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Synthesis (Stuttgart), ISSN 0039-7881, 2016, Volume 48, Issue 8, pp. 1122 - 1130
We describe the hitherto unknown use of N-Boc-protected hydrazine in the Ugi tetrazole reaction to access a library of highly substituted... 
tert butyl 2 [1 (1 benzyl 1h tetrazol 5 yl) 3 methylbutyl]hydrazine 1 carboxylic acid | tert butyl 2 [2 methyl 1 (1 phenethyl 1h tetrazol 5 yl)propyl]hydrazine 1 carboxylic acid | unclassified drug | proton transport | Ugi reaction | Ugi tetrazole reaction | tert butyl 2[1 (1 tert butyl 1h tetrazol 5 yl) 3 phenylpropyl]hydrazine 1 carboxylic acid | hydrazine | drug isolation | electrospray mass spectrometry | isocyanides | benzyl 4 [2 (tert butoxycarbonyl)hydrazino] 4[1 [2 (1h indol 3 yl)ethyl] 1h tetrazol 5 yl]piperidine 1 carboxylic acid | deprotection reaction | tert butyl 2 [1 (1 benzyl 1h tetrazol 5 yl) 3 phenylpropyl]hydrazine 1 carboxylic acid | tert butyl 2 [1 (1 benzyl 1h tetrazol 5 yl) 2 phenylethyl]hydrazine 1 carboxylic acid | tert butyl 2 [2 [1 (1 methoxy 4 methyl 1 oxopentan 2 yl) 1h tetrazol 5 yl]propan 2 yl]hydrazine 1 carboxylic acid | mass spectrometry | tert butyl 2 [1 (1 benzyl 1h tetrazol 5 yl) 2 methylpropyl]hydrazine 1 carboxylic acid | tert butyl 2 [cyclohexyl(1 cyclohexyl 1h tetrazol 5 yl)methyl]hydrazine 1 carboxylic acid | proton nuclear magnetic resonance | hydrazine derivative | drug screening | chemical reaction | supercritical fluid chromatography | tert butyl 2 [1 (1 benzyl 1h tetrazol 5 yl)(cyclohexyl)methyl]hydrazine 1 carboxylic acid | tert butyl 2 [1 (1 phenethyl 1h tetrazol 5 yl)cyclohexyl]hydrazine 1 carboxylic acid | article | carbon nuclear magnetic resonance | To be checked by Faculty | tert butyl 2 [3 methyl 1 (1 phenethyl 1h tetrazol 5 yl)butyl]hydrazine 1 carboxylic acid | one pot synthesis | tetrazoles | tert butyl 2 [1 chloro 2 [1 (4 chlorobenzyl) 1h tetrazol 5 yl]propan 2 yl]hydrazine 1 carboxylic acid | tert butyl 2 [2 [1 (4 chlorobenzyl) 1h tetrazol 5 yl]butan 2 yl]hydrazine 1 carboxylic acid | tert butyl 2 [1 [1 benzyl 4 [1 (4 chlorobenzyl) 1h tetrazol 5 yl]piperidin 4 yl]]hydrazine 1 carboxylic acid | tert butyl 2 [cyclohexyl (1 phenethyl 1h tetrazol 5 yl)methyl]hydrazine 1 carboxylic acid | multicomponent reaction | tert butyl 2 [2 chloro 1 [1 (4 chlorobenzyl) 1h tetrazol 5 yl]ethyl]hydrazine 1 carboxylic acid | paper | 3-COMPONENT REACTION | CHEMISTRY, ORGANIC | ALPHA-AMINO-ACIDS | MULTICOMPONENT REACTIONS | DIASTEREOSELECTIVE SYNTHESIS | CHEMISTRY | DIVERSITY | LEWIS-ACIDS | 4-COMPONENT CONDENSATION | EFFICIENT
Journal Article
Bioorganic & medicinal chemistry, ISSN 0968-0896, 06/2015, Volume 23, Issue 11, pp. 2699 - 2715
[Display omitted] Scaffold diversity is key in the ongoing exercise of discovery of novel bioactive compounds using high throughput screening (HTS). Based on... 
Synthesis | Tetrazol | Parallel | Isocyanide | Ugi | Pictet–Spengler | unclassified drug | n [[(4 chlorophenyl)[1 (2,2 dimethoxyethyl) 1h tetrazole 5 yl]methyl] 2 3,4 dimethoxyphenyl]ethanamine | 8 ethyl 2,3 dimethoxy 8 methyl 6,8,13,13a tetrahydro 5h tetrazolo[1',5' 4,5]pyrazino [2,1 a]isoquinoline | n [2 (1h indol 3 yl)ethyl] 1 [1 (2,2 dimethoxyethyl) 1h tetrazole 5 yl]propan 1 amine | tetracyclic tetrazole scaffold | 1 [1 (2,2 dimethoxyethyl) 1h tetrazole 5 yl] n (3,4 dimethoxyphenethyl)cyclohexanamine | n [[1 (2,2 dimethoxyethyl) 1h tetrazole 5 yl](4 fluorophenyl)methyl] 2 (3,4 dimethoxy phenyl)ethanamine | 8 (4 chlorophenyl) 2,3 dimethoxy 6,8,13,13a tetrahydro 5h tetrazolo[1',5' 4,5]pyrazino [2,1 a]isoquinoline | 8 isopropyl 2,3 dimethoxy 6,8,13,13a tetrahydro 5h tetrazoleo[1',5' 4,5]pyrazino [2,1 a]isoquinoline | 1 [1 (2,2 dimethoxyethyl) 1h tetrazole 5 yl] n (3,4 dimethoxyphenethyl) 2 phenylethanamine | high throughput screening | mass spectrometry | Pictet-Spengler | multicomponent reaction chemistry | 1 [1 (2,2 dimethoxyethyl) 1h tetrazole 5 yl] n (3,4 dimethoxyphenethyl)propan 1 amine | thin layer chromatography | 1 benzyl 4 [1 (2,2 dimethoxyethyl) 1h tetrazole 5 yl] n (3,4 dimethoxy phenethyl)piperidin 4 amine | proton nuclear magnetic resonance | n [2 (1h indol 3 yl)ethyl] 1 benzyl 4 [1 (2,2 dimethoxyethyl) 1h tetrazole 5 yl]piperidin 4 amine | 2,3 dimethoxy 8 phenyl 6,8,13,13a tetrahydro 5h tetrazolo[1',5' 4,5]pyrazino [2,1 a]isoquinoline | 7',12',12b',13' tetrahydro 6'h spiro[cyclohexane 1,4' tetrazolo[1'',5'' 4',5']pyrazino[1',2' 1,2]pyrido[3,4 b]indole] | 1 [1 (2,2 dimethoxyethyl) 1h tetrazole 5 yl] n (3,4 dimethoxyphenethyl) 2 phenylpropan 1 amine | 2,3 dimethoxy 8 phenethyl 6,8,13,13a tetrahydro 5h tetrazoleo[1',5' 4,5]pyrazino [2,1 a]isoquinoline | chemical reaction | supercritical fluid chromatography | tetrazole derivative | n [2 (1h indol 3 yl)ethyl] 1 [1 (2,2 dimethoxyethyl) 1h tetrazole 5 yl]cyclohexanamine | article | carbon nuclear magnetic resonance | n [[1,1' biphenyl] 4 yl[1 (2,2 dimethoxyethyl) 1h tetrazole 5 yl]methyl] 2 (3,4 dimethoxyphenyl)ethanamine | controlled study | 8 (4 fluorophenyl) 2,3 dimethoxy 6,8,13,13a tetrahydro 5h tetrazolo[1',5' 4,5]pyrazino [2,1 a]isoquinoline | 8 benzyl 2,3 dimethoxy 6,8,13,13a tetrahydro 5h tetrazoleo[1',5' 4,5]pyrazino [2,1 a]isoquinoline | 8 ethyl 2,3 dimethoxy 6,8,13,13a tetrahydro 5h tetrazoleo[1',5' 4,5]pyrazino [2,1 a]isoquinoline | 1 [1 (2,2 dimethoxyethyl) 1h tetrazole 5 yl] n (3,4 dimethoxyphenethyl) 2 methylpropan 1 amine | 8 [[1,1' biphenyl] 4 yl] 2,3 dimethoxy 6,8,13,13a tetrahydro 5h tetrazolo[1',5' 4,5]pyrazino [2,1 a]isoquinoline | 1 benzyl 2',3'dimethoxy 5',6',13',13a' tetrahydrospiro[piperidine 4,8' tetrazolo[1',5' 4,5]pyrazino [2,1 a]isoquinoline] | 4 ethyl 4,6,7,12,12b,13 hexahydro tetrazolo[1'',5'' 4',5']pyrazino[1',2' 1,2]pyrido[3,4 b]indole | 2',3'dimethoxy 5',6',13',13a' tetrahydrospiro[cyclohexane 1,8' tetrazolo[1',5' 4,5]pyrazino [2,1 a]isoquinoline] | unindexed drug | pharmacophore | n [[1 (2,2 dimethoxyethyl) 1h tetrazole 5 yl](phenyl)methyl] 2 (3,4 dimethoxy phenyl)ethanamine | 2 [1 (2,2 dimethoxyethyl) 1h tetrazole 5 yl] n (3,4 dimethoxyphenethyl)butan 2 amine | CHEMISTRY, MEDICINAL | ONE-POT | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | PRAZIQUANTEL | LIBRARIES | MULTICOMPONENT REACTIONS | CHEMISTRY | DIVERSITY | EFFICIENT | DERIVATIVES | Models, Molecular | Molecular Structure | Tetrazoles - chemical synthesis | Polycyclic Compounds - chemical synthesis | Drug Discovery | Pictet-spengler
Journal Article
Journal Article
Acta materialia, ISSN 1359-6454, 05/2018, Volume 149, pp. 97 - 107
The ω phase transformation in numerous group IV transition metals plays a key role to change the phase stability and modify mechanical properties, although its... 
{1 1 2}<1 1 1>β | Deformation twinning | ITB-ω phase | {1 1 0}<1 1 0>α | Stress-induced martensitic transformation | Interfacial phase | {1 1 2}<1 1 1> | {1 1 0}<1 1 0> | Mechanics | Engineering Sciences | Mechanics of materials
Journal Article
Letters in Drug Design and Discovery, ISSN 1570-1808, 2016, Volume 13, Issue 1, pp. 64 - 76
A series of 6,7-disubstituted-3-{2-[4-(substituted) piperazin-1-yl]-2-oxoethyl}quinazoline-2,4(1H, 3H)-dione derivatives (7-34) were synthesized and their... 
Cytotoxicity | Sulforhodamine B method | Quinazoline | Anticancer | Quinazoline-2,4(1H,3H)-dione | Piperazine | SUBSTITUTED QUINAZOLINEDIONES | DESIGN | CHEMISTRY, MEDICINAL | AMPA | PROTEIN | piperazine | sulforhodamine B method | ANTICONVULSANT | anticancer | QUINAZOLINE-2,4-DIONE | IN-VITRO | DNA GYRASE | INHIBITORS | TOPOISOMERASE-IV | cytotoxicity | quinazoline-2,4(1H,3H)-dione
Journal Article
Journal Article
Autophagy, ISSN 1554-8627, 05/2015, Volume 11, Issue 5, pp. 740 - 747
BECN1/Beclin 1 is regarded as a critical component in the class III phosphatidylinositol 3-kinase (PtdIns3K) complex to trigger autophagy in mammalian cells.... 
BECN1 | MAP1LC3B/LC3B, microtubule-associated protein 1 light chain 3 β | MAP1LC3/LC3, microtubule-associated protein 1 light chain 3 | BCL2L1/Bcl | PtdIns3K | BECN1, Beclin 1, autophagy related | BafA1, bafilomycin A | BECN1P1/BECN2, Beclin 1, autophagy related, pseudogene 1 | EM, electron microscopy | UVRAG, UV radiation resistance associated | MAP1LC3-II/LC3-II, proteolytically processed and lipid-modified microtubule-associated protein 1 light chain 3 | LC3 | ZFYVE1/DFCP1, zinc finger, FYVE domain containing 1 | GAPDH, glyceraldehyde-3-phosphate dehydrogenase | TALEN, transcription activator-like effector nuclease | GFP, green fluorescent protein | autophagy | SQSTM1/p62, sequestosome 1 | xL, BCL2-like 1 | PtdIns3K, phosphatidylinositol 3-kinase | PIK3R4/VPS15, phosphoinositide-3-kinase, regulatory subunit 4 | TUBB, tubulin, β class I | KO, knockout | MAP1LC3-I/LC3-I, soluble, proteolytically processed microtubule-associated protein 1 light chain 3 | ATG, autophagy related | autophagosome | PIK3C3/VPS34, phosphatidylinositol 3-kinase, catalytic subunit type 3 | Autophagosome | Autophagy | CANCER-CELLS | ATG PROTEINS | COMPLEX | PHOSPHATIDYLINOSITOL 3-KINASE | BECLIN 1-INDEPENDENT AUTOPHAGY | MACROAUTOPHAGY | ARSENIC TRIOXIDE | CELL BIOLOGY | 1 PHOSPHORYLATION | PATHWAY | RUBICON | Beclin-1 | Microtubule-Associated Proteins - metabolism | Humans | Phagosomes - metabolism | Class III Phosphatidylinositol 3-Kinases - metabolism | Molecular Sequence Data | Apoptosis Regulatory Proteins - metabolism | Membrane Proteins - deficiency | Lipids - chemistry | Apoptosis Regulatory Proteins - deficiency | Base Sequence | Phagosomes - ultrastructure | Membrane Proteins - metabolism | HeLa Cells
Journal Article
Redox biology, ISSN 2213-2317, 2015, Volume 4, Issue C, pp. 6 - 13
Journal Article
Journal of Vascular and Interventional Radiology, ISSN 1051-0443, 2012, Volume 23, Issue 11, pp. 1516 - 1521
Abstract Purpose To clarify the configuration change of N -butyl cyanoacrylate (NBCA) polymerization with increasing proportion of ethanol, the properties of a... 
Radiology | NBCA, lipiodol, and ethanol mixture | NLE110 | NLE112 | NLE211 | NLE111 | NLE213 | NLE312 | NLE411 | NLE113 | NLE212 | NLE311 | NLE | NLE413 | NLE313 | NLE412 | NLE at a ratio of 4:1:1 | NLE at a ratio of 4:1:3 | NLE at a ratio of 4:1:2 | NBCA, lipiodol, and ethanol mixture at a ratio of 1:1:1 | NLE at a ratio of 2:1:1 | N-butyl cyanoacrylate | NLE at a ratio of 1:1:3 | NLE at a ratio of 1:1:2 | NLE at a ratio of 2:1:2 | NLE at a ratio of 2:1:3 | NBCA | NBCA mixed with lipiodol at a ratio of 1:1 | NLE at a ratio of 3:1:3 | NLE at a ratio of 3:1:2 | NLE at a ratio of 3:1:1 | SWINE MODEL | ARTERIOVENOUS-MALFORMATIONS | TRANSCATHETER ARTERIAL EMBOLIZATION | POLYMERIZATION TIME | ANEURYSMS | 2-CYANOACRYLATE | PERIPHERAL VASCULAR DISEASE | EXPERIENCE | GUGLIELMI DETACHABLE COILS | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Viscosity | Rheology | Adhesiveness | Ethanol - administration & dosage | Polymerization | Materials Testing | Ethiodized Oil - chemistry | Enbucrilate - chemistry | Feasibility Studies | Ethiodized Oil - administration & dosage | Particle Size | Radiography | Aneurysm - therapy | Carotid Artery Diseases - therapy | Animals | Carotid Artery Diseases - diagnostic imaging | Ethanol - chemistry | Female | Aneurysm - diagnostic imaging | Embolization, Therapeutic - methods | Enbucrilate - administration & dosage | Disease Models, Animal
Journal Article
Nature reviews. Drug discovery, ISSN 1474-1784, 2014, Volume 13, Issue 3, pp. 197 - 216
The nuclear receptors REV-ERB (consisting of REV-ERB alpha and REV-ERB beta) and retinoic acid receptor-related orphan receptors (RORs; consisting of ROR... 
KAPPA-B ACTIVATION | RETINOIC ACID | PERIPHERAL CIRCADIAN CLOCKS | SKELETAL-MUSCLE CELLS | URSOLIC ACID PROMOTES | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | X-RAY-STRUCTURE | GENE-EXPRESSION | ORPHAN RECEPTOR | PHARMACOLOGY & PHARMACY | LIGAND-BINDING DOMAIN | T(H)17 CELL-DIFFERENTIATION | Neoplasms - metabolism | Nuclear Receptor Subfamily 1, Group D, Member 1 - chemistry | Humans | Receptors, Retinoic Acid - chemistry | Nuclear Receptor Subfamily 1, Group D, Member 1 - antagonists & inhibitors | Nuclear Receptor Subfamily 1, Group F, Member 1 - metabolism | Receptors, Cytoplasmic and Nuclear - chemistry | Nuclear Receptor Subfamily 1, Group D, Member 1 - metabolism | Nuclear Receptor Subfamily 1, Group F, Member 1 - chemistry | Atherosclerosis - drug therapy | Diabetes Mellitus - drug therapy | Diabetes Mellitus - metabolism | Receptors, Retinoic Acid - antagonists & inhibitors | Receptors, Retinoic Acid - metabolism | Nuclear Receptor Subfamily 1, Group F, Member 1 - antagonists & inhibitors | Atherosclerosis - metabolism | Neoplasms - drug therapy | Animals | Signal Transduction - drug effects | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Ligands | Signal Transduction - physiology | Drug Delivery Systems - trends | Drug Delivery Systems - methods | Receptors, Cytoplasmic and Nuclear - metabolism | Drug targeting | Cell receptors | Pharmacology, Experimental | Research | Properties
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