X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (859) 859
γ-secretase (806) 806
humans (621) 621
gamma-secretase (577) 577
alzheimer's disease (572) 572
animals (560) 560
amyloid precursor protein secretases - metabolism (346) 346
amyloid precursor protein (345) 345
alzheimers-disease (339) 339
neurosciences (327) 327
mice (320) 320
presenilin (293) 293
biochemistry & molecular biology (278) 278
notch (239) 239
alzheimer’s disease (222) 222
amyloid precursor protein secretases - antagonists & inhibitors (222) 222
amyloid beta-peptides - metabolism (181) 181
cell biology (173) 173
amyloid beta-protein precursor - metabolism (168) 168
alzheimer disease - metabolism (160) 160
membrane proteins - metabolism (158) 158
γ-secretase inhibitor (148) 148
amyloid precursor protein secretases (139) 139
presenilin-1 (137) 137
in-vivo (136) 136
gamma-secretase inhibitor (126) 126
chemistry, medicinal (124) 124
γ‐secretase (124) 124
intracellular domain (123) 123
nicastrin (119) 119
expression (115) 115
male (111) 111
enzyme inhibitors - pharmacology (110) 110
signal transduction (108) 108
cells, cultured (107) 107
article (106) 106
app (105) 105
cell line, tumor (105) 105
membrane proteins - genetics (104) 104
rats (103) 103
amyloid precursor protein secretases - genetics (101) 101
endopeptidases - metabolism (100) 100
receptors, notch - metabolism (99) 99
cleavage (98) 98
alzheimer disease - drug therapy (96) 96
female (96) 96
a-beta (95) 95
cell line (95) 95
mutation (93) 93
alzheimer disease - genetics (92) 92
secretase (91) 91
γ-secretase inhibitors (89) 89
aspartic acid endopeptidases (88) 88
gamma-secretase inhibitors (87) 87
apoptosis (85) 85
chemistry, organic (82) 82
brain (80) 80
peptide fragments - metabolism (80) 80
proteins (80) 80
amyloid beta-protein precursor - genetics (79) 79
biophysics (78) 78
complex (78) 78
familial alzheimers-disease (77) 77
gamma-secretase activity (77) 77
mice, transgenic (77) 77
neurology (77) 77
β-secretase (76) 76
alzheimer disease (75) 75
brain - metabolism (75) 75
oncology (75) 75
pharmacology & pharmacy (75) 75
structure-activity relationship (75) 75
precursor protein (71) 71
presenilin-1 - metabolism (71) 71
beta-secretase (70) 70
amyloid-beta (69) 69
proteolysis (69) 69
presenilin-1 - genetics (67) 67
activation (66) 66
mice, knockout (66) 66
transfection (66) 66
transgenic mice (66) 66
alzheimer disease - enzymology (65) 65
neurons - metabolism (65) 65
protein (65) 65
β-amyloid (65) 65
amyloid (64) 64
amyloid beta-protein (64) 64
intramembrane proteolysis (63) 63
protein structure, tertiary (62) 62
dose-response relationship, drug (60) 60
signal transduction - physiology (60) 60
transmembrane domain (60) 60
alzheimer disease - pathology (59) 59
disease models, animal (59) 59
amyloid-β (58) 58
hek293 cells (57) 57
membrane glycoproteins - metabolism (57) 57
cancer (55) 55
clinical neurology (55) 55
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (1215) 1215
Chinese (5) 5
Japanese (5) 5
French (2) 2
German (2) 2
Korean (2) 2
Polish (1) 1
Spanish (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Biological Psychiatry, ISSN 0006-3223, 02/2018, Volume 83, Issue 4, pp. 320 - 327
The genetic evidence implicating amyloid-β in the initial stage of Alzheimer’s disease is unequivocal. However, the long biochemical and cellular prodromal... 
Prevention | Therapy | β-Secretase | Amyloid-β | Alzheimer | γ-Secretase
Journal Article
British Journal of Cancer, ISSN 0007-0920, 06/2009, Volume 100, Issue 12, pp. 1879 - 1888
Journal Article
Neuroscience, ISSN 0306-4522, 2016, Volume 330, pp. 236 - 246
Highlights • ILEI shows widespread expression in neurons. • Neuronal ILEI primarily resides in the trans -Golgi network. • ILEI is enriched in the active... 
Neurology | amyloid-β | FAM3C | Alzheimer’s disease | γ-secretase | ILEI | age
Journal Article
Cellular Signalling, ISSN 0898-6568, 07/2019, Volume 59, pp. 76 - 84
Single agent treatment of the γ-secretase inhibitor (GSI-I) or proteasome inhibitor in anaplastic lymphoma kinase positive anaplastic large cell lymphoma (ALK+... 
Synergistic effect | Anaplastic large cell lymphoma | γ-secretase inhibitor | Proteasome inhibitor | Apoptosis
Journal Article
Brain Research, ISSN 0006-8993, 2016, Volume 1633, pp. 73 - 86
Abstract Previous studies of γ-secretase inhibitors (GSIs) and Notch-sparing GSIs have shown reduced amyloid-β (Aβ) peptide levels but increased Notch-related... 
Neurology | γ-Secretase inhibitor | Compound-1 | γ-Secretase modulator
Journal Article
International Journal of Oncology, ISSN 1019-6439, 04/2010, Volume 36, Issue 4, pp. 817 - 822
Journal Article
Pharmaceuticals, ISSN 1424-8247, 03/2019, Volume 12, Issue 1, p. 41
Alzheimer's disease (AD) is a growing global health concern with a massive impact on affected individuals and society. Despite the considerable advances... 
Alzheimer’s disease | γ-secretase | Amyloid hypothesis | BACE-1 | amyloid hypothesis
Journal Article
Acta Neuropathologica, ISSN 0001-6322, 3/2015, Volume 129, Issue 3, pp. 363 - 381
Alzheimer’s disease (AD) is the most common form of dementia in the elderly. This brain neuropathology is characterized by a progressive synaptic dysfunction... 
Pathology | Neurosciences | Medicine & Public Health | Alzheimer’s disease | Presenilins | Endolysosomal trafficking | Autophagy | γ-Secretase | Review
Journal Article
Journal of Cell Science, ISSN 0021-9533, 2015, Volume 128, Issue 8, pp. 1507 - 1517
Journal Article
Journal of Alzheimer's disease : JAD, ISSN 1387-2877, 2012, Volume 31, Issue 2, pp. 335 - 341
Amyloid-β (Aβ) producing enzymes are key targets for disease-modifying Alzheimer’s disease (AD) therapies since Aβ trafficking is at the core of AD... 
γ-secretase | Amyloid | Alzheimer’s
Journal Article
Cell, ISSN 0092-8674, 07/2017, Volume 170, Issue 3, pp. 443 - 456.e14
Alzheimer’s disease (AD)-linked mutations in Presenilins (PSEN) and the amyloid precursor protein (APP) lead to production of longer amyloidogenic Aβ peptides.... 
protein thermosability | Alzheimer’s disease | amyloid precursor protein | presenilin | enzyme thermoactivity | γ-secretase | amyloid beta
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 01/2017, Volume 114, Issue 4, pp. E476 - E485
Journal Article
Autophagy, ISSN 1554-8627, 08/2019, Volume 15, Issue 8, pp. 1407 - 1418
Mutations in the γ-secretase complex are strongly associated with familial Alzheimer disease. Both proteolytic and non-proteolytic functions for the... 
development | autophagy | Dictyostelium | Alzheimer disease | presenilin | γ-secretase | lysosomal trafficking | PROTEIN | gamma-secretase | MACROPINOCYTOSIS | DYSFUNCTION | CELL BIOLOGY
Journal Article
No results were found for your search.

Cannot display more than 1000 results, please narrow the terms of your search.