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1. The Clinical Spectrum of Adults with Tetralogy of Fallot: Cardiac and Extra-cardiac Features and Late Outcomes
by Piran, Sara
11/2010
Tetralogy of Fallot (TOF) is a form of complex congenital heart disease (CHD) with clinical and genetic heterogeneity. Of the few known causes, 22q11.2... 
0564
Dissertation
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2. Complications following Total Joint Arthroplasty in Patients with Rheumatoid Arthritis
by Ravi, Bheeshma
11/2013
Background: Total joint arthroplasty (TJA) is indicated in persons with end-stage arthritis of the hip and knee (THA and TKA, respectively). While most TJAs... 
0766 | 0564
Dissertation
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3. Insulin Promotes Elastin Production in Cultures of Human Aortic Smooth Muscle Cells and Skin Fibroblasts
by Shi, Junyan Jr
03/2011
Elastic fibers are major components of ECM, providing tissues with resilience and elastic recoil. They consist of the insoluble elastin made of cross-linked... 
0564 | Elastin
Dissertation
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4. Umbilical Cord Perivascular Cells: A Mesenchymal Cell Source for Treatment of Tendon and Ligament Injuries
by Emrani, Hamideh
06/2010
We investigated the capacity of human umbilical cord perivascular cells (HUCPVCs) to repair tendon damage in a collagenase tendon injury model in rats. Our... 
0379 | 0564
Dissertation
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5. Long-term Outcomes of Operatively and Non-operatively Treated Spina Bifida Scoliosis
by Khoshbin, Amir
03/2014
Background The purpose of this study was to evaluate outcomes in Spina Bifida Cystica adults, treated non-operatively or operatively for scoliosis during... 
Scoliosis | 0564 | Spina Bifida
Dissertation
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6. Developing and Validating Prognostic Scores for Patients with Acute Intracerebral Hemorrhage
by Huynh, Thien
11/2013
Objective: To develop a score for hematoma expansion prediction, identify predictors of outcome, and validated existing prognostic scores in acute... 
Stroke | Computer Tomography | 0564
Dissertation
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7. Early Versus Delayed Cholecystectomy for Acute Calculous Cholecystitis
by de Mestral, Charles William Armand
11/2013
Introduction: Despite evidence in favour of cholecystectomy early during first presenting admission for most patients with acute calculous cholecystitis,... 
acute cholecystitis | cholecystectomy | 0564
Dissertation
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8. Studies on Angiotensin Converting Enzyme 2, Angiotensin-(1-7), and p47phox-Dependent NADPH Oxidase and their Roles in Diabetic Nephropathy
by Liu, George
11/2012
Diabetic nephropathy is the leading cause of end-stage renal disease, yet the mechanisms responsible for hyperglycemia-induced kidney injury have not been... 
0564 | Diabetic nephropathy | Diabetes
Dissertation
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9. Predicting the Risk of Traumatic Lumbar Punctures in Children with Acute Lymphoblastic Leukemia: a Retrospective Cohort Study using Repeated-measures Analyses
by Shaikh, Furqan
11/2012
Traumatic lumbar punctures (TLPs) in children with acute lymphoblastic leukemia are associated with a poorer prognosis. The objective of this study was to... 
leukemia | 0564 | lumbar punctures
Dissertation
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10. Childhood Fracture Begets Childhood Fracture: A Population-based Study of Longitudinal Fracture Patterns in Ontario Children
by Escott, Benjamin
11/2012
Objectives: The objectives of this study were two-fold: (1) to describe the epidemiology of childhood fractures in Ontario; (2) to determine if having a... 
0766 | 0564 | fracture | pediatric
Dissertation
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11. Urinary Composition and Stone Formation
by Shafiee, Mohammad Ali Jr
11/2012
Background: Kidney stone disease is a common and often debilitating disorder, yet its pathophysiology is poorly understood. This dissertation studies... 
Nephrology | Medical Science | 0564
Dissertation
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12. Host Pathogen Interactions in Malaria and Tuberculosis: Experimental Models and Translation to Novel Adjunctive Therapies
by Hawkes, Michael
06/2012
Malaria and tuberculosis together account for more than 2 million deaths worldwide each year. The present body of work examines interactions between these... 
0564 | tuberculosis | malaria
Dissertation
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13. Proteomics of Thyroid Carcinoma: Detection of Potential Biomarkers of Aggressive and Non-aggressive Subtypes
by Kashat, Lawrence
03/2012
In search of thyroid carcinoma biomarkers, proteins secreted by thyroid cancer cell lines, papillary-derived TPC-1 and anaplastic-derived CAL62, were analyzed... 
0564 | Oncology | Thyroid
Dissertation
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14. Mechanism(s) of Action of the Novel Immunoregulatory Molecule, CD200
by Yu, Kai
11/2011
Both CD200 and its receptor(s), CD200R(s), are type I membrane glycoproteins belonging to the immunoglobulin (Ig) supergene family. CD200:CD200R(s) interaction... 
0982 | 0564 | immunotolerance | CD200
Dissertation
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15. Discovery of a VEGF-A Responsive lincRNA in Human Endothelial Cells with Disease Relevance and Anti-angiogenic Therapeutic Potential in Glioblastoma Multiforme
by Wang, Jenny Jing
03/2014
Large intergenic RNAs (lincRNA) are involved in numerous cellular processes, including many relevant to normal development and cancer progression. In my... 
0379 | 0992 | 0564 | Glioblastoma | lincRNAs
Dissertation
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16. Perceptions of Plastic Surgeons, Orthodontists, and Laypersons to Altered Facial Balance
by Marcy, Sean
11/2010
Objective: To quantify the acceptability of facial asymmetry to plastic surgeons, orthodontists and the lay population. Methods: Facial images were animated... 
Facial Asymmetry | 0564 | Perception
Dissertation
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17. Partial Nephrectomy for the Treatment of Renal Cell Carcinoma and the Risk of End Stage Renal Disease
by Yap, Stanley
11/2013
The surgical management of renal masses involves either radical nephrectomy (RN) or partial nephrectomy (PN). The relationship between treatment choice and... 
dialysis | kidney | 0564 | cancer | surgery
Dissertation
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18. Phenotypic Characterization of Alveolar Macrophages in a Murine Model of Hemorrhagic Shock Induced Acute Respiratory Distress Syndrome
by Dana, Safavian
11/2013
Acute Respiratory Distress Syndrome is a late cause of morbidity and mortality following hemorrhagic shock and resuscitation. Previous work in our laboratory... 
0564 | Macrophage Phenotype | Hemorrhagic Shock
Dissertation
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19. Source and Carrier Effect on the Bioactivity of BMP Bio-implants
by Di Lullo, Sylvie
11/2013
Bone morphogenetic protein-2 (BMP-2) plays a critical role in bone formation. The aim of this study was to compare the activity of the mammalian cell BMP-2 to... 
0567 | BMP | Bio-Implants | 0564
Dissertation
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20. Integration of Tissue-engineered Cartilage – An In Vitro Model
by Theodoropoulos, John
11/2012
The ability of articular cartilage to self-repair after injury is limited due to the nature of the tissue. Biological repair is a promising treatment for... 
tissue engineering | chondrocytes | 0564 | transplantation
Dissertation
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