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STEM CELLS, ISSN 1066-5099, 01/2013, Volume 31, Issue 1, pp. 137 - 145
The regeneration of the hematopoietic system following total body irradiation is supported by host‐derived mesenchymal stromal cells (MSCs) within the bone... 
Mesenchymal stromal cells | DNA damage checkpoints | DNA damage response | DNA repair | γ‐Radiation | Apoptosis | γ-radiation | NICHE | CANCER | gamma-Radiation | TRANSPLANTATION | CELL & TISSUE ENGINEERING | CELL BIOLOGY | IRRADIATION | MICROENVIRONMENT | ONCOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | MURINE BONE-MARROW | BLOOD STEM-CELL | HEMATOPOIETIC RECOVERY | DIFFERENTIATION | IONIZING-RADIATION | HEMATOLOGY | Mesenchymal Stromal Cells - radiation effects | CD4-Positive T-Lymphocytes - radiation effects | DNA Repair - radiation effects | Histones - biosynthesis | DNA Breaks, Double-Stranded - radiation effects | CD8-Positive T-Lymphocytes - radiation effects | Mesenchymal Stromal Cells - cytology | bcl-X Protein - biosynthesis | DNA Ligases - biosynthesis | Radiation, Ionizing | Cell Differentiation - radiation effects | Cell Line | Signal Transduction | Cell Cycle Proteins - biosynthesis | Ataxia Telangiectasia Mutated Proteins | Proto-Oncogene Proteins c-bcl-2 - biosynthesis | Protein-Serine-Threonine Kinases - biosynthesis | Cell Cycle Checkpoints | Animals | Radiation Tolerance - physiology | Checkpoint Kinase 2 | DNA Ligase ATP | Mice | Histones - metabolism | Tumor Suppressor Proteins - biosynthesis | DNA-Binding Proteins - biosynthesis | DNA Damage - radiation effects | Cell Proliferation - radiation effects | DNA damage | Oncology, Experimental | Automated teller machines | Transplantation | Information management | Research | Radiotherapy | Financial disclosure | Gamma rays | Nuclear radiation | Ligases | Analysis | DNA | Stem cells | Physiological aspects | Bone marrow | Cancer | Transplants & implants | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2014, Volume 9, Issue 1, pp. e87079 - e87079
Tissue consequences of radiation exposure are dependent on radiation quality and high linear energy transfer (high-LET) radiation, such as heavy ions in space... 
POLYCYSTIC-OVARY-SYNDROME | BREAST-CANCER | MURINE MODEL | INFLAMMATORY-BOWEL-DISEASE | MULTIDISCIPLINARY SCIENCES | GASTROINTESTINAL-TRACT | PYRUVIC-ACID | SPACE EXPLORATION | IONIZING-RADIATION | PROSTAGLANDIN E-2 | SPECTROMETRY-BASED METABOLOMICS | Immunohistochemistry | Gamma Rays - adverse effects | Mice, Inbred C57BL | Immunoblotting | Intestines - metabolism | Chromatography, High Pressure Liquid | Metabolomics - methods | Amino Acids - metabolism | Animals | Mass Spectrometry | Gene Expression Regulation - radiation effects | Female | Mice | Heavy Ions - adverse effects | Radiation Injuries, Experimental - metabolism | Disease | Guanosine | Radiation | Biochemistry | Proteins | Signal transduction | Alterations | Animal tissues | Bioindicators | Heavy ion radiation | Radiation effects | γ Radiation | Cytokines | Spatial analysis | Mass spectroscopy | Liquid chromatography | Exposure | Metabolism | Radiation dosage | Uridine | Biomarkers | Mass spectrometry | Energy transfer | Radiation damage | Oxidative stress | Metabolomics | Inflammatory bowel diseases | Heavy ions | Spatial discrimination | Amino acids | Biosynthesis | Kinases | Quadrupoles | Metabolites | Linear energy transfer (LET) | Intestine | Risk assessment | Radiation injuries | Extraterrestrial radiation | Chronic illnesses | Urine | Adenine | Inflammation | Radiation therapy | Signaling | Space missions | Cellular biology | Astronauts | α Radiation | Cancer | Long-term effects | Index Medicus
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2012, Volume 7, Issue 8, pp. e42224 - e42224
Ionizing radiation-induced oxidative stress is attributed to generation of reactive oxygen species (ROS) due to radiolysis of water molecules and is short... 
NADPH-OXIDASE | INFLAMMATORY-BOWEL-DISEASE | BIOLOGICAL EFFECTIVENESS | INDUCED GENOMIC INSTABILITY | EPITHELIAL-CELLS | MULTIDISCIPLINARY SCIENCES | DNA-DAMAGE | ANTIOXIDANT ENZYMES | MITOCHONDRIAL DYSFUNCTION | IONIZING-RADIATION | REPLICATIVE SENESCENCE | Epithelial Cells - radiation effects | Epithelial Cells - metabolism | Reactive Oxygen Species - metabolism | Gamma Rays - adverse effects | Intestines - radiation effects | Mice, Inbred C57BL | Cells, Cultured | NADPH Oxidases - metabolism | Animals | Cosmic Radiation - adverse effects | Female | Mice | Oxidative Stress - radiation effects | DNA Damage - radiation effects | Heavy Ions - adverse effects | Intestines - cytology | Gamma rays | Oxidative stress | Reactive oxygen species | Physiological aspects | Causes of | Development and progression | Research | Immunohistochemistry | Flow cytometry | Transformation | Senescence | Laboratories | Epithelial cells | DNA damage | Oxidase | Irradiated | Biology | Biochemistry | NAD(P)H oxidase | Cosmic rays | Antioxidants | Iron isotopes | Mitochondria | Ionizing radiation | Linear energy transfer (LET) | Intestine | Rodents | Animal tissues | Radiolysis | Tumorigenesis | Membrane potential | Heavy ion radiation | Deoxyribonucleic acid--DNA | Stresses | Enzymes | Radiation effects | Damage assessment | Water chemistry | γ Radiation | Superoxide | Exposure | Radiation therapy | Gene expression | Stress | Radiation dosage | Studies | Cytometry | Cell death | Intracellular | Energy transfer | Radiation damage | Cancer | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2015, Volume 10, Issue 11, pp. e0143606 - e0143606
Radiotherapy of individuals suffering with head & neck or brain tumors subserve the risk of sensorineural hearing loss. Here, we evaluated the protective... 
AMIFOSTINE | MULTIDISCIPLINARY SCIENCES | RADIATION-THERAPY | PROTECTS | Spiral Ganglion - drug effects | Spiral Ganglion - radiation effects | Guinea Pigs | Sulfhydryl Compounds - pharmacology | Hair Cells, Auditory - radiation effects | Hearing Loss, Sensorineural - prevention & control | Injections, Intraperitoneal | Cochlea - radiation effects | Radiotherapy - adverse effects | Ear, Inner - drug effects | Hair Cells, Auditory - drug effects | Hearing | Animals | Evoked Potentials, Auditory, Brain Stem | Ear, Inner - radiation effects | Cochlea - drug effects | Hearing Loss, Sensorineural - etiology | Radiation-Protective Agents - pharmacology | Audiometry, Pure-Tone | Diamines - pharmacology | Sulfhydryl Compounds - chemistry | Dose-Response Relationship, Radiation | Usage | Research | Guinea pigs | Health aspects | Central nervous system | Radiation | Brain | Pediatrics | Spiral ganglion | Brain stem | Hair cells | Brain tumors | Brain cancer | Irradiated | Otolaryngology | Cytotoxicity | Oncology | Hearing protection | Cancer therapies | Inner ear | Neurodegeneration | Surgery | Radiation injuries | Degeneration | Neck | Drug dosages | Post-radiation | Hair | Radiation effects | γ Radiation | Head | Radiation therapy | Hearing impairment | Radiation dosage | Hearing loss | Studies | Gamma rays | Otology | Brain research | Gamma radiation | Ear | Cochlea | Radiation damage | Peritoneum | Tumors | Apoptosis | Index Medicus
Journal Article
Nuclear Inst. and Methods in Physics Research, A, ISSN 0168-9002, 09/2004, Volume 531, Issue 1-2, pp. 18 - 37
We discuss the potential benefits of using compound semiconductors for the detection of X- and γ-ray radiation. While Si and Ge have become detection standards... 
Compound semiconductors | γ-Rays | X-rays | Detectors | NUCLEAR-PARTICLE DETECTOR | RESOLUTION X-RAY | GAMMA-RAY DETECTORS | PHYSICS, NUCLEAR | detectors | CRYSTAL | SILICON-CARBIDE | compound semiconductors | CVD DIAMOND | TRANSPORT | INSTRUMENTS & INSTRUMENTATION | SPECTROSCOPY | SPECTROMETERS | NUCLEAR SCIENCE & TECHNOLOGY | THALLIUM LEAD IODIDE | gamma-rays | PHYSICS, PARTICLES & FIELDS
Journal Article
Neurotoxicology, ISSN 0161-813X, 05/2017, Volume 60, pp. 70 - 81
Effect of ionizing radiation on the brain affects neuronal, glial, and endothelial cell population and lead to significant morphological, metabolic, and... 
Radiation-induced injury | Dentate gyrus | Fractionated irradiation | SVZ-OB axis | Neurogenesis | 1H MRS | H MRS | MOUSE-BRAIN | ULTRASTRUCTURAL-CHANGES | ADULT NEUROGENESIS | NEUROSCIENCES | H-1 MRS | PHARMACOLOGY & PHARMACY | CENTRAL-NERVOUS-SYSTEM | TOXICOLOGY | FRACTIONATED-IRRADIATION | CRANIAL IRRADIATION | TNF-ALPHA | HIPPOCAMPAL NEUROGENESIS | RADIATION-INJURY | FLUORO-JADE | Olfactory Bulb - pathology | Rats, Wistar | Corpus Striatum - radiation effects | Microtubule-Associated Proteins - metabolism | Olfactory Bulb - radiation effects | Male | Neuropeptides - metabolism | Brain - radiation effects | Hippocampus - pathology | Olfactory Bulb - metabolism | Corpus Striatum - metabolism | Organ Size - radiation effects | Brain - metabolism | Astrocytes - radiation effects | Hippocampus - metabolism | Animals | Proton Magnetic Resonance Spectroscopy | Body Weight - radiation effects | Hippocampus - radiation effects | Brain - pathology | Neurogenesis - radiation effects | Neurons - radiation effects | Corpus Striatum - pathology | Immunohistochemistry | Neuroimaging | Brain | Image processing | Confocal microscopy | Confocal | Creatine | Neuronal-glial interactions | Magnetic resonance spectroscopy | Proton magnetic resonance | T-cell receptor | Ionizing radiation | γ-Aminobutyric acid | Histopathology | Metabolites | Neurodegeneration | Neostriatum | Inhibition | Lesions | Food irradiation | Spectroscopy | Radiation effects | Astrocytes | Rats | Inflammation | Radiation dosage | Image analysis | Gliosis | Microscopy | Cell death | Irradiation | Olfactory bulb | Laboratory animals | Viability | Neurotransmission | Histochemistry | α Radiation | Hippocampus | Index Medicus
Journal Article
Journal Article
Archives of Physiology and Biochemistry, ISSN 1381-3455, 03/2018, Volume 124, Issue 2, pp. 185 - 193
This study was designed to evaluate the effect of rutin on PI3K/AKT-signalling in case of acrylamide or gamma-radiation-induced neurotoxicity. To induce brain... 
γ-radiation | acrylamide | MDA | IL-1β | Rutin | PI3K/AKT/GSK-3β/NRF-2 | APOPTOSIS | OXIDATIVE STRESS | PHYSIOLOGY | RATS | ISCHEMIA | IL-1 beta | MECHANISMS | DAMAGE | IRRADIATION | ENDOCRINOLOGY & METABOLISM | gamma-radiation | GENE-EXPRESSION | HEME OXYGENASE-1 | HEALTH | PI3K/AKT/GSK-beta 3 /NRF-2 | Neuroprotective Agents - therapeutic use | Neurons - pathology | Gamma Rays - adverse effects | Male | Brain - metabolism | Neurotoxicity Syndromes - pathology | Protein Processing, Post-Translational - drug effects | Neurons - metabolism | Oxidative Stress - radiation effects | Environmental Pollutants - toxicity | Phosphorylation - drug effects | Neurons - drug effects | Neurotoxicity Syndromes - immunology | MAP Kinase Signaling System - radiation effects | Radiation Injuries - immunology | Nerve Tissue Proteins - radiation effects | Protein Processing, Post-Translational - radiation effects | Neurotoxicity Syndromes - prevention & control | Brain - radiation effects | Nerve Tissue Proteins - drug effects | Rats, Sprague-Dawley | Brain - drug effects | Gene Expression Regulation - drug effects | Antioxidants - therapeutic use | Phosphorylation - radiation effects | Acrylamide - toxicity | Animals | MAP Kinase Signaling System - drug effects | Radiation Injuries - prevention & control | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Brain - pathology | Gene Expression Regulation - radiation effects | Neurotoxicity Syndromes - metabolism | Radiation-Protective Agents - therapeutic use | Radiation Injuries - pathology | Oxidative Stress - drug effects | Neurons - radiation effects | Radiation Injuries - metabolism | Rutin - therapeutic use | Dietary Supplements | Index Medicus
Journal Article
Toxicology, ISSN 0300-483X, 2009, Volume 262, Issue 1, pp. 43 - 49
Abstract The present study aimed to evaluate the radioprotective effect of lycopene, a naturally occurring dietary carotenoid on γ-radiation-induced toxicity.... 
Emergency | Translocation | Radioprotectors | Lymphocytes | Micronuclei | γ-Radiation | Dicentric aberration | Lycopene | INDUCED DNA-DAMAGE | OXIDATIVE STRESS | LIPID-PEROXIDATION | RATS | PREVENTION | gamma-Radiation | CHROMOSOME-ABERRATIONS | GLUTATHIONE | ENZYMES | PHARMACOLOGY & PHARMACY | TOXICOLOGY | IONIZING-RADIATION | Gamma Rays | Lipid Peroxidation - radiation effects | Catalase - drug effects | Humans | Radiation-Protective Agents - administration & dosage | Carotenoids - pharmacology | Dose-Response Relationship, Drug | Young Adult | Superoxide Dismutase - radiation effects | Chromosome Aberrations - drug effects | Lipid Peroxidation - drug effects | Micronuclei, Chromosome-Defective - drug effects | Radiation-Protective Agents - pharmacology | Adult | Catalase - radiation effects | Glutathione Peroxidase - drug effects | Micronuclei, Chromosome-Defective - radiation effects | DNA Damage - drug effects | Chromosome Aberrations - radiation effects | Cells, Cultured | Thiobarbituric Acid Reactive Substances - metabolism | Antioxidants - pharmacology | Radiation Dosage | Superoxide Dismutase - drug effects | Lymphocytes - drug effects | Antioxidants - administration & dosage | Carotenoids - administration & dosage | Glutathione Peroxidase - radiation effects | Lymphocytes - radiation effects | DNA Damage - radiation effects | Index Medicus
Journal Article