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FEBS Letters, ISSN 0014-5793, 12/2015, Volume 589, Issue 24, pp. 3760 - 3772
Glial cell line-derived neurotrophic factor (GDNF) and its canonical receptor Ret can signal together or independently to fulfill many important functions in... 
Rearranged during transfection | Parkinson disease | Drug addiction | Mouse model | Dopaminergic system | Glia cell line-derived neurotrophic factor | MAOA/MAOB | orphan nuclear receptor and transcription factor | cytoplasmic SH2 domain containing protein tyrosine phosphatase | Ras | RRF | COMT | PTEN-induced putative kinase 1 | SH3 and multiple ankyrin repeat domains 3, proline-rich synapse-associated protein 2 (ProSAP2) | PI3K | sorting protein-related receptor with A-type repeats, a member of the mammal Vps10p domain receptor | subunits of the Ca2+-sensitive, voltage gated A-type K+ channel | SH2 domain containing transforming protein 1 | Nurr1 | proprotein convertases | protein kinase B, serine/threonine-specific protein kinase | calcium-calmodulin-dependent protein kinase II β isoform | FRS2 | phosphatase and tensin homolog | catecholamine | SHP-2 | growth factor receptor-bound protein 2, 7 and 10, adaptor proteins | fibroblast growth factor receptor substrate 2, adaptor protein | monoamine oxidases A and B | carbonyl cyanide m-chlorophenyl hydrazone | ERK | brain derived neurotrophic factor | deglycase, oxidative stress sensor and redox-sensitive chaperone and protease | VTA | tyrosines, which can be phosphorylated | cAMP | extracellular-signal-regulated kinases, classical MAPKs | CaMKIIβ | Kv4.3 and KChip3 | GRB2/7/10 | Ser/Thr | SNP | endoplasmatic reticulum | nerve growth factor | monoamine, neurotransmitter type including dopamine, epinephrine (adrenaline) and norepinephrine (noradrenaline) | TGF-β | Akt, PKB | phospholipase γ cleaves the phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2) into diacyl glycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) ppp3R1/ppp3CB, calcineurin subunits | PC5A, PC5B, and PC7 | EGR1 | proprotein convertase subtilisin/kexin type 6 | substantia nigra | phosphotyrosine-interaction domain | BDNF | adaptor protein of the PDZ-LIM family | γ-aminobutyric acid, inhibitory neurotransmitter in mammalian central nervous system | Tyr | FosB/ΔFosB | IRS1/2 | LIM | dopamine transporter | enhanced green fluorescent protein | GDNF | DAT | SOS | 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine | retro-rubal field | transforming growth factor β is a secreted protein that controls proliferation and cellular differentiation | MPTP | GTPase | hypoxia-inducible factor-1alpha | GDNF family of ligands | Ret | GPI | Shank3 | NCAM | Enigma | JNK | (rearranged during transfection) canonical GDNF receptor, a receptor tyrosine kinase | PTEN | 6-OHDA | DJ-1 | (rapidly accelerated fibrosarcoma/rat fibrosarcoma) family of serine/threonine-protein kinase | SHC | NF-κB | (acronym combining the first letters of three proteins – post synaptic density protein (PSD95), Drosophila disc large tumor suppressor (Dlg1), and zonula occludens-1 protein (zo-1) that have this common domain) protein interaction domain | phosphotyrosine-binding domains | insulin receptor substrate 1, adaptor protein, contains a PTB and PH domain | Rac1 | GFRα | nuclear factor ‘kappa-light-chain-enhancer’ of activated B-cells, transcription factor family with Rel homology domain (RHD) | catechol-O-methyltransferase | early growth response protein 1, Zif268 (zinc finger protein 225), NGFI-A (nerve growth factor-induced protein A), is a zinc finger transcription factor | serine and threonine, which can be phosphorylated | GDNF family receptor α | PKA | protein kinase A, a family of cAMP-dependent protein kinase | MAPK | NGF | SorLA | ventral tegmental area | son of sevenless, family of guanine nucleotide exchange factors that act on Ras | GABA | HIF-1a | Ras-related C3 botulinum toxin substrate 1 (Rho family), a small GTPase, like CDC42 | GAP1/2 | PTB | (Rat sarcoma) family of small membrane-associated GTPase | cycles between an active GTP-bound and an inactive GDP-bound state | glycogen synthase kinase 3β | Src | glia cell line-derived neurotrophic factor | PACE4, PCSK6 | pleckstrin homology domain | co-repressor for element-1-silencing transcription factor, a chromatin-modifying corepressor complex that acts with REST (repressor for element-1 silencing transcription factor) complex | c-Jun N-terminal kinases, members of the MAPK family of proteins | EGFP | cell division control protein 42 homolog, a plasma membrane-associated small GTPase of the Rho family | (acronym combining the first letters of three proteins – Lin11, Isl-1 and Mec-3 – that have this common domain) protein interaction domain of two contiguous zinc finger domains, separated by a two-amino acid residue hydrophobic linker | CCCP | (sarcoma protein) membrane-associated tyrosine kinase with different Src homology (SH) domains characteristic for all 9 members of the Src family kinases | DOK1/4/5/6 | (Ras homolog) family of small GTPases including Cdc42, Rac1, and RhoA | single-nucleotide polymorphism analysis | VPS10P | Rho | MEN2B | phosphatidylinositol-4,5-bisphosphate 3-kinase | 6-hydroxy-dopamine | mitogen-activated protein kinase, can phosphorylate serine, threonine, and tyrosine, e.g. p38MAPK | Cdc42 | docking proteins, have a PH and SH3 domain | GFLs | PDZ | vacuolar protein sorting 10 protein-domain receptors are type 1 transmembrane proteins | PLCγ | GTPase-activating proteins 1 and 2 | 3′,5′-cyclic adenosine monophosphate | neuronal cell adhesion molecule | TIEG | TGF-β-inducible early-response gene, a zinc finger transcription factor Vav2, adaptor protein and guanine nucleotide exchange factor for the Rho family of Ras-related GTPases | PINK1 | Raf | CoREST | multiple endocrine neoplasia 2 type B, mutation in the kinase domain of the Ret leading to constitutive active receptor | dopaminergic | glycosylphosphatidylinositol | FBJ murine osteosarcoma viral oncogene homolog B, a transcription factor with a truncated Δ form | gsk3β | ENTERIC NERVOUS-SYSTEM | BIOCHEMISTRY & MOLECULAR BIOLOGY | SUBSTANTIA-NIGRA | CELL BIOLOGY | MICE LACKING GDNF | C-RET | BIOPHYSICS | NEUROTROPHIC FACTOR PROMOTES | MULTIPLE ENDOCRINE NEOPLASIA | SURVIVAL IN-VIVO | RECEPTOR TYROSINE KINASE | CELL-LINE | EARLY-ONSET PARKINSONISM | Glial Cell Line-Derived Neurotrophic Factor - physiology | Parkinson Disease - pathology | Animals | Proto-Oncogene Proteins c-ret - physiology | Dopamine - physiology | Mesencephalon - metabolism | Humans | Dopaminergic Neurons - physiology | Parkinson Disease - metabolism | Synaptic Transmission | Mesencephalon - pathology | Physiological aspects | Neurons | Parkinson's disease
Journal Article
Tissue Barriers, ISSN 2168-8362, 04/2015, Volume 3, Issue 1-2, pp. e978720 - e978720
The barrier properties of endothelial cells are critical for the maintenance of water and protein balance between the intravascular and extravascular... 
NO, Nitric oxide | MLC, Myosin light chain | PAF, Platelet activating factor | IL-1β, Interleukin 1 beta | TJ, Tight junctions | MMP, Matrix metalloproteinases | EAE, Experimental autoimmune encephalomyelitis | HMGB-1, High mobility group box 1 | S1P, Sphingosine-1-phosphate | JAM, Junctional adhesion molecules | vascular permeability | MEK, Mitogen-activated protein kinase kinase | VE, Vascular endothelial | GDNF, Glial cell-derived neurotrophic factor | GAG, Glycosaminoglycans | VCAM-1, Vascular cell adhesion molecule 1 | HRAS, Harvey rat sarcoma viral oncogene homolog | cAMP, 3'-5'-cyclic adenosine monophosphate | SOCS-3, Suppressors of cytokine signaling 3 | platelets | Rap1, Ras-related protein 1 | GPCR, G-protein coupled receptors | AJ, Adherens junctions | PDE, Phosphodiesterase | Src, Sarcoma family of protein kinases | BBB, blood brain barrier | GJ, Gap junctions | FA, Focal adhesions | SCID, Severe combined immunodeficient | AQP, Aquaporins | PKA, Protein kinase A | erythrocytes | TEER, Transendothelial electrical resistance | MLCK, Myosin light-chain kinase | VVO, Vesiculo-vacuolar organelle | ANG-1, Angiopoietin 1 | EPAC1, Exchange protein activated by cyclic AMP | leukocytes | RhoA, Ras homolog gene family, member A | ERK1/2, Extracellular signal-regulated kinases 1 and 2 | Shp-2, Src homology 2 domain-containing phosphatase 2 | CNS, Central nervous system | GTPase, Guanosine 5'-triphosphatase | FoxO1, Forkhead box O1 | OSM, Oncostatin M | FAK, focal adhesion tyrosine kinase | Rac1, Ras-related C3 botulinum toxin substrate 1 | ZO, Zonula occludens | TNF-, Tumor necrosis factor alpha | pSrc, Phosphorylated Src | TGF-beta1, Transforming growth factor-beta1 | COPD, Chronic obstructive pulmonary disease | ICAM-1, Intercellular adhesion molecule 1 | VEGF, Vascular endothelial growth factor | PNA, Platelet-neutrophil aggregates | Endothelial barrier | VE-PTP, Vascular endothelial receptor protein tyrosine phosphatase | ROS, Reactive oxygen species | IP3, Inositol 1,4,5-triphosphate | Leukocytes | Platelets | Vascular permeability | Erythrocytes
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/1997, Volume 94, Issue 7, pp. 3028 - 3033
Journal Article
International Journal of Cancer, ISSN 0020-7136, 09/1991, Volume 49, Issue 3, pp. 471 - 479
Ras oncogenes encode 21‐kDa (p21s) GTP binding proteins that are capable of transforming immortalized cells in culture. The ras‐related rap 1A/Krev‐1/smgp21A... 
RAS-P21 GTPASE | TRANSFORMATION | CELLS | SARCOMA-VIRUS | DOMAIN | ONCOLOGY | GTPASE-ACTIVATING PROTEIN | BINDING PROTEIN | IDENTIFICATION | GENE-PRODUCT | P21 | Cell Division - genetics | Phenotype | Animals | Transfection | Base Sequence | Gene Products, vpr - genetics | Molecular Sequence Data | Rats | Gene Products, vpr - metabolism | Genes, ras | Mutation - genetics | Cell Line, Transformed
Journal Article
Journal Article
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