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Publication Date医学与哲学：临床决策论坛版, ISSN 1002-0772, 2013, Volume 34, Issue 11, pp. 65 - 67
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Loading Rights生物学教学, ISSN 1004-7549, 2015, Volume 40, Issue 4, pp. 2 - 4
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Loading Rights分子植物, ISSN 1674-2052, 2011, Volume 4, Issue 4, pp. 748 - 758
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Loading Rights生物学教学, ISSN 1004-7549, 2013, Volume 38, Issue 11, pp. 72 - 73
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Loading Rights生物学教学, ISSN 1004-7549, 2008, Issue 5, pp. 5 - 7
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蛋白質與纏繞成染色質絲的DNA的交互作用很可能會被核小體列或是更高級的結構所阻擋。為了解決此問題，在酵母菌Sacchromyces cerevisiae中的三磷酸腺苷依賴之染色質重塑複合物 (ATP-dependent chromatin remodeling...
Rsc8 | RSC | chromatin remodeling | SWIRM | 染色質重塑
Rsc8 | RSC | chromatin remodeling | SWIRM | 染色質重塑
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细胞研究：英文版, ISSN 1001-0602, 2011, Volume 21, Issue 3, pp. 396 - 420
Macromolecular assemblies that regulate chromatin structure using the energy of ATP hydrolysis have critical roles in development, cancer, and stem cell...
机制 | 染色质结构 | ATP酶 | 曝气生物滤池 | 干细胞生物学 | 遗传学 | 基因组学 | 染色质重塑 | Chromatin | development | genetics | BAF | biochemistry | SWI/SNF | ACTIN-RELATED PROTEINS | CELL NUCLEAR ANTIGEN | SWI/SNF COMPLEXES | DNA-DAMAGE RESPONSE | chromatin | HISTONE VARIANT H2A.Z | CELL BIOLOGY | RETINOBLASTOMA PROTEIN | TUMOR-SUPPRESSOR | REGULATORY CIRCUITRY | HOMOLOGOUS RECOMBINATION | SNF2 FAMILY-MEMBER | Saccharomyces cerevisiae - metabolism | Transcription Factors - metabolism | Chromosomal Proteins, Non-Histone - metabolism | Adenosine Triphosphate - metabolism | Humans | Actins - metabolism | Adenosine Triphosphatases - metabolism | Chromatin Assembly and Disassembly - genetics | Adenosine Triphosphatases - genetics | BRG1 protein | Transcription | Neurons | Macromolecules | Adenosinetriphosphatase | Genetic screening | Chromatin remodeling | Hydrolysis | Cell fate | Energy | Stem cells | Histones | Subunit structure | Evolution | Nucleosomes | genomics | ATP | Cancer | Tumors | SWI | SNF | Review
机制 | 染色质结构 | ATP酶 | 曝气生物滤池 | 干细胞生物学 | 遗传学 | 基因组学 | 染色质重塑 | Chromatin | development | genetics | BAF | biochemistry | SWI/SNF | ACTIN-RELATED PROTEINS | CELL NUCLEAR ANTIGEN | SWI/SNF COMPLEXES | DNA-DAMAGE RESPONSE | chromatin | HISTONE VARIANT H2A.Z | CELL BIOLOGY | RETINOBLASTOMA PROTEIN | TUMOR-SUPPRESSOR | REGULATORY CIRCUITRY | HOMOLOGOUS RECOMBINATION | SNF2 FAMILY-MEMBER | Saccharomyces cerevisiae - metabolism | Transcription Factors - metabolism | Chromosomal Proteins, Non-Histone - metabolism | Adenosine Triphosphate - metabolism | Humans | Actins - metabolism | Adenosine Triphosphatases - metabolism | Chromatin Assembly and Disassembly - genetics | Adenosine Triphosphatases - genetics | BRG1 protein | Transcription | Neurons | Macromolecules | Adenosinetriphosphatase | Genetic screening | Chromatin remodeling | Hydrolysis | Cell fate | Energy | Stem cells | Histones | Subunit structure | Evolution | Nucleosomes | genomics | ATP | Cancer | Tumors | SWI | SNF | Review
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Loading Rights基因组蛋白质组与生物信息学报：英文版, ISSN 1672-0229, 2016, Volume 14, Issue 1, pp. 42 - 54
Long non-coding RNAs （ineRNAs） play important roles in cancer. They are involved in chromatin remodeling, as well as transcriptional and post-transcriptional...
反义寡核苷酸 | 癌症 | 非编码RNA | 工作机制 | 社会机制 | 转录后调控 | 染色质重塑 | lncRNAs | Antisense oligonucleotides | Chromatin | Transcription regulation | Cancer | LncRNAs | CELL LUNG-CANCER | HEPATOCELLULAR-CARCINOMA | COLORECTAL CANCERS | POOR-PROGNOSIS | GENETICS & HEREDITY | GENE-EXPRESSION | CHROMOSOME CONFORMATION | ENHANCER RNAS | CHROMATIN INTERACTIONS | UP-REGULATION | ANTISENSE OLIGONUCLEOTIDES | Chromatin - metabolism | MicroRNAs - antagonists & inhibitors | Humans | Gene Expression Regulation | Oligonucleotides, Antisense - metabolism | Chromatin Assembly and Disassembly | MicroRNAs - metabolism | RNA, Long Noncoding - genetics | Neoplasms - genetics | MicroRNAs - genetics | Neoplasms - pathology | RNA, Long Noncoding - antagonists & inhibitors | RNA, Long Noncoding - metabolism | Chromatin - chemistry | Review
反义寡核苷酸 | 癌症 | 非编码RNA | 工作机制 | 社会机制 | 转录后调控 | 染色质重塑 | lncRNAs | Antisense oligonucleotides | Chromatin | Transcription regulation | Cancer | LncRNAs | CELL LUNG-CANCER | HEPATOCELLULAR-CARCINOMA | COLORECTAL CANCERS | POOR-PROGNOSIS | GENETICS & HEREDITY | GENE-EXPRESSION | CHROMOSOME CONFORMATION | ENHANCER RNAS | CHROMATIN INTERACTIONS | UP-REGULATION | ANTISENSE OLIGONUCLEOTIDES | Chromatin - metabolism | MicroRNAs - antagonists & inhibitors | Humans | Gene Expression Regulation | Oligonucleotides, Antisense - metabolism | Chromatin Assembly and Disassembly | MicroRNAs - metabolism | RNA, Long Noncoding - genetics | Neoplasms - genetics | MicroRNAs - genetics | Neoplasms - pathology | RNA, Long Noncoding - antagonists & inhibitors | RNA, Long Noncoding - metabolism | Chromatin - chemistry | Review
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Loading Rights细胞研究：英文版, ISSN 1001-0602, 2011, Volume 21, Issue 3, pp. 502 - 517
Cancer evolution at all stages is driven by both epigenetic abnormalities as well as genetic alterations. Dysregulation of epigenetic control events may lead...
DNA甲基化 | 连接 | 基础生物学 | 蛋白质复合物 | 后生异常 | 表观遗传学 | 染色质重塑 | 临床 | DNA methylation | polycomb proteins | cancer stem cells | biomarkers | Cancer epigenetics | epigenetic therapy | HEPATOCELLULAR-CARCINOMA CELLS | HISTONE DEACETYLASE INHIBITION | TUMOR-SUPPRESSOR GENES | cancer epigenetics | ACUTE MYELOID-LEUKEMIA | DE-NOVO METHYLATION | HUMAN COLORECTAL-CANCER | CELL BIOLOGY | GENOME-WIDE HYPOMETHYLATION | H4 LYSINE-20 TRIMETHYLATION | EMBRYONIC STEM-CELLS | HMLH1 PROMOTER HYPERMETHYLATION | Chromatin - metabolism | DNA Methylation | Neoplasms - therapy | Neoplasms - genetics | Neoplastic Stem Cells - metabolism | Epigenesis, Genetic | Humans | Biomarkers, Tumor - metabolism | Histones - metabolism | Reactive oxygen species | Translation | Data processing | Inflammation | polycomb group proteins | Embryos | Stress | epigenetics | Chromatin remodeling | Molecular modelling | Stem cells | Histones | Evolution | Cancer | Review
DNA甲基化 | 连接 | 基础生物学 | 蛋白质复合物 | 后生异常 | 表观遗传学 | 染色质重塑 | 临床 | DNA methylation | polycomb proteins | cancer stem cells | biomarkers | Cancer epigenetics | epigenetic therapy | HEPATOCELLULAR-CARCINOMA CELLS | HISTONE DEACETYLASE INHIBITION | TUMOR-SUPPRESSOR GENES | cancer epigenetics | ACUTE MYELOID-LEUKEMIA | DE-NOVO METHYLATION | HUMAN COLORECTAL-CANCER | CELL BIOLOGY | GENOME-WIDE HYPOMETHYLATION | H4 LYSINE-20 TRIMETHYLATION | EMBRYONIC STEM-CELLS | HMLH1 PROMOTER HYPERMETHYLATION | Chromatin - metabolism | DNA Methylation | Neoplasms - therapy | Neoplasms - genetics | Neoplastic Stem Cells - metabolism | Epigenesis, Genetic | Humans | Biomarkers, Tumor - metabolism | Histones - metabolism | Reactive oxygen species | Translation | Data processing | Inflammation | polycomb group proteins | Embryos | Stress | epigenetics | Chromatin remodeling | Molecular modelling | Stem cells | Histones | Evolution | Cancer | Review
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DNA methylation and chromatin accessibility profiling of mouse and human fetal germ cells
细胞研究：英文版, ISSN 1001-0602, 2017, Volume 27, Issue 2, pp. 165 - 183
Chromatin remodeling is important for the epigenetic reprogramming of human primordial germ cells. However, the comprehensive chromatin state has not yet been...
DNA甲基化 | 可及性 | 小鼠 | 生殖细胞发育 | 胚胎生殖细胞 | 表观遗传 | 原始生殖细胞 | 染色质重塑 | development | transcription | chromatin | stem cell biology | epigenetics | EARLY EMBRYOS | GENOME | NUCLEOSOME ORGANIZATION | CELL BIOLOGY | PLURIPOTENT STEM-CELLS | SINGLE-CELL | IN-VITRO | GENE | DYNAMICS | MICE | METHYLOME LANDSCAPES | Mammals - genetics | Chromatin - metabolism | Genomic Imprinting | Repetitive Sequences, Nucleic Acid - genetics | Humans | Nucleosomes - metabolism | Male | DNA Methylation - genetics | Promoter Regions, Genetic - genetics | Fetus - cytology | Organ Specificity - genetics | Animals | Mice | Germ Cells - metabolism | Cellular Reprogramming - genetics | Original
DNA甲基化 | 可及性 | 小鼠 | 生殖细胞发育 | 胚胎生殖细胞 | 表观遗传 | 原始生殖细胞 | 染色质重塑 | development | transcription | chromatin | stem cell biology | epigenetics | EARLY EMBRYOS | GENOME | NUCLEOSOME ORGANIZATION | CELL BIOLOGY | PLURIPOTENT STEM-CELLS | SINGLE-CELL | IN-VITRO | GENE | DYNAMICS | MICE | METHYLOME LANDSCAPES | Mammals - genetics | Chromatin - metabolism | Genomic Imprinting | Repetitive Sequences, Nucleic Acid - genetics | Humans | Nucleosomes - metabolism | Male | DNA Methylation - genetics | Promoter Regions, Genetic - genetics | Fetus - cytology | Organ Specificity - genetics | Animals | Mice | Germ Cells - metabolism | Cellular Reprogramming - genetics | Original
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Loading Rights细胞研究：英文版, ISSN 1001-0602, 2015, Volume 25, Issue 7, pp. 837 - 850
The eukaryotic genome is organized into chromatins, the physiological template for DNA-dependent processes including replication, recombination, repair, and...
组蛋白修饰 | DNA损伤 | 脱氧核糖核酸 | 转录调控 | 迁移率 | 介导 | 标志物 | 染色质重塑 | TGFβ1 | γ-H2AX | Transcription | DNA damage | Chromatin-associated proteins | Gata6 | HMGA2 | ATM | CANCER-CELLS | TGF beta 1 | gamma-H2AX | transcription | CHROMATIN | chromatin-associated proteins | LUNG DEVELOPMENT | CELL-CYCLE ARREST | H2AX PHOSPHORYLATION | CELL BIOLOGY | GENERATION SEQUENCING DATA | HMG PROTEINS | HISTONE H1 | GENE-EXPRESSION | ATAXIA-TELANGIECTASIA | Animals | DNA Damage - physiology | DNA Replication - physiology | High Mobility Group Proteins - metabolism | Humans | Cell Cycle Proteins - metabolism | DNA Repair - physiology | Signal Transduction - physiology | Mice | Histones - metabolism | Proteomics - methods | Chromatin Assembly and Disassembly - physiology | Original
组蛋白修饰 | DNA损伤 | 脱氧核糖核酸 | 转录调控 | 迁移率 | 介导 | 标志物 | 染色质重塑 | TGFβ1 | γ-H2AX | Transcription | DNA damage | Chromatin-associated proteins | Gata6 | HMGA2 | ATM | CANCER-CELLS | TGF beta 1 | gamma-H2AX | transcription | CHROMATIN | chromatin-associated proteins | LUNG DEVELOPMENT | CELL-CYCLE ARREST | H2AX PHOSPHORYLATION | CELL BIOLOGY | GENERATION SEQUENCING DATA | HMG PROTEINS | HISTONE H1 | GENE-EXPRESSION | ATAXIA-TELANGIECTASIA | Animals | DNA Damage - physiology | DNA Replication - physiology | High Mobility Group Proteins - metabolism | Humans | Cell Cycle Proteins - metabolism | DNA Repair - physiology | Signal Transduction - physiology | Mice | Histones - metabolism | Proteomics - methods | Chromatin Assembly and Disassembly - physiology | Original
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