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ets (2) 2
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11/2011
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that mediates the effects of aromatic hydrocarbons, such as... 
0383 | 0419
Dissertation
11/2011
Oxidative stress and reactive oxygen species (ROS) such as hydrogen peroxide (H2O2), which is detoxified by catalase, are implicated in fetal death and birth... 
Catalase | embryonic development | 0383
Dissertation
11/2008
Drug induced idiosyncratic agranulocytosis has been attributed to oxidation by hypochlorite formed by bone marrow myeloperoxidase (MPO). Idiosyncratic liver... 
Inflammation, Oxidative Stress, Hepatocytes | 0383
Dissertation
11/2008
Hepatotoxicity is a serious adverse health effect caused by drugs and other chemical toxins generally detected in the later stages of drug development or in... 
QSAR | hepatotoxicity | 0383 | xenobiotic metabolism
Dissertation
06/2014
Methylmercury (MeHg) is an environmental toxin to which we are exposed through the consumption of seafood. Reactive oxygen species (ROS) have been implicated... 
Reactive Oxygen Species | DNA Repair | Methylmercury | Neurodevelopment | 0383 | 0419
Dissertation
11/2010
Identification of maternal opioid abuse in pregnancy is often difficult to ascertain in the absence of reliable self report. For this reason, physicians and... 
Drug | Opiate | Hair | Prenatal | 0383 | 0419
Dissertation
06/2010
High chronic fructose consumption is linked to a nonalcoholic steatohepatitis (NASH) type of hepatotoxicity. Oxalate is the major endpoint of fructose... 
0383 | Hyperoxaluria | Fructose | Hepatocyte toxicity | Nonalcoholic Steatohepatitis
Dissertation
by Zhu, Xu
11/2012
Clinical characteristics of idiosyncratic drug reactions (IDRs) suggest that they are immune mediated. Penicillamine-induced autoimmunity in Brown Norway rats... 
adverse drug reactions | 0383 | T helper 17 cells
Dissertation
11/2011
Recent epidemiological evidence suggests that many chronic health disorders in the developed world are associated with endogenous toxins formed from the... 
Oxidative stress | 0383 | Isolated rat hepatocytes | B vitamins
Dissertation
11/2011
High chronic fructose consumption has been linked to many diseases. Sugar metabolites, especially glyoxal and methylglyoxal can form advanced glycation... 
Protein carbonylation | Oxidative Stress | Dicarbonyls | 0383 | AGEs | 0491 | Diabetes | Fructose
Dissertation
03/2008
Dioxins are environmental contaminants that raise concern because they are potent and persistent. The most potent dioxin congener,... 
expression array | Dioxin | 0383 | aryl hydrocarbon receptor
Dissertation
11/2010
An animal model of nevirapine (NVP)-induced skin rash was used to test the hypothesis that sulfonation of 12-OH NVP, a metabolite of NVP proven essential for... 
nevirapine | adverse drug reactions | drug metabolism | 0383 | idiosyncratic drug reactions
Dissertation
11/2013
The toxic metal ion cadmium (Cd2+) is pro-oxidant and specifically disrupts the actin cytoskeleton in renal mesangial cells. This study investigated the role... 
actin cytoskeleton | 0379 | focal adhesions | glutathionylation | CaMK-II | ROS | 0383 | cadmium toxicology
Dissertation
11/2013
There is a strong association between estrogen exposure and breast cancer risk. Estrogen can activate estrogen receptor alpha (ERalpha) to increase cell... 
Aryl Hydrocarbon Receptor | Estrogen Receptor | Nuclear Factor Erythroid-2 Like 2 | 0383
Dissertation
06/2010
Gestational diabetes, a common medical complication in pregnancy, may lead to severe fetal consequences if left untreated. A major concern with the use of... 
insulin glargine | placental transport | glyburide | gestational diabetes | 0383 | 0419
Dissertation
03/2010
Nausea and vomiting of pregnancy (NVP) is the most common medical condition in pregnancy, and, unfortunately, variability exists among pregnant women in the... 
nausea and vomiting of pregnancy | pregnancy | 0383 | 0419
Dissertation
06/2013
There is a growing need to develop rapid and cost-effective ecotoxicological tools for risk assessment because traditional methods examine endpoints such as... 
Ecotoxicology | 0486 | 0487 | Metabolic Profiling | 0383 | PAHs | PFOA | Earthworms | Environmental Chemistry | PFOS | Soil contamination
Dissertation
06/2013
We previously observed that postnatal exposure of mice to the procarcinogen 4-aminobiphenyl (ABP) produced liver tumors only in wild-type males, while... 
0433 | Aromatic amines | Diethylnitrosamine | 4-aminobiphenyl | 0383 | Hepatocellular carcinoma | Inflammation | 0419 | 0307 | Carcinogenesis | Hepatotoxicity
Dissertation
11/2009
Mercury is an environmental contaminant of global concern. The distribution of mercury in freshwater systems is poorly characterized in Mexico, despite... 
0425 | wetland | mercury | effluents | 0383 | Mexico | fisheries | 0768
Dissertation
03/2012
Human epithelium-specific ETS transcription factor-1 (ESE-1), which is also known as E74-like factor-3 (Elf3) in mice, is strongly expressed in lung during... 
transcription factor | airway epithelial regeneration | ETS | ESE-1 | 0383 | 0571 | 0719 | airway epithelial injury
Dissertation
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