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Journal Article
Nuclear Medicine and Biology, ISSN 0969-8051, 2013, Volume 40, Issue 7, pp. 873 - 878
Abstract Introduction Positron emission tomography (PET) with [11 C]verapamil, either in racemic form or in form of the ( R )-enantiomer, has been used to... 
Radiology | P-glycoprotein | Multidrug resistance protein 1 | Positron emission tomography | Breast cancer resistance protein | (R)-[11C]verapamil | Blood–brain barrier | Blood-brain barrier | C]verapamil | (R)- | VITRO | POSITRON-EMISSION-TOMOGRAPHY | SUBSTRATE | CENTRAL-NERVOUS-SYSTEM | (R)-[C-11]verapamil | EPILEPSY | ANTIEPILEPTIC DRUGS | IN-VIVO EVALUATION | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | PET | CANCER RESISTANCE PROTEIN | VERAPAMIL | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Positron-Emission Tomography | Neoplasm Proteins - metabolism | ATP-Binding Cassette Transporters - deficiency | Blood-Brain Barrier - diagnostic imaging | ATP-Binding Cassette Transporters - genetics | Biological Transport | Madin Darby Canine Kidney Cells | ATP-Binding Cassette Transporters - metabolism | ATP-Binding Cassette, Sub-Family B, Member 1 - deficiency | Female | Multidrug Resistance-Associated Proteins - genetics | Neoplasm Proteins - genetics | Gene Knockout Techniques | Blood-Brain Barrier - metabolism | Animals | Multidrug Resistance-Associated Proteins - deficiency | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Dogs | Mice | Neoplasm Proteins - deficiency | Multidrug Resistance-Associated Proteins - metabolism | Verapamil - metabolism | Carbon Radioisotopes | Enantiomers | Index Medicus
Journal Article
European Journal of Nuclear Medicine and Molecular Imaging, ISSN 1619-7070, 1/2012, Volume 39, Issue 1, pp. 149 - 159
One important mechanism for chemoresistance of tumours is overexpression of the adenosine triphosphate-binding cassette transporter P-glycoprotein (Pgp). Pgp... 
P-glycoprotein | [ 11 C]Elacridar | ( R )-[ 11 C]Verapamil | Medicine & Public Health | Orthopedics | Multidrug resistance | Oncology | Nuclear Medicine | Cardiology | Imaging / Radiology | [ 11 C]Tariquidar | Positron emission tomography | c] Verapamil | c]Tariquidar | (R)- | c]Elacridar | TOMOGRAPHY | [C-11]Elacridar | TRANSPORTERS | RADIOTRACER | BLOOD-BRAIN-BARRIER | (R)-[C-11] Verapamil | [C-11]Tariquidar | SUBSTRATE | IN-VIVO | MULTIDRUG-RESISTANCE | INHIBITOR | TARIQUIDAR | XR9576 | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Quinolines | Acridines | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Gene Expression Regulation, Neoplastic | Drug Resistance, Neoplasm | Positron-Emission Tomography - methods | Feasibility Studies | Phenotype | Animals | Breast Neoplasms - genetics | Biological Transport | Breast Neoplasms - pathology | Cell Line, Tumor | Female | Verapamil | Mice | Breast Neoplasms - diagnostic imaging | Tetrahydroisoquinolines | Doxorubicin - pharmacology | Carbon Radioisotopes | Disease Models, Animal | Proteins | Comparative studies | Breast cancer | Gene expression | Nuclear medicine | Adenosine | Animal models | Carcinoma | Chemoresistance | Mammary gland | P-Glycoprotein | Doxorubicin | Western blotting | Tracers | Tumors | [11C]tariquidar | positron emission tomography | [11C]elacridar | (R)-[11C]verapamil
Journal Article
Epilepsia, ISSN 0013-9580, 09/2007, Volume 48, Issue 9, pp. 1774 - 1784
Journal Article
European Journal of Nuclear Medicine and Molecular Imaging, ISSN 1619-7070, 5/2010, Volume 37, Issue 5, pp. 942 - 953
Overactivity of the multidrug efflux transporter P-glycoprotein (P-gp) at the blood-brain barrier (BBB) is believed to play an important role in resistance to... 
P-glycoprotein | Small animal PET | Elacridar | Medicine & Public Health | ( R )-[ 11 C]verapamil | Tariquidar | Orthopedics | Oncology | Blood-brain barrier, regional | Nuclear Medicine | Cardiology | Imaging / Radiology | Blood-brain barrier | C]verapamil | Regional | (R)- | VIVO | METABOLISM | TRACER | MICROPET | (R)-[C-11]verapamil | EPILEPSY | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Tetrahydroisoquinolines - pharmacology | Stereoisomerism | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Rats | Positron-Emission Tomography | Tetrahydroisoquinolines - administration & dosage | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Blood Proteins - metabolism | Quinolines - administration & dosage | Blood-Brain Barrier - drug effects | Rats, Sprague-Dawley | Quinolines - pharmacology | Blood-Brain Barrier - metabolism | Verapamil - chemistry | Dose-Response Relationship, Drug | Gene Expression Regulation - drug effects | Animals | Blood-Brain Barrier - diagnostic imaging | Acridines - pharmacology | Acridines - administration & dosage | Female | Biological Transport - drug effects | Verapamil - metabolism | Carbon Radioisotopes | Brain | Nuclear medicine | Rodents | Tomography | Glycoproteins | Pharmacology | Gene expression | tariquidar | P-glycoprotein, blood-brain barrier, regional | (R)–[11C]verapamil | small animal PET | elacridar
Journal Article
Journal Article
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, ISSN 1619-7070, 01/2008, Volume 35, Issue 1, pp. 116 - 123
Journal Article
Clinical pharmacology and therapeutics, ISSN 0009-9236, 2/2012, Volume 91, Issue 2, pp. 227 - 233
Using positron emission tomography (PET) imaging we assessed in vivo the interaction between a microdose of ( R )-[ 11 C]verapamil, a P-glycoprotein (Pgp)... 
P-glycoprotein | blood-brain barrier | rat | (R)-[11C]verapamil | tariquidar | positron emission tomography | drug-drug interaction | human
Journal Article
Journal Article
Journal of Labelled Compounds and Radiopharmaceuticals, ISSN 0362-4803, 03/2013, Volume 56, Issue 3-4, pp. 68 - 77
Brain penetration of radiopharmaceuticals or therapeutic drugs may be restricted by adenosine triphosphate‐binding cassette (ABC) transporters, such as... 
blood–brain barrier | 11C | multidrug resistance‐associated proteins | breast cancer resistance protein | [11C]‐N‐desmethyl‐loperamide | adenosine‐triphosphate binding cassette (ABC) transporter | (R)‐[11C]verapamil | P‐glycoprotein | positron emission tomography | 18F | blood-brain barrier | P-glycoprotein | C]-N-desmethyl-loperamide | C]verapamil | adenosine-triphosphate binding cassette (ABC) transporter | multidrug resistance-associated proteins | (R)- | CHEMISTRY, ANALYTICAL | LIVING BRAIN | CHEMISTRY, MEDICINAL | TYROSINE KINASE | (R)-[11C]verapamil | BIOCHEMICAL RESEARCH METHODS | [11C]-N-desmethyl-loperamide | POSITRON-EMISSION-TOMOGRAPHY | CYCLOSPORINE-A | bloodbrain barrier | QUANTITATIVE ASSESSMENT | MULTIDRUG-RESISTANCE | IN-VIVO EVALUATION | PRECLINICAL EVALUATION | PET | CANCER RESISTANCE PROTEIN | Tetrahydroisoquinolines - pharmacology | Humans | Tetrahydroisoquinolines - chemical synthesis | Radiopharmaceuticals - chemical synthesis | Verapamil - chemical synthesis | Verapamil - pharmacology | Quinolines - pharmacology | Quinolines - chemical synthesis | Acridines - chemical synthesis | Carbon Radioisotopes - chemistry | Animals | Blood-Brain Barrier - diagnostic imaging | Acridines - pharmacology | Radionuclide Imaging | ATP-Binding Cassette Transporters - metabolism | Isotope Labeling | Radiopharmaceuticals - pharmacology | ATP-Binding Cassette Transporters - antagonists & inhibitors | Drugs | Medical colleges | Loperamide | Brain | PET imaging | Drug resistance | Muscle proteins | Adenosine triphosphate
Journal Article