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03/2012
Epithelial polarity is established by polarity proteins and maintained by polarized trafficking through intricate interdependent mechanisms. In the Drosophila... 
0379
Dissertation
06/2014
Chlamydia trachomatis is the leading cause of bacterial sexually transmitted infections worldwide and it has been linked to increased risks of cervical cancer.... 
0379 | Chlamydia | cytokinesis
Dissertation
06/2014
The Corticotropin Releasing Factor (CRF) peptides are an evolutionarily conserved peptide family integral to the stress response. In 2002, an investigation was... 
0379 | Stress | Endocrinology
Dissertation
03/2014
This thesis explores the unequal partitioning of damaged proteins during mitosis and its implications for cell fate. Initially described in unicellular... 
0379 | Mitosis | Stem cell
Dissertation
11/2013
Colorectal cancer (CRC) is the third leading cause of death from cancer in North America. The KRAS gene is mutated in approximately 40-50% of all CRC, and this... 
0379 | c-MET | KRAS
Dissertation
11/2013
Neutrophils, key cells of the innate immune system, are responsible for preventing bacterial infections. They are rapidly recruited to sites of infection where... 
0379 | neutrophils | gene expression
Dissertation
06/2010
We investigated the capacity of human umbilical cord perivascular cells (HUCPVCs) to repair tendon damage in a collagenase tendon injury model in rats. Our... 
0379 | 0564
Dissertation
06/2014
HIV is a predominantly sexually transmitted infection that has infected over 60 million people and been responsible for 60 million deaths. To date,... 
0379 | HIV | T cells | Circumcision
Dissertation
11/2012
Legionella pneumophila (Lp) is the pathogen responsible for Legionnaires disease. Lp invades and survives in human macrophages to form an intracellular... 
0379 | 0410 | Legionella | Macrophages
Dissertation
11/2012
Recently, we demonstrated that the anti-bacterial agent tigecycline preferentially induces death in leukemia cells through the inhibition of mitochondrial... 
0379 | mitochondria | metabolism
Dissertation
11/2012
Osteoclasts are multinucleated, bone resorbing cells that carry out their function using specialized actin-based structures called actin rings and podosomes.... 
Rho GTPases | 0379 | osteoclast
Dissertation
03/2014
Large intergenic RNAs (lincRNA) are involved in numerous cellular processes, including many relevant to normal development and cancer progression. In my... 
0379 | 0992 | 0564 | Glioblastoma | lincRNAs
Dissertation
06/2009
Retroviral infection requires an initial interaction between the host cell and the virion. This interaction is predominantly mediated by an envelope (env)... 
0379 | 0720
Dissertation
06/2012
Mutations in the chloride-proton antiporter, ClC-5, cause Dent’s disease, a kidney disease defined by excessive loss of proteins in the urine. ClC-5 resides on... 
ClC-5 | Dent's Disease | 0379
Dissertation
11/2013
The role of antioxidants in cancer has been controversial for a long time. Although the public’s belief is that antioxidants prevent and/or inhibit cancer,... 
antioxidant | 0379 | 0760 | cancer | 0307
Dissertation
11/2013
Integral membrane proteins are targeted to discrete compartments through the action of a number of transport pathways. The post-translational modification of... 
RNF126 | 0379 | Rabring7 | trafficking | ubiquitin
Dissertation
03/2012
Hsp104 is a protein remodeling factor that is crucially important for induced thermotolerance and prion propagation in yeast. Recent work demonstrates that... 
0379 | Hsp104 | Sup35
Dissertation
03/2012
The presence of microglia at sites of CNS injury can potentially shift the balance between neuronal survival and death; however, the mechanisms regulating... 
podosomes | 0379 | SK3 | Microglia
Dissertation
11/2011
The pediatric sarcoma alveolar rhabdomyosarcoma (ARMS) is highly aggressive with a poor prognosis for diagnosed patients. Here, we demonstrate that targeting... 
0379 | 0992 | 0307
Dissertation
11/2011
In a previous study, three determinants of fitness were identified as mutant alleles (each designated "e") that arose in yeast populations propagated in... 
0379 | epistasis | yeast | 0306
Dissertation
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