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11/2013
Inflammatory bowel disease (IBD) is a composite classification for a range of gastrointestinal disorders. The two most common forms of IBD are Crohn’s disease... 
0369 | Transcriptome | IBD | 0715
Dissertation
11/2011
Short linear motifs (SLM) play critical roles in cell signaling and are associated with important biochemical events such as phosphorylation, glycosylation,... 
cdk1 | phosphorylation | 0715 | 0306
Dissertation
11/2010
This thesis explores chromatin modification (CM) as a biological system and uses known CM factors in four model organisms; yeast, worm, fly, and human to... 
Evolution | 0715 | Chromatin modification
Dissertation
06/2008
Bioinformatic methods were applied to address biological questions. Two new eFP browser web tools were constructed for the intuitive visualization of data from... 
Bioinformatics | 0715
Dissertation
11/2010
Plasma membrane (PM) proteins are at the interface between the cell and the external environment and are therefore the most accessible to therapeutic drugs. I... 
Cardiovascular | Proteomics | 0719 | 0715
Dissertation
03/2013
Global quantitative analysis of genetic interactions provides a powerful approach for deciphering the roles of genes and mapping functional relationships... 
0369 | networks | genetic interactions | 0715 | yeast
Dissertation
11/2012
Over the past two decades, high-throughput (HTP) technologies such as microarrays and mass spectrometry have fundamentally changed the landscape of aging and... 
biomarkers | bioinformatics | genomics | aging | 0715
Dissertation
06/2012
Protein phosphorylation is a prevalent reversible post-translational modification that influences protein functions. The advent of phospho-proteomic... 
Signal transduction | Phosphoproteomics | Evolution | 0307 | 0715
Dissertation
03/2012
Anthracycline- and taxane-based regimens have been the mainstay in treating breast cancer patients using chemotherapy. Yet, the genetic make-up of patients and... 
0564 | Breast cancer | 0419 | 0307 | 0715 | Pharmacogenomics
Dissertation
2010, Biographie Payot, ISBN 2228905674, 430 p., [4] p. of plates
Book
06/2011
The shikimate pathway links carbohydrate metabolism to the biosynthesis of the aromatic amino acids and an enormous variety of aromatic compounds with... 
shikimate kinase | gene duplication | 0307 | 0715
Dissertation
06/2011
The currently known network of human protein-protein interactions (PPIs) is providing new insights into diseases and helping to identify potential therapies.... 
data mining | 0715 | protein-protein interactions
Dissertation
11/2013
The past few decades have witnessed an array of advances in DNA science including the introduction of genomics and bioinformatics. The quest for complete... 
Chromatin | Genomics | Archaea | Drug resistance | 0307 | 0715 | Chemical Genomics
Dissertation
11/2013
Many protein-protein interactions, especially those involved in eukaryotic signalling, are mediated by PDZ domains through the recognition of hydrophobic... 
PDZ domains | machine learning | 0715 | interaction prediction | protein-protein interactions
Dissertation
11/2013
Cancer is a complex and deadly disease that is caused by genetic lesions in somatic cells. Further research in computational methodology for detecting and... 
Machine learning | Cancer heterogeneity | 0715 | Single nucleotide variant
Dissertation
11/2012
Post-transcriptional regulation is carried out by RNA-binding proteins (RBPs) that bind to specific RNA molecules and control their processing, localization,... 
0984 | Computer Science | Computational Biology | Machine Learning | 0715
Dissertation
11/2012
Pulmonary metastasis is the most frequent cause of osteosarcoma (OS) mortality. The aim of this study was to discover and characterize genetic networks... 
0369 | metastasis | network analysis | 0307 | 0715 | osteosarcoma
Dissertation
11/2012
This work focuses on the use of network graph theory in biological networks. I explore how network graph theory informs our understanding of biological... 
systems biology | 0487 | cancer | network biology | 0307 | 0715
Dissertation
06/2012
DNA copy number variations (CNVs), which involve the deletion or duplication of subchromosomal segments of the genome, have become a focus of genetics... 
Bayesian HMM | DNA copy number | SNP array | 0308 | 0715
Dissertation
03/2012
Medicago sativa (Alfalfa) is an important agricultural plant for animal forage and nitrogen fixation, and has potential value in ligno-cellulosic energy... 
0369 | Bioinformatic | 0715 | Genomic | Reduced Representation Library
Dissertation
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