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Clinical and Experimental Pharmacology and Physiology, ISSN 0305-1870, 09/2019, Volume 46, Issue 9, pp. 791 - 797
The aim of this study was to investigate whether the glutathione peroxidase‐1 gene (GPx‐1) affects cocaine‐induced conditioned place preference (CPP) using a... 
cocaine | conditioned place preference | glutathione peroxidase‐1 gene | σ‐1 receptor | Nucleus accumbens | Glutathione peroxidase | Rodents | Transgenic mice | Mice | Cocaine | Peroxidase | Immunoreactivity | Inhibition | Conditioning | Glutathione | Index Medicus
Journal Article
Neuroscience, ISSN 0306-4522, 2016, Volume 332, pp. 53 - 60
Journal Article
Neuroscience, ISSN 0306-4522, 2011, Volume 177, pp. 12 - 22
Abstract The sigma receptor 1 (σR1) has been shown to modulate the activity of several voltage- and ligand-gated channels. Using patch-clamp techniques in rat... 
Neurology | neurotransmission | σR1 | NMDA receptor | retina | ganglion cells | G protein | Retina | Ganglion cells | Neurotransmission | PROTEIN-KINASE-C | INTRACELLULAR CALCIUM | SYNAPTIC-TRANSMISSION | PHOSPHOLIPASE-C | NEUROSCIENCES | PREFRONTAL CORTEX | IN-VITRO | PITUITARY MELANOTROPE CELLS | NEURONS | LIGAND (+)-PENTAZOCINE | sigma R1 | METHYL-D-ASPARTATE
Journal Article
Neuropharmacology, ISSN 0028-3908, 2006, Volume 50, Issue 3, pp. 380 - 392
Dehydroepiandrosterone sulfate (DHEAS), one of the most abundant neurosteroids synthesized de novo in the nervous system, has well characterized effects on... 
Sigma 1 (σ 1) receptor | Optical recording | Long-term potentiation (LTP) | Hippocampus | Dehydroepiandrosterone sulfate (DHEAS) | receptor | Sigma | sigma | hippocampus | optical recordin.g | GLUTAMATE RELEASE | (sigma) receptor | ALZHEIMERS-DISEASE | long-term potentiation (LTP) | SYNAPTIC-TRANSMISSION | MEMORY RETENTION | dehydroepiandrosterone sulfate (DHEAS) | NEUROSCIENCES | INDUCED LEARNING IMPAIRMENT | VIVO ANTISENSE STRATEGY | PREGNENOLONE SULFATE | PHARMACOLOGY & PHARMACY | ELECTRICAL-ACTIVITY | BINDING-SITES | METHYL-D-ASPARTATE | Excitatory Postsynaptic Potentials - radiation effects | Rats, Wistar | Anisoles - pharmacology | Male | Hippocampus - drug effects | Excitatory Postsynaptic Potentials - drug effects | Diagnostic Imaging - methods | Excitatory Postsynaptic Potentials - physiology | Drug Interactions | Long-Term Potentiation - drug effects | Membrane Proteins - physiology | Endoplasmic Reticulum - drug effects | 6-Cyano-7-nitroquinoxaline-2,3-dione - pharmacology | Long-Term Potentiation - physiology | Tetrodotoxin - pharmacology | Electric Stimulation - methods | Haloperidol - pharmacology | Endoplasmic Reticulum - physiology | Rats | Excitatory Amino Acid Antagonists - pharmacology | Bicuculline - pharmacology | Hippocampus - cytology | Long-Term Potentiation - radiation effects | GABA Antagonists - pharmacology | Dehydroepiandrosterone Sulfate - administration & dosage | Animals | Propylamines - pharmacology | In Vitro Techniques | Dose-Response Relationship, Radiation | Drug Combinations | Dehydroepiandrosterone | Androgens | Physiological aspects | Tetanus | Haloperidol | Glutamate | Sulfates | Dyes and dyeing
Journal Article
Bioorganic and Medicinal Chemistry, ISSN 0968-0896, 12/2011, Volume 19, Issue 24, pp. 7612 - 7622
Starting from two carbocyclic analogs, a series of 3,3-dimethylpiperidine derivatives was prepared and tested in radioligand binding assays at σ and σ... 
σ Binding | Sterol isomerase binding | Structure-activity relationship | Ligands | 3,3-Dimethylpiperidines
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 2010, Volume 45, Issue 7, pp. 3116 - 3124
Based on a contiguous and structurally as well as biologically diverse set of 87 σ ligands, a 5D-QSAR study was conducted in which a quasi-atomistic receptor... 
Spirocyclic piperidines | 5D-QSAR | σ 1 Receptor ligands | σ 1 Receptor surface
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 2011, Volume 19, Issue 10, pp. 3141 - 3151
Various pharmacophore models for potent σ ligands specify a basic amino group flanked by two different hydrophobic regions in defined distances to the basic... 
Structure–σ 1 affinity relationships | Spirocyclic σ 1 ligands | Conformational analysis | σ 1 Pharmacophore models | σ 1 Receptor ligands | X-ray | Diastereoselectivity
Journal Article
NeuroReport, ISSN 0959-4965, 09/1998, Volume 9, Issue 13, pp. 3069 - 3073
THIS study examined the effects of neurosteroids dehydroepiandrosterone sulfate (DHEAS) and pregnenolone sulfate (PS) and progesterone on the Porsolt forced... 
Antidepressant | Immobility | Dehydroepiandrosterone sulfate | Neurosteroids | Pregnenolone sulfate | σ receptors | NMDA | Mice | immobility | NOREPINEPHRINE | neurosteroids | BEHAVIOR | antidepressant | RELEASE | DEHYDROEPIANDROSTERONE | mice | NEUROSCIENCES | sigma receptors | POTENTIATION | GABA-A | dehydroepiandrosterone sulfate | BINDING | BRAIN | pregnenolone sulfate | METHYL-D-ASPARTATE
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 2009, Volume 17, Issue 10, pp. 3630 - 3641
Several 3 -spiro[[2]benzofuran-1,4′-piperidines] bearing a -fluorobenzyl residue at the N-atom and various substituents in position 3 of the benzofuran system... 
Neuroimaging | Spirocyclic piperidines | 18F Radiotracer | Structure–affinity-relationships | Metabolism | σ 1 Receptor antagonists
Journal Article
Journal of Pharmacological Sciences, ISSN 1347-8613, 2011, Volume 115, Issue 3, pp. 279 - 292
Abstract. Selective agonists ofthe sigma-1 (σ1) ligand-operated chaperone protein, like igmesine or PRE-084, are antidepressants in preclinical depression... 
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 2006, Volume 553, Issue 1, pp. 141 - 145
Methamphetamine and 3,4-methylenedioxymethamphetamine (MDMA) are structurally similar and represent a serious and growing health threat. Earlier studies in our... 
σ Receptor | BD1063 | Locomotor | MDMA
Journal Article
Applied Radiation and Isotopes, ISSN 0969-8043, 2010, Volume 68, Issue 3, pp. 459 - 465
Carbon-11-labeled piperidine ring of -[ -(6-methoxynaphthalen-1-yl)alkyl] derivatives were first designed and synthesized as new selective PET receptor probes.... 
Imaging | Radiotracers | Positron emission tomography | Sigma ( σ) receptors | Piperidine ring of N-[ ω-(6-methoxynaphthalen-1-yl)alkyl] derivatives
Journal Article
Neuropharmacology, ISSN 0028-3908, 2008, Volume 55, Issue 2, pp. 127 - 138
Herein, we show that a single injection of P4 (4 mg/kg) at 1 h or 48 h, but not 96 h, before middle cerebral artery occlusion (MCAO) produces significant... 
Sigma 1 (σ 1) receptor | Extracellular receptor kinase (ERK) | Progesterone (P4) | NMDA receptor (NMDAr) | Middle cerebral artery occlusion (MCAO) | receptor | Sigma 1 (σ | middle cerebral artery occlusion (MCAO) | NMDA RECEPTOR | CEREBELLAR PURKINJE-CELLS | TYROSINE PHOSPHORYLATION | PROTEIN-KINASE | progesterone (P4) | PRECONDITIONING-INDUCED ACTIVATION | HIPPOCAMPAL CA1 REGION | NEUROSCIENCES | CEREBRAL-ARTERY OCCLUSION | PHARMACOLOGY & PHARMACY | RAT HIPPOCAMPUS | extracellular receptor kinase (ERK) | LONG-TERM POTENTIATION | sigma 1(sigma) receptor | METHYL-D-ASPARTATE | Memory - drug effects | Infarction, Middle Cerebral Artery - physiopathology | Infarction, Middle Cerebral Artery - prevention & control | Calcium - metabolism | Progesterone - administration & dosage | Male | Protein Transport - drug effects | N-Methylaspartate - pharmacology | Time Factors | Space Perception - drug effects | Infarction, Middle Cerebral Artery - genetics | Behavior, Animal - drug effects | Cell Death - drug effects | Neuroprotective Agents - administration & dosage | Disease Models, Animal | Rats | Hippocampus - pathology | Infarction, Middle Cerebral Artery - pathology | Maze Learning - drug effects | Rats, Sprague-Dawley | Hormone Antagonists - pharmacology | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Signal Transduction - drug effects | Signal Transduction - physiology | Mifepristone - pharmacology | Neurofilament Proteins - metabolism | Physiological aspects | Brain damage | Progesterone
Journal Article