacology | Disease Models, Animal | Alzheimer Disease - physiopathology | Administration, Oral | Aspartic Acid Endopeptidases - antagonists & inhibitors | Amyloid beta-Peptides - biosynthesis | Brain - physiopathology | Enzyme Inhibitors - pharmacology | Alzheimer Disease - drug therapy | Mice, Transgenic | Treatment Outcome | Down-Regulation - drug effects | Enzyme Inhibitors - therapeutic use | Thiazines - chemical synthesis | Brain - drug effects | Down-Regulation - physiology | Amyloid Precursor Protein Secretases - metabolism | Animals | Aspartic Acid Endopeptidases - metabolism | Alzheimer Disease - metabolism | Cell Line, Tumor | Mice | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Index Medicus
Journal Article