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06/2014
The non-cluster homeobox gene TLX1 was initially identified at the breakpoint of the t(10;14)(q24;q11) chromosome translocation in the malignant cells. Three... 
cell biology | genetics | 0379 | Leukemia | immunology
Dissertation
06/2014
The Corticotropin Releasing Factor (CRF) peptides are an evolutionarily conserved peptide family integral to the stress response. In 2002, an investigation was... 
0379 | Stress | Endocrinology
Dissertation
06/2014
The Rho family small GTPases are key regulators of the cytoskeleton, through which they impact and control many vital cellular functions, including growth,... 
Tumour Necrosis Factor-alpha (TNF) | Rho GTPases | 0379 | Hyperosmotic stress | GEF-H1 | 0307 | Cytoskeletal remodelling | Guanine Nucleotide Exchange Factors
Dissertation
06/2014
HIV is a predominantly sexually transmitted infection that has infected over 60 million people and been responsible for 60 million deaths. To date,... 
0379 | HIV | T cells | Circumcision
Dissertation
06/2014
The HECT E3 ubiquitin ligase Nedd4-1 was previously shown to regulate diverse processes such as cell and animal growth, insulin signaling, and lysosomal... 
0379 | Ubiquitin ligase | Angiomotin | Nedd4 | biochemistry
Dissertation
06/2014
Chlamydia trachomatis is the leading cause of bacterial sexually transmitted infections worldwide and it has been linked to increased risks of cervical cancer.... 
0379 | Chlamydia | cytokinesis
Dissertation
03/2014
Large intergenic RNAs (lincRNA) are involved in numerous cellular processes, including many relevant to normal development and cancer progression. In my... 
0379 | 0992 | 0564 | Glioblastoma | lincRNAs
Dissertation
03/2014
This thesis explores the unequal partitioning of damaged proteins during mitosis and its implications for cell fate. Initially described in unicellular... 
0379 | Mitosis | Stem cell
Dissertation
03/2014
Cystic Fibrosis (CF) is a life-threatening autosomal recessive disease affecting 1:3600 children born in Canada. CF is caused by mutations in the Cystic... 
0379 | Cystic Fibrosis | 0719 | 0419 | phosphorylation | CFTR
Dissertation
03/2014
Tie-2 expressing monocytes (TEMs) were identified to be a subset of monocytes that was potent inducer of tumor angiogenesis in various types of cancer. On the... 
Angiogenesis | Monocytes | 0379 | Tie-2 | Angiopoietins | Inflammation | Signalling | 0307
Dissertation
11/2013
The tumour-associated stroma, consisting of fibroblasts, inflammatory cells, vasculature and extracellular matrix proteins, plays a critical role in tumour... 
cell motility | cancer-associated fibroblast | microvesicle | Wnt signalling | 0379 | PCP signalling | breast cancer | tumour microenvironment | 0307 | exosome
Dissertation
11/2013
Neutrophils, key cells of the innate immune system, are responsible for preventing bacterial infections. They are rapidly recruited to sites of infection where... 
0379 | neutrophils | gene expression
Dissertation
11/2013
Current therapy for chronic kidney disease (CKD) is limited; however, recent studies have shown that a subpopulation of cells derived from the bone marrow,... 
conditioned medium | chronic kidney disease | 0379 | 0564 | modular tissue engineering | early outgrowth cells
Dissertation
11/2013
Colorectal cancer (CRC) is the third leading cause of death from cancer in North America. The KRAS gene is mutated in approximately 40-50% of all CRC, and this... 
0379 | c-MET | KRAS
Dissertation
11/2013
In addition to the well-characterized Induced Pluripotent Stem cells (iPSCs) that closely resemble Embryonic Stem cells (ESCs), a recent study has proven the... 
0369 | miR-214 | MicroRNA | Reprogramming | 0379 | iPSC | miRNA | Induced Pluripotent Stem Cell | 0307
Dissertation
11/2013
Somatic cells can be reprogrammed to induced pluripotent stem (iPS) cells by expression of defined embryonic factors. My thesis is focused on exploring the... 
reprogramming | 0369 | 0379 | stem cell | 0307
Dissertation
11/2013
The role of antioxidants in cancer has been controversial for a long time. Although the public’s belief is that antioxidants prevent and/or inhibit cancer,... 
antioxidant | 0379 | 0760 | cancer | 0307
Dissertation
11/2013
The toxic metal ion cadmium (Cd2+) is pro-oxidant and specifically disrupts the actin cytoskeleton in renal mesangial cells. This study investigated the role... 
actin cytoskeleton | 0379 | focal adhesions | glutathionylation | CaMK-II | ROS | 0383 | cadmium toxicology
Dissertation
11/2013
G-protein coupled receptors (GPCRs) have been shown to interact with an array of accessory proteins that modulate their function. I hypothesize that the... 
Protein Interactions | 0379 | 0410 | GLP-1 Receptor
Dissertation
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